A white colonial church with ornate architecture and a large wooden door.

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Check prices for these dates

This weekend
6 Nov - 8 Nov
Next weekend
13 Nov - 15 Nov

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Our top choices for Santa Ana hotels

A two-story building with yellow walls, a balcony with purple flowers, and multiple windows with metal bars.

1. Villas Santa Ana-Ricardo

Villas Santa Ana-Ricardo
3.5 star property
Santa Ana
9.0 out of 10, Wonderful, (17 reviews)
"Beautiful place to stay at!"
United States
Nery
The price is ฿3,800
฿4,636 total
includes taxes & fees
8 Nov - 9 Nov
Villas Santa Ana-Ricardo
A spacious indoor area with a staircase, a red sofa, and various potted plants.

2. Castillo De Los Gigantes

Castillo De Los Gigantes
2.0 star property
Santa Ana
8.0 out of 10, Very good, (2 reviews)
"This property should be listed on Airbnb, it is not a hostel/hotel, it's more like a spare room in someone's home. There's nothing nearby. It was a saviour during semana santa, but otherwise not a particularly good place to stay. That being said the people were lovely, and the room was decent for the price."
American Samoa
Ella
The price is ฿448
฿546 total
includes taxes & fees
5 Nov - 6 Nov
Castillo De Los Gigantes
A spacious courtyard with red chairs and tables, surrounded by lush greenery and potted plants.

3. El Carmen Hotel

El Carmen Hotel
3.0 star property
Historic Center, 1.3 km from Santa Ana
9.0 out of 10, Wonderful, (960 reviews)
"The breakfast and staff are incredible! Great location!"
United States
Jennifer
The price is ฿3,709
฿4,525 total
includes taxes & fees
1 Dec - 2 Dec
El Carmen Hotel
A garden pathway leading to a building with a green lawn and a clear blue sky.

4. Hotel Soleil La Antigua

Hotel Soleil La Antigua
4.0 star property
1.8 km from Santa Ana
8.8 out of 10, Excellent, (1,000 reviews)
"Good place to stay"
United States
Michael
The price is ฿4,146
฿5,058 total
includes taxes & fees
1 Dec - 2 Dec
Hotel Soleil La Antigua
A courtyard with a tiled roof, a building with a dome, and a mountain in the background.

5. Hotel Camino Real Antigua

Hotel Camino Real Antigua
4.0 star property
Historic Center, 1.4 km from Santa Ana
9.6 out of 10, Exceptional, (1,000 reviews)
"Fabulous food, wonderful spa!!"
United States
Elizabeth
The price is ฿6,912
฿9,275 total
includes taxes & fees
8 Nov - 9 Nov
Hotel Camino Real Antigua
A stone-walled corridor with steps leading to a wooden door, surrounded by lush greenery and potted plants.

6. Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo
4.5 star property
Barrio de La Concepción, 1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1,191 reviews)
"Great stay. Spa is amazing"
United States
Julio
The price is ฿11,736
฿14,729 total
includes taxes & fees
9 Nov - 10 Nov
Hotel Museo Spa Casa Santo Domingo
A restaurant with a brick wall, wine racks, and tables set for dining.

7. Los Pasos Boutique Hotel & Spa

Los Pasos Boutique Hotel & Spa
4.5 star property
0.7 km from Santa Ana
9.4 out of 10, Exceptional, (1,000 reviews)
"Nice hotel friendly staff and helpful"
United States
Hilda
The price is ฿5,426
฿6,823 total
includes taxes & fees
16 Nov - 17 Nov
Los Pasos Boutique Hotel & Spa
A covered outdoor seating area with wicker furniture and hanging lights.

8. Ciel-Luxe Hotels

Ciel-Luxe Hotels
3.5 star property
Historic Center, 1.4 km from Santa Ana
8.8 out of 10, Excellent, (473 reviews)
"I had a great stay at Ciel Luxe Hotel! The room was clean and comfortable, the staff was friendly, and the location was convenient. I’d definitely stay here again!"
United States
Corey
The price is ฿2,860
฿3,489 total
includes taxes & fees
12 Nov - 13 Nov
Ciel-Luxe Hotels
A corridor with arches, tiled flooring, and potted plants.

9. Hotel Las Farolas

Hotel Las Farolas
3.5 star property
1.2 km from Santa Ana
9.2 out of 10, Wonderful, (811 reviews)
"Very nice hotel!"
United States
Katie
The price is ฿4,552
฿5,553 total
includes taxes & fees
12 Nov - 13 Nov
Hotel Las Farolas
A stone pathway leading to a central fountain, flanked by walls adorned with framed artwork.

10. Porta Hotel Antigua

Porta Hotel Antigua
4.5 star property
1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1,001 reviews)
"Very nice property, location was great and amenities were excellent."
United States
Oscar
The price is ฿6,551
฿7,992 total
includes taxes & fees
9 Nov - 10 Nov
Porta Hotel Antigua
A covered outdoor area with stone flooring, potted plants, and a wooden pergola.

11. San Rafael Hotel

San Rafael Hotel
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.8 out of 10, Exceptional, (501 reviews)
"We loved it!! The location is great. The room was amazing, the breakfast, the staff… everything was perfect."
Mexico
Francisco Benjamin Macias
The price is ฿6,989
฿8,628 total
includes taxes & fees
1 Dec - 2 Dec
San Rafael Hotel
A covered walkway with wooden pillars and tropical plants.

12. Good Hotel Antigua Guatemala, a Member of Design Hotels

Good Hotel Antigua Guatemala, a Member of Design Hotels
4.0 star property
0.8 km from Santa Ana
9.4 out of 10, Exceptional, (571 reviews)
"The hotel was very wonderful!! Saul Bistro connects to the hotel which was amazing and convenient. The staff was the best!! I can’t say enough great things about this place"
United States
Brandon Jordani
The price is ฿9,274
฿11,314 total
includes taxes & fees
1 Dec - 2 Dec
Good Hotel Antigua Guatemala, a Member of Design Hotels
An indoor courtyard with stone flooring, multiple seating areas, and string lights.

13. Hotel Casa Carmina by AHS

Hotel Casa Carmina by AHS
4.0 star property
1.2 km from Santa Ana
8.8 out of 10, Excellent, (388 reviews)
"The staff was wonderful! The location was perfect! The hotel was beautiful! I would definitely recommend! There’s hot water, and WiFi!"
United States
Carlos
The price is ฿2,130
฿2,599 total
includes taxes & fees
5 Nov - 6 Nov
Hotel Casa Carmina by AHS
A garden with a pergola, potted plants, and a chair.

14. Casa Santa Rosa Hotel Boutique

Casa Santa Rosa Hotel Boutique
3.5 star property
Historic Center, 1.4 km from Santa Ana
9.6 out of 10, Exceptional, (418 reviews)
"Delicious breakfast, nive place, close to everything, I really enjoyed staying there"
United States
Ligia
The price is ฿5,704
฿6,959 total
includes taxes & fees
9 Nov - 10 Nov
Casa Santa Rosa Hotel Boutique
A yellow building with a clock tower and an archway.

15. Hotel Convento Santa Catalina

Hotel Convento Santa Catalina
3.5 star property
Historic Center, 1.6 km from Santa Ana
8.2 out of 10, Very good, (679 reviews)
"Great hotel, great location !"
United States
christina
The price is ฿2,241
฿2,735 total
includes taxes & fees
30 Nov - 1 Dec
Hotel Convento Santa Catalina
A bedroom with a four-poster bed, two armchairs, a desk, and a nightstand.

16. El Convento Boutique Hotel

El Convento Boutique Hotel
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (954 reviews)
"This hotel is incredible. If we ever go back to Antigua, we will stay here again! The staff go above and beyond to make your stay what you want it to be."
United States
Calvin
The price is ฿8,820
฿11,266 total
includes taxes & fees
2 Dec - 3 Dec
El Convento Boutique Hotel
A stone building with arched entrances and a balcony with wrought iron railings.

17. Meson Panza Verde

Meson Panza Verde
4.0 star property
1.1 km from Santa Ana
9.2 out of 10, Wonderful, (515 reviews)
"Great place to stay"
United States
Mauricio
The price is ฿3,950
฿4,818 total
includes taxes & fees
8 Nov - 9 Nov
Meson Panza Verde
A courtyard with stone walls, a fountain, and various plants and flowers.

18. Hotel Posada de Don Rodrigo Antigua

Hotel Posada de Don Rodrigo Antigua
3.5 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (790 reviews)
"Excellent location helps to have short walking distance to all nearby highlights."
United States
jose
The price is ฿8,429
฿10,283 total
includes taxes & fees
15 Nov - 16 Nov
Hotel Posada de Don Rodrigo Antigua
A modern, triangular wooden structure with a glass entrance, surrounded by lush greenery.

19. Santo Cielo by Casa Santo Domingo

Santo Cielo by Casa Santo Domingo
3.5 star property
0.9 km from Santa Ana
9.4 out of 10, Exceptional, (580 reviews)
"Great place and staff"
United States
Ricardo
The price is ฿7,161
฿9,148 total
includes taxes & fees
11 Nov - 12 Nov
Santo Cielo by Casa Santo Domingo
A corridor with a bench, potted plants, and a hanging light fixture.

20. Nico Hotel

Nico Hotel
3.0 star property
2.1 km from Santa Ana
9.0 out of 10, Wonderful, (472 reviews)
"Good place to stay"
United States
Michael
The price is ฿2,156
฿2,630 total
includes taxes & fees
27 Nov - 28 Nov
Nico Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Santa Ana

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A two-story building with yellow walls, a balcony with purple flowers, and multiple windows with metal bars.
Villas Santa Ana-Ricardo
3.5 star property
9.0
Wonderful
17 reviews
View
A spacious indoor area with a staircase, a red sofa, and various potted plants.
Castillo De Los Gigantes
2.0 star property
8.0
Very good
2 reviews
View
A courtyard with a tiled roof, a building with a dome, and a mountain in the background.
Hotel Camino Real Antigua
4.0 star property
9.6
Exceptional
1,000 reviews
View
A stone-walled corridor with steps leading to a wooden door, surrounded by lush greenery and potted plants.
Hotel Museo Spa Casa Santo Domingo
4.5 star property
9.4
Exceptional
1,191 reviews
View
A restaurant with a brick wall, wine racks, and tables set for dining.
Los Pasos Boutique Hotel & Spa
4.5 star property
9.4
Exceptional
1,000 reviews
View

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.
A historic yellow archway leading to a clock tower, surrounded by old buildings.

Historic Center

If you're spending some time in Historic Center, Central Park and Santa Catalina Arch are top sights worth seeing.

A town with a prominent volcano in the background.

Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum.

Top Santa Ana Hotel Reviews

Best Western Plus Hotel Stofella

Best Western Plus Hotel Stofella

8/10 Good
"Buen hotel, es antiguo pero está limpio y tiene una muy buena ocupacion"
Rina 1-night trip
Posted less than an hour ago
Best Western Plus Hotel Stofella

Frequently asked questions

What's it like in Santa Ana?
Travellers to the Santa Ana neighbourhood in Antigua Guatemala will be sure to enjoy their stay.
What's a favourite place to stay in Santa Ana?
Based on our traveller data, Casa Buho B&B is one of the top choices for your stay in Santa Ana. This hotel offers a restaurant and free parking.
How many hotels will I be able to find in Santa Ana?
If you're searching for places to stay in Antigua Guatemala, choose from one of Expedia's 15 hotels and other accommodation options in Santa Ana.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most hotel reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view top deals in Santa Ana.
What are the top things to see and do in Santa Ana?
House of the Giants, Santa Clara Convent and Jade Maya Factory and Museum are just a few of the places to visit in and around Santa Ana. While you're out sightseeing in Antigua Guatemala, make sure that you visit other sights such as Tanque La Unión or Museo del Hermano Pedro.