A white colonial church with ornate architecture and a large wooden door.

Search Hotels in Santa Ana, Antigua Guatemala

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Our top choices for Santa Ana hotels

1. Casa Buho B&B

Casa Buho B&B
3.0 star property
Santa Ana
9.2 out of 10, Wonderful, (54 reviews)
"Great place !!"
United States
Abner Israel Polanco
The price is ฿1,590
฿1,940 total
includes taxes & fees
7 Aug - 8 Aug
Casa Buho B&B

2. Villas Santa Ana-Ricardo

Villas Santa Ana-Ricardo
3.5 star property
Santa Ana
9.0 out of 10, Wonderful, (17 reviews)
"Beautiful place to stay at!"
United States
Nery
The price is ฿3,761
฿4,589 total
includes taxes & fees
6 Aug - 7 Aug
Villas Santa Ana-Ricardo

3. Hostal Casa Buho

Hostal Casa Buho
3.0 star property
Santa Ana
8.8 out of 10, Excellent, (25 reviews)
"This place has two parts, the hotel and a hostel, I stayed in the private room of the hostel part, it wasn’t very good, but the whole place is very nice, like an oasis with a lot of plants, the hotel Part would be very nice."
United States
SUSAN
The price is ฿1,134
฿1,383 total
includes taxes & fees
1 Sept - 2 Sept
Hostal Casa Buho

4. Castillo De Los Gigantes

Castillo De Los Gigantes
2.0 star property
Santa Ana
6.0 out of 10, (1 review)
"This property should be listed on Airbnb, it is not a hostel/hotel, it's more like a spare room in someone's home. There's nothing nearby. It was a saviour during semana santa, but otherwise not a particularly good place to stay. That being said the people were lovely, and the room was decent for the price."
American Samoa
Ella
The price is ฿441
฿944 total
includes taxes & fees
16 Aug - 17 Aug
Castillo De Los Gigantes

5. Los Pasos Boutique Hotel & Spa

Los Pasos Boutique Hotel & Spa
4.5 star property
0.7 km from Santa Ana
9.4 out of 10, Exceptional, (1,003 reviews)
"As a solo traveler I absolutely loved this hotel. Clean, staff were so kind, breakfast was phenomenal, and drinks were delish."
United States
Ebone
The price is ฿5,002
฿6,302 total
includes taxes & fees
23 Aug - 24 Aug
Los Pasos Boutique Hotel & Spa

6. Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo
4.5 star property
Barrio de La Concepción, 1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1,097 reviews)
"A beyond lovely stay, couldn’t recommend enough!"
United States
August
The price is ฿8,195
฿10,404 total
includes taxes & fees
12 Aug - 13 Aug
Hotel Museo Spa Casa Santo Domingo

7. El Carmen Hotel

El Carmen Hotel
3.0 star property
Historic Center, 1.3 km from Santa Ana
9.0 out of 10, Wonderful, (866 reviews)
"Great location, amazing staff and delicious breakfast!"
United States
Sabrina
The price is ฿3,112
฿3,797 total
includes taxes & fees
25 Aug - 26 Aug
El Carmen Hotel

8. Hotel Las Farolas

Hotel Las Farolas
3.5 star property
1.2 km from Santa Ana
9.2 out of 10, Wonderful, (785 reviews)
"Very nice hotel!"
United States
Katie
The price is ฿3,007
฿3,669 total
includes taxes & fees
9 Aug - 10 Aug
Hotel Las Farolas

9. Santo Cielo by Casa Santo Domingo

Santo Cielo by Casa Santo Domingo
3.5 star property
0.9 km from Santa Ana
9.4 out of 10, Exceptional, (560 reviews)
"Overall beautiful and peaceful"
United States
Eric
The price is ฿7,062
฿9,021 total
includes taxes & fees
12 Aug - 13 Aug
Santo Cielo by Casa Santo Domingo

10. Hotel Camino Real Antigua

Hotel Camino Real Antigua
4.0 star property
Historic Center, 1.4 km from Santa Ana
9.6 out of 10, Exceptional, (1,003 reviews)
"Amazing property with great service and good food with nice amenities"
United States
Ricardo
The price is ฿5,847
฿7,969 total
includes taxes & fees
24 Aug - 25 Aug
Hotel Camino Real Antigua

11. Hotel Casa Carmina by AHS

Hotel Casa Carmina by AHS
4.0 star property
1.2 km from Santa Ana
8.8 out of 10, Excellent, (355 reviews)
"Great location. Beautiful lobby. Overnight stay and just what we needed."
United States
Shannon
The price is ฿1,909
฿2,329 total
includes taxes & fees
6 Aug - 7 Aug
Hotel Casa Carmina by AHS

12. Villa Colonial

Villa Colonial
3.0 star property
0.7 km from Santa Ana
9.2 out of 10, Wonderful, (203 reviews)
"The hotel is beautiful and very well kept. The staff were very friendly and helpful. The restaurant at the hotel is very clean and friendly atmosphere. Parking lot was very easy to get to. Overall this hotel is a great stay with a good location a little outside of downtown. Very quiet and clean !"
United States
Astrid
The price is ฿2,843
฿3,468 total
includes taxes & fees
31 Aug - 1 Sept
Villa Colonial

13. Hotel Genessis

Hotel Genessis
3.5 star property
0.9 km from Santa Ana
9.2 out of 10, Wonderful, (133 reviews)
"Excellent hotel! So happy we chose Hotel Genessis for our stay. Its location is convenient, breakfast was great, and staff were super sweet."
United States
Jasmine
The price is ฿3,243
฿3,957 total
includes taxes & fees
23 Aug - 24 Aug
Hotel Genessis

14. Casa Noble Hotel

Casa Noble Hotel
3.0 star property
0.9 km from Santa Ana
9.6 out of 10, Exceptional, (234 reviews)
"Love it, my room was clean and very comfortable, bed it bit to high I am 5'3 lol. Love the decor. Breakfast ok. Staff very nice. They accommodated me when I had to switch rooms. Would recommend, and would stay again."
United States
theresa
The price is ฿2,894
฿3,531 total
includes taxes & fees
25 Aug - 26 Aug
Casa Noble Hotel

15. Hotel Convento Santa Catalina

Hotel Convento Santa Catalina
3.5 star property
Historic Center, 1.6 km from Santa Ana
8.2 out of 10, Very good, (609 reviews)
"Beautiful and clean staff are excellent the only thing was the rooms need a whole body mirror"
United States
Miguel
The price is ฿1,905
฿2,324 total
includes taxes & fees
30 Aug - 31 Aug
Hotel Convento Santa Catalina

16. Hotel Posada de Don Rodrigo Antigua

Hotel Posada de Don Rodrigo Antigua
3.5 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (768 reviews)
"Beautiful place and excellent service"
United States
Milagros
The price is ฿6,733
฿8,214 total
includes taxes & fees
15 Aug - 16 Aug
Hotel Posada de Don Rodrigo Antigua

17. Ciel-Luxe Hotels

Ciel-Luxe Hotels
3.5 star property
Historic Center, 1.4 km from Santa Ana
8.8 out of 10, Excellent, (448 reviews)
"Wonderful location and beautiful garden"
United States
Yushan
The price is ฿3,391
฿4,137 total
includes taxes & fees
19 Aug - 20 Aug
Ciel-Luxe Hotels

18. Las Camelias Inn

Las Camelias Inn
3.0 star property
Historic Center, 1.2 km from Santa Ana
8.8 out of 10, Excellent, (681 reviews)
"One of the nicest cleanest hotels I’ve ever been to would definitely book again"
United States
Javier
The price is ฿2,455
฿2,995 total
includes taxes & fees
16 Aug - 17 Aug
Las Camelias Inn

19. Porta Hotel Antigua

Porta Hotel Antigua
4.5 star property
1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1,000 reviews)
"great location!"
United States
Rosa
The price is ฿6,436
฿8,517 total
includes taxes & fees
17 Aug - 18 Aug
Porta Hotel Antigua

20. Casa Barrilete

Casa Barrilete
3.0 star property
0.7 km from Santa Ana
9.2 out of 10, Wonderful, (25 reviews)
"Very clean, family friendly,"
United States
mirella
The price is ฿1,353
฿1,651 total
includes taxes & fees
1 Sept - 2 Sept
Casa Barrilete
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.

Historic Center

If you're spending some time in Historic Center, Central Park and Santa Catalina Arch are top sights worth seeing.

Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum.

Top Santa Ana Hotel Reviews

Frequently asked questions

What's it like in Santa Ana?
Travellers to the Santa Ana neighbourhood in Antigua Guatemala will be sure to enjoy their stay.
What's a favourite place to stay in Santa Ana?
Based on our traveller data, Casa Buho B&B is one of the top choices for your stay in Santa Ana. This hotel offers a restaurant and free parking.
How many hotels will I be able to find in Santa Ana?
If you're searching for places to stay in Antigua Guatemala, choose from one of Expedia's 15 hotels and other accommodation options in Santa Ana.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most hotel reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view top deals in Santa Ana.
What are the top things to see and do in Santa Ana?
House of the Giants, Santa Clara Convent and Jade Maya Factory and Museum are just a few of the places to visit in and around Santa Ana. While you're out sightseeing in Antigua Guatemala, make sure that you visit other sights such as Tanque La Unión or Museo del Hermano Pedro.