What is Medical Center District like?

Travellers are sure to enjoy a stay in San Antonio's Medical Center District neighbourhood. Consider a visit to Cinemark San Antonio 16 as part of your Medical Center District travel plans.

What's a favourite hotel to stay in Medical Center District?

Based on our traveller data, La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW is one of the top choices for your stay in Medical Center District. This hotel offers free breakfast and an outdoor pool. Other good options for your stay in the area include Drury Inn & Suites San Antonio Northwest Medical Center and Courtyard by Marriott Medical Center San Antonio .

How many hotels will I be able to find in Medical Center District?

Expedia has 124 hotels and other accommodation options in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Medical Center District.

What can I see and do in this San Antonio neighbourhood?

Cinemark San Antonio 16 is an attraction you might want to check out while you're in Medical Center District. Wonderland of the Americas Mall and Regal Huebner Oaks are also worth a visit when you're out sightseeing in San Antonio.

The Best Hotels in Medical Center District, San Antonio - 2026 Updated Prices

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Our top choices for Medical Center District hotels

A spacious lobby with multiple seating areas, a central coffee table, and a view of the upper floors.

1. Drury Inn & Suites San Antonio Northwest Medical Center

Medical Center District

Alba

฿3,599 total

includes taxes & fees

12 Oct - 13 Oct

A modern living room with a fireplace, a flat-screen TV, and a stone accent wall.

2. Fairfield Inn & Suites by Marriott San Antonio Medical Center

Medical Center District

Freddie

฿3,394 total

includes taxes & fees

1 Nov - 2 Nov

A hotel dining area with multiple tables and chairs, a counter with a coffee machine, and a view of the outside through large windows.

3. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

Medical Center District

Gilbert

฿3,551 total

includes taxes & fees

12 Oct - 13 Oct

A modern bar area with wooden bar counters, black bar stools, and pendant lighting.

4. Courtyard by Marriott Medical Center San Antonio

Medical Center District

Erik

฿3,923 total

includes taxes & fees

21 Oct - 22 Oct

A spacious lobby with a central staircase, seating area, and large windows.

5. San Antonio Marriott Northwest Medical Center

Medical Center District

Adreanne

฿4,328 total

includes taxes & fees

6 Nov - 7 Nov

A modern kitchen with a large window, wooden counter, and two bar stools.

6. Park Inn by Radisson, Medical Center

Medical Center District

Joanne

฿2,635 total

includes taxes & fees

27 Oct - 28 Oct

A hotel room with two beds, a desk, a chair, a mirror, and a bathroom.

7. Studio 6 San Antonio, Tx - Northwest Medical Center

Medical Center District

Ruben

฿1,878 total

includes taxes & fees

11 Oct - 12 Oct

A modern bedroom with a large bed, bedside tables, a desk, and a chair.

8. Motel 6 San Antonio, TX - Northwest Medical Center

Medical Center District

Brian

฿1,895 total

includes taxes & fees

10 Oct - 11 Oct

A gas station with a sign for 'Atria Inn & Suites' and a 'Clearance - 12' sign.

9. Atria Inn & Suites

Medical Center District

Jose Rolando

฿2,267 total

includes taxes & fees

8 Oct - 9 Oct

A building entrance with a glass door, a Pepsi vending machine, and a yellow bollard.

10. OYO Inn & Suites Medical Center San Antonio

Medical Center District

Melanie

฿2,764 total

includes taxes & fees

20 Oct - 21 Oct

A hotel room with a large bed, a desk with a chair, a television on a stand, and a mirror on the wall.

11. Flex Studios

Medical Center District

Jasper

฿1,760 total

includes taxes & fees

13 Oct - 14 Oct

A hotel room with two beds, a TV, a desk, and a kitchenette in the background.

12. Studio 6 Extended Stay - San Antonio, TX - Medical Center

Medical Center District

Jerron

A modern bar area with a central island, bar stools, and a kitchen counter with appliances.

13. Hyatt Place San Antonio-Northwest/Medical Center

3.7 km from Medical Center District

Alejandra

฿3,767 total

includes taxes & fees

18 Oct - 19 Oct

A covered outdoor seating area with lounge chairs and umbrellas, a pool in the background, and potted plants.

14. Embassy Suites by Hilton San Antonio Landmark

La Cantera District, 9.2 km from Medical Center District

Lenita

฿7,358 total

includes taxes & fees

1 Nov - 2 Nov

A modern lobby with a sofa, patterned chairs, a central ottoman, and a chandelier.

15. Drury Plaza Hotel San Antonio Airport

9 km from Medical Center District

Jay

฿4,559 total

includes taxes & fees

13 Oct - 14 Oct

A Holiday Inn Express reception desk with a modern design, featuring a large illuminated sign, a reception area, and a potted plant.

16. Holiday Inn Express San Antonio-Airport by IHG

8.9 km from Medical Center District

Liz

฿4,359 total

includes taxes & fees

11 Oct - 12 Oct

A hotel with a modern design, featuring a covered parking area and multiple parking spaces.

17. Best Western Medical Center North Inn & Suites Near Six Flags

Northwest Side, 5.2 km from Medical Center District

Jesus

฿2,753 total

includes taxes & fees

8 Oct - 9 Oct

A spacious dining area with multiple tables and chairs, a bar area, and a television mounted on the wall.

18. Hampton Inn & Suites San Antonio Northwest/Medical Center

Northwest Side, 4.7 km from Medical Center District

Efrain

฿3,308 total

includes taxes & fees

1 Nov - 2 Nov

A modern kitchen with a central island, built-in appliances, and a coffee station.

19. Wyndham Garden San Antonio Airport

Uptown Central, 9.2 km from Medical Center District

SWAROOP JADHAV

฿3,446 total

includes taxes & fees

11 Oct - 12 Oct

A modern building with a distinctive roof structure and a large illuminated sign.

20. Aloft by Marriott San Antonio UTSA Area

Northwest Side, 7.8 km from Medical Center District

Juan

฿4,238 total

includes taxes & fees

11 Oct - 12 Oct

View all properties

Compare popular hotels in Medical Center District

Property	Property class	Guest rating
Drury Inn & Suites San Antonio Northwest Medical Center	3.0 star property	9.2 Wonderful 1,482 reviews	View
Fairfield Inn & Suites by Marriott San Antonio Medical Center	3.0 star property	9.0 Wonderful 1,095 reviews	View
Courtyard by Marriott Medical Center San Antonio	3.0 star property	8.8 Excellent 1,000 reviews	View
San Antonio Marriott Northwest Medical Center	3.5 star property	8.6 Excellent 1,171 reviews	View
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW	3.0 star property	8.4 Very good 3,704 reviews	View

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most.

A boat tour on a canal with a bridge in the background.

Downtown San Antonio

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

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A riverside walkway with colorful umbrellas, a stone bridge, and historic buildings.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

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A riverside walkway adorned with colorful umbrellas and festive lights.

Uptown Central

If you're spending some time in Uptown Central, Marion Koogler McNay Art Museum and Alamo Quarry Market are top sights worth seeing.

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A historic stone building with a central arched doorway, a flagpole with a flag, and a paved courtyard.

Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Crystal Ice Palace are top sights worth seeing.

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A historic stone building with a large wooden door, arched windows, and ornate columns.

Stone Oak

Stone Oak is known for its abundant dining options, and you can plan a trip to Shops at Hardy Oak and Alta Vista at Stone Oak while you're in town.

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Top Medical Center District Hotel Reviews

Signia by Hilton La Cantera Resort & Spa

10/10 Excellent

"The resort was fantastic! The rooms were very adequate. We would have loved a better view. We had a huge tree obstructing our view of the courtyard. However, the resort was great."

Menger Hotel

8/10 Good

"You can not beat the location! Alamo and River---perfect! The room was OK but the bed bottom sheet was not put on the mattress and a pillow case was ribbed and the fire alarm was chirping! I called housekeeping and they came and photographed and corrected it! Lots of people working the valet parking, but texting them requesting your car do not seem to work as they asked on the ticket! Still I would stay there again!"

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

8/10 Good

"The staff was amazing, great customer service, and ready to help. The room was comfortable and clean but there was a smell to the room and the sheets. The air conditioner was working but the room felt humid and that might have led to smell. Overall it was nothing that would keep me from staying there again. The walk to the Alamodome was easy and saved us money from not having to get an uber!"

Riverwalk Plaza

10/10 Excellent

"Liked the fact that your key card made elevator go up and down, security check. Room was clean ,tv worked, pull down shade instead of curtains. Better room darkening effect. Did still hear people in next room giggling and carrying on. No clean towels by the pool in the evening ,all holders were checked. Towels aren’t kept by front desk either. The room didn’t come with parking. We parked on the street was cheaper.Overall would stay there again. If you have Uber or Lift could rent electric scooters or bikes."

Search Hotels in Medical Center District, San Antonio

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Our top choices for Medical Center District hotels

1. Drury Inn & Suites San Antonio Northwest Medical Center

2. Fairfield Inn & Suites by Marriott San Antonio Medical Center

3. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

4. Courtyard by Marriott Medical Center San Antonio

5. San Antonio Marriott Northwest Medical Center

6. Park Inn by Radisson, Medical Center

7. Studio 6 San Antonio, Tx - Northwest Medical Center

8. Motel 6 San Antonio, TX - Northwest Medical Center

9. Atria Inn & Suites

10. OYO Inn & Suites Medical Center San Antonio

11. Flex Studios

12. Studio 6 Extended Stay - San Antonio, TX - Medical Center

13. Hyatt Place San Antonio-Northwest/Medical Center

14. Embassy Suites by Hilton San Antonio Landmark

15. Drury Plaza Hotel San Antonio Airport

16. Holiday Inn Express San Antonio-Airport by IHG

17. Best Western Medical Center North Inn & Suites Near Six Flags

18. Hampton Inn & Suites San Antonio Northwest/Medical Center

19. Wyndham Garden San Antonio Airport

20. Aloft by Marriott San Antonio UTSA Area

Compare popular hotels in Medical Center District

Where to stay in Medical Center District

Downtown San Antonio

Far West Side

Uptown Central

Northwest Side

Stone Oak

Top Medical Center District Hotel Reviews

Signia by Hilton La Cantera Resort & Spa

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