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Search Hotels in Guadalupe District, Santa Fe

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Our top choices for Guadalupe District hotels

Honeymoon Suite (Room 11, Upstairs) | Deep-soaking bathtub
Guadalupe Inn

Guadalupe Inn

Guadalupe Inn
2.0 star property
Guadalupe District
9.2 out of 10, Wonderful, (1000)
"Cozy, quiet, and great for couples!"
United States
Emerson
The price is ฿3,769
฿4,436 total
includes taxes & fees
1 Jan - 2 Jan 2026
Guadalupe Inn
Terrace/patio
The Sage Hotel

The Sage Hotel

The Sage Hotel
3.0 star property
Don Diego, 0.6 km from Guadalupe District
8.0 out of 10, Very good, (2125)
"Clean room, friendly staff, great restaurant / bar and all at an incredible price!"
United States
Michael
The price is ฿1,867
฿2,622 total
includes taxes & fees
4 Jan - 5 Jan 2026
The Sage Hotel
Lobby sitting area
Coyote South

Coyote South

Coyote South
3.5 star property
Southside, 6.3 km from Guadalupe District
8.4 out of 10, Very good, (2987)
"Great stay, clean and affordable"
United States
Carlos
The price is ฿2,450
฿3,136 total
includes taxes & fees
21 Dec - 22 Dec
Coyote South
Reception
Inn at Santa Fe, SureStay Collection by Best Western

Inn at Santa Fe, SureStay Collection by Best Western

Inn at Santa Fe, SureStay Collection by Best Western
3.0 star property
Southside, 11 km from Guadalupe District
8.6 out of 10, Excellent, (2083)
"Great customer service, clean rooms, and a great breakfast.⭐️⭐️⭐️⭐️ "
United States
Anna
The price is ฿2,233
฿2,573 total
includes taxes & fees
1 Jan - 2 Jan 2026
Inn at Santa Fe, SureStay Collection by Best Western
Exterior
El Sendero Inn, an Ascend Collection Hotel

El Sendero Inn, an Ascend Collection Hotel

El Sendero Inn, an Ascend Collection Hotel
2.5 star property
Downtown Santa Fe, 1.2 km from Guadalupe District
9.0 out of 10, Wonderful, (1528)
"Clean, friendly staff, close to restaurants and shopping "
United States
Lydia
The price is ฿2,835
฿3,265 total
includes taxes & fees
5 Jan - 6 Jan 2026
El Sendero Inn, an Ascend Collection Hotel
Indoor pool, seasonal outdoor pool, pool cabanas (surcharge)
Hilton Santa Fe Buffalo Thunder

Hilton Santa Fe Buffalo Thunder

Hilton Santa Fe Buffalo Thunder
4.0 star property
19.9 km from Guadalupe District
8.6 out of 10, Excellent, (1006)
"I love staying here, the golf and Casino, restaurants, spa are all amazing!"
United States
JESSICA
The price is ฿3,425
฿3,915 total
includes taxes & fees
5 Jan - 6 Jan 2026
Hilton Santa Fe Buffalo Thunder
Exterior
Eldorado Hotel & Spa

Eldorado Hotel & Spa

Eldorado Hotel & Spa
4.0 star property
Downtown Santa Fe, 0.8 km from Guadalupe District
8.8 out of 10, Excellent, (1011)
"Courteous staff and great hotel"
United States
Jacob
The price is ฿3,442
฿5,063 total
includes taxes & fees
5 Jan - 6 Jan 2026
Eldorado Hotel & Spa
Exterior
Hilton Vacation Club Villas de Santa Fe

Hilton Vacation Club Villas de Santa Fe

Hilton Vacation Club Villas de Santa Fe
3.0 star property
Northeast Santa Fe, 1 km from Guadalupe District
9.2 out of 10, Wonderful, (1002)
"It's a great place to stay! "
United States
Tonya
The price is ฿2,736
฿3,152 total
includes taxes & fees
19 Jan - 20 Jan 2026
Hilton Vacation Club Villas de Santa Fe
Exterior
La Quinta Inn by Wyndham Santa Fe

La Quinta Inn by Wyndham Santa Fe

La Quinta Inn by Wyndham Santa Fe
3.0 star property
Southside, 8.3 km from Guadalupe District
7.0 out of 10, Good, (1601)
"Convenient location "
United States
INDIRA
The price is ฿1,880
฿2,165 total
includes taxes & fees
11 Jan - 12 Jan 2026
La Quinta Inn by Wyndham Santa Fe
Exterior
Hampton Inn Santa Fe South

Hampton Inn Santa Fe South

Hampton Inn Santa Fe South
2.5 star property
Southside, 6.5 km from Guadalupe District
8.8 out of 10, Excellent, (756)
"Clean, comfortable rooms, and friendly staff:)"
United States
Christin
The price is ฿2,999
฿3,455 total
includes taxes & fees
9 Jan - 10 Jan 2026
Hampton Inn Santa Fe South
Front of property – evening/night
Inn and Spa at Loretto

Inn and Spa at Loretto

Inn and Spa at Loretto
4.0 star property
Downtown Santa Fe, 1.1 km from Guadalupe District
9.0 out of 10, Wonderful, (1002)
"Yes … staff was excellent Outstanding"
United States
Charles
The price is ฿4,391
฿6,248 total
includes taxes & fees
4 Jan - 5 Jan 2026
Inn and Spa at Loretto
Rooftop bar
Drury Plaza Hotel in Santa Fe

Drury Plaza Hotel in Santa Fe

Drury Plaza Hotel in Santa Fe
3.5 star property
Downtown Santa Fe, 1.4 km from Guadalupe District
9.6 out of 10, Exceptional, (1420)
"The room, cleanliness, breakfast, hospitality, the location and front desk staff - everything was fantastic!"
United States
Manju
The price is ฿4,672
฿5,381 total
includes taxes & fees
5 Jan - 6 Jan 2026
Drury Plaza Hotel in Santa Fe
Terrace/patio
The Inn at Vanessie

The Inn at Vanessie

The Inn at Vanessie
4.5 star property
West Guadaloupe, 0.6 km from Guadalupe District
8.8 out of 10, Excellent, (1000)
"Had a great time and we are very excited that the bar is back open"
United States
Eddy
The price is ฿2,497
฿3,962 total
includes taxes & fees
13 Jan - 14 Jan 2026
The Inn at Vanessie
Front of property – evening/night
Hotel Santa Fe

Hotel Santa Fe

Hotel Santa Fe
4.0 star property
Railyard Arts District, 0.5 km from Guadalupe District
9.2 out of 10, Wonderful, (1084)
"Lovely stay"
United States
Richard
The price is ฿4,212
฿5,511 total
includes taxes & fees
14 Jan - 15 Jan 2026
Hotel Santa Fe
Lobby
Hilton Santa Fe Historic Plaza

Hilton Santa Fe Historic Plaza

Hilton Santa Fe Historic Plaza
4.0 star property
Downtown Santa Fe, 0.8 km from Guadalupe District
8.2 out of 10, Very good, (1001)
"Beautifully maintained- incredibly helpful staff and the perfect location to see the historic plaza and more. "
United States
Patricia
The price is ฿3,580
฿4,124 total
includes taxes & fees
7 Jan - 8 Jan 2026
Hilton Santa Fe Historic Plaza
Indoor pool
Best Western Plus Inn of Santa Fe

Best Western Plus Inn of Santa Fe

Best Western Plus Inn of Santa Fe
2.5 star property
Southside, 6.9 km from Guadalupe District
8.8 out of 10, Excellent, (1002)
"the room was clean, the employees were nice, breakfast was good, the hotel had great parking and was quiet. Overall a good value for Santa Fe stay!"
United States
Ernest
The price is ฿3,203
฿3,690 total
includes taxes & fees
3 Jan - 4 Jan 2026
Best Western Plus Inn of Santa Fe
Lobby sitting area
Cities Of Gold Casino

Cities Of Gold Casino

Cities Of Gold Casino
3.0 star property
23.6 km from Guadalupe District
8.0 out of 10, Very good, (1064)
"Always love staying here everything was good"
United States
Rafael
The price is ฿1,842
฿2,106 total
includes taxes & fees
18 Jan - 19 Jan 2026
Cities Of Gold Casino
Premium bedding, pillow-top beds, in-room safe, desk
Inn of the Governors

Inn of the Governors

Inn of the Governors
3.5 star property
Downtown Santa Fe, 0.9 km from Guadalupe District
9.6 out of 10, Exceptional, (1476)
"Incrediblen would one hundred percent stay again. Great location. Great food good prices great staff and clean!!"
United States
michael
The price is ฿4,680
฿5,391 total
includes taxes & fees
5 Jan - 6 Jan 2026
Inn of the Governors
Free buffet breakfast
Holiday Inn Express & Suites Santa Fe by IHG

Holiday Inn Express & Suites Santa Fe by IHG

Holiday Inn Express & Suites Santa Fe by IHG
2.5 star property
Southside, 6.3 km from Guadalupe District
9.0 out of 10, Wonderful, (856)
"Room was clean, the night staff was very friendly and helpful. "
United States
Trudy
The price is ฿3,206
฿3,693 total
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express & Suites Santa Fe by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Guadalupe District

Find the best Guadalupe District areas for the activities you enjoy most.

Downtown Santa Fe

Visitors to Downtown Santa Fe rave about its fascinating museums, popular shops and acclaimed art galleries. You might also want to make some time to see Santuario De Nuestra Senora de Guadalupe or Lensic Performing Arts Center while you're exploring the neighbourhood.

Canyon Road featuring art and interior views

Historic Eastside

While visiting Historic Eastside, you might make a stop by sights like Canyon Road and ViVO Contemporary.

Southside

Southside is known for its popular shops, and with sights like Meow Wolf and International Museum of Collage, Assemblage & Construction, you won't get bored spending a day wandering around this part of Santa Fe.

Tesuque

Tesuque is noteworthy for its spas, and you can make a stop at top attractions like Shidoni Foundry and Glenn Green Galleries & Sculpture Garden.

Northeast Santa Fe

While Northeast Santa Fe isn't home to many top sights, New Mexico Museum of Art and Cathedral Basilica of Saint Francis of Assisi are some notable places to visit nearby.

Top Guadalupe District Hotel Reviews

La Fonda on the Plaza

La Fonda on the Plaza

10/10 Excellent
"hot tub was closed at 4pm didnt know about free breakfast, ate at french creperie"
earl 1-night trip
Posted 3 days ago
La Fonda on the Plaza
Rosewood Inn of the Anasazi

Rosewood Inn of the Anasazi

10/10 Excellent
"Excellent "
Louis 1-night trip
Posted 11 days ago
Rosewood Inn of the Anasazi

Frequently asked questions

What's it like in Guadalupe District?
You'll be sure to have fun exploring Santa Fe's Guadalupe District neighbourhood. Make sure that you visit Santa Fe Railyard and Santuario De Nuestra Senora de Guadalupe as part of your Guadalupe District travel plans.
What's a favourite place to stay in Guadalupe District?
Based on Expedia customer reviews, Guadalupe Inn is the highest ranked property in Guadalupe District. This hotel is a short 14-minute walk from Santa Fe Plaza, and it offers free breakfast and free WiFi.
How many hotels are there in the Guadalupe District area?
If you're searching for places to stay in Santa Fe, Expedia has something to meet your needs with 65 Guadalupe District hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in Guadalupe District, will I receive a refund?
Yes! You'll find that most hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to get the best options available in Guadalupe District.
What can I see and do in this Santa Fe neighbourhood?
Sights like El Museo Cultural, Art Vault and TAI Modern can be part of your cultural tour of Guadalupe District. As you're discovering the neighbourhood, Santa Fe Railyard and Santuario De Nuestra Senora de Guadalupe are some other places worth a visit. Santa Fe Farmers Market, SITE Santa Fe and Harrell House of Natural Oddities and Bug Museum are just a few of the places to visit in and around Guadalupe District. While you're out sightseeing, Andrea Fisher Fine Pottery and Lensic Performing Arts Center are a couple of additional sights to visit in Santa Fe.
How can I get around Guadalupe District and the greater Santa Fe area?
If you want to head out of town, you can hop aboard a train at Santa Fe Depot.