Find hotels in Defiance, MO from ฿2,113

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Check prices for these dates

Tonight
28 Feb - 1 Mar
Tomorrow
1 Mar - 2 Mar
Next weekend
6 Mar - 8 Mar
In two weeks
13 Mar - 15 Mar

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Our top choices for Defiance hotels

Exterior

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
9.0 out of 10, Wonderful, (45 reviews)
"Super clean , quiet place "
United States
Phoenix
The price is ฿2,763
฿3,271 total
includes taxes & fees
1 Mar - 2 Mar
WoodSpring Suites St Peters-OFallon
Indoor pool

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.4 out of 10, Good, (1,000 reviews)
"Nice place and nice people "
United States
Columbus
The price is ฿2,235
฿2,553 total
includes taxes & fees
1 Mar - 2 Mar
Baymont by Wyndham Warrenton
43-inch LED TV with digital channels, TV

Comfort Inn & Suites St. Louis - O'Fallon

Comfort Inn & Suites St. Louis - O'Fallon
2.5 star property
O'Fallon
7.6 out of 10, Good, (1,000 reviews)
"Nice room, good front desk help"
United States
jeffrey
The price is ฿2,593
฿3,058 total
includes taxes & fees
29 Mar - 30 Mar
Comfort Inn & Suites St. Louis - O'Fallon
Lobby

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very good, (944 reviews)
"Clean rooms, pleasant staff."
United States
Karen
The price is ฿2,296
฿2,593 total
includes taxes & fees
8 Mar - 9 Mar
Quality Inn Foristell
Reception

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
8.0 out of 10, Very good, (1,109 reviews)
"Great room, great people, great breakfast "
United States
Jaiden
The price is ฿2,771
฿3,200 total
includes taxes & fees
1 Mar - 2 Mar
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Exterior

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very good, (1,001 reviews)
"Great hotel for the money"
United States
Jere
The price is ฿2,841
฿3,265 total
includes taxes & fees
8 Mar - 9 Mar
Comfort Suites St Charles - St Louis
Exterior

Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG
2.5 star property
Wentzville
9.4 out of 10, Exceptional, (872 reviews)
"Beautiful hotel, friendly staff, good breakfast."
United States
Erika
The price is ฿4,191
฿4,994 total
includes taxes & fees
29 Mar - 30 Mar
Holiday Inn Express & Suites Wentzville St Louis West by IHG
Lobby

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
St. Peters
9.4 out of 10, Exceptional, (1,002 reviews)
"Comfortable room. Quiet even though next to interstate. Excellent food "
United States
Geo
The price is ฿3,415
฿3,925 total
includes taxes & fees
5 Mar - 6 Mar
Drury Inn & Suites St. Louis St. Peters
Standard Room, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout curtains

Super 8 by Wyndham Warrenton

Super 8 by Wyndham Warrenton
2.0 star property
Warrenton
7.4 out of 10, Good, (629 reviews)
"It all went well . Room has been remodeled it was nice ."
United States
Charles
The price is ฿1,689
฿1,929 total
includes taxes & fees
7 Mar - 8 Mar
Super 8 by Wyndham Warrenton
Lobby

Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
2.5 star property
Washington
9.2 out of 10, Wonderful, (662 reviews)
"Clean room and hotel with a nice breakfast, have stayed here two times while visiting family."
United States
Brooks
The price is ฿4,005
฿4,559 total
includes taxes & fees
1 Mar - 2 Mar
Best Western Plus Washington Hotel
Cleanliness standards

Relax Inn Saint Charles

Relax Inn Saint Charles
2.0 star property
St. Charles
6.8 out of 10, (1,005 reviews)
"Clean room very nice staff it’s nice"
United States
Mercedez
The price is ฿1,956
฿2,248 total
includes taxes & fees
1 Mar - 2 Mar
Relax Inn Saint Charles
Lobby lounge

Fairfield Inn & Suites Wentzville

Fairfield Inn & Suites Wentzville
3.0 star property
Wentzville
9.0 out of 10, Wonderful, (658 reviews)
"Hotel staff was friendly and room was very clean "
United States
Danielle
The price is ฿3,970
฿4,544 total
includes taxes & fees
8 Mar - 9 Mar
Fairfield Inn & Suites Wentzville
Free daily buffet breakfast

Best Western Plus Fenton

Best Western Plus Fenton
2.5 star property
Fenton
9.2 out of 10, Wonderful, (216 reviews)
"Stay was great, and the pool was perfect for my daughter and her friend. Wonderful spot for an easy "stay cation" with the girls. "
United States
Melissa
The price is ฿2,831
฿3,270 total
includes taxes & fees
1 Mar - 2 Mar
Best Western Plus Fenton
Premium bedding, desk, iron/ironing board, free WiFi

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,002 reviews)
"Friendly staff, clean room, comfy bed, excellent breakfast buffet."
United States
Kathy
The price is ฿2,459
฿2,900 total
includes taxes & fees
15 Mar - 16 Mar
Sleep Inn & Suites O'Fallon MO - Technology Drive
Terrace/patio

Courtyard by Marriott St. Louis St. Peters

Courtyard by Marriott St. Louis St. Peters
3.0 star property
St. Peters
9.0 out of 10, Wonderful, (678 reviews)
"Clean spacious room, friendly staff, provided extra pillows upon request. Easy check in and check out! "
United States
Renee
The price is ฿3,508
฿4,188 total
includes taxes & fees
8 Mar - 9 Mar
Courtyard by Marriott St. Louis St. Peters
Front of property – evening/night

Cedar Creek

Cedar Creek
3.0 star property
New Haven
9.0 out of 10, Wonderful, (264 reviews)
"We got a surprise upgrade to our room. The cottage was beautiful and clean. The staff was perfect."
United States
Joan
Cedar Creek
Exterior

Holiday Inn Express Warrenton by IHG

Holiday Inn Express Warrenton by IHG
2.5 star property
Warrenton
9.0 out of 10, Wonderful, (524 reviews)
"Very helpful and friendly staff"
United States
TONY
The price is ฿4,470
฿5,106 total
includes taxes & fees
1 Mar - 2 Mar
Holiday Inn Express Warrenton by IHG
Lobby

Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis
3.0 star property
Valley Park
9.6 out of 10, Exceptional, (1,000 reviews)
"Great stay"
United States
Maureen
The price is ฿3,570
฿4,176 total
includes taxes & fees
4 Mar - 5 Mar
Drury Inn & Suites Southwest St. Louis
Lobby

Super 8 by Wyndham Union

Super 8 by Wyndham Union
2.0 star property
Union
8.2 out of 10, Very good, (638 reviews)
"Good stay. Clean quiet comfortable"
United States
Frances
The price is ฿2,459
฿2,716 total
includes taxes & fees
8 Mar - 9 Mar
Super 8 by Wyndham Union
Reception

Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (664 reviews)
"Prompt service, quick check in. "
United States
Emily
The price is ฿3,701
฿4,235 total
includes taxes & fees
8 Mar - 9 Mar
Hampton Inn St. Louis Wentzville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Missouri wineries have some of the most superb wine we've ever tasted! We recommend sipping on some chambourcin while basking in the sunshine.
Photo by Pages of Travel
Open Photo by Pages of Travel

Chandler Hill Vineyards

This elegant Missouri winery showcases local and California wines from its hillside setting. Savour varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.
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Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri

August A. Busch Memorial Conservation Area

This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment.
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Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters

10/10 Excellent
"I booked an additional night through Hotels.com due to my home flooding but accidentally selected the wrong date. Payment was made at 12:06 p.m., and I immediately corrected the date once I realized the mistake. Despite providing proof, the general manager required us to leave, citing a five hour policy that had not yet been exceeded. I was traveling with three children, and the situation was handled with no flexibility or professionalism. Very disappointing experience."
Brandon 1-night trip
Posted 2 days ago
Drury Inn & Suites St. Louis St. Peters

More cheap stays in Defiance

Relax Inn Saint Charles

Relax Inn Saint Charles

3800 Harry S Truman Blvd St. Charles MO
The price is ฿1,956 per night from 1 Mar to 2 Mar
฿1,956
฿2,248 total
1 Mar - 2 Mar
includes taxes & fees
6.8/10 (1,005 reviews)

Frequently asked questions

What's the best place to stay in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, located 17.9 mi (28.8 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are The Wildwood Hotel and Ameristar Casino Resort and Spa. See all available top hotels, or vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
What are some accommodation options with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Features an indoor pool, an outdoor pool and buffet. The Wildwood Hotel and Ameristar Casino Resort and Spa are two additional hotels with an on-site pool. View all hotels with pools in Defiance.
How is it staying in Defiance?
Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station, Busch Stadium and Gateway Arch. In Defiance, there are 19 hotels and other accommodation options to choose from. Find out more about Defiance.
What should I do while I'm visiting Defiance?
Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River and Matson Hill Park Trailhead. A couple of additional sights to add to your itinerary are Yellow Farmhouse Winery and Chandler Hill Vineyards. Take a look at what more there is to see and do in Expedia's Defiance guide.
What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

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