A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Find hotels in Defiance, MO from ฿2,421

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Our top choices for Defiance hotels

Super 8 by Wyndham St Charles

Super 8 by Wyndham St Charles
2.0 star property
St. Charles
8.2 out of 10, Very good, (1,013 reviews)
"Great location, of staying away from busy intersections!!"
United States
David
The price is ฿2,682
฿3,083 total
includes taxes & fees
19 Jul - 20 Jul
Super 8 by Wyndham St Charles

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very good, (1,000 reviews)
"Nice place, good location and comfortable bed"
United States
Alice
The price is ฿2,803
฿3,166 total
includes taxes & fees
22 Jul - 23 Jul
Quality Inn Foristell

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
7.8 out of 10, Good, (1,444 reviews)
"Room was very nice with very comfortable beds and pillows."
United States
rodney
The price is ฿3,159
฿3,649 total
includes taxes & fees
20 Jul - 21 Jul
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Holiday Inn Express & Suites St Peters by IHG

Holiday Inn Express & Suites St Peters by IHG
2.5 star property
St. Peters
9.4 out of 10, Exceptional, (429 reviews)
"Wonderful stay from start to finish!"
United States
Brittany
The price is ฿3,469
฿4,022 total
includes taxes & fees
19 Jul - 20 Jul
Holiday Inn Express & Suites St Peters by IHG

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
7.8 out of 10, Good, (1,292 reviews)
"Enjoyed my stay."
United States
Robert
The price is ฿2,989
฿3,451 total
includes taxes & fees
16 Jul - 17 Jul
Wingate by Wyndham St. Louis/Fenton Route 66

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
St. Peters
9.4 out of 10, Exceptional, (1,015 reviews)
"We enjoyed the breakfast and dinner that was available. The room was clean and the staff was very friendly, going out of their way to ask how things were and if you needed anything. We will definitely be staying here again when in the area."
United States
Angela M
The price is ฿3,683
฿4,234 total
includes taxes & fees
26 Jul - 27 Jul
Drury Inn & Suites St. Louis St. Peters

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very good, (1,000 reviews)
"We liked that it was very close to the I terstate"
United States
Michelle
The price is ฿3,817
฿4,386 total
includes taxes & fees
4 Aug - 5 Aug
Hampton Inn St. Charles St. Peters

Comfort Inn & Suites St. Louis - O'Fallon

Comfort Inn & Suites St. Louis - O'Fallon
2.5 star property
O'Fallon
7.6 out of 10, Good, (1,010 reviews)
"The room was very clean, staff was very courteous. we didnt stay for breakfast. The AC worked fine, the pool area looked great. Overall it was a good place to stay."
United States
Tony
The price is ฿2,425
฿2,860 total
includes taxes & fees
5 Aug - 6 Aug
Comfort Inn & Suites St. Louis - O'Fallon

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.6 out of 10, Good, (1,000 reviews)
"Staff was friendly and helpful"
United States
Jared
The price is ฿2,893
฿3,305 total
includes taxes & fees
9 Aug - 10 Aug
Baymont by Wyndham Warrenton

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,043 reviews)
"very nice and clean room, breakfast selection was very nice, the staff was very courteous and professional. We will stay there again. "
United States
Helmuth
The price is ฿2,806
฿3,309 total
includes taxes & fees
20 Jul - 21 Jul
Sleep Inn & Suites O'Fallon MO - Technology Drive

Super 8 by Wyndham O'Fallon MO/St. Louis Area

Super 8 by Wyndham O'Fallon MO/St. Louis Area
2.0 star property
O'Fallon
7.0 out of 10, Good, (1,009 reviews)
"Clean room, friendly staff"
United States
Shelly
The price is ฿2,220
฿2,619 total
includes taxes & fees
6 Aug - 7 Aug
Super 8 by Wyndham O'Fallon MO/St. Louis Area

Economy Inn Wentzville

Economy Inn Wentzville
2.0 star property
Wentzville
6.4 out of 10, (550 reviews)
"Room was clean but basic"
United States
James
The price is ฿2,344
฿2,659 total
includes taxes & fees
16 Jul - 17 Jul
Economy Inn Wentzville

Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
2.5 star property
Washington
9.2 out of 10, Wonderful, (709 reviews)
"Clean and quiet space to stay."
United States
Irica
The price is ฿4,320
฿4,918 total
includes taxes & fees
19 Jul - 20 Jul
Best Western Plus Washington Hotel

Holiday Inn Express Warrenton by IHG

Holiday Inn Express Warrenton by IHG
2.5 star property
Warrenton
9.0 out of 10, Wonderful, (545 reviews)
"Very good breakfast, especially good coffee, clean rooms, friendly staff, comfortable beds"
United States
Tom
The price is ฿4,469
฿5,105 total
includes taxes & fees
29 Jul - 30 Jul
Holiday Inn Express Warrenton by IHG

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis
3.5 star property
Riverport
8.6 out of 10, Excellent, (2,222 reviews)
"Great hotel"
United States
Brandon
The price is ฿4,353
฿5,567 total
includes taxes & fees
19 Jul - 20 Jul
Hollywood Casino & Hotel St. Louis

Days Inn by Wyndham St Peters/St Charles

Days Inn by Wyndham St Peters/St Charles
2.0 star property
St. Peters
6.2 out of 10, (1,000 reviews)
"Good place to stay"
United States
Jeremy
The price is ฿2,107
฿2,421 total
includes taxes & fees
5 Aug - 6 Aug
Days Inn by Wyndham St Peters/St Charles

Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis
3.0 star property
Valley Park
9.6 out of 10, Exceptional, (1,017 reviews)
"Very nice hotel. Lots of amenities and very clean."
United States
Tanya
The price is ฿4,286
฿5,014 total
includes taxes & fees
2 Aug - 3 Aug
Drury Inn & Suites Southwest St. Louis

Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield
3.0 star property
Chesterfield
9.6 out of 10, Exceptional, (1,204 reviews)
"Had a great stay"
United States
Madeleine
The price is ฿4,554
฿5,282 total
includes taxes & fees
6 Aug - 7 Aug
Drury Plaza Hotel St. Louis Chesterfield

Embassy Suites by Hilton St. Louis St. Charles

Embassy Suites by Hilton St. Louis St. Charles
3.5 star property
St. Charles
8.8 out of 10, Excellent, (1,000 reviews)
"It was a great stay"
United States
Denise
The price is ฿4,915
฿5,649 total
includes taxes & fees
29 Jul - 30 Jul
Embassy Suites by Hilton St. Louis St. Charles

Fairfield Inn & Suites by Marriott St. Louis Chesterfield

Fairfield Inn & Suites by Marriott St. Louis Chesterfield
3.0 star property
Chesterfield
9.0 out of 10, Wonderful, (1,000 reviews)
"Overall wonderful stay and will return"
United States
Wichita
The price is ฿4,189
฿4,859 total
includes taxes & fees
1 Aug - 2 Aug
Fairfield Inn & Suites by Marriott St. Louis Chesterfield
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Top Defiance Hotel Reviews

More cheap stays in Defiance

Frequently asked questions

What's the best place to stay in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, located 17.9 mi (28.8 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are Hollywood Casino & Hotel St. Louis and Hilton St. Louis Frontenac. See all available top hotels, or vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
What are some accommodation options with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Features an indoor pool, an outdoor pool and buffet. Hilton St. Louis Frontenac and The Wildwood Hotel are two additional hotels with an on-site pool. View all hotels with pools in Defiance.
How is it staying in Defiance?
Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station, Busch Stadium and Gateway Arch. In Defiance, there are 19 hotels and other accommodation options to choose from. Find out more about Defiance.
What should I do while I'm visiting Defiance?
The picturesque setting of August A. Busch Memorial Conservation Area and Missouri River exemplify the area's natural beauty. A couple of additional sights to add to your itinerary are Chandler Hill Vineyards and Sugar Creek Winery. Take a look at what more there is to see and do in Expedia's Defiance guide.
What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

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