
Find hotels in Defiance, MO from ฿2,167
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Our top choices for Defiance hotels

Sleep Inn & Suites O'Fallon MO - Technology Drive
Sleep Inn & Suites O'Fallon MO - Technology DriveO'Fallon
9.0 out of 10, Wonderful, (1,000 reviews)
The price is ฿2,428
฿2,864 total
includes taxes & fees
12 Feb - 13 Feb

Hampton Inn St. Charles St. Peters
Hampton Inn St. Charles St. PetersSt. Charles
8.0 out of 10, Very good, (1,006 reviews)
The price is ฿2,792
฿3,209 total
includes taxes & fees
5 Feb - 6 Feb

Quality Inn Foristell
Quality Inn ForistellForistell
8.2 out of 10, Very good, (921 reviews)
The price is ฿2,310
฿2,610 total
includes taxes & fees
18 Jan - 19 Jan

WoodSpring Suites St Peters-OFallon
WoodSpring Suites St Peters-OFallonSt. Peters
9.4 out of 10, Exceptional, (31 reviews)
The price is ฿2,781
฿3,292 total
includes taxes & fees
14 Jan - 15 Jan

Super 8 by Wyndham Warrenton
Super 8 by Wyndham WarrentonWarrenton
7.4 out of 10, Good, (623 reviews)
The price is ฿1,806
฿2,063 total
includes taxes & fees
20 Jan - 21 Jan


Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Heritage Inn & Suites St. Louis/Fenton, Trademark by WyndhamFenton
8.0 out of 10, Very good, (1,073 reviews)
The price is ฿2,656
฿3,067 total
includes taxes & fees
1 Feb - 2 Feb

Comfort Inn & Suites St. Louis - O'Fallon
Comfort Inn & Suites St. Louis - O'FallonO'Fallon
7.6 out of 10, Good, (1,007 reviews)
The price is ฿2,175
฿2,565 total
includes taxes & fees
23 Jan - 24 Jan

Baymont by Wyndham Warrenton
Baymont by Wyndham WarrentonWarrenton
7.4 out of 10, Good, (1,001 reviews)
The price is ฿2,306
฿2,634 total
includes taxes & fees
14 Jan - 15 Jan

Holiday Inn Express & Suites St Peters by IHG
Holiday Inn Express & Suites St Peters by IHGSt. Peters
9.2 out of 10, Wonderful, (381 reviews)
The price is ฿3,155
฿3,815 total
includes taxes & fees
18 Jan - 19 Jan

Wingate by Wyndham St. Louis/Fenton Route 66
Wingate by Wyndham St. Louis/Fenton Route 66Fenton
7.8 out of 10, Good, (1,139 reviews)
The price is ฿2,470
฿2,852 total
includes taxes & fees
14 Jan - 15 Jan

Hampton Inn St. Louis Wentzville
Hampton Inn St. Louis WentzvilleWentzville
9.0 out of 10, Wonderful, (643 reviews)
The price is ฿3,724
฿4,262 total
includes taxes & fees
25 Jan - 26 Jan

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport WestMaryland Heights
7.4 out of 10, Good, (1,000 reviews)
The price is ฿2,227
฿2,583 total
includes taxes & fees
21 Jan - 22 Jan

Best Western Plus The Charles Hotel
Best Western Plus The Charles HotelSt. Charles
8.2 out of 10, Very good, (1,001 reviews)
The price is ฿2,722
฿3,155 total
includes taxes & fees
14 Jan - 15 Jan

Super 8 by Wyndham Eureka/Six Flags Nearby
Super 8 by Wyndham Eureka/Six Flags NearbyEureka
7.0 out of 10, Good, (1,008 reviews)
The price is ฿1,992
฿2,320 total
includes taxes & fees
1 Feb - 2 Feb

Economy Inn Wentzville
Economy Inn WentzvilleWentzville
6.4 out of 10, (513 reviews)
The price is ฿1,875
฿2,127 total
includes taxes & fees
16 Jan - 17 Jan

Holiday Inn St. Louis West Six Flags by IHG
Holiday Inn St. Louis West Six Flags by IHGEureka
9.0 out of 10, Wonderful, (1,000 reviews)
The price is ฿3,624
฿4,222 total
includes taxes & fees
3 Feb - 4 Feb

Comfort Inn Near Six Flags St. Louis
Comfort Inn Near Six Flags St. LouisPacific
8.4 out of 10, Very good, (883 reviews)
The price is ฿2,840
฿3,251 total
includes taxes & fees
30 Jan - 31 Jan

Relax Inn Saint Charles
Relax Inn Saint CharlesSt. Charles
6.6 out of 10, (1,001 reviews)
The price is ฿1,968
฿2,262 total
includes taxes & fees
14 Jan - 15 Jan

Holiday Inn Express St. Louis West - O'Fallon by IHG
Holiday Inn Express St. Louis West - O'Fallon by IHGO'Fallon
8.6 out of 10, Excellent, (858 reviews)
The price is ฿2,968
฿3,501 total
includes taxes & fees
15 Jan - 16 Jan
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions
Learn more about Defiance
Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

Top Defiance Hotel Reviews

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
10/10 Excellent
More cheap stays in Defiance

Relax Inn Saint Charles
3800 Harry S Truman Blvd St. Charles MO
The price is ฿1,968 per night from 14 Jan to 15 Jan
฿1,968
฿2,262 total
14 Jan - 15 Jan
includes taxes & fees
6.6/10 (999 reviews)







































































