Defiance Holiday Rentals, St. Louis: Private House Rentals

A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

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Our top choices for Defiance hotels

A hotel room with two beds, a desk with a chair, a television, and a window with curtains.

A modern hotel room with a desk, chair, and a large mirror.

A reception desk with a modern design, featuring a blue geometric wall and a wooden finish.

A Holiday Inn Express hotel with a brick facade, a covered entrance, and a clear sky.

1. Holiday Inn Express St. Louis West - O'Fallon by IHG

O'Fallon

Greg

฿3,122

฿3,682 total

includes taxes & fees

18 Oct - 19 Oct

A hotel room with a bed, a sofa, a coffee table, and wall art.

An indoor swimming pool with a clear view of the outside, a metal ladder, and a ceiling with recessed lighting.

A Sleep Inn & Suites hotel with a modern brick facade, a covered entrance, and a parking lot.

A hotel lobby with a reception desk, seating area, and a large potted plant.

2. Sleep Inn & Suites O'Fallon MO - Technology Drive

O'Fallon

Tim

฿2,768

฿3,264 total

includes taxes & fees

8 Nov - 9 Nov

An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.

A modern kitchen with wooden cabinets, a stainless steel countertop, and various appliances including a coffee maker and a rice cooker.

A hotel room with a sofa, a side table, a lamp, a flat-screen TV, and a bed with a red blanket.

A multi-story hotel with a brick facade, a covered outdoor seating area with a fire feature, and a sign indicating it is a Marriott property.

3. TownePlace Suites by Marriott St. Louis Chesterfield

Chesterfield

Bobbi jo

฿3,994

฿4,688 total

includes taxes & fees

25 Oct - 26 Oct

A multi-story hotel with a central entrance featuring a covered patio area.

A hotel room with a desk, chair, sofa, and a window with curtains.

A hotel room with a sofa, armchair, bedside table, lamp, TV, and a bed with patterned bedding.

A hotel with a swimming pool, outdoor seating, and a covered patio area.

4. Staybridge Suites O'Fallon Chesterfield by IHG

O'Fallon

Norman

฿3,122

฿3,682 total

includes taxes & fees

18 Oct - 19 Oct

A spacious lobby with a stone fireplace, seating area, and a bar with high stools.

A modern living room with a fireplace, a flat-screen TV, a sofa, a coffee table, and a dining area.

A hotel lobby with a seating area featuring two armchairs, a round coffee table, and a flat-screen TV mounted on a wooden wall.

A multi-story hotel with a central entrance, large windows, and a well-maintained lawn.

5. Residence Inn by Marriott O'Fallon

O'Fallon

Rianna

฿4,397

฿5,187 total

includes taxes & fees

30 Oct - 31 Oct

A modern dining area with a brick fireplace, yellow and blue chairs, and a blue sofa.

A hotel room with two beds, a desk, a mirror, and a wardrobe.

An indoor swimming pool with a blue interior, surrounded by white chairs and tables, and a blue ceiling.

A gym with a treadmill, elliptical, stationary bike, and a rack of dumbbells.

6. Comfort Inn & Suites Chesterfield - St. Louis

Chesterfield

Brenda

฿2,825

฿3,404 total

includes taxes & fees

25 Oct - 26 Oct

A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

A modern bathroom with a large mirror, white vanity, and a bathtub.

A formal dining table set for six with a vase of white flowers, candles, and a view of buildings through large windows.

A spacious living area with a staircase, a large painting, and a chandelier.

7. The Wildwood Hotel

Wildwood

Rachell

฿2,776

฿3,234 total

includes taxes & fees

26 Oct - 27 Oct

A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

A spacious lobby with a sofa, a coffee station, and a reception desk.

A shop with a variety of snacks and beverages, including a refrigerated section with drinks and a display of packaged snacks.

A spacious lobby with a fireplace, comfortable seating, a large painting, and a view of the kitchen area.

8. Hilton Garden Inn St. Louis/O'Fallon MO

O'Fallon

Kassie

฿3,663

฿4,343 total

includes taxes & fees

1 Nov - 2 Nov

A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

A swimming pool with a tiled deck, a sunlit room with a view, and a seating area with chairs.

A modern hotel entrance with a glass canopy, large windows, and a brick facade.

A hotel room with three computer workstations, each with a monitor, keyboard, and a lamp.

9. Hyatt Place St. Louis/Chesterfield

Chesterfield

Debbie

฿4,048

฿4,695 total

includes taxes & fees

18 Oct - 19 Oct

A courtyard with a central seating area, surrounded by trees and a building with a pitched roof.

A modern hotel room with a large window, a desk with a flat-screen TV, a comfortable seating area, and a decorative wall piece.

A reception desk with a "WELCOME TO THE SHOW ME STATE" sign, a wooden counter, and a Hilton Honors sign.

A store interior with a 'Treats' sign, snack shelves, and a chalkboard with a welcome message.

10. Hampton Inn & Suites St. Louis/Chesterfield

Chesterfield

Vijay

฿3,966

฿4,615 total

includes taxes & fees

1 Nov - 2 Nov

A modern kitchen area with a breakfast bar, a coffee machine, and a refrigerator displaying menu options.

A pool area with a blue pool lift chair, a pool user capacity sign, and a tiled wall.

A Holiday Inn Express & Suites building with a brick facade, a covered entrance, and a numbered address.

A coffee station with two coffee machines and a display of coffee pods and cups.

11. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Chesterfield

Terry

฿3,692

฿4,297 total

includes taxes & fees

18 Oct - 19 Oct

An outdoor patio area with wicker furniture and a central fire feature.

A modern hotel lobby with a reception desk, seating area, and a television screen displaying a map.

A hotel room with a bed, a sofa, a desk, and a chair.

A modern hotel lobby with a bar area, seating arrangements, and a reception desk.

12. Courtyard by Marriott St. Louis Chesterfield

Chesterfield

Kelly

฿3,897

฿4,535 total

includes taxes & fees

29 Oct - 30 Oct

A spacious lobby with a central round table, two sofas, and a chandelier.

An indoor swimming pool area with clear signage indicating a depth of 3 feet and a no diving warning.

A buffet setup with various food items and a decorative vase of flowers.

A hotel room with two beds, a patterned wall, and a view of the city through sheer curtains.

13. Drury Plaza Hotel St. Louis Chesterfield

Chesterfield

Chasity

฿4,363

฿5,061 total

includes taxes & fees

18 Oct - 19 Oct

Two people in a swimming pool with colorful inflatable rings.

A lobby with a grand staircase, two patterned sofas, a glass coffee table, and a large mirror.

A spacious lobby with a stone fireplace, a chandelier, and a staircase.

A hotel room with a large bed, a desk, a TV, and a view of a pool through the glass door.

14. Holiday Inn St. Louis West Six Flags by IHG

Eureka

Rob

฿4,532

฿5,279 total

includes taxes & fees

9 Nov - 10 Nov

An outdoor patio with a built-in grill, seating area, and stone walls.

A spacious lounge area with a stone fireplace, comfortable seating, and a large TV screen.

A modern lobby with a stone accent wall, a flat-screen TV, a reception desk, seating area with sofas and ottomans, and a patterned rug.

An indoor swimming pool with clear glass walls, sunlit seating area, and lifeguard station.

15. Residence Inn by Marriott St. Louis Chesterfield

Chesterfield

Chelsea

฿6,344

฿7,422 total

includes taxes & fees

22 Oct - 23 Oct

An indoor swimming pool with a hot tub, clear signage, and a view of the outside through large windows.

A spacious living area with a blue wall, yellow armchairs, a blue sofa, and a wooden coffee table.

A modern hotel room with a grey sofa, a wooden coffee table, a flat-screen TV, a wooden dresser, and a large window with curtains.

A modern dining area with yellow and blue chairs, a flat-screen TV, and a kitchen area with appliances.

16. Comfort Inn Near Six Flags St. Louis

Pacific

Gail

฿3,023

฿3,461 total

includes taxes & fees

9 Nov - 10 Nov

A spacious lobby with a high ceiling, a dining area, and a kitchen in the background.

A lobby with a checkered carpet, a marble coffee table, two armchairs with patterned cushions, a sofa, and a dining table with chairs.

A hotel room with a bathroom, a bed, a nightstand, and a window.

An indoor swimming pool with stone flooring, white walls, and a green stripe. There are chairs and a door with a sign.

17. Quality Inn Near Six Flags St. Louis

Pacific

Chantelle

฿3,007

฿3,443 total

includes taxes & fees

9 Nov - 10 Nov

A spacious hotel lobby with a long reception desk, multiple seating areas, and large windows allowing natural light.

A modern hotel room with a neatly made bed, a bedside table with a lamp, a wall-mounted artwork, and a small seating area with a bench.

A Hampton Inn with a brick facade, outdoor seating area, and a clear sky.

An indoor swimming pool with a clear water area, a shallow end, and a tiled deck surrounding the pool. There are lounge chairs and tables on the deck, and a sign indicating a maximum capacity of 62.

18. Hampton Inn St. Louis Wentzville

Wentzville

Jill

฿4,822

฿5,470 total

includes taxes & fees

1 Nov - 2 Nov

A hotel reception area with a counter, coffee machines, a refrigerated display, and artwork on the wall.

A snack bar with shelves of chips, candies, and bottled water.

A reception desk with a wooden finish, a clock, and a sign for Marriott Bonvoy.

A hotel room with a bed, desk, TV, and a view of the outdoors.

19. Fairfield Inn & Suites by Marriott St. Louis Chesterfield

Chesterfield

Charles

฿3,595

฿4,170 total

includes taxes & fees

26 Oct - 27 Oct

An indoor swimming pool with clear water, a tiled border, and a no diving sign.

A lobby with patterned orange chairs, a round table with a decorative vase, and two hanging lamps.

A modern kitchen with a central island, bar stools, and a patterned rug.

A hotel room with a large bed, a desk, a chair, and a lamp.

20. Hampton Inn St. Louis/Chesterfield

Chesterfield

Monica

฿3,538

฿4,104 total

includes taxes & fees

26 Oct - 27 Oct

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Stay near popular Defiance attractions

A glass of red wine on a wooden table with a vineyard in the background.

Chandler Hill Vineyards

7.8/10 (7 reviews)

This elegant Missouri winery showcases local and California wines from its hillside setting. Savour varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.

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A wooden dock extending into a pond with lily pads, surrounded by lush greenery and a clear blue sky.

August A. Busch Memorial Conservation Area

8.6/10 (7 reviews)

This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment.

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Historic Daniel Boone Home and Heritage Center

9.6/10 (4 reviews)

Step into the limestone home where Daniel Boone's son Nathan crafted a frontier masterpiece with seven fireplaces. Explore the surrounding historic village for an authentic glimpse into 19th-century pioneer life.

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Sugar Creek Winery

8.0/10 (1 review)

Sip award-winning Missouri wines at this hillside vineyard along the scenic Katy Trail. Relax on covered decks with your own picnic while enjoying live weekend music and panoramic countryside views.

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Yellow Farmhouse Winery

This boutique winery in Defiance, Missouri was known for its distinctive unfiltered wines and relaxed atmosphere. Visitors could enjoy tastings with live music while picnicking on scenic grounds with vineyard views.

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Broemmelsiek Park

This 494-acre natural playground offers nine miles of trails through forests and around serene lakes. Attend a monthly stargazing event at the astronomy viewing area for a uniquely celestial park experience.

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Matson Hill Park Trailhead

Wander through 475 acres of rugged forest terrain with challenging hiking paths and gravity-flow mountain bike trails. The historic 1830s Hays Home offers a glimpse into pioneer life amid the natural splendour.

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Hamburg Trail Trailhead

This moderate 6.9-mile loop winds through the scenic Weldon Spring Conservation Area, connecting to the Katy Trail State Park. Spot native wildlife while traversing diverse landscapes of shaded woodlands and open fields.

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Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance

Top Defiance Hotel Reviews

Drury Inn & Suites Southwest St. Louis

8/10 Good

"Room was clean, quiet and comfortable. Nice feature with the food and drink set up in the evening,"

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

10/10 Excellent

"Room was clean, breakfast was good, no problems checking in or out. I have stayed twice and will stay again."

Country Inn & Suites by Radisson, St. Charles Historic District

10/10 Excellent

"Excellent location. Good parking. Clean rooms."

Drury Plaza Hotel St. Louis Chesterfield

10/10 Excellent

"Excellent Hotel! Great staff, rooms, food and location."

Drury Plaza Hotel St. Louis Creve Coeur

10/10 Excellent

"Thanks for an excellent stay. We will be back."

Wingate by Wyndham St. Louis/Fenton Route 66

10/10 Excellent

"Clean, comfortable, easy access. Good Price, Perfect for a 4 day stay."

Ameristar Casino Resort and Spa

8/10 Good

"Wonderful stay for a small bachelorette party. Had a wonderful time!"

More cheap stays in Defiance

Country Inn & Suites by Radisson, St. Peters, MO

3877 Veterans Memorial Pkwy St. Charles MO

฿2,825

฿3,247 total

1 Nov - 2 Nov

includes taxes & fees

Sleep Inn & Suites O'Fallon MO - Technology Drive

1147 Technology Drive O'Fallon MO

฿2,768

฿3,264 total

8 Nov - 9 Nov

includes taxes & fees

Quality Inn Foristell

12 Highway W Foristell MO

฿2,991

฿3,378 total

19 Oct - 20 Oct

includes taxes & fees

Comfort Suites St Charles - St Louis

1400 S 5th St St. Charles MO

฿3,251

฿3,737 total

1 Nov - 2 Nov

includes taxes & fees

Hampton Inn St. Charles St. Peters

3720 W Clay St St. Charles MO

฿3,984

฿4,578 total

25 Oct - 26 Oct

includes taxes & fees

Country Inn & Suites by Radisson, St. Charles Historic District

1190 S Main St St. Charles MO

฿4,380

฿5,034 total

1 Nov - 2 Nov

includes taxes & fees

9.4/10 Exceptional! (1,103 reviews)

Frequently asked questions

What's the best place to stay in Defiance?

Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are Sonesta ES Suites St. Louis - Chesterfield and Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham. See all available top hotels, or vacation rentals in Defiance.

If I need to cancel my hotel reservation in Defiance, will I receive a refund?

Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.

What are some accommodation options with pools in Defiance?

Sonesta ES Suites St. Louis - Chesterfield: Offers daily, a seasonal outdoor pool and free self parking. Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and Ameristar Casino Resort and Spa are two additional hotels with an on-site pool. View all hotels with pools in Defiance.

How is it staying in Defiance?

Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station and St. Louis Zoo. In Defiance, there are 19 hotels and other accommodation options to choose from. Find out more about Defiance.

What should I do while I'm visiting Defiance?

Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River and Matson Hill Park Trailhead. A couple of additional sights to add to your itinerary are Yellow Farmhouse Winery and Chandler Hill Vineyards. Take a look at what more there is to see and do in Expedia's Defiance guide.

What's the weather like in Defiance?

The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

Explore a world of travel with Expedia

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Book Hotels in Defiance on Expedia.com

Find hotels in Defiance, MO from ฿3,234

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Defiance

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Defiance hotels

1. Holiday Inn Express St. Louis West - O'Fallon by IHG

2. Sleep Inn & Suites O'Fallon MO - Technology Drive

3. TownePlace Suites by Marriott St. Louis Chesterfield

4. Staybridge Suites O'Fallon Chesterfield by IHG

5. Residence Inn by Marriott O'Fallon

6. Comfort Inn & Suites Chesterfield - St. Louis

7. The Wildwood Hotel

8. Hilton Garden Inn St. Louis/O'Fallon MO

9. Hyatt Place St. Louis/Chesterfield

10. Hampton Inn & Suites St. Louis/Chesterfield

11. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

12. Courtyard by Marriott St. Louis Chesterfield

13. Drury Plaza Hotel St. Louis Chesterfield

14. Holiday Inn St. Louis West Six Flags by IHG

15. Residence Inn by Marriott St. Louis Chesterfield

16. Comfort Inn Near Six Flags St. Louis

17. Quality Inn Near Six Flags St. Louis

18. Hampton Inn St. Louis Wentzville

19. Fairfield Inn & Suites by Marriott St. Louis Chesterfield

20. Hampton Inn St. Louis/Chesterfield

Stay near popular Defiance attractions

Chandler Hill Vineyards

August A. Busch Memorial Conservation Area

Historic Daniel Boone Home and Heritage Center

Sugar Creek Winery

Yellow Farmhouse Winery

Broemmelsiek Park

Matson Hill Park Trailhead

Hamburg Trail Trailhead

Learn more about Defiance

Top Defiance Hotel Reviews

Drury Inn & Suites Southwest St. Louis

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Country Inn & Suites by Radisson, St. Charles Historic District

Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Creve Coeur

Wingate by Wyndham St. Louis/Fenton Route 66

Ameristar Casino Resort and Spa

More cheap stays in Defiance

Country Inn & Suites by Radisson, St. Peters, MO

Sleep Inn & Suites O'Fallon MO - Technology Drive

Quality Inn Foristell

Comfort Suites St Charles - St Louis

Hampton Inn St. Charles St. Peters

Country Inn & Suites by Radisson, St. Charles Historic District

Frequently asked questions

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