Find hotels in Defiance, MO from ฿2,167

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Our top choices for Defiance hotels

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,000 reviews)
"Very good place to stay"
United States
Jasur
The price is ฿2,428
฿2,864 total
includes taxes & fees
12 Feb - 13 Feb
Sleep Inn & Suites O'Fallon MO - Technology Drive

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very good, (1,006 reviews)
"Great location and friendly staff "
United States
Heather
The price is ฿2,792
฿3,209 total
includes taxes & fees
5 Feb - 6 Feb
Hampton Inn St. Charles St. Peters

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very good, (921 reviews)
"Clean rooms, pleasant staff."
United States
Karen
The price is ฿2,310
฿2,610 total
includes taxes & fees
18 Jan - 19 Jan
Quality Inn Foristell

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
9.4 out of 10, Exceptional, (31 reviews)
"Super clean , quiet place "
United States
Phoenix
The price is ฿2,781
฿3,292 total
includes taxes & fees
14 Jan - 15 Jan
WoodSpring Suites St Peters-OFallon

Super 8 by Wyndham Warrenton

Super 8 by Wyndham Warrenton
2.0 star property
Warrenton
7.4 out of 10, Good, (623 reviews)
"Room was clean. Staff very helpful, accommodating. "
United States
Ranata
The price is ฿1,806
฿2,063 total
includes taxes & fees
20 Jan - 21 Jan
Super 8 by Wyndham Warrenton

The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1,622 reviews)
"Clean room, friendly staff and lots of activities in the immediate area."
United States
Anonymous traveller
The Wildwood Hotel

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
8.0 out of 10, Very good, (1,072 reviews)
"Rooms were good qnd clean, beds were comfortable and staff was very nice and accommodating "
United States
Daniel
The price is ฿2,656
฿3,067 total
includes taxes & fees
1 Feb - 2 Feb
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Comfort Inn & Suites St. Louis - O'Fallon

Comfort Inn & Suites St. Louis - O'Fallon
2.5 star property
O'Fallon
7.6 out of 10, Good, (1,007 reviews)
"Nice room, good front desk help"
United States
jeffrey
The price is ฿2,175
฿2,565 total
includes taxes & fees
23 Jan - 24 Jan
Comfort Inn & Suites St. Louis - O'Fallon

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.4 out of 10, Good, (1,001 reviews)
"Nice place and nice people "
United States
Columbus
The price is ฿2,306
฿2,634 total
includes taxes & fees
14 Jan - 15 Jan
Baymont by Wyndham Warrenton

Holiday Inn Express & Suites St Peters by IHG

Holiday Inn Express & Suites St Peters by IHG
2.5 star property
St. Peters
9.2 out of 10, Wonderful, (381 reviews)
"Very Nice Hotel… easy and friendly check in. Very clean and comfortable rooms"
United States
Cindy
The price is ฿3,155
฿3,815 total
includes taxes & fees
18 Jan - 19 Jan
Holiday Inn Express & Suites St Peters by IHG

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
7.8 out of 10, Good, (1,139 reviews)
"Clean rooms, quiet, AC worked great and good breakfast "
United States
Karen
The price is ฿2,470
฿2,852 total
includes taxes & fees
14 Jan - 15 Jan
Wingate by Wyndham St. Louis/Fenton Route 66

Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (643 reviews)
"Easy check in accessible room, comfortable bed and chairs"
United States
Maurine
The price is ฿3,724
฿4,262 total
includes taxes & fees
25 Jan - 26 Jan
Hampton Inn St. Louis Wentzville

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
3.0 star property
Maryland Heights
7.4 out of 10, Good, (1,000 reviews)
"The room was wonderful I was very impressed. The staff was very friendly and polite."
United States
Karen
The price is ฿2,227
฿2,583 total
includes taxes & fees
21 Jan - 22 Jan
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Best Western Plus The Charles Hotel

Best Western Plus The Charles Hotel
3.0 star property
St. Charles
8.2 out of 10, Very good, (1,001 reviews)
"Clean room, great stay"
United States
Becky
The price is ฿2,722
฿3,155 total
includes taxes & fees
14 Jan - 15 Jan
Best Western Plus The Charles Hotel

Super 8 by Wyndham Eureka/Six Flags Nearby

Super 8 by Wyndham Eureka/Six Flags Nearby
2.0 star property
Eureka
7.0 out of 10, Good, (1,008 reviews)
"Chris was a great night host. He was kind, friendly, and very accommodating. "
United States
Kristi
The price is ฿1,992
฿2,320 total
includes taxes & fees
1 Feb - 2 Feb
Super 8 by Wyndham Eureka/Six Flags Nearby

Economy Inn Wentzville

Economy Inn Wentzville
2.0 star property
Wentzville
6.4 out of 10, (513 reviews)
"The room was dirty so dirty we left didn't spend the night there, and the smell in the building weed or something else not sure which, it was ridiculous so we went to Hannibal and stayed at the Days inn "
United States
paul
The price is ฿1,875
฿2,127 total
includes taxes & fees
16 Jan - 17 Jan
Economy Inn Wentzville

Holiday Inn St. Louis West Six Flags by IHG

Holiday Inn St. Louis West Six Flags by IHG
3.0 star property
Eureka
9.0 out of 10, Wonderful, (1,000 reviews)
"Clean rooms and kids really enjoyed the pool area."
United States
VeAnn
The price is ฿3,624
฿4,222 total
includes taxes & fees
3 Feb - 4 Feb
Holiday Inn St. Louis West Six Flags by IHG

Comfort Inn Near Six Flags St. Louis

Comfort Inn Near Six Flags St. Louis
2.5 star property
Pacific
8.4 out of 10, Very good, (883 reviews)
"The room was impeccable and the front desk and custodial staff incredibly hospitable."
United States
Scott
The price is ฿2,840
฿3,251 total
includes taxes & fees
30 Jan - 31 Jan
Comfort Inn Near Six Flags St. Louis

Relax Inn Saint Charles

Relax Inn Saint Charles
2.0 star property
St. Charles
6.6 out of 10, (1,001 reviews)
"Great place to stay "
United States
Askar
The price is ฿1,968
฿2,262 total
includes taxes & fees
14 Jan - 15 Jan
Relax Inn Saint Charles

Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.6 out of 10, Excellent, (858 reviews)
"A very nice stay with very pleasant staff"
United States
Clifford
The price is ฿2,968
฿3,501 total
includes taxes & fees
15 Jan - 16 Jan
Holiday Inn Express St. Louis West - O'Fallon by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

More cheap stays in Defiance

Frequently asked questions

What's the best place to stay in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, located 17.9 mi (28.8 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are The Wildwood Hotel and Ameristar Casino Resort and Spa. See all available top hotels, or vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
What are some accommodation options with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Features an indoor pool, an outdoor pool and buffet. The Wildwood Hotel and Ameristar Casino Resort and Spa are two additional hotels with an on-site pool. View all hotels with pools in Defiance.
How is it staying in Defiance?
Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station, Busch Stadium and Gateway Arch. In Defiance, there are 20 hotels and other accommodation options to choose from. Find out more about Defiance.
What should I do while I'm visiting Defiance?
Natural beauty is on display at Matson Hill Park Trailhead, August A. Busch Memorial Conservation Area and Missouri River. A couple of additional sights to add to your itinerary are Yellow Farmhouse Winery and Chandler Hill Vineyards. Take a look at what more there is to see and do in Expedia's Defiance guide.
What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

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