Find hotels in Defiance, MO from ฿2,421
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Defiance
Family friendly
Apartment
Check prices for these dates
Our top choices for Defiance hotels
Super 8 by Wyndham St Charles
Super 8 by Wyndham St CharlesSt. Charles
8.2 out of 10, Very good, (1,013 reviews)
"Great location, of staying away from busy intersections!!"
David
The price is ฿2,682
฿3,083 total
includes taxes & fees
19 Jul - 20 Jul
Quality Inn Foristell
Quality Inn ForistellForistell
8.2 out of 10, Very good, (1,000 reviews)
"Nice place, good location and comfortable bed"
Alice
The price is ฿2,803
฿3,166 total
includes taxes & fees
22 Jul - 23 Jul
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Heritage Inn & Suites St. Louis/Fenton, Trademark by WyndhamFenton
7.8 out of 10, Good, (1,444 reviews)
"Room was very nice with very comfortable beds and pillows."
rodney
The price is ฿3,159
฿3,649 total
includes taxes & fees
20 Jul - 21 Jul
Holiday Inn Express & Suites St Peters by IHG
Holiday Inn Express & Suites St Peters by IHGSt. Peters
9.4 out of 10, Exceptional, (429 reviews)
"Wonderful stay from start to finish!"
Brittany
The price is ฿3,469
฿4,022 total
includes taxes & fees
19 Jul - 20 Jul
Wingate by Wyndham St. Louis/Fenton Route 66
Wingate by Wyndham St. Louis/Fenton Route 66Fenton
7.8 out of 10, Good, (1,292 reviews)
"Enjoyed my stay."
Robert
The price is ฿2,989
฿3,451 total
includes taxes & fees
16 Jul - 17 Jul
Drury Inn & Suites St. Louis St. Peters
Drury Inn & Suites St. Louis St. PetersSt. Peters
9.4 out of 10, Exceptional, (1,015 reviews)
"We enjoyed the breakfast and dinner that was available. The room was clean and the staff was very friendly, going out of their way to ask how things were and if you needed anything. We will definitely be staying here again when in the area."
Angela M
The price is ฿3,683
฿4,234 total
includes taxes & fees
26 Jul - 27 Jul
Hampton Inn St. Charles St. Peters
Hampton Inn St. Charles St. PetersSt. Charles
8.0 out of 10, Very good, (1,000 reviews)
"We liked that it was very close to the I terstate"
Michelle
The price is ฿3,817
฿4,386 total
includes taxes & fees
4 Aug - 5 Aug
Comfort Inn & Suites St. Louis - O'Fallon
Comfort Inn & Suites St. Louis - O'FallonO'Fallon
7.6 out of 10, Good, (1,010 reviews)
"The room was very clean, staff was very courteous. we didnt stay for breakfast. The AC worked fine, the pool area looked great. Overall it was a good place to stay."
Tony
The price is ฿2,425
฿2,860 total
includes taxes & fees
5 Aug - 6 Aug
Baymont by Wyndham Warrenton
Baymont by Wyndham WarrentonWarrenton
7.6 out of 10, Good, (1,000 reviews)
"Staff was friendly and helpful"
Jared
The price is ฿2,893
฿3,305 total
includes taxes & fees
9 Aug - 10 Aug
Sleep Inn & Suites O'Fallon MO - Technology Drive
Sleep Inn & Suites O'Fallon MO - Technology DriveO'Fallon
9.0 out of 10, Wonderful, (1,043 reviews)
"very nice and clean room, breakfast selection was very nice, the staff was very courteous and professional. We will stay there again. "
Helmuth
The price is ฿2,806
฿3,309 total
includes taxes & fees
20 Jul - 21 Jul
Super 8 by Wyndham O'Fallon MO/St. Louis Area
Super 8 by Wyndham O'Fallon MO/St. Louis AreaO'Fallon
7.0 out of 10, Good, (1,009 reviews)
"Clean room, friendly staff"
Shelly
The price is ฿2,220
฿2,619 total
includes taxes & fees
6 Aug - 7 Aug
Economy Inn Wentzville
Economy Inn WentzvilleWentzville
6.4 out of 10, (550 reviews)
"Room was clean but basic"
James
The price is ฿2,344
฿2,659 total
includes taxes & fees
16 Jul - 17 Jul
Best Western Plus Washington Hotel
Best Western Plus Washington HotelWashington
9.2 out of 10, Wonderful, (709 reviews)
"Clean and quiet space to stay."
Irica
The price is ฿4,320
฿4,918 total
includes taxes & fees
19 Jul - 20 Jul
Holiday Inn Express Warrenton by IHG
Holiday Inn Express Warrenton by IHGWarrenton
9.0 out of 10, Wonderful, (545 reviews)
"Very good breakfast, especially good coffee, clean rooms, friendly staff, comfortable beds"
Tom
The price is ฿4,469
฿5,105 total
includes taxes & fees
29 Jul - 30 Jul
Hollywood Casino & Hotel St. Louis
Hollywood Casino & Hotel St. LouisRiverport
8.6 out of 10, Excellent, (2,222 reviews)
"Great hotel"
Brandon
The price is ฿4,353
฿5,567 total
includes taxes & fees
19 Jul - 20 Jul
Days Inn by Wyndham St Peters/St Charles
Days Inn by Wyndham St Peters/St CharlesSt. Peters
6.2 out of 10, (1,000 reviews)
"Good place to stay"
Jeremy
The price is ฿2,107
฿2,421 total
includes taxes & fees
5 Aug - 6 Aug
Drury Inn & Suites Southwest St. Louis
Drury Inn & Suites Southwest St. LouisValley Park
9.6 out of 10, Exceptional, (1,017 reviews)
"Very nice hotel. Lots of amenities and very clean."
Tanya
The price is ฿4,286
฿5,014 total
includes taxes & fees
2 Aug - 3 Aug
Drury Plaza Hotel St. Louis Chesterfield
Drury Plaza Hotel St. Louis ChesterfieldChesterfield
9.6 out of 10, Exceptional, (1,204 reviews)
"Had a great stay"
Madeleine
The price is ฿4,554
฿5,282 total
includes taxes & fees
6 Aug - 7 Aug
Embassy Suites by Hilton St. Louis St. Charles
Embassy Suites by Hilton St. Louis St. CharlesSt. Charles
8.8 out of 10, Excellent, (1,000 reviews)
"It was a great stay"
Denise
The price is ฿4,915
฿5,649 total
includes taxes & fees
29 Jul - 30 Jul
Fairfield Inn & Suites by Marriott St. Louis Chesterfield
Fairfield Inn & Suites by Marriott St. Louis ChesterfieldChesterfield
9.0 out of 10, Wonderful, (1,000 reviews)
"Overall wonderful stay and will return"
Wichita
The price is ฿4,189
฿4,859 total
includes taxes & fees
1 Aug - 2 Aug
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Defiance attractions
Learn more about Defiance
Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.
Top Defiance Hotel Reviews
Hollywood Casino & Hotel St. Louis
8/10 Good
More cheap stays in Defiance
Motel 6 Maryland Heights, MO
12330 Dorsett Rd Maryland Heights MO
The price is ฿2,177 per night from 16 Jul to 17 Jul
฿2,177
฿2,525 total
16 Jul - 17 Jul
includes taxes & fees
6.2/10 (1,010 reviews)
