Cape Girardeau Holiday Rentals, Missouri: Private House Rentals

A calm body of water, a sandy beach, and a forested area in the distance.

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Our top choices for Cape Girardeau hotels

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

1. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Sandra

฿3,321

฿3,746 total

includes taxes & fees

20 Sept - 21 Sept

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.

A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.

2. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

ELAINE

฿3,354

฿3,818 total

includes taxes & fees

20 Sept - 21 Sept

A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.

A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.

A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.

A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.

3. Drury Inn & Suites Cape Girardeau

Cape Girardeau

Teresa

฿2,989

฿3,372 total

includes taxes & fees

20 Sept - 21 Sept

A spacious lobby with marble flooring, elegant seating, and a grand staircase.

A spacious living room with a sofa set, a coffee table, and a dining area.

A lobby with seating areas, a reception desk, and a bar.

A modern hotel lobby with a framed advertisement for breakfast at the new Bistro, a seating area with sofas and a coffee table, and a decorative mirror reflecting the space.

4. Courtyard by Marriott Cape Girardeau Downtown

Cape Girardeau

Kristin

฿4,155

฿4,708 total

includes taxes & fees

27 Sept - 28 Sept

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

A Dear Tree Inn building with a covered entrance and a clear sky at dusk.

A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.

A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.

5. Pear Tree Inn Cape Girardeau West

Cape Girardeau

Raidas

฿2,391

฿2,697 total

includes taxes & fees

20 Sept - 21 Sept

A spacious dining area with high ceilings, large windows, and modern lighting fixtures.

A hotel room with a bed, a desk with a television, a chair, a suitcase, and a map on the wall.

An outdoor patio with stone walls, wicker furniture, and large windows.

A gym with exercise equipment, a treadmill, and a wall-mounted TV.

6. Hampton Inn Cape Girardeau I 55 East

Cape Girardeau

Rebekah

฿3,513

฿3,963 total

includes taxes & fees

27 Sept - 28 Sept

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A modern outdoor seating area with a glass-top table and a fire feature, overlooking a sunset view.

A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.

A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

7. The Riverview

Cape Girardeau

Alyssa

฿3,796

฿4,282 total

includes taxes & fees

20 Sept - 21 Sept

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.

A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

8. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Carlos

฿3,359

฿3,790 total

includes taxes & fees

27 Sept - 28 Sept

A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.

A hotel room with a flat-screen TV, a microwave, a sofa, a lamp, and a window with curtains.

A hotel room with a large bathtub, a bed with a wooden headboard, a nightstand with a lamp, and a painting of a building on the wall.

A restaurant with multiple tables and chairs, an exit sign, a television, and a counter with food items.

9. Quality Inn Cape Girardeau North

Cape Girardeau

Stephen

฿1,973

฿2,226 total

includes taxes & fees

27 Sept - 28 Sept

A modern retail area with a display of local items and snacks.

A hotel room with two beds, a desk, a chair, a TV, and a window with a view.

A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.

An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.

10. Tru By Hilton Cape Girardeau

Cape Girardeau

Darlene

฿2,968

฿3,378 total

includes taxes & fees

22 Sept - 23 Sept

A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.

A hotel entrance with a large tree, a well-maintained garden with various plants and flowers, and a parking lot.

A hotel patio with a gazebo, outdoor seating, and a view of the road.

An indoor swimming pool with tiled flooring, a seating area with chairs, and a staircase leading to a door.

11. Candlewood Suites Cape Girardeau by IHG

Cape Girardeau

Samuel

฿2,823

฿3,367 total

includes taxes & fees

11 Oct - 12 Oct

A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.

A motel with multiple floors, a parking lot, and a staircase leading to the upper floors.

A hotel room with a large bed, two bedside tables, a nightstand, a telephone, and two wall-mounted lamps.

A hotel room with a kitchenette, a bed, a dining table with chairs, a TV mounted on the wall, and a dresser.

12. Town House Inn Cape Giradreau

Cape Girardeau

Joshua

฿2,491

฿2,910 total

includes taxes & fees

24 Sept - 25 Sept

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.

A hotel room with two beds, a nightstand, a lamp, and a chair.

An outdoor patio with tables and chairs, a stone wall, and large windows.

13. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

Elaine

฿2,795

฿3,025 total

includes taxes & fees

22 Sept - 23 Sept

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

A hotel room with two beds, a brick wall, and a wooden headboard.

An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

A restaurant with a brick wall, a flat-screen TV, and a bar area.

14. Drury Inn & Suites Jackson MO

Jackson

William

฿2,756

฿2,914 total

includes taxes & fees

21 Sept - 22 Sept

A spacious lobby with large windows, comfortable seating, and a modern ceiling design.

A hotel room with a bed, a dark sofa, an ottoman, a lamp, and artwork on the wall.

A breakfast bar with coffee machines, a cereal dispenser, and a fruit display.

A gym with treadmills, an elliptical, a bench, and a rack of dumbbells.

15. Comfort Suites Jackson-Cape Girardeau

Jackson

VICTORIA

฿2,518

฿2,725 total

includes taxes & fees

11 Oct - 12 Oct

A kitchen with dark wooden cabinets, a stainless steel refrigerator, a black stove, a microwave, and a sink.

A trophy labeled "Town House Inn" with "Cape Girardeau County, Missouri" and "2025" on it.

A bathroom with a granite countertop sink, a mirror, two hair dryers mounted on the wall, and a trash bin.

16. Town House Inn

Jackson

Taylor

฿2,367

฿2,562 total

includes taxes & fees

27 Sept - 28 Sept

A living room with a blue wall, a fireplace, a sofa, and a chair.

A brick building with a sign reading "Mercantile & Hotel".

A bar area with stools and a counter where a bartender is serving drinks.

A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.

17. EC Reed's Mercantile and Hotel

Marble Hill

JANEEN

฿3,359

฿3,656 total

includes taxes & fees

17 Sept - 18 Sept

A rustic lodge with a steeply pitched roof, a central entrance with a door, and a porch with multiple lights.

A cozy living room with a brown leather sofa, a wooden coffee table, and a window with a view of trees.

A rustic building with a thatched roof, surrounded by dense greenery and a gravel path leading to it.

A stone building with a patio area, string lights, and outdoor seating.

18. Makanda Inn

Makanda

Michele

฿8,699

฿9,917 total

includes taxes & fees

17 Sept - 18 Sept

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Stay near popular Cape Girardeau attractions

A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.

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A cable-stayed bridge over a river with a rocky shoreline in the foreground.

Riverfront Bridge Park

8.8/10 (129 reviews)

Enjoy panoramic views of the Mississippi River and Bill Emerson Memorial Bridge from this peaceful riverside park. Stroll along the well-maintained walking paths and find perfect spots for memorable photographs.

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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants.

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Hunter Valley Winery

7.4/10 (48 reviews)

Sip award-winning Chambourcin and Chardonnay at this picturesque Missouri estate with lake views. Bring a picnic basket and enjoy live weekend music on the deck overlooking the sculpture garden.

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Show Me Center

8.6/10 (40 reviews)

The Show Me Centre hosts Southeast Missouri State basketball and major concerts in a versatile arena setting. Catch Redhawks games or enjoy performances by renowned artists in this regional entertainment hub.

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Riverfront Park

8.0/10 (2 reviews)

This riverside haven features terraced seating overlooking the Mississippi and a flood wall adorned with historical murals. Stroll the riverfront trail while watching paddle boats dock at this picturesque park.

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Cape Splash Family Aquatic Center

8.6/10 (21 reviews)

This 3.5-acre water park thrills with a 265-foot free-fall slide and 700-foot lazy river. Families can splash in the pirate ship playground or relax in shaded lounge areas during summer months.

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Cape Rock Park

8.6/10 (36 reviews)

Perched on a limestone bluff, Cape Rock Park offers panoramic views of the Mississippi River and passing barges. Bring binoculars to spot wildlife at this historic former trading post.

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Learn more about Cape Girardeau

Explore the mighty Mississippi from the riverfront park where historic murals tell stories of river life. Climb to the top of Academic Hall at Southeast Missouri State or hunt for antiques along downtown's brick-paved streets.

See all hotels in Cape Girardeau

A nighttime view of a bridge with its cables illuminated against a starry sky.

Top Cape Girardeau Hotel Reviews

Drury Inn & Suites Jackson MO

10/10 Excellent

"What a great stay! It’s the best buffet breakfast in the area."

EC Reed's Mercantile and Hotel

10/10 Excellent

"This hotel is perfect!!! We loved the check in process which is the easiest i have ever encountered. The hotel is so cute and nostalgic. I fell in love with the room, the lobby and the restaurant. Very nice people here. The food was absolutely delicious. The music playing in the hotel lobby was lite and relaxing. The bed in room 6 was so comfortable like a big fluffy cloud. The mercantile has the most unique items. I wish i would have time to visit the old time soda shop. The coffee bar was awesome. I love the patriot coffee k cups . The honey for the coffee was top tier. There is nothing about this place that we did not love. Please do yourself a favor and stop by, i promise its worth the stop. There is also a small barber shop at the entrance of the hotel. Thank yall for the kindness shown to us and we cant wait to visit again"

Tru By Hilton Cape Girardeau

10/10 Excellent

"Excellent hotel!! Great water pressure in showers!"

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"Great experience- food, cleanliness, friendly staff"

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent

"Excellent breakfast,friendly staff and clean rooms"

Fairfield Inn & Suites by Marriott Cape Girardeau

10/10 Excellent

"The receptionist was very courteous. Helped answer all my questions. We loved the room. And we had a great breakfast before we left."

Town House Inn Cape Giradreau

8/10 Good

"The outside needed cleaning, but the room was very clean and well maintained."

Hotel 7 Inn Anna

10/10 Excellent

"Staff were very accommodating and made the stay very pleasant."

More cheap stays in Cape Girardeau

Quality Inn Cape Girardeau North

2011 North Kingshighway Cape Girardeau MO

฿1,973

฿2,226 total

27 Sept - 28 Sept

includes taxes & fees

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

฿2,391

฿2,697 total

20 Sept - 21 Sept

includes taxes & fees

Candlewood Suites Cape Girardeau by IHG

485 S Mount Auburn Rd Cape Girardeau MO

฿2,823

฿3,367 total

11 Oct - 12 Oct

includes taxes & fees

8/10 Very good! (1,000 reviews)

Tru By Hilton Cape Girardeau

2520 Veterans Memorial Dr Cape Girardeau MO

฿2,968

฿3,378 total

22 Sept - 23 Sept

includes taxes & fees

9.6/10 Exceptional! (179 reviews)

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO

฿3,354

฿3,818 total

20 Sept - 21 Sept

includes taxes & fees

9.4/10 Exceptional! (1,000 reviews)

Hampton Inn Cape Girardeau I 55 East

207 S Mt Auburn Rd Cape Girardeau MO

฿3,513

฿3,963 total

27 Sept - 28 Sept

includes taxes & fees

Frequently asked questions

What's the best place to stay in Cape Girardeau?

Drury Plaza Hotel Cape Girardeau Conference Center is one of the top choices for your stay based on our traveller data. This hotel offers free breakfast and a restaurant. Other good options for your visit include The Riverview and Pear Tree Inn Cape Girardeau West. See all available top hotels, or vacation rentals in Cape Girardeau.

If I need to cancel my hotel reservation in Cape Girardeau, will I receive a refund?

Yes! You'll find that most hotel reservations are refundable provided that you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Cape Girardeau.

What's the best accommodation for a budget-friendly stay in Cape Girardeau?

Based on reviews, Pear Tree Inn Cape Girardeau West is a popular hotel for our travellers who want a more economical choice, and features free buffet breakfast and free Wi-Fi. View all budget hotels in Cape Girardeau.

What's the best family accommodation in Cape Girardeau?

Drury Plaza Hotel Cape Girardeau Conference Center is a hotel with an indoor pool and a restaurant, and it's a top choice on Expedia for families. Pear Tree Inn Cape Girardeau West is another good option for your stay with the kids. Also, attractions such as Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center are fun for children of all ages. Find more child-friendly accommodations in Cape Girardeau.

What's the best LGBTQ-friendly hotel in Cape Girardeau?

Drury Plaza Hotel Cape Girardeau Conference Center is a top LGBTQ-friendly hotel that features free breakfast and free Wi-Fi. Candlewood Suites Cape Girardeau by IHG and Drury Inn & Suites Cape Girardeau are other good options for your stay. See all available hotels listed as LGBTQ-friendly in Cape Girardeau.

What's the best dog-friendly hotel in Cape Girardeau?

Drury Plaza Hotel Cape Girardeau Conference Center is a top hotel for people travelling with their pets, and offers a restaurant and free WiFi for its human guests. Two other good options for you and your pet's trip include Candlewood Suites Cape Girardeau by IHG and Drury Inn & Suites Cape Girardeau. See more pet-friendly hotel accommodations in Cape Girardeau.

What are some accommodation options with pools in Cape Girardeau?

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is a top hotel with a pool, a full-service spa and free WiFi. View all hotels with pools in Cape Girardeau.

What is the best spa hotel in Cape Girardeau?

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is a top spa hotel featuring a pool and a fitness centre. See all spa hotels in Cape Girardeau.

What is staying in Cape Girardeau like?

History buffs will enjoy exploring Cape Girardeau, and visitors give high marks for the top-notch restaurants. Tourists who journey to this welcoming city can discover its riverfront, university setting and shopping. In Cape Girardeau, there are 68 hotels and other accommodation options to choose from. Find out more about Cape Girardeau.

What should I do while I'm visiting Cape Girardeau?

Favorite family attractions include Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center. Landmarks like The Glenn House and Fort D Historic Site might be worth a visit. Natural beauty is on display at Shawnee National Forest, Mississippi River and Cape Rock Park. Take a look at what more there is to see and do in Expedia's Cape Girardeau guide.

What's the weather like in Cape Girardeau?

The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Cape Girardeau is 1495 mm.

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Book Hotels in Cape Girardeau on Expedia.com

Find hotels in Cape Girardeau, MO from ฿2,226

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Cape Girardeau

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Cape Girardeau hotels

1. Drury Plaza Hotel Cape Girardeau Conference Center

2. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3. Drury Inn & Suites Cape Girardeau

4. Courtyard by Marriott Cape Girardeau Downtown

5. Pear Tree Inn Cape Girardeau West

6. Hampton Inn Cape Girardeau I 55 East

7. The Riverview

8. Fairfield Inn & Suites by Marriott Cape Girardeau

9. Quality Inn Cape Girardeau North

10. Tru By Hilton Cape Girardeau

11. Candlewood Suites Cape Girardeau by IHG

12. Town House Inn Cape Giradreau

13. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

14. Drury Inn & Suites Jackson MO

15. Comfort Suites Jackson-Cape Girardeau

16. Town House Inn

17. EC Reed's Mercantile and Hotel

18. Makanda Inn

Stay near popular Cape Girardeau attractions

Southeast Missouri State University

Riverfront Bridge Park

Century Casino & Hotel Cape Girardeau

Hunter Valley Winery

Show Me Center

Riverfront Park

Cape Splash Family Aquatic Center

Cape Rock Park

Learn more about Cape Girardeau

Top Cape Girardeau Hotel Reviews

Drury Inn & Suites Jackson MO

EC Reed's Mercantile and Hotel

Tru By Hilton Cape Girardeau

Drury Plaza Hotel Cape Girardeau Conference Center

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Fairfield Inn & Suites by Marriott Cape Girardeau

Town House Inn Cape Giradreau

Hotel 7 Inn Anna

More cheap stays in Cape Girardeau

Quality Inn Cape Girardeau North

Pear Tree Inn Cape Girardeau West

Candlewood Suites Cape Girardeau by IHG

Tru By Hilton Cape Girardeau

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Hampton Inn Cape Girardeau I 55 East

Frequently asked questions

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