Cheap American Airlines flights from McAllen to San Diego (MFE→SAN)

Apply the "Price (lowest to highest)" filter on Expedia to search for cheap American Airlines round-trip flights from MFE to SAN. Affordable one-way options are also available.*

*These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

January is one of the most affordable months to jet off to San Diego with American Airlines. You could also find great prices on one-way and round-trip tickets in November.

Fill in your dates, hit search and tick the "Nonstop" filter on Expedia to find any direct flights from MFE to SAN with American Airlines or other carriers.

San Diego Intl. Airport (SAN) is the main San Diego gateway for American Airlines flights from Miller Intl. Airport (MFE).

It's generally possible to reschedule or cancel your flight, although there may be a charge if you booked more than 24 hours ago. Need flexible options? Use Expedia's "No cancel fee" or "Changes included" filter to find flights that won't charge extra if you need to revise your plans. To make changes, go to "Trips," select your flight and click on "Manage Booking" for further information.