Cheap American Airlines flights from Knoxville to San Diego (TYS→SAN)

  • notification illustration

    Be in the know

    Get alerts if flight prices drop or rise*
  • deals illustration

    Book smarter

    Save up to 40% on select hotels after you book a flight*
  • trophy illustration

    Earn twice

    Earn your airline miles on top of our rewards
    Sign in
Flight from Knoxville to San Diego route information
Origin airport
McGhee Tyson
Destination airport
San Diego Intl.
Distance
3038 km

Frequently asked questions

How much is an American Airlines flight from McGhee Tyson Airport (TYS) to San Diego Intl. Airport (SAN)?
You can discover budget-friendly return American Airlines flights from TYS to SAN by sorting your results from "Price (lowest to highest)" on Expedia. Or look for deals for a one-way journey.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.
What is the cheapest month to fly from TYS to SAN with American Airlines?
American Airlines flights to San Diego are typically more affordable in the quieter months of January and November. Whether you're in search of a one-way or round-trip ticket, you could find a better deal then.
Does American Airlines fly nonstop from McGhee Tyson Airport (TYS) to San Diego Intl. Airport (SAN)?
Use the "Nonstop" filter when browsing for direct American Airlines flights from TYS to SAN. It's also a great way to compare other airlines servicing the same nonstop trip.
What airports does American Airlines fly into in San Diego?
San Diego Intl. Airport (SAN) is the main San Diego hub for American Airlines flights from McGhee Tyson Airport (TYS).
Can I change or cancel my American Airlines flight from McGhee Tyson Airport (TYS) to San Diego Intl. Airport (SAN)?
Changes are often free within 24 hours of making a booking, but your airline may charge you after that. For further information about modifying your flights, check out your "Trips," select your flight and click on "Manage Booking." If you want the freedom to make changes without being charged, apply the "Changes included" or "No cancel fee" filter when planning your next getaway.
*Available to Expedia members.