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21 Aug - 23 Aug
Next weekend
28 Aug - 30 Aug

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Our top choices for Medical Center District hotels

A modern living room with a fireplace, a flat-screen TV, and a stone accent wall.

1. Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center
3.0 star property
Medical Center District
9.0 out of 10, Wonderful, (1,052 reviews)
"Great Stay!"
United States
Matthew
The price is ฿2,843
฿3,319 total
includes taxes & fees
6 Sept - 7 Sept
Fairfield Inn & Suites by Marriott San Antonio Medical Center
A hotel dining area with multiple tables and chairs, a counter with a coffee machine, and a view of the outside through large windows.

2. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
3.0 star property
Medical Center District
8.4 out of 10, Very good, (3,599 reviews)
"Great location and very clean/nice."
United States
Melissa
The price is ฿2,919
฿3,450 total
includes taxes & fees
23 Aug - 24 Aug
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
A modern bar area with wooden bar counters, black bar stools, and pendant lighting.

3. Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio
3.0 star property
Medical Center District
8.8 out of 10, Excellent, (1,010 reviews)
"Clean, friendly staff . Would book again"
United States
Elizabeth
The price is ฿2,926
฿3,458 total
includes taxes & fees
28 Aug - 29 Aug
Courtyard by Marriott Medical Center San Antonio
A spacious lobby with multiple seating areas, a central coffee table, and a view of the upper floors.

4. Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center
3.0 star property
Medical Center District
9.2 out of 10, Wonderful, (1,421 reviews)
"Amazaing stay friendly staff!"
United States
Melissa
The price is ฿2,958
฿3,497 total
includes taxes & fees
25 Aug - 26 Aug
Drury Inn & Suites San Antonio Northwest Medical Center
A spacious lobby with a central staircase, seating area, and large windows.

5. San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center
3.5 star property
Medical Center District
8.6 out of 10, Excellent, (1,151 reviews)
"Great hotel"
United States
Mario
The price is ฿3,539
฿4,205 total
includes taxes & fees
20 Sept - 21 Sept
San Antonio Marriott Northwest Medical Center
A modern kitchen with a large window, wooden counter, and two bar stools.

6. Park Inn by Radisson, Medical Center

Park Inn by Radisson, Medical Center
2.0 star property
Medical Center District
7.4 out of 10, Good, (1,003 reviews)
"Room was very clean, walking distance from hospitals. Ample parking"
United States
Gloria
The price is ฿2,189
฿2,556 total
includes taxes & fees
8 Sept - 9 Sept
Park Inn by Radisson, Medical Center
A modern bedroom with a large bed, bedside tables, a desk, and a chair.

7. Motel 6 San Antonio, TX - Northwest Medical Center

Motel 6 San Antonio, TX - Northwest Medical Center
2.0 star property
Medical Center District
6.0 out of 10, (1,000 reviews)
"front desk reps very friendly and helpful"
United States
Rachel
The price is ฿1,547
฿1,960 total
includes taxes & fees
24 Aug - 25 Aug
Motel 6 San Antonio, TX - Northwest Medical Center
A gas station with a sign for 'Atria Inn & Suites' and a 'Clearance - 12' sign.

8. Atria Inn & Suites

Atria Inn & Suites
2.0 star property
Medical Center District
7.4 out of 10, Good, (309 reviews)
"👌"
United States
Gloria
The price is ฿1,948
฿2,274 total
includes taxes & fees
21 Aug - 22 Aug
Atria Inn & Suites
A hotel room with two beds, a desk, a chair, a mirror, and a bathroom.

9. Studio 6 San Antonio, Tx - Northwest Medical Center

Studio 6 San Antonio, Tx - Northwest Medical Center
2.0 star property
Medical Center District
7.4 out of 10, Good, (356 reviews)
"Good staff great room for the price Quiet area"
United States
RUDY AGUIRRE
The price is ฿1,542
฿1,800 total
includes taxes & fees
24 Aug - 25 Aug
Studio 6 San Antonio, Tx - Northwest Medical Center
A building entrance with a glass door, a Pepsi vending machine, and a yellow bollard.

10. OYO Inn & Suites Medical Center San Antonio

OYO Inn & Suites Medical Center San Antonio
2.0 star property
Medical Center District
7.4 out of 10, Good, (245 reviews)
"It was quiet and clean and the staff was very friendly"
United States
Ronnie
The price is ฿1,668
฿2,115 total
includes taxes & fees
3 Sept - 4 Sept
OYO Inn & Suites Medical Center San Antonio
A hotel room with two beds, a TV, a desk, and a kitchenette in the background.

11. Studio 6 Extended Stay - San Antonio, TX - Medical Center

Studio 6 Extended Stay - San Antonio, TX - Medical Center
2.0 star property
Medical Center District
6.8 out of 10, (976 reviews)
"Friendly staff, room was cleaned and well kept."
United States
Jose
The price is ฿1,709
฿2,086 total
includes taxes & fees
21 Aug - 22 Aug
Studio 6 Extended Stay - San Antonio, TX - Medical Center
A hotel room with a large bed, a desk with a chair, a television on a stand, and a mirror on the wall.

12. Flex Studios

Flex Studios
2.5 star property
Medical Center District
6.2 out of 10, (565 reviews)
"Yes I would stay again"
United States
Jasper
The price is ฿1,302
฿1,539 total
includes taxes & fees
23 Aug - 24 Aug
Flex Studios
An indoor swimming pool with a hot tub, tiled flooring, and a seating area with tables and chairs.

13. Drury Inn & Suites Near La Cantera Parkway

Drury Inn & Suites Near La Cantera Parkway
3.0 star property
La Cantera District, 9.5 km from Medical Center District
9.4 out of 10, Exceptional, (1,919 reviews)
"Love staying here !"
United States
Samantha
The price is ฿3,090
฿3,652 total
includes taxes & fees
25 Aug - 26 Aug
Drury Inn & Suites Near La Cantera Parkway
A buffet with various food items, including omelets and cheese.

14. Holiday Inn Express San Antonio-Airport by IHG

Holiday Inn Express San Antonio-Airport by IHG
2.5 star property
8.9 km from Medical Center District
9.4 out of 10, Exceptional, (1,012 reviews)
"Excellent hotel, clean, great breakfast and amenities."
United States
Edgar
The price is ฿3,221
฿3,808 total
includes taxes & fees
20 Sept - 21 Sept
Holiday Inn Express San Antonio-Airport by IHG
A modern bar area with a central island, bar stools, and a kitchen counter with appliances.

15. Hyatt Place San Antonio-Northwest/Medical Center

Hyatt Place San Antonio-Northwest/Medical Center
3.0 star property
3.7 km from Medical Center District
8.4 out of 10, Very good, (1,024 reviews)
"Clean cold room, welcoming great location"
United States
Daniel
The price is ฿3,057
฿3,654 total
includes taxes & fees
26 Aug - 27 Aug
Hyatt Place San Antonio-Northwest/Medical Center
A modern hotel with a prominent sign reading "LA QUINTA".

16. La Quinta Inn & Suites by Wyndham San Antonio Seaworld/LAFB

La Quinta Inn & Suites by Wyndham San Antonio Seaworld/LAFB
3.0 star property
9 km from Medical Center District
9.2 out of 10, Wonderful, (1,180 reviews)
"The staff was very helpful and it was close to everything we planned on going to"
United States
Ruben
The price is ฿3,386
฿3,953 total
includes taxes & fees
23 Aug - 24 Aug
La Quinta Inn & Suites by Wyndham San Antonio Seaworld/LAFB
A spacious dining area with multiple tables and chairs, a bar area, and a television mounted on the wall.

17. Hampton Inn & Suites San Antonio Northwest/Medical Center

Hampton Inn & Suites San Antonio Northwest/Medical Center
2.5 star property
Northwest Side, 4.7 km from Medical Center District
8.4 out of 10, Very good, (1,053 reviews)
"Solid property… friendly staff, and great for an overnight business trip"
United States
James
The price is ฿2,938
฿3,539 total
includes taxes & fees
27 Aug - 28 Aug
Hampton Inn & Suites San Antonio Northwest/Medical Center
A modern lobby with seating areas, a stone accent wall, and a wooden ceiling.

18. Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

Heritage Inn & Suites San Antonio Airport, Trademark Wyndham
2.5 star property
Uptown, 9.3 km from Medical Center District
9.0 out of 10, Wonderful, (2,105 reviews)
"Exelent place to stay"
United States
Victor M.
The price is ฿2,629
฿3,108 total
includes taxes & fees
23 Aug - 24 Aug
Heritage Inn & Suites San Antonio Airport, Trademark Wyndham
A modern building with a distinctive roof structure and a large illuminated sign.

19. Aloft by Marriott San Antonio UTSA Area

Aloft by Marriott San Antonio UTSA Area
3.0 star property
Northwest Side, 7.8 km from Medical Center District
9.0 out of 10, Wonderful, (1,008 reviews)
"Enjoyed our stay. Conveniently located"
United States
Mark
The price is ฿3,208
฿3,792 total
includes taxes & fees
6 Sept - 7 Sept
Aloft by Marriott San Antonio UTSA Area
A modern kitchen with a central island, built-in appliances, and a coffee station.

20. Wyndham Garden San Antonio Airport

Wyndham Garden San Antonio Airport
3.0 star property
Uptown, 9.2 km from Medical Center District
8.6 out of 10, Excellent, (1,830 reviews)
"Wonderful stay & very convenient to the airport!"
United States
Michelle
The price is ฿2,799
฿3,309 total
includes taxes & fees
13 Sept - 14 Sept
Wyndham Garden San Antonio Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Medical Center District

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A spacious lobby with multiple seating areas, a central coffee table, and a view of the upper floors.
Drury Inn & Suites San Antonio Northwest Medical Center
3.0 star property
9.2
Wonderful
1,421 reviews
View
A modern living room with a fireplace, a flat-screen TV, and a stone accent wall.
Fairfield Inn & Suites by Marriott San Antonio Medical Center
3.0 star property
9.0
Wonderful
1,052 reviews
View
A modern bar area with wooden bar counters, black bar stools, and pendant lighting.
Courtyard by Marriott Medical Center San Antonio
3.0 star property
8.8
Excellent
1,010 reviews
View
A spacious lobby with a central staircase, seating area, and large windows.
San Antonio Marriott Northwest Medical Center
3.5 star property
8.6
Excellent
1,151 reviews
View
A hotel dining area with multiple tables and chairs, a counter with a coffee machine, and a view of the outside through large windows.
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
3.0 star property
8.4
Very good
3,599 reviews
View

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most.
A boat tour on a canal with a bridge in the background.

Downtown San Antonio

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

A large, abstract sculpture with a flowing design, set against a dramatic sky.
Photo by Sarah C.
Open Photo by Sarah C.

Uptown

If you're spending some time in Uptown, Alamo Quarry Market and San Antonio Zoo and Aquarium are top sights worth seeing.

A large, modern building with a blue and white color scheme, featuring a prominent circular window and a 'Welcome' sign.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

A nighttime amusement park with roller coasters, a bridge, and a full moon.

La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

A historic stone building with a central arched doorway, a flagpole with a flag, and a paved courtyard.

Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Dub Farris Athletic Complex are top sights worth seeing.

Top Medical Center District Hotel Reviews

Omni La Mansion del Rio

Omni La Mansion del Rio

10/10 Excellent
"If you want to stay on the Riverwalk, you won't find a better location than this hotel. The hotel is a little older but very clean. The pool is nice. The staff were all friendly and professional."
Lucy D 4-night trip
Posted less than an hour ago
Omni La Mansion del Rio

Frequently asked questions

What is Medical Center District like?
Travellers are sure to enjoy a stay in San Antonio's Medical Center District neighbourhood. Are you looking for Medical Center District travel tips? Make sure that you visit USAA Corporate Office Headquarters and Cinemark San Antonio 16 while you're in the neighbourhood.
What's a favourite hotel to stay in Medical Center District?
Based on our traveller data, La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW is one of the top choices for your stay in Medical Center District. This hotel offers free breakfast and an outdoor pool. Other good options for your stay in the area include Courtyard by Marriott Medical Center San Antonio and Drury Inn & Suites San Antonio Northwest Medical Center.
How many hotels will I be able to find in Medical Center District?
Expedia has 125 hotels and other accommodation options in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.
If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?
Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Medical Center District.
What can I see and do in this San Antonio neighbourhood?
A few attractions you might want to check out while you're in Medical Center District are USAA Corporate Office Headquarters and Cinemark San Antonio 16. Wonderland of the Americas Mall and Regal Huebner Oaks are also worth a visit when you're out sightseeing in San Antonio.