Southeast Missouri Holiday Rentals, Missouri: Private House Rentals

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Our top choices for Southeast Missouri hotels

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a microwave.

A building with a red awning labeled "Shepherd Mountain Inn."

A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.

1. Shepherd Mountain Inn

Ironton

Michael

฿4,138

฿4,520 total

includes taxes & fees

6 Oct - 7 Oct

A motel with a covered entrance, a flag, and a phone number.

A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.

A living room with a black leather sofa, a wooden coffee table with a vase of flowers, a green potted plant, and a lamp.

2. Madison Inn Lodge

Fredericktown

Bawan

฿2,718

฿2,968 total

includes taxes & fees

3 Nov - 4 Nov

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

3. Hampton Inn & Suites By Hilton Festus

Festus

Abram

฿3,000

฿3,430 total

includes taxes & fees

29 Oct - 30 Oct

A hotel room with a large bed, a nightstand, a lamp, a chair, and a mirror.

A buffet with various food items, including omelets and other dishes, served in metal containers with glass lids.

A hotel lobby with a seating area, a reception desk, and a bar.

A kitchen counter with a coffee machine, a kettle, and storage boxes.

4. Holiday Inn Express & Suites Perryville by IHG

Perryville

Lisa

฿3,389

฿3,880 total

includes taxes & fees

1 Nov - 2 Nov

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

A reception area with a wooden counter, a coffee machine, and a display of pastries.

A corner market with a refrigerated display case and a pantry area.

An outdoor patio with a table and chairs, a large umbrella, and a glass door leading to an interior space.

5. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

Nancy

฿3,394

฿3,835 total

includes taxes & fees

11 Oct - 12 Oct

An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

A modern bathroom with a bathtub, a window with curtains, and a view of a green landscape.

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

A spacious hotel lobby with a dining area, kitchen, and large windows.

6. Crown Pointe Lodge, BW Signature Collection

Farmington

Stephanie

฿3,680

฿4,208 total

includes taxes & fees

6 Oct - 7 Oct

A modern kitchen with a coffee machine, a refrigerator, and a microwave.

A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

A hotel room with a large bed, a smaller bed, a nightstand with a lamp, and two large framed pictures on the wall.

A laundry room with a front-loading washer and dryer, a door, and a light fixture.

7. Super 8 by Wyndham Farmington

Farmington

Marisa

฿1,997

฿2,283 total

includes taxes & fees

11 Oct - 12 Oct

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

8. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Allen

฿3,389

฿3,838 total

includes taxes & fees

11 Oct - 12 Oct

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.

A restaurant with a brick wall, a flat-screen TV, and a bar area.

9. Drury Inn & Suites Jackson MO

Jackson

Thomas

฿2,684

฿2,838 total

includes taxes & fees

11 Oct - 12 Oct

A living room with a blue wall, a fireplace, a sofa, and a chair.

A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.

A brick building with a sign reading "Mercantile & Hotel".

A bar area with stools and a counter where a bartender is serving drinks.

10. EC Reed's Mercantile and Hotel

Marble Hill

JANEEN

฿3,528

฿3,841 total

includes taxes & fees

6 Oct - 7 Oct

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

11. Hampton Inn Poplar Bluff

Poplar Bluff

Rhonda

฿3,052

฿3,418 total

includes taxes & fees

18 Oct - 19 Oct

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

A hotel room with a large bed, two sofas, a desk with a lamp, a microwave, and a TV.

A hotel reception area with a glass partition, a reception desk, and a digital kiosk.

A gym with cardio equipment, a bench press, and a squat rack.

12. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

Mark

฿1,826

฿2,088 total

includes taxes & fees

1 Nov - 2 Nov

A modern lobby with seating areas, a patterned carpet, and a cityscape mural on the wall.

A spacious lobby with a modern design, featuring a large seating area with purple and gray chairs, a patterned carpet, and a cityscape mural on the wall.

A modern hotel with a prominent 'La Quinta' sign, large windows, and a well-lit entrance.

A hotel room with a large bed, a bedside table with a lamp, a vanity with a mirror, and a wall with framed pictures.

13. La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Festus

Lisa-Marie

฿2,824

฿3,229 total

includes taxes & fees

8 Oct - 9 Oct

A hotel room with a bed, a sofa, a desk, and a chair.

A coffee station with two coffee machines, a coffee press, and various coffee-related items on a wooden counter.

An indoor swimming pool with a tiled edge, surrounded by lounge chairs and potted plants.

A hotel lobby with a central reception desk, multiple seating areas, and a tiled floor.

14. Holiday Inn Express & Suites Farmington by IHG

Farmington

Sheila

฿4,094

฿4,682 total

includes taxes & fees

11 Oct - 12 Oct

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

An outdoor pool area with lounge chairs and an umbrella.

A hotel room with a television, a desk, a chair, a dresser, a radiator, and a bathroom visible through an open door.

A reception desk with a woman standing behind it, a man with a suitcase, and another person standing to the left.

15. Fort Davidson Hotel

Ironton

richard

฿4,027

฿4,399 total

includes taxes & fees

27 Oct - 28 Oct

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

16. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Sandra

฿3,356

฿3,786 total

includes taxes & fees

11 Oct - 12 Oct

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

A hotel room with a kitchenette, a large mirror, a sofa, and a patterned carpet.

A spacious lobby with a checkered floor, two sofas with patterned cushions, a computer desk, and a reception area with a glass door.

A hotel room with a large bed, a desk with a chair, a television, and a small table with a lamp.

17. Super 8 by Wyndham Perryville

Perryville

paulette

฿2,311

฿2,645 total

includes taxes & fees

25 Oct - 26 Oct

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

18. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Carlos

฿3,394

฿3,829 total

includes taxes & fees

11 Oct - 12 Oct

A spacious lobby with a reception desk, seating area, and large windows.

An indoor swimming pool with a clear view of the outside through large windows.

A hotel room with a bed, a desk, a chair, a sofa, and a TV.

A spacious lobby with a high ceiling, a mezzanine level, and a seating area with a sofa and chairs.

19. Drury Inn & Suites Poplar Bluff

Poplar Bluff

Dean

฿3,154

฿3,563 total

includes taxes & fees

18 Oct - 19 Oct

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A hotel room with two beds, a desk, a chair, and a view of the city.

A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.

A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.

20. The Riverview

Cape Girardeau

Alyssa

฿3,836

฿4,327 total

includes taxes & fees

7 Oct - 8 Oct

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Holiday Rentals in Southeast Missouri

Cabin

A view through a window with a stone wall and a wooden structure in the background.

A room with two bunk beds, a single bed, a ceiling fan, and a window with blinds.

Sam A Baker State Park

Patterson

"Pet friendly, great staff. "

Cabin

A bedroom with a bed, a wooden headboard, a window with a view of greenery, and a tray with breakfast items.

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"The stay here gets better every time."

Aparthotel

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A building with a dark exterior, a large window, and a sign that reads "The Atrium."

A fireplace with a decorative mantel, a framed sign, and a small table with plants.

A bedroom with a brick wall, a bed with patterned bedding, and a shelf with decorative items.

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Aparthotel

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.

A bedroom with a bed, a bench, a ceiling fan, a mirror, and a wooden floor.

A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

Urban Lofts

Perryville

"Beautiful place and staff was amazing!"

Cottage

A dining area with a checkered tablecloth, wooden chairs, and a red rug.

A modern kitchen with wooden cabinets, a microwave, and a refrigerator. There is a staircase leading to another level. A gray sofa with a red pillow is in the living area, and a checkered curtain covers a window.

A swimming pool with a wooden deck, surrounded by a white picket fence, and featuring colorful umbrellas.

An outdoor patio with a table and chairs, a grill, and a large umbrella.

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Ironton

"Stroller, pack n play and high chair. This was amazing "

Holiday Home

A wooden deck with two Adirondack chairs and a hammock.

A spacious living room with wooden floors, a stone fireplace, and a mounted television.

A spacious living room with a wooden ceiling, a fireplace, and a television.

A spacious living room with a wooden ceiling, a ceiling fan, a sofa set, a coffee table, and a large window offering a view of the outdoors.

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Cabin

A calm lake with a wooden dock and a forested island in the distance.

A bedroom with a wooden bed, a bench, and a window.

Lake Wappapello

Williamsville

"Pet friendly. Family-friendly "

Cottage

A bedroom with a large bed, a sofa, a wooden wardrobe, and a ceiling fan.

A single-story house with a front porch, a stone foundation, and a well-maintained lawn.

A kitchen with wooden cabinets, a central island, and a dining area with a table set for four.

A covered porch with yellow chairs, a bench, and a small table.

Walk to Dtwn: Ironton Home in Historic District

Ironton

"Clean and comfortable "

Cottage

A small, single-story house with a dark roof and white siding.

A cozy cabin interior with a wooden interior, a fireplace, a television, and a comfortable seating area.

Walk to Current River: Ozarks Adventure Home!

Van Buren

"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."

Cottage

A spacious living room with a high wooden ceiling, two sofas, a coffee table, a TV, and a bookshelf.

A red house with a wooden deck, large sliding glass doors, and a chimney.

A bedroom with a bed, two bedside tables, a dresser, a ceiling fan, and a window with curtains.

A dining area with a glass table and chairs, wooden flooring, and large windows.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

Cottage

A bedroom with a bed, nightstand, lamp, and curtains.

A living room with a sofa, coffee table, TV stand, and ceiling fan.

A kitchen with granite countertops, white cabinets, a coffee maker, a kettle, and a sink.

A single-story house with a front porch, a small front yard, and a red roof.

Cottage w/ Yard, Walk to Historic Attractions

Ste Genevieve

"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.

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A sunset over a lake with boats and ducks.

Lake Wappapello

8.8/10 (54 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants.

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Century Casino Caruthersville

7.0/10 (57 reviews)

Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

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Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

Crown Pointe Lodge, BW Signature Collection

10/10 Excellent

"Enjoyed the very clean modern room and the nice view of the golf course. Great place to relax in Farmington"

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent

"Perfect location, beds were awesome & staff were friendly & accommodating!"

Drury Inn & Suites Cape Girardeau

10/10 Excellent

"No exhaust fan in the bathroom. Other than that very clean comfortable hotel"

Hampton Inn Poplar Bluff

10/10 Excellent

"Very clean and spacious room, staff were friendly and courteous, shops and restaurants nearby. Would stay here again."

Drury Plaza Hotel Cape Girardeau Conference Center

8/10 Good

"Needs some more luxurious bedding. My sheets were worn and scratchy."

The Riverview

10/10 Excellent

"Great room. Beds were comfortable. Staff was nice and helpful. Not too crowded. Real nice place. Will go there again"

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"The stay here gets better every time."

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent

"Great place"

Drury Inn & Suites Hayti Caruthersville

10/10 Excellent

"The food & drinks were great & the staff was very friendly. Room was very nice."

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

฿1,826

฿2,088 total

1 Nov - 2 Nov

includes taxes & fees

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

฿2,225

฿2,536 total

1 Nov - 2 Nov

includes taxes & fees

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

฿2,416

฿2,725 total

11 Oct - 12 Oct

includes taxes & fees

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO

฿2,389

฿2,792 total

1 Nov - 2 Nov

includes taxes & fees

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

฿2,651

฿2,969 total

6 Oct - 7 Oct

includes taxes & fees

8/10 Very good! (1,004 reviews)

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO

฿3,052

฿3,418 total

18 Oct - 19 Oct

includes taxes & fees

9.4/10 Exceptional! (964 reviews)

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Book Hotels in Southeast Missouri on Expedia.com

Find hotels in Southeast Missouri, MO from ฿2,088

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Southeast Missouri

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Southeast Missouri hotels

1. Shepherd Mountain Inn

2. Madison Inn Lodge

3. Hampton Inn & Suites By Hilton Festus

4. Holiday Inn Express & Suites Perryville by IHG

5. Fairfield Inn & Suites by Marriott Poplar Bluff

6. Crown Pointe Lodge, BW Signature Collection

7. Super 8 by Wyndham Farmington

8. Fairfield Inn & Suites by Marriott Sikeston

9. Drury Inn & Suites Jackson MO

10. EC Reed's Mercantile and Hotel

11. Hampton Inn Poplar Bluff

12. Baymont Inn and Suites by Wyndham Farmington, MO

13. La Quinta Inn & Suites by Wyndham Festus - St. Louis South

14. Holiday Inn Express & Suites Farmington by IHG

15. Fort Davidson Hotel

16. Drury Plaza Hotel Cape Girardeau Conference Center

17. Super 8 by Wyndham Perryville

18. Fairfield Inn & Suites by Marriott Cape Girardeau

19. Drury Inn & Suites Poplar Bluff

20. The Riverview

Holiday Rentals in Southeast Missouri

Sam A Baker State Park

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

The Atrium - A Boutique Hotel

Urban Lofts

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Tiny Houses of French Village

Lake Wappapello

Walk to Dtwn: Ironton Home in Historic District

Walk to Current River: Ozarks Adventure Home!

Cozy Belgrade Cottage w/ Wood-burning Stove!

Cottage w/ Yard, Walk to Historic Attractions

Stay near popular Southeast Missouri attractions

Elephant Rocks State Park

Southeast Missouri State University

Lake Wappapello

Century Casino & Hotel Cape Girardeau

Century Casino Caruthersville

Learn more about Southeast Missouri

Top Southeast Missouri Hotel Reviews

Crown Pointe Lodge, BW Signature Collection

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Drury Inn & Suites Cape Girardeau

Hampton Inn Poplar Bluff

Drury Plaza Hotel Cape Girardeau Conference Center

The Riverview

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Super 8 by Wyndham Sikeston/Miner Area

Drury Inn & Suites Hayti Caruthersville

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Days Inn and Suites by Wyndham Sikeston

Pear Tree Inn Cape Girardeau West

Comfort Inn Festus - St Louis South

Motel 6 Poplar Bluff, MO

Hampton Inn Poplar Bluff

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