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Tonight
11 Nov - 12 Nov
Tomorrow
12 Nov - 13 Nov
This weekend
13 Nov - 15 Nov
Next weekend
20 Nov - 22 Nov

Our top choices for Siesta Isle LGBT-friendly hotels

A row of turquoise Adirondack chairs with umbrellas, a wooden deck, and a marina in the background.

1. Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
Siesta Isle
9.0 out of 10, Wonderful, (1,000 reviews)
"This place was quiet and very clean, we were able to do kayaking & there's a lot of places to eat around. 3-5min from the beaches, shopping & restaurants."
United States
Maria
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
An outdoor patio with tables and chairs, umbrellas, and a pool in the background.

2. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
Fort Myers Beach
9.2 out of 10, Wonderful, (1,005 reviews)
"Clean Hotel! Convenient for one night stay, close to airport and beaches."
United States
Kimberly
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
A spacious lobby with a high ceiling, a seating area with a sofa and chairs, a small round table, and a decorative wall with artwork.

3. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
3.0 star property
Fort Myers Beach
8.8 out of 10, Excellent, (1,007 reviews)
"I enjoyed my stay - peaceful, wonderful staff & great location"
United States
Melanie
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
A boat named 'Carolina Daze' with a covered seating area, a steering wheel, and a view of a waterway with greenery and buildings in the background.

4. Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
Fort Myers Beach
8.6 out of 10, Excellent, (1,003 reviews)
"Great place to stay, especially on a fishing trip!"
United States
Mitchel
Latitude 26 Waterfront Resort & Marina
A hotel pool area with multiple lounge chairs and umbrellas, surrounded by a fence and palm trees.

5. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
Fort Myers
8.2 out of 10, Very good, (1,405 reviews)
"The staff was very helpful during my stay."
United States
Samantha
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
A spacious dining area with multiple tables and chairs, large windows, and a modern chandelier.

6. Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
Fort Myers
8.8 out of 10, Excellent, (1,000 reviews)
"Loved the balcony view, breakfast spread, hot tub and heated pool."
United States
Lora
Residence Inn by Marriott Fort Myers Sanibel
A balcony with wicker furniture, a view of a beach, and a clear sky.

7. Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
Fort Myers Beach
8.8 out of 10, Excellent, (2,192 reviews)
"Excellent location"
United States
yeny
Lani Kai Beachfront Resort
A hotel entrance with a sign reading 'Candlewood Suites' and a parking lot with a handicapped parking space.

8. Candlewood Suites Fort Myers Sanibel Gateway by IHG

Candlewood Suites Fort Myers Sanibel Gateway by IHG
3.0 star property
South Fort Myers
7.6 out of 10, Good, (1,000 reviews)
"I was satisfied with the price for a short stay."
United States
James
Candlewood Suites Fort Myers Sanibel Gateway by IHG
A balcony with a table and chairs, large windows, and a view of the sea.

9. The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village
4.0 star property
Pelican
9.0 out of 10, Wonderful, (1,000 reviews)
"Very clean and nice place!"
United States
Charles
The Westin Cape Coral Resort At Marina Village
A waterfront hotel with multiple buildings, a dock, and a calm body of water reflecting the structures.

10. Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa
4.0 star property
Punta Rassa
8.6 out of 10, Excellent, (1,000 reviews)
"I love everything about this hotel"
United States
Yunior
Marriott Sanibel Harbour Resort & Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Siesta Isle

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A row of turquoise Adirondack chairs with umbrellas, a wooden deck, and a marina in the background.
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
9.0
Wonderful
1,000 reviews
View
An outdoor patio with tables and chairs, umbrellas, and a pool in the background.
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
9.2
Wonderful
1,005 reviews
View
A spacious lobby with a high ceiling, a seating area with a sofa and chairs, a small round table, and a decorative wall with artwork.
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
3.0 star property
8.8
Excellent
1,007 reviews
View
A boat named 'Carolina Daze' with a covered seating area, a steering wheel, and a view of a waterway with greenery and buildings in the background.
Latitude 26 Waterfront Resort & Marina
3.0 star property
8.6
Excellent
1,003 reviews
View
A hotel pool area with multiple lounge chairs and umbrellas, surrounded by a fence and palm trees.
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
8.2
Very good
1,405 reviews
View

Top Siesta Isle Hotel Reviews

An outdoor patio with tables and chairs, umbrellas, and a pool in the background.
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
Fort Myers Beach

10/10 Excellent

Clean room, quiet and very comfortable bed.
United Kingdom
Helen
Reviewed January 20, 2026
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Frequently Asked Questions

Looking for gay-friendly accommodation in Siesta Isle?

Book a place where you can be yourself! You'll find gay-friendly hotels in Siesta Isle on Expedia. Discover the people, places and traditions found only in Siesta Isle.

What are the top places to visit in Siesta Isle?

During your trip, get out and enjoy everything Siesta Isle has to offer. You and your travelling companions may want to visit San Carlos Bay - Bunche Beach Preserve. While you're here, capture some great memories of your trip with a stop at Key West Express.

What is a gay-friendly hotel in Siesta Isle?

LGBTQ-friendly hotels welcome all travellers who identify as LGBTQIA+. We have worked with the International Gay and Lesbian Travel Association (IGLTA) to compile a selection of gay-friendly hotels worldwide. In Siesta Isle, hotels affiliated with IGLTA operate in a spirit of inclusiveness, prioritising a diverse environment in which guests are welcomed, respected and not obliged to declare or hide their sexual orientation.

What can I expect from an LGBTQ-friendly Siesta Isle hotel?

Stay at a gay-friendly hotel in Siesta Isle and you won't have to hide or your sexuality or your gender identity when you check in. Some of Expedia's LGBTQ-friendly hotels go the extra mile and offer community-specific packages, exclusive tours and opportunities for social interaction.