Search Hotels in Santo Tomas, Mexico City

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
30 Dec - 31 Dec
Tomorrow
31 Dec - 1 Jan
This weekend
2 Jan - 4 Jan
Next weekend
9 Jan - 11 Jan

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Santo Tomas hotels

Front of property
Camino Real Aeropuerto Mexico

Camino Real Aeropuerto Mexico

Camino Real Aeropuerto Mexico
4.0 star property
Venustiano Carranza, 11.2 km from Santo Tomas
8.8 out of 10, Excellent, (11960)
"Convenient and comfortable hotel right at the airport. Great staff, clean rooms and a great night sleep!"
United States
Charles
The price is ฿4,624
฿5,526 total
includes taxes & fees
8 Jan - 9 Jan 2026
Camino Real Aeropuerto Mexico
Breakfast, lunch, dinner served; Mexican cuisine
Hotel Catedral

Hotel Catedral

Hotel Catedral
4.0 star property
Historic Center, 7.2 km from Santo Tomas
9.4 out of 10, Exceptional, (2641)
"Great location and good clean rooms in this hotel makes it a winner"
United States
Chandra
Hotel Catedral
Mexican cuisine
We Hotel Aeropuerto

We Hotel Aeropuerto

We Hotel Aeropuerto
3.5 star property
Venustiano Carranza, 10.9 km from Santo Tomas
8.4 out of 10, Very good, (2158)
"easy to check in, facility clean and staff friendly "
Canada
William
The price is ฿2,781
฿3,324 total
includes taxes & fees
1 Jan - 2 Jan 2026
We Hotel Aeropuerto
Exterior
Fiesta Inn Ciudad de Mexico Aeropuerto

Fiesta Inn Ciudad de Mexico Aeropuerto

Fiesta Inn Ciudad de Mexico Aeropuerto
3.5 star property
Venustiano Carranza, 10.9 km from Santo Tomas
8.8 out of 10, Excellent, (3242)
"Clean and nice, airport shuttle was great! "
United States
Ginger
The price is ฿3,724
฿4,450 total
includes taxes & fees
4 Jan - 5 Jan 2026
Fiesta Inn Ciudad de Mexico Aeropuerto
Daily buffet breakfast (USD 24 per person)
Barceló México Reforma

Barceló México Reforma

Barceló México Reforma
4.5 star property
6.3 km from Santo Tomas
9.4 out of 10, Exceptional, (5121)
"Great hotel!"
United States
Alma
The price is ฿3,463
฿4,138 total
includes taxes & fees
6 Jan - 7 Jan 2026
Barceló México Reforma
Interior
Courtyard Mexico City Airport

Courtyard Mexico City Airport

Courtyard Mexico City Airport
4.0 star property
Venustiano Carranza, 11.3 km from Santo Tomas
9.4 out of 10, Exceptional, (1808)
"Great staff clean room and so easy to access from airport "
Canada
Jean
The price is ฿4,986
฿5,958 total
includes taxes & fees
17 Jan - 18 Jan 2026
Courtyard Mexico City Airport
Outdoor pool, open 8:00 AM to 8:00 PM, pool loungers
Hotel Century Reforma

Hotel Century Reforma

Hotel Century Reforma
3.5 star property
Zona Rosa, 7 km from Santo Tomas
8.6 out of 10, Excellent, (1259)
"Great location and accommodations "
United States
Daniel
The price is ฿2,847
฿3,402 total
includes taxes & fees
1 Jan - 2 Jan 2026
Hotel Century Reforma
Exterior
Hampton Inn & Suites Mexico City - Centro Historico

Hampton Inn & Suites Mexico City - Centro Historico

Hampton Inn & Suites Mexico City - Centro Historico
3.0 star property
Historic Center, 7.6 km from Santo Tomas
9.0 out of 10, Wonderful, (1106)
"Always a great place to stay while in CDMX "
United States
Juan
The price is ฿2,265
฿2,707 total
includes taxes & fees
6 Jan - 7 Jan 2026
Hampton Inn & Suites Mexico City - Centro Historico
Standard Room, 1 King Bed | Premium bedding, in-room safe, desk, blackout curtains
Holiday Inn Express Mexico Basilica by IHG

Holiday Inn Express Mexico Basilica by IHG

Holiday Inn Express Mexico Basilica by IHG
3.0 star property
6 km from Santo Tomas
9.2 out of 10, Wonderful, (1054)
"I've stayed at this hotel twice already, and both times were good"
United States
Apolinar
The price is ฿2,126
฿2,541 total
includes taxes & fees
11 Jan - 12 Jan 2026
Holiday Inn Express Mexico Basilica by IHG
Outdoor pool
Galeria Plaza Reforma

Galeria Plaza Reforma

Galeria Plaza Reforma
4.0 star property
Zona Rosa, 6.8 km from Santo Tomas
9.4 out of 10, Exceptional, (3235)
"Excellent stay "
United States
Arturo
The price is ฿3,721
฿4,447 total
includes taxes & fees
26 Jan - 27 Jan 2026
Galeria Plaza Reforma
Deluxe Suite, 1 King Bed | Egyptian cotton sheets, premium bedding, down duvets, in-room safe
Econo Express Hotel

Econo Express Hotel

Econo Express Hotel
3.5 star property
Benito Juarez, 12.3 km from Santo Tomas
9.0 out of 10, Wonderful, (1611)
"Excellent stay overall. The room was very clean and comfortable, and the staff was friendly, professional, and welcoming. The hotel is well located and offers great value for the price. I would definitely recommend this place and would stay here again."
Canada
Gachenel
Econo Express Hotel
Suite | In-room safe, desk, soundproofing, iron/ironing board
Grand Prix-WeEnjoyHotels-Aeropuerto

Grand Prix-WeEnjoyHotels-Aeropuerto

Grand Prix-WeEnjoyHotels-Aeropuerto
3.5 star property
12.4 km from Santo Tomas
9.0 out of 10, Wonderful, (3917)
"Excelente hotel"
Mexico
Daniel
The price is ฿2,296
฿2,744 total
includes taxes & fees
4 Jan - 5 Jan 2026
Grand Prix-WeEnjoyHotels-Aeropuerto
View from room
Hotel Punto MX

Hotel Punto MX

Hotel Punto MX
3.5 star property
Historic Center, 7.4 km from Santo Tomas
9.0 out of 10, Wonderful, (1465)
"I love this hotel...pretty clean, staff courteous, nice location...."
United States
Martha
The price is ฿1,554
฿1,857 total
includes taxes & fees
6 Jan - 7 Jan 2026
Hotel Punto MX
Outdoor pool
Holiday Inn Zona Centro by IHG

Holiday Inn Zona Centro by IHG

Holiday Inn Zona Centro by IHG
3.5 star property
5.3 km from Santo Tomas
9.2 out of 10, Wonderful, (1007)
"Todo excelente "
Mexico
Gabriela
The price is ฿2,642
฿3,158 total
includes taxes & fees
24 Jan - 25 Jan 2026
Holiday Inn Zona Centro by IHG
Exterior
Fiesta Americana Reforma

Fiesta Americana Reforma

Fiesta Americana Reforma
4.0 star property
Juárez, 6.3 km from Santo Tomas
9.2 out of 10, Wonderful, (4130)
"Excellent room service, great amenities provided while staying. "
United States
Edgar
The price is ฿3,474
฿4,151 total
includes taxes & fees
16 Jan - 17 Jan 2026
Fiesta Americana Reforma
Food and drink
Verticca Hotel

Verticca Hotel

Verticca Hotel
3.0 star property
29.6 km from Santo Tomas
9.4 out of 10, Exceptional, (252)
"Excelente Hotel"
Mexico
juan Ricardo
Verticca Hotel
Front of property
Historico Central Hotel

Historico Central Hotel

Historico Central Hotel
4.0 star property
Historic Center, 7.1 km from Santo Tomas
9.8 out of 10, Exceptional, (2424)
"Excellent service - beautiful decor- great location!"
United States
Debra
The price is ฿4,991
฿5,964 total
includes taxes & fees
26 Jan - 27 Jan 2026
Historico Central Hotel
Exterior
Hotel PF

Hotel PF

Hotel PF
3.5 star property
Zona Rosa, 7 km from Santo Tomas
9.0 out of 10, Wonderful, (2289)
"Clean room, nice amenities in the restroom, friendly and accommodating staff, walkable neighborhood with plenty of restaurants and stores."
United States
Brigette
The price is ฿2,392
฿2,859 total
includes taxes & fees
28 Jan - 29 Jan 2026
Hotel PF
Food and drink
Camino Real Polanco Mexico

Camino Real Polanco Mexico

Camino Real Polanco Mexico
4.5 star property
6.5 km from Santo Tomas
9.2 out of 10, Wonderful, (3169)
"Great location "
United States
Christina
The price is ฿4,531
฿5,415 total
includes taxes & fees
7 Jan - 8 Jan 2026
Camino Real Polanco Mexico
Exterior
Holiday Inn Express Mexico Aeropuerto by IHG

Holiday Inn Express Mexico Aeropuerto by IHG

Holiday Inn Express Mexico Aeropuerto by IHG
3.0 star property
12.5 km from Santo Tomas
9.2 out of 10, Wonderful, (1599)
"The stay was excellent and the breakfast buffet was outstanding. I highly recommend this hotel all the staff members were very friendly! "
United States
Elvia
The price is ฿2,930
฿3,501 total
includes taxes & fees
14 Jan - 15 Jan 2026
Holiday Inn Express Mexico Aeropuerto by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Santo Tomas

Find the best Santo Tomas areas for the activities you enjoy most.

Roma Norte

Known for its fascinating museums and popular shops, there's plenty to explore in Roma Norte. Check out top attractions like Avenida Insurgentes and MUCA Roma, and jump on the metro at Insurgentes Station or Sevilla Station to see more of the city.

Polanco which includes heritage architecture, a church or cathedral and a park

Polanco

Visit the most diverse section of Mexico City for sophisticated shopping, dining, accommodations and sightseeing.

La Condesa featuring café scenes

La Condesa

Enjoy 20th-century history in these two sections of Mexico City, with interesting art and architecture reflecting European influences.

Metropolitan Cathedral which includes a church or cathedral, heritage elements and heritage architecture

Historic Center

Consider a visit to Zócalo and take some time to enjoy the interesting museums during your time in Historic Center. If you want to see more of the city, jump on the metro at Allende Station or Bellas Artes Station.

Reforma which includes a city, night scenes and central business district

Reforma

Consider a visit to Paseo de la Reforma and take some time to enjoy the important monuments during your time in Reforma. If you want to see more of the city, jump on the metro at Insurgentes Station or Cuauhtemoc Station.

Top Santo Tomas Hotel Reviews

ULIV Mexico City

ULIV Mexico City

10/10 Excellent
"ULIV was a fantastic spot in CDMX. The location is ideal and it’s in a great neighborhood that is close to great places to eat and also just a few blocks away from the Metro. The apartment itself was clean, spacious and secure. I felt safe and they have the kindest staff. There is a great roof top and laundry room which is a bonus. I can’t wait to book my next stay in this great city at ULIV! "
Laura Liera 6-night trip
Posted 3 days ago
ULIV Mexico City

Frequently asked questions

What is Santo Tomas like?
Travellers will be sure to find plenty to entertain them in Mexico City's Santo Tomas neighbourhood. Consider a visit to Hospital de Jesus Nazareno as part of your Santo Tomas travel plans.
If I need to cancel my hotel reservation in Santo Tomas, will I receive a refund?
Yes! The majority of room reservations are fully refundable if cancelled prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you might be able to cancel it and get a refund within 24 hours of booking. Put your dates in and click on "Search", then use the filter option "fully refundable" to review the top deals on offer in Santo Tomas.
What is there to do around this Mexico City neighbourhood?
Hospital de Jesus Nazareno is an attraction you might want to check out while you're in Santo Tomas. While you're out sightseeing, Mexico City Arena and TecnoParque are a couple of additional sights to visit in Mexico City.