Bald cypress trees with very young needles stand at the edge of Lake Marion in the Santee National Wildlife Refuge in Summerton, South Carolina.; Shutterstock ID 620988272; Purchase Order: -

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Check prices for these dates

Next weekend
26 Jun - 28 Jun
In two weeks
3 Jul - 5 Jul

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Our top choices for Santee National Wildlife Refuge hotels

Exterior

1. Best Western Plus Santee Inn

Best Western Plus Santee Inn
2.5 star property
7 km from Santee National Wildlife Refuge
8.8 out of 10, Excellent, (1,002 reviews)
"We loved our one night stay, it’s was quiet and warming."
United States
Lisett
The price is ฿3,613
฿4,011 total
includes taxes & fees
23 Jun - 24 Jun
Best Western Plus Santee Inn
Free breakfast

2. Hampton Inn Santee-I-95

Hampton Inn Santee-I-95
2.5 star property
7 km from Santee National Wildlife Refuge
9.6 out of 10, Exceptional, (1,001 reviews)
"Nice breakfast, rooms spacious, convenient location"
United States
Gloria
The price is ฿4,111
฿4,563 total
includes taxes & fees
6 Jul - 7 Jul
Hampton Inn Santee-I-95
Property amenity

3. Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee
3.0 star property
7 km from Santee National Wildlife Refuge
9.8 out of 10, Exceptional, (1,003 reviews)
"Nice hotel stay, excellent staff and accommodations."
United States
Carl
The price is ฿4,421
฿4,907 total
includes taxes & fees
28 Jun - 29 Jun
Fairfield Inn & Suites by Marriott Santee
Room, 2 Queen Beds, Non Smoking | Desk, blackout curtains, iron/ironing board, free WiFi

4. Baymont by Wyndham Santee

Baymont by Wyndham Santee
2.5 star property
7.2 km from Santee National Wildlife Refuge
8.0 out of 10, Very good, (1,472 reviews)
"Great overnight stop"
United States
Gary
The price is ฿2,472
฿2,744 total
includes taxes & fees
30 Jun - 1 Jul
Baymont by Wyndham Santee
Free daily buffet breakfast

5. Tru By Hilton Santee

Tru By Hilton Santee
2.5 star property
7.2 km from Santee National Wildlife Refuge
9.2 out of 10, Wonderful, (861 reviews)
"The room was very clean and the staff were extremely friendly"
United States
Jeffrey
The price is ฿3,494
฿3,879 total
includes taxes & fees
28 Jun - 29 Jun
Tru By Hilton Santee
Room, 2 Double Beds, Accessible, Non Smoking (Mobility) | Bathroom | Combined shower/bathtub, free toiletries, hair dryer, towels

6. Super 8 by Wyndham Santee/I-95

Super 8 by Wyndham Santee/I-95
2.0 star property
7 km from Santee National Wildlife Refuge
6.8 out of 10, (468 reviews)
"Ok hotel when money is tight. Only stayed one night but the room was clean and the beds were pretty comfy."
United States
Christalyn
The price is ฿2,090
฿2,320 total
includes taxes & fees
28 Jun - 29 Jun
Super 8 by Wyndham Santee/I-95
Frette Italian sheets, premium bedding, pillow-top beds

7. Comfort Inn & Suites Santee

Comfort Inn & Suites Santee
2.5 star property
7.2 km from Santee National Wildlife Refuge
8.0 out of 10, Very good, (1,001 reviews)
"Clean rooms that were connecting which we requested. Friendly staff. Good breakfast. Met all our needs while traveling with six children."
United States
Leah
The price is ฿3,461
฿3,842 total
includes taxes & fees
14 Jul - 15 Jul
Comfort Inn & Suites Santee
Children’s activities

8. Holiday Inn Santee by IHG

Holiday Inn Santee by IHG
3.0 star property
7.2 km from Santee National Wildlife Refuge
8.2 out of 10, Very good, (1,000 reviews)
"Room was super clean and nice. Convenient location off of 95 and near Santee state park. Only minor complaint is the pool wasn't heated as stated. "
United States
Stefanie
The price is ฿3,344
฿3,712 total
includes taxes & fees
28 Jun - 29 Jun
Holiday Inn Santee by IHG
In-room safe, iron/ironing board, free WiFi, bed sheets

9. Travelodge by Wyndham Santee

Travelodge by Wyndham Santee
2.0 star property
7.1 km from Santee National Wildlife Refuge
7.2 out of 10, Good, (741 reviews)
"Staff was very friendly. "
United States
Sriram
The price is ฿2,077
฿2,305 total
includes taxes & fees
21 Jun - 22 Jun
Travelodge by Wyndham Santee
Exterior

10. Red Roof Inn Santee

Red Roof Inn Santee
2.0 star property
7 km from Santee National Wildlife Refuge
6.6 out of 10, (656 reviews)
"Yes, great room."
United States
Gerald
The price is ฿2,065
฿2,293 total
includes taxes & fees
28 Jun - 29 Jun
Red Roof Inn Santee
Free daily full breakfast

11. Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95
2.5 star property
6.9 km from Santee National Wildlife Refuge
6.0 out of 10, (544 reviews)
"Rooms are clean and staff was super nice and accommodating "
United States
Will
The price is ฿1,826
฿2,209 total
includes taxes & fees
12 Jul - 13 Jul
Quality Inn & Suites Santee I-95
Lobby

12. Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95
2.0 star property
7.1 km from Santee National Wildlife Refuge
6.4 out of 10, (565 reviews)
"The room was very clean, the staff very friendly, and the restaurant/bar had good food and drinks and the pool tables added a unique touch!"
United States
Phyllis
The price is ฿2,378
฿2,640 total
includes taxes & fees
5 Jul - 6 Jul
Ramada by Wyndham Santee I-95
Desk, iron/ironing board, free WiFi, bed sheets

13. Econo Lodge Santee

Econo Lodge Santee
2.0 star property
7.1 km from Santee National Wildlife Refuge
6.4 out of 10, (314 reviews)
"Very clean room, fast staff, a lot of food spots nearby! "
United States
Santiana
The price is ฿1,991
฿2,210 total
includes taxes & fees
5 Jul - 6 Jul
Econo Lodge Santee
Restaurant

14. Sunset Inn Manning I 95

Sunset Inn Manning I 95
2.0 star property
18.9 km from Santee National Wildlife Refuge
4.8 out of 10, (55 reviews)
"Ok good value"
United States
William
The price is ฿1,662
฿1,845 total
includes taxes & fees
25 Jun - 26 Jun
Sunset Inn Manning I 95
1 bedroom

15. Starlight Stays

Starlight Stays
2.5 star property
19.8 km from Santee National Wildlife Refuge
7.2 out of 10, Good, (21 reviews)
"staff is Dependable and reliable and very kind "
United States
Andreana
The price is ฿2,213
฿2,457 total
includes taxes & fees
28 Jun - 29 Jun
Starlight Stays
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels close to Santee National Wildlife Refuge

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Exterior
Best Western Plus Santee Inn
2.5 star property
8.8
Excellent
1,002 reviews
View
Free breakfast
Hampton Inn Santee-I-95
2.5 star property
9.6
Exceptional
1,001 reviews
View
Property amenity
Fairfield Inn & Suites by Marriott Santee
3.0 star property
9.8
Exceptional
1,003 reviews
View
Room, 2 Queen Beds, Non Smoking | Desk, blackout curtains, iron/ironing board, free WiFi
Baymont by Wyndham Santee
2.5 star property
8.0
Very good
1,472 reviews
View
Free daily buffet breakfast
Tru By Hilton Santee
2.5 star property
9.2
Wonderful
861 reviews
View

Top Santee National Wildlife Refuge Hotel Reviews

Tru By Hilton Santee

Tru By Hilton Santee

10/10 Excellent
"Enjoyed my stay overnight."
Dina 1-night trip
Posted 2 hours ago
Tru By Hilton Santee

Hotels near other Santee National Wildlife Refuge attractions

Pine Island

Commune with nature and explore the great outdoors at Pine Island during your travels in Summerton. While you're in the area, wander around the parks.
See properties

Frequently asked questions

What's the area like around Santee National Wildlife Refuge?
Santee National Wildlife Refuge is located in a welcoming area of Summerton known for its array of dining options and golfing. You'll find 124 hotels and other accommodations within a few miles for a convenient home base.
What's the best hotel to stay near Santee National Wildlife Refuge?
Baymont by Wyndham Santee is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and free parking. It's located 4.5 mi (7.2 km) from Santee National Wildlife Refuge. Other good choices within a few miles include Fairfield Inn & Suites by Marriott Santee and Tru By Hilton Santee.
How many hotels should I expect to find near Santee National Wildlife Refuge?
Expedia has 124 hotels and other accommodation options a few miles from Santee National Wildlife Refuge.
If I need to cancel the hotel reservation for my stay near Santee National Wildlife Refuge, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and get a refund within a 24-hour period of your booking. Put your dates in and click on "Search", then you can filter by "fully refundable" to get the best options available near Santee National Wildlife Refuge.