Santa Maria Packages (Flight + Hotel)

Book a Hotel + Flight or Car together to unlock savings

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    Save up to ฿4,531 when you book a flight and hotel together*
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    With over 300,000 hotels worldwide, it's easy to create a perfect package
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Where to stay in Santa Maria

Find the best Santa Maria areas and neighborhoods for the activities you enjoy most. Learn more about Santa Maria
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Downtown Guayaquil

Travellers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Central Market and Sports Federation of Guayas while you're in town.

Find hotels in Downtown Guayaquil

Top hotels in Santa Maria

Oro Verde Guayaquil

Oro Verde Guayaquil

5 out of 5
9 De Octubre Y Garcia Moreno, Guayaquil, Guayas
Fully refundableReserve now, pay when you stay
The price is ฿2,884 per night from 31 Oct to 1 Nov
฿2,884
฿3,253 total
31 Oct - 1 Nov
9.4/10 Exceptional! (1,000 reviews)
"The hotel was everything offered and more, the staff is extraordinary, from the outside security, front desk receptionists, servers throughout all the restaurants, housekeepers and more, these people know what it is to host. I’m planing my next trip to Ecuador and be certain that I won’t need to ..."

Reviewed on 26 Sept 2025

Oro Verde Guayaquil
Wyndham Garden Guayaquil

Wyndham Garden Guayaquil

3.5 out of 5
Juan Tanca Marengo Ave, Abel Romero St. Plaza Del Sol, Guayaquil, Guayas
Fully refundableReserve now, pay when you stay
The price is ฿2,741 per night from 25 Oct to 26 Oct
฿2,741
฿3,064 total
25 Oct - 26 Oct
9/10 Wonderful! (1,000 reviews)
"Great service! Highly recommend"

Reviewed on 22 Sept 2025

Wyndham Garden Guayaquil
Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG

3.5 out of 5
Av. de Las Américas,junto al Aeropuerto, Intl. Jose Joaquin de Olmedo, Guayaquil, Guayas
Fully refundable
The price is ฿3,181 per night from 13 Oct to 14 Oct
฿3,181
฿3,580 total
13 Oct - 14 Oct
9.2/10 Wonderful! (1,013 reviews)
"Excellent hotel with superb food and service. Shuttle service to and from airport a big plus."

Reviewed on 29 Sept 2025

Holiday Inn Guayaquil Airport by IHG
See all 401 properties in Santa Maria
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Maria holiday package cost?
Get set to book, because a getaway to Santa Maria starts from a tempting . When you combine your hotels, flights and car rentals into a travel package, you'll enjoy the lowest prices.
How do I get a cheap travel package to Santa Maria?
Bundle your hotels and flights with Expedia to save big on your next trip. With more than 550 air carriers and 1,000,000 hotels worldwide, your Santa Maria holiday package can be customized exactly to suit your travel style. With all that extra cash, why not add a few fun activities and tours? It's an easy way to unlock even more savings. Your dream holiday in Santa Maria is closer than you thought!
Where should I stay in Santa Maria?
Make sightseeing easy by staying someplace right around the corner from Santa Maria's biggest attractions. Malecon 2000 and Banco Pichincha Monumental Stadium are two visitor favourites.
How far in advance should I book my Santa Maria holiday?
Your safest bet is to book early. Airlines usually release flight tickets nearly 12 months prior to departure, and this is a great opportunity to score some rock-bottom prices. Just been told you should take your holiday time next month? No sweat. Expedia are never short on fantastic bargains to help you have the getaway of your dreams, at an affordable price.
What does an Expedia Santa Maria travel package include?
Select from any combination of flights, hotels and rental cars. Once you've made your booking, you can add activities and experiences. Want to pick your airfare class? That's easy to do too. The choice is all yours when it comes to arranging your dream Santa Maria escape.
What should I know before booking a Santa Maria travel package?
Get set to save with an Expedia travel package. Combine your flights, rental cars and hotels and enjoy exciting discounts. Hotels aren't your only choice, however. Book with us and choose from beach villas, creek-side mountain cabins and just about everything in between!
Can I choose my airline with a Santa Maria Expedia holiday package?
Expedia offers access to more than 550 airline partners globally, so you certainly can. Just pick your preferred air carrier and put together your ideal Santa Maria escape.
If I'm not able to travel, can I cancel my Santa Maria holiday package?
Yes, you can cancel your Santa Maria booking if your travel plans have been upended. Whether you'll incur a fee or not depends on your airline, hotel or car rental company. It may be possible to cancel or change your booking for free if you booked in the last 24 hours. Head to our Customer Service Portal to learn more.

Things to do

City Winery - Two Hemispheres

Wine Tasting Experience with Tasting Menu

฿1,880
per adult
Wine Tasting Experience with Tasting Menu
San Francisco Plaza

Shared Walking Tour in Guayaquil City

฿1,275
per adult
Shared Walking Tour in Guayaquil City
Ecuador Paragliding Guayaquil

Ecuador Paragliding Guayaquil

฿2,390
per adult
Ecuador Paragliding Guayaquil
See all activities in Guayaquil
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.