Santa Maria Packages (Flight + Hotel)

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to ฿27,000 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Where to stay in Santa Maria

Find the best Santa Maria areas and neighborhoods for the activities you enjoy most. Learn more about Santa Maria
Fachada colorida de estilo colonial, barrio de Santa Ana, Guayaquil, Ecuador

Ecuador

Ecuador might not have many top sights, but C.C. Riocentro Sur and Mall del Sur are two attractions nearby that you can check out.

Find hotels in Ecuador

Top hotels in Santa Maria

Oro Verde Guayaquil

Oro Verde Guayaquil

5 out of 5
9 De Octubre Y Garcia Moreno Guayaquil Guayas
Fully refundableReserve now, pay when you stay
The price is ฿2,566 per night from 17 May to 18 May
฿2,566
฿2,904 total
17 May - 18 May
9.6/10 Exceptional! (1,006 reviews)
Always a great stay not my first time and won’t be my last time,recommend anytime to anyone

Reviewed on 6 May 2026

Oro Verde Guayaquil
Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana

4.5 out of 5
Calle Numa Pompilio Llona S N Guayaquil Guayas
Fully refundableReserve now, pay when you stay
The price is ฿3,245 per night from 25 May to 26 May
฿3,245
฿3,651 total
25 May - 26 May
9.2/10 Wonderful! (1,002 reviews)
Amazing service

Reviewed on 5 May 2026

Wyndham Guayaquil Puerto Santa Ana
Unipark by Oro Verde Hotels

Unipark by Oro Verde Hotels

4 out of 5
Clemente Ballén 406 Guayaquil Guayas
Fully refundableReserve now, pay when you stay
The price is ฿2,339 per night from 16 May to 17 May
฿2,339
฿2,654 total
16 May - 17 May
9.2/10 Wonderful! (1,001 reviews)
Great place for a long overnight stay.

Reviewed on 30 Apr 2026

Unipark by Oro Verde Hotels
See all 431 properties in Santa Maria
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Maria holiday package cost?
Get set to book, because a getaway to Santa Maria starts from a tempting . When you combine your hotels, flights and car rentals into a travel package, you'll enjoy the lowest prices.
How do I get a cheap travel package to Santa Maria?
Bundle your hotels and flights with Expedia to save big on your next trip. With more than 550 air carriers and 1,000,000 hotels worldwide, your Santa Maria holiday package can be customized exactly to suit your travel style. With all that extra cash, why not add a few fun activities and tours? It's an easy way to unlock even more savings. Your dream holiday in Santa Maria is closer than you thought!
Where should I stay in Santa Maria?
Make sightseeing easy by staying someplace right around the corner from Santa Maria's biggest attractions. Malecon 2000 and Banco Pichincha Monumental Stadium are two visitor favourites.
How far in advance should I book my Santa Maria holiday?
Your safest bet is to book early. Airlines usually release flight tickets nearly 12 months prior to departure, and this is a great opportunity to score some rock-bottom prices. Just been told you should take your holiday time next month? No sweat. Expedia are never short on fantastic bargains to help you have the getaway of your dreams, at an affordable price.
What does an Expedia Santa Maria travel package include?
Select from any combination of flights, hotels and rental cars. Once you've made your booking, you can add activities and experiences. Want to pick your airfare class? That's easy to do too. The choice is all yours when it comes to arranging your dream Santa Maria escape.
What should I know before booking a Santa Maria travel package?
Get set to save with an Expedia travel package. Combine your flights, rental cars and hotels and enjoy exciting discounts. Hotels aren't your only choice, however. Book with us and choose from beach villas, creek-side mountain cabins and just about everything in between!
Can I choose my airline with a Santa Maria Expedia holiday package?
Expedia offers access to more than 550 airline partners globally, so you certainly can. Just pick your preferred air carrier and put together your ideal Santa Maria escape.
If I'm not able to travel, can I cancel my Santa Maria holiday package?
Yes, you can cancel your Santa Maria booking if your travel plans have been upended. Whether you'll incur a fee or not depends on your airline, hotel or car rental company. It may be possible to cancel or change your booking for free if you booked in the last 24 hours. Head to our Customer Service Portal to learn more.

Things to do

Half Day Walking Tour of Guayaquil Pearl of the Pacific

Half Day Walking Tour of Guayaquil Pearl of the Pacific

฿3,193
per adult
Half Day Walking Tour of Guayaquil Pearl of the Pacific
City Winery - Two Hemispheres

Wine Tasting Experience with Tasting Menu

฿2,059
per adult
100% of travellers recommend
Wine Tasting Experience with Tasting Menu
Guayaquil: City Highlights Tour with Cable Car Ride

Guayaquil: City Highlights Tour with Cable Car Ride

฿3,768
per adult
Guayaquil: City Highlights Tour with Cable Car Ride
See all activities in Guayaquil
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.