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9 Dec - 10 Dec
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10 Dec - 11 Dec
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12 Dec - 14 Dec
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Top Trending Hotels Near Santa Maria, Guayaquil

Rooftop bar, al fresco dining, open daily
Wyndham Garden Guayaquil

Wyndham Garden Guayaquil

3.5 star property
Simón Bolívar, 4.8 km from Santa Maria
9.0 out of 10, Wonderful, (1003)
"Airport shuttle was very convenient "
Canada
Arlene
The price is ฿2,632
฿2,944 total
19 Dec - 20 Dec
Wyndham Garden Guayaquil
Outdoor pool
Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG

3.5 star property
5.5 km from Santa Maria
9.4 out of 10, Exceptional, (1007)
"Great stay"
United States
Susan
The price is ฿2,680
฿3,028 total
24 Dec - 25 Dec
Holiday Inn Guayaquil Airport by IHG
2 restaurants, breakfast, lunch, dinner served; Regional cuisine
Sheraton Guayaquil Hotel

Sheraton Guayaquil Hotel

5.0 star property
Simón Bolívar, 4.8 km from Santa Maria
9.0 out of 10, Wonderful, (605)
"Very friendly front desk thank you for a comfortable and enjoyable stay. "
United States
Andrew
The price is ฿3,443
฿3,867 total
19 Dec - 20 Dec
Sheraton Guayaquil Hotel
Exterior
TRYP by Wyndham Guayaquil Airport

TRYP by Wyndham Guayaquil Airport

4.5 star property
Simón Bolívar, 4.9 km from Santa Maria
9.0 out of 10, Wonderful, (1004)
"💯"
United States
Sreenidhi
The price is ฿3,039
฿3,423 total
14 Dec - 15 Dec
TRYP by Wyndham Guayaquil Airport
Outdoor pool, pool loungers
Radisson Hotel Guayaquil

Radisson Hotel Guayaquil

5.0 star property
Kennedy, 4.9 km from Santa Maria
9.2 out of 10, Wonderful, (631)
"Good service "
United States
Genny
The price is ฿3,051
฿3,436 total
15 Dec - 16 Dec
Radisson Hotel Guayaquil
Lobby
DC Suites Aeropuerto

DC Suites Aeropuerto

3.0 star property
Simón Bolívar, 5.2 km from Santa Maria
9.0 out of 10, Wonderful, (578)
"Great location and clean hotel"
United States
Elvin
DC Suites Aeropuerto
Lobby
Courtyard by Marriott Guayaquil

Courtyard by Marriott Guayaquil

3.5 star property
Kennedy, 4.8 km from Santa Maria
9.0 out of 10, Wonderful, (1004)
"Great stay and they were able to accommodate our last minute booking. We had an amazing view of the city and the room was spotless."
United States
Cesar
The price is ฿2,297
฿2,575 total
2 Jan - 3 Jan 2026
Courtyard by Marriott Guayaquil
Exterior
Hotel GH Galeria

Hotel GH Galeria

3.5 star property
Downtown Guayaquil, 6.9 km from Santa Maria
8.4 out of 10, Very good, (392)
"Location "
United States
Marcelo
Hotel GH Galeria
Outdoor pool, open 8:00 AM to 9:00 PM, pool loungers
Grand Hotel Guayaquil, an Ascend Collection Hotel

Grand Hotel Guayaquil, an Ascend Collection Hotel

4.0 star property
Rocafuerte, 7.9 km from Santa Maria
9.2 out of 10, Wonderful, (985)
"Great place to Stay.!"
United States
Erwin
The price is ฿2,872
฿3,207 total
25 Dec - 26 Dec
Grand Hotel Guayaquil, an Ascend Collection Hotel
Exterior
Iguanazu Bed & Breakfast

Iguanazu Bed & Breakfast

3.5 star property
2.9 km from Santa Maria
9.2 out of 10, Wonderful, (46)
"Excelente Todo "
Costa Rica
Cesar
The price is ฿1,867
฿2,085 total
14 Dec - 15 Dec
Iguanazu Bed & Breakfast
Restaurant
Ibis Styles El Malecon Guayaquil

Ibis Styles El Malecon Guayaquil

4.0 star property
Downtown Guayaquil, 8 km from Santa Maria
9.4 out of 10, Exceptional, (272)
"Great location and great hotel "
United States
José
The price is ฿1,915
฿2,154 total
14 Dec - 15 Dec
Ibis Styles El Malecon Guayaquil
Reception
Unipark by Oro Verde Hotels

Unipark by Oro Verde Hotels

4.0 star property
Rocafuerte, 8 km from Santa Maria
9.2 out of 10, Wonderful, (1002)
"Nice place to stay"
United States
Victor
The price is ฿2,183
฿2,481 total
7 Jan - 8 Jan 2026
Unipark by Oro Verde Hotels
Outdoor pool, pool loungers
Hotel Patrimonial by Greenfield

Hotel Patrimonial by Greenfield

3.5 star property
Downtown Guayaquil, 7.5 km from Santa Maria
8.6 out of 10, Excellent, (132)
"Excellent location and close to the airport."
United States
Martin Gerardo
Hotel Patrimonial by Greenfield
Presidential Suite, 1 King Bed, Jetted Tub, River View | Egyptian cotton sheets, premium bedding, down duvets, pillow-top beds
Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana

4.5 star property
Puerto Santa Ana, 7.5 km from Santa Maria
9.2 out of 10, Wonderful, (1002)
"The hotel and service were great!"
United States
Rolando
The price is ฿3,518
฿3,950 total
14 Dec - 15 Dec
Wyndham Guayaquil Puerto Santa Ana
In-room safe, blackout curtains, soundproofing, iron/ironing board
Doubletree By Hilton Guayaquil

Doubletree By Hilton Guayaquil

3.5 star property
Rocafuerte, 8.1 km from Santa Maria
9.0 out of 10, Wonderful, (70)
"We stayed here twice and both the times to staff was excellent, the property was centrally located, it felt safe, and welcoming. I highly recommend this hotel and felt like it exceeded our expectations."
United States
Ravi
The price is ฿2,226
฿2,847 total
4 Jan - 5 Jan 2026
Doubletree By Hilton Guayaquil
Garden
Dreamkapture Hostel

Dreamkapture Hostel

2.0 star property
Alborada, 3 km from Santa Maria
8.8 out of 10, Excellent, (19)
"Good Pool !"
Australia
Julie
Dreamkapture Hostel
Executive Suite, Kitchenette, City View | Private kitchen | Microwave, electric kettle, griddle, cookware/dishes/utensils
Suitesecu Rentals Guayaquil

Suitesecu Rentals Guayaquil

4.5 star property
Simón Bolívar, 4.9 km from Santa Maria
9.2 out of 10, Wonderful, (7)
"You can walk to the airport."
United States
Digna
The price is ฿847
฿1,055 total
4 Jan - 5 Jan 2026
Suitesecu Rentals Guayaquil
Lobby
Hilton Colon Guayaquil

Hilton Colon Guayaquil

4.5 star property
Kennedy, 4.2 km from Santa Maria
8.6 out of 10, Excellent, (812)
"Great room"
United States
Trevor
The price is ฿3,009
฿3,390 total
27 Dec - 28 Dec
Hilton Colon Guayaquil
Children’s activities
Oro Verde Guayaquil

Oro Verde Guayaquil

5.0 star property
Downtown Guayaquil, 6.9 km from Santa Maria
9.4 out of 10, Exceptional, (1009)
"Very good stay , recommend 100%"
United States
Lenin
The price is ฿2,840
฿3,204 total
16 Dec - 17 Dec
Oro Verde Guayaquil
Terrace/patio
Hotel del Parque

Hotel del Parque

4.5 star property
7 km from Santa Maria
9.8 out of 10, Exceptional, (106)
"I love"
United States
Maria
The price is ฿13,689
฿15,058 total
29 Dec - 30 Dec
Hotel del Parque
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Santa Maria

Find the best Santa Maria areas for the activities you enjoy most.

Downtown Guayaquil

Travellers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like San Francisco Square and Central Market while you're in town.

Ecuador

Ecuador might not have many top sights, but C.C. Riocentro Sur and Mall del Sur are two attractions nearby that you can check out.

Puerto Santa Ana

Restaurants and river views are some things travellers note about Puerto Santa Ana. Check out Santa Ana Hill or Botanical Garden while you're familiarising yourself with the larger area.

Urdesa

Urdesa is well liked for its restaurants. If you'd like to do some sightseeing in the greater Guayaquil area, you might plan a trip to San Marino Mall or Alban Borja Commercial Center.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

Top Santa Maria Hotel Reviews

Doubletree By Hilton Guayaquil

Doubletree By Hilton Guayaquil

10/10 Excellent
"Everything worked perfectly. The air conditioner kept the temp all night. The bathroom was large and clean. All staff was friendly. We enjoyed our food and drinks on the rooftop when we arrived. "
Heather 1-night trip
Posted 2 months ago
Doubletree By Hilton Guayaquil
Hotel Puerto Pacifico Guayaquil Airport

Hotel Puerto Pacifico Guayaquil Airport

10/10 Excellent
"I didn't eat breakfast. Overall my stay was excellent. Had staff meet me at airport and take me to the hotel. Check-in was very quick. Found the room to be spacious, very clean, and the bathroom was well stocked with the shower necessities. Was very pleased with my stay and highly recommend the hotel."
Joe 1-night trip
Posted 2 months ago
Hotel Puerto Pacifico Guayaquil Airport

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Frequently asked questions

What is Santa Maria like?
Travellers are sure to enjoy a stay in Guayaquil's Santa Maria neighbourhood.
If I need to cancel my hotel reservation in Santa Maria, will I receive a refund?
Yes, you'll find most room reservations are fully refundable if cancelled before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you booked a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to view the best deals in Santa Maria.
What can I see and do in this Guayaquil neighbourhood?
Salón de Eventos Rubi, City Mall and Guayaquil Parrot are just a few of the places to visit in and around Santa Maria. La Rotonda Shopping Center and Santa Ana Port are also worth a visit when you're out sightseeing in Guayaquil.