Find hotels in Santa Fe, FL from ฿1,923

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25 Dec - 26 Dec
Tomorrow
26 Dec - 27 Dec
This weekend
26 Dec - 28 Dec
Next weekend
2 Jan - 4 Jan

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Our top choices for Santa Fe hotels

BBQ/picnic Area
Staybridge Suites Gainesville I-75 by IHG

Staybridge Suites Gainesville I-75 by IHG

Staybridge Suites Gainesville I-75 by IHG
3.0 star property
Gainesville
9.4 out of 10, Exceptional, (909)
"Great hotel with clean rooms and friendly staff!"
United States
Denise
The price is ฿4,320
฿4,860 total
includes taxes & fees
1 Jan - 2 Jan 2026
Staybridge Suites Gainesville I-75 by IHG
Lobby
Fairfield Inn & Suites by Marriott Gainesville I-75

Fairfield Inn & Suites by Marriott Gainesville I-75

Fairfield Inn & Suites by Marriott Gainesville I-75
2.5 star property
Gainesville
9.6 out of 10, Exceptional, (1000)
"Yes, the room was spacious and clean and the staff very nice."
United States
Rosangela
The price is ฿3,702
฿4,164 total
includes taxes & fees
11 Jan - 12 Jan 2026
Fairfield Inn & Suites by Marriott Gainesville I-75
Standard Double Room | Desk, laptop workspace, iron/ironing board, free WiFi
Soho Inn Waldo

Soho Inn Waldo

Soho Inn Waldo
2.0 star property
Waldo
The price is ฿2,175
฿2,447 total
includes taxes & fees
24 Jan - 25 Jan 2026
Soho Inn Waldo
Lobby
Hampton Inn Gainesville

Hampton Inn Gainesville

Hampton Inn Gainesville
2.5 star property
Gainesville
8.8 out of 10, Excellent, (988)
"Room was super clean, the staff was very nice. The breakfast was very good! "
United States
Chad
The price is ฿2,270
฿2,554 total
includes taxes & fees
2 Jan - 3 Jan 2026
Hampton Inn Gainesville
Lobby
Hyatt Place Gainesville Downtown

Hyatt Place Gainesville Downtown

Hyatt Place Gainesville Downtown
3.0 star property
Downtown Gainesville
9.2 out of 10, Wonderful, (1105)
"Great location great staff great experience I have stayed at the hotel before multiple times an again."
United States
Charles
The price is ฿2,774
฿3,120 total
includes taxes & fees
28 Dec - 29 Dec
Hyatt Place Gainesville Downtown
Exterior
Sweetwater Branch Inn

Sweetwater Branch Inn

Sweetwater Branch Inn
3.5 star property
Gainesville
9.6 out of 10, Exceptional, (986)
"Wonderful place to stay. "
United States
Miranda
The price is ฿4,447
฿5,003 total
includes taxes & fees
30 Dec - 31 Dec
Sweetwater Branch Inn
Exterior
Aloft Gainesville University Area

Aloft Gainesville University Area

Aloft Gainesville University Area
3.0 star property
Gainesville
8.8 out of 10, Excellent, (1000)
"Staff was welcoming , room was clean "
United States
alison
The price is ฿3,014
฿3,391 total
includes taxes & fees
4 Jan - 5 Jan 2026
Aloft Gainesville University Area
Luxury Apartment | In-room dining
Grand Two Bedroom Two Bathroom Apartment with Balcony by The Scholar

Grand Two Bedroom Two Bathroom Apartment with Balcony by The Scholar

Grand Two Bedroom Two Bathroom Apartment with Balcony by The Scholar
4.0 star property
Gainesville
8.4 out of 10, Very good, (8)
"The unit was located in the perfect are, there was so much to do around within 10 minutes driving distance. The unit was was spacious and comfortable we felt like home."
United States
NANCY
The price is ฿3,133
฿7,894 total
includes taxes & fees
28 Dec - 29 Dec
Grand Two Bedroom Two Bathroom Apartment with Balcony by The Scholar
Exterior
Hotel Eleo at the University of Florida

Hotel Eleo at the University of Florida

Hotel Eleo at the University of Florida
3.0 star property
Gainesville
9.4 out of 10, Exceptional, (1290)
"Second time here and will be coming back. Love this place"
United States
Nate
The price is ฿3,462
฿3,895 total
includes taxes & fees
11 Jan - 12 Jan 2026
Hotel Eleo at the University of Florida
Breakfast area
Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75
2.5 star property
Alachua
9.4 out of 10, Exceptional, (474)
"Staff very helpful- clean updated facility. "
United States
bethany
The price is ฿3,287
฿3,698 total
includes taxes & fees
1 Jan - 2 Jan 2026
Hampton Inn & Suites Alachua I-75
BBQ/picnic Area
Holiday Inn Express & Suites Gainesville I-75 by IHG

Holiday Inn Express & Suites Gainesville I-75 by IHG

Holiday Inn Express & Suites Gainesville I-75 by IHG
2.5 star property
Gainesville
9.4 out of 10, Exceptional, (1000)
"Clean room; great coffee in lobby; nice courtyard "
United States
Pam
The price is ฿3,671
฿4,129 total
includes taxes & fees
27 Dec - 28 Dec
Holiday Inn Express & Suites Gainesville I-75 by IHG
Exterior
DoubleTree by Hilton Gainesville

DoubleTree by Hilton Gainesville

DoubleTree by Hilton Gainesville
4.0 star property
Gainesville
7.8 out of 10, Good, (1009)
"Friendly staff, clean hotel. The kids enjoyed the welcome cookie. "
United States
Janelle
The price is ฿2,615
฿2,942 total
includes taxes & fees
25 Jan - 26 Jan 2026
DoubleTree by Hilton Gainesville
Property amenity
Hotel Indigo Gainesville-Celebration Pointe by IHG

Hotel Indigo Gainesville-Celebration Pointe by IHG

Hotel Indigo Gainesville-Celebration Pointe by IHG
3.5 star property
Gainesville
9.0 out of 10, Wonderful, (1001)
" Nice hotel,excellent breakfast"
United States
Axel
The price is ฿2,893
฿3,287 total
includes taxes & fees
25 Jan - 26 Jan 2026
Hotel Indigo Gainesville-Celebration Pointe by IHG
Exterior
Country Inn & Suites by Radisson, Gainesville, FL

Country Inn & Suites by Radisson, Gainesville, FL

Country Inn & Suites by Radisson, Gainesville, FL
3.0 star property
Gainesville
9.2 out of 10, Wonderful, (1633)
"Quiet and clean overnight stay, we will be back , breakfast was good . "
United States
Ralph
The price is ฿2,741
฿3,084 total
includes taxes & fees
1 Jan - 2 Jan 2026
Country Inn & Suites by Radisson, Gainesville, FL
Exterior
La Quinta by Wyndham Gainesville

La Quinta by Wyndham Gainesville

La Quinta by Wyndham Gainesville
3.0 star property
Gainesville
9.0 out of 10, Wonderful, (1129)
"Excellent food and lots of choices"
United States
Marianne
The price is ฿3,191
฿3,590 total
includes taxes & fees
26 Dec - 27 Dec
La Quinta by Wyndham Gainesville
Restaurant
Home2 Suites by Hilton Gainesville Medical Center

Home2 Suites by Hilton Gainesville Medical Center

Home2 Suites by Hilton Gainesville Medical Center
3.0 star property
Gainesville
9.0 out of 10, Wonderful, (896)
"Everything was perfect, nice room, good breakfast and friendly assistants"
United States
Andrea
The price is ฿3,160
฿3,555 total
includes taxes & fees
1 Jan - 2 Jan 2026
Home2 Suites by Hilton Gainesville Medical Center
Meeting facility
Hilton University of Florida Conference Center Gainesville

Hilton University of Florida Conference Center Gainesville

Hilton University of Florida Conference Center Gainesville
3.5 star property
Gainesville
8.4 out of 10, Very good, (1000)
"I will recommend my friends and family to come at this location anytime they are in gainesville "
United States
Recardo
The price is ฿3,010
฿3,386 total
includes taxes & fees
1 Jan - 2 Jan 2026
Hilton University of Florida Conference Center Gainesville
Exterior
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
2.0 star property
High Springs
10.0 out of 10, Exceptional, (157)
"Fantastic place! Very nice amenities and service was wonderful"
United States
Annette
The price is ฿3,077
฿6,119 total
includes taxes & fees
22 Jan - 23 Jan 2026
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
Luxury Apartment, 2 Bedrooms, Lanai, Courtyard View | Private kitchen | Mini-fridge, microwave, coffee/tea maker, toaster
Depot Village

Depot Village

Depot Village
2.0 star property
Gainesville
9.6 out of 10, Exceptional, (71)
"Fantastic stay and would be back in an instant"
United Kingdom
Jack
The price is ฿1,137
฿3,377 total
includes taxes & fees
28 Dec - 29 Dec
Depot Village
Outdoor pool
Best Western Waldo Inn and Suites

Best Western Waldo Inn and Suites

Best Western Waldo Inn and Suites
2.5 star property
Waldo
8.8 out of 10, Excellent, (952)
"Great stay"
United States
Cathy
The price is ฿3,170
฿3,566 total
includes taxes & fees
2 Jan - 3 Jan 2026
Best Western Waldo Inn and Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Fe Hotel Reviews

Hotel Eleo at the University of Florida

Hotel Eleo at the University of Florida

10/10 Excellent
"Friendly staff, very clean. "
Ruth 1-night trip
Posted 3 days ago
Hotel Eleo at the University of Florida

More cheap stays in Santa Fe

Days Inn by Wyndham Gainesville University I-75

Days Inn by Wyndham Gainesville University I-75

920 Nw 69th Ter Gainesville FL
The price is ฿1,981 per night from 28 Dec to 29 Dec
฿1,981
฿2,229 total
28 Dec - 29 Dec
includes taxes & fees
5.4/10 (1,004 reviews)

Frequently asked questions

What's the best place for a stay in Santa Fe?
Located 17.4 mi (28 km) from the heart of Santa Fe, Hilton University of Florida Conference Center Gainesville is a top choice for your stay, based on our traveller data. Other good choices for your stay in the area are Hotel Eleo at the University of Florida and DoubleTree by Hilton Gainesville. See all available top hotels, or vacation rentals in Santa Fe.
If I need to cancel my hotel reservation in Santa Fe, will I receive a refund?
Yes! Most hotel room reservations are fully refundable if cancelled before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Fe.
What is staying in Santa Fe like?
Travellers to Santa Fe will find plenty to explore and enjoy. There are 722 hotels and other accommodation options in the surrounding area. Find out more about Santa Fe.
What is there to see in Santa Fe?
Places to visit in the wider area include O'Leno State Park, San Felasco Hammock Preserve State Park and Devil's Milhopper Geological State Park. You'll also find Gainesville Raceway and Poe Springs Park in the area. Take a look at what more there is to see and do in Expedia's Santa Fe guide.
What's the weather like in Santa Fe?
The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 15°C. The rainiest months in Santa Fe are August, June, July and September, with each month seeing an average of 177 mm of rainfall.

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