Search Hotels in Sanctuary, Sanibel

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Sanctuary hotels

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
21.8 km from Sanctuary
9.0 out of 10, Wonderful, (1,462 reviews)
"Loved the resort and amenities"
United States
Steven
The price is ฿5,207
฿6,527 total
includes taxes & fees
11 May - 12 May
Lani Kai Beachfront Resort

The Bay Inn at Lani Kai

The Bay Inn at Lani Kai
3.0 star property
21.8 km from Sanctuary
7.6 out of 10, Good, (403 reviews)
"front desk workers were extremely pleasant"
United States
Dave
The price is ฿3,741
฿4,890 total
includes taxes & fees
11 May - 12 May
The Bay Inn at Lani Kai

Pointe Estero Beach Resort

Pointe Estero Beach Resort
2.0 star property
27.3 km from Sanctuary
9.2 out of 10, Wonderful, (1,006 reviews)
"Love this place!!"
United States
Teneille
The price is ฿5,215
฿16,279 total
includes taxes & fees
12 May - 13 May
Pointe Estero Beach Resort

Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina
4.0 star property
20.4 km from Sanctuary
9.4 out of 10, Exceptional, (1,345 reviews)
"Staff very friendly, room clean and property very clean "
United States
Kenneth
The price is ฿7,534
฿10,527 total
includes taxes & fees
20 May - 21 May
Pink Shell Beach Resort and Marina

The Palmetto Inn

The Palmetto Inn
3.0 star property
31.2 km from Sanctuary
8.2 out of 10, Very good, (117 reviews)
"Wonderful location in the center of Boca Grande. Easy walk to beachside. "
United States
Maria
The price is ฿5,961
฿6,647 total
includes taxes & fees
13 May - 14 May
The Palmetto Inn

Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,869 reviews)
"Loved the room and the location, the grounds were beautiful and had a convenient beach access, very charming!"
United States
Hillary
The price is ฿8,371
฿10,142 total
includes taxes & fees
31 May - 1 Jun
Sanibel Island Beach Resort

The Anchor Inn

The Anchor Inn
2.0 star property
Mid Island, 12.8 km from Sanctuary
10.0 out of 10, Exceptional, (32 reviews)
"Anchor Inn is not only in a great location but beautiful. We used the bikes every day!"
United States
Renee
The price is ฿6,141
฿7,332 total
includes taxes & fees
14 May - 15 May
The Anchor Inn

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
21.5 km from Sanctuary
8.8 out of 10, Excellent, (1,009 reviews)
"Amazing place to stay! "
United States
Kristen
The price is ฿3,057
฿3,408 total
includes taxes & fees
11 May - 12 May
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

1 Island Hideaway

1 Island Hideaway
3.0 star property
24.3 km from Sanctuary
8.6 out of 10, Excellent, (32 reviews)
"Clean and modern apartment and we stayed on first floor. Walking distance to beach with hot tub and pool. Not really walking distance to bars/restaurants so probably best to have a car. Worth the price."
United States
Howard
The price is ฿6,412
฿14,299 total
includes taxes & fees
13 May - 14 May
1 Island Hideaway

Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
22 km from Sanctuary
8.6 out of 10, Excellent, (1,006 reviews)
"Place is quiet and right down the street from the beach"
United States
Bryan
The price is ฿3,544
฿3,952 total
includes taxes & fees
13 May - 14 May
Latitude 26 Waterfront Resort & Marina

Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
19.3 km from Sanctuary
8.8 out of 10, Excellent, (1,001 reviews)
"Loved having two bedrooms, two bathrooms, and a full sized refrigerator. Breakfast was fantastic! Lots of choices!"
United States
Sheila Margaret
The price is ฿3,319
฿3,701 total
includes taxes & fees
10 May - 11 May
Residence Inn by Marriott Fort Myers Sanibel

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
23.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,445 reviews)
"Love it here! Clean rooms, great staff, great breakfast!"
United States
Amy
The price is ฿3,555
฿3,964 total
includes taxes & fees
1 Jun - 2 Jun
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Sundial Beach Resort & Spa

Sundial Beach Resort & Spa
5.0 star property
Mid Island, 12.8 km from Sanctuary
8.6 out of 10, Excellent, (2,644 reviews)
"Great place! Very clean, great amenities."
United States
Karen
The price is ฿12,212
฿15,377 total
includes taxes & fees
21 May - 22 May
Sundial Beach Resort & Spa

Best Western Plus Beach Resort

Best Western Plus Beach Resort
2.5 star property
20.9 km from Sanctuary
9.4 out of 10, Exceptional, (1,002 reviews)
"This is an amazing hotel! Every staff member was kind, friendly, and welcoming. The room was clean and had everything we needed for our stay. "
United States
Stephanie
The price is ฿7,821
฿8,721 total
includes taxes & fees
27 May - 28 May
Best Western Plus Beach Resort

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
19.9 km from Sanctuary
8.2 out of 10, Very good, (1,144 reviews)
"Clean room, nice pool, near beaches, good breakfast."
United States
Kenneth
The price is ฿2,224
฿2,479 total
includes taxes & fees
3 Jun - 4 Jun
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
3.0 star property
30.1 km from Sanctuary
8.6 out of 10, Excellent, (864 reviews)
"Best Fairfield we have stayed in."
United States
Martin
The price is ฿2,871
฿3,201 total
includes taxes & fees
27 May - 28 May
Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

MALU LANI Inn & Marina

MALU LANI Inn & Marina
3.5 star property
24.7 km from Sanctuary
10.0 out of 10, Exceptional, (6 reviews)
"Beautiful property, peaceful, clean rental. Super responsive owner and all the things you need. Perfect location for boaters. Loved this stay and would definitely rent again! "
United States
April
The price is ฿7,018
฿13,599 total
includes taxes & fees
21 May - 22 May
MALU LANI Inn & Marina

DiamondHead Beach Resort

DiamondHead Beach Resort
3.5 star property
22.3 km from Sanctuary
9.2 out of 10, Wonderful, (1,165 reviews)
"Great room, great staff and great beach! Really enjoyed the location as well. Would stay here again"
United States
Kristen
The price is ฿6,420
฿8,415 total
includes taxes & fees
11 May - 12 May
DiamondHead Beach Resort

Angler's Inn

Angler's Inn
2.5 star property
18.8 km from Sanctuary
9.4 out of 10, Exceptional, (329 reviews)
"Great location and close to lots of restaurants. Jeannette is a great host. Love this place an will stay again "
United States
Cindy
The price is ฿4,994
฿5,569 total
includes taxes & fees
13 May - 14 May
Angler's Inn

Matlacha Tiny Village

Matlacha Tiny Village
3.0 star property
18.8 km from Sanctuary
8.8 out of 10, Excellent, (287 reviews)
"Super cute place!! Super clean and comfortable."
United States
Francesca
The price is ฿3,704
฿8,978 total
includes taxes & fees
9 May - 10 May
Matlacha Tiny Village
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Sanctuary

Find the best Sanctuary areas for the activities you enjoy most.

Mid Island

If you're spending some time in Mid Island, Periwinkle Way and Sanibel Island Southern Beach are top sights worth seeing.

West End

If you're spending some time in West End, J. N. Ding Darling National Wildlife Refuge and Bowman's Beach are top sights worth seeing.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Beachview Country Club Estates

While visiting Beachview Country Club Estates, you might make a stop by sights like Periwinkle Way and Sanibel Island Golf Club.

Shell Harbor

While Shell Harbor isn't home to many top sights, Sanibel Moorings Botanical Gardens and Sanibel Sea School are some notable places to visit nearby.

Top Sanctuary Hotel Reviews

Frequently asked questions

What is Sanctuary like?
Travellers are sure to enjoy a stay in Sanibel's Sanctuary neighbourhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels will I be able to find in the Sanctuary area?
With 10 Expedia hotels and other accommodation options in Sanctuary to choose from, this is a good starting point for exploring the greater Sanibel area.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to get the best deals available in Sanctuary.
What is there to do around this Sanibel neighbourhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

Explore a world of travel with Expedia