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Our top choices for Sanctuary hotels

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
21.8 km from Sanctuary
9.0 out of 10, Wonderful, (1,472 reviews)
"Beach view fabulous, all the staff was very helpful and polite "
United States
Shari
The price is ฿5,477
฿6,825 total
includes taxes & fees
14 May - 15 May
Lani Kai Beachfront Resort

The Anchor Inn

The Anchor Inn
2.0 star property
Mid Island, 12.8 km from Sanctuary
10.0 out of 10, Exceptional, (35 reviews)
"Anchor Inn is not only in a great location but beautiful. We used the bikes every day!"
United States
Renee
The price is ฿6,459
฿7,685 total
includes taxes & fees
31 May - 1 Jun
The Anchor Inn

Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina
4.0 star property
20.4 km from Sanctuary
9.4 out of 10, Exceptional, (1,352 reviews)
"Great stay!"
United States
John
The price is ฿11,128
฿14,527 total
includes taxes & fees
5 Jun - 6 Jun
Pink Shell Beach Resort and Marina

The Bay Inn at Lani Kai

The Bay Inn at Lani Kai
3.0 star property
21.8 km from Sanctuary
7.6 out of 10, Good, (407 reviews)
"front desk workers were extremely pleasant"
United States
Dave
The price is ฿3,738
฿4,886 total
includes taxes & fees
12 May - 13 May
The Bay Inn at Lani Kai

Pointe Estero Beach Resort

Pointe Estero Beach Resort
2.0 star property
27.3 km from Sanctuary
9.2 out of 10, Wonderful, (1,008 reviews)
"Love this place!!"
United States
Teneille
The price is ฿5,212
฿16,268 total
includes taxes & fees
12 May - 13 May
Pointe Estero Beach Resort

1 Island Hideaway

1 Island Hideaway
3.0 star property
24.3 km from Sanctuary
8.6 out of 10, Excellent, (32 reviews)
"Clean and modern apartment and we stayed on first floor. Walking distance to beach with hot tub and pool. Not really walking distance to bars/restaurants so probably best to have a car. Worth the price."
United States
Howard
The price is ฿6,408
฿14,290 total
includes taxes & fees
12 May - 13 May
1 Island Hideaway

Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
19.3 km from Sanctuary
8.8 out of 10, Excellent, (1,003 reviews)
"Wonderful location and accommodations!"
United States
Karen
The price is ฿3,317
฿3,698 total
includes taxes & fees
12 May - 13 May
Residence Inn by Marriott Fort Myers Sanibel

Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,881 reviews)
"Loved the room and the location, the grounds were beautiful and had a convenient beach access, very charming!"
United States
Hillary
The price is ฿8,340
฿10,104 total
includes taxes & fees
31 May - 1 Jun
Sanibel Island Beach Resort

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
21.5 km from Sanctuary
8.8 out of 10, Excellent, (1,014 reviews)
"Amazing place to stay! "
United States
Kristen
The price is ฿2,916
฿3,251 total
includes taxes & fees
12 May - 13 May
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
22 km from Sanctuary
8.6 out of 10, Excellent, (1,008 reviews)
"Place is quiet and right down the street from the beach"
United States
Bryan
The price is ฿2,975
฿3,317 total
includes taxes & fees
12 May - 13 May
Latitude 26 Waterfront Resort & Marina

Best Western Plus Beach Resort

Best Western Plus Beach Resort
2.5 star property
20.9 km from Sanctuary
9.4 out of 10, Exceptional, (1,006 reviews)
"We enjoyed staying right on the beach. Grounds were clean and well kept, and the pool was lovely."
United States
Laura Elizabeth
The price is ฿8,936
฿9,964 total
includes taxes & fees
1 Jun - 2 Jun
Best Western Plus Beach Resort

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
19.9 km from Sanctuary
8.2 out of 10, Very good, (1,148 reviews)
"Clean room, nice pool, near beaches, good breakfast."
United States
Kenneth
The price is ฿3,065
฿3,418 total
includes taxes & fees
24 May - 25 May
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

The Palmetto Inn

The Palmetto Inn
3.0 star property
31.2 km from Sanctuary
8.2 out of 10, Very good, (117 reviews)
"Wonderful location in the center of Boca Grande. Easy walk to beachside. "
United States
Maria
The price is ฿5,957
฿6,642 total
includes taxes & fees
12 May - 13 May
The Palmetto Inn

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
23.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,011 reviews)
"The room was clean and comfortable"
United States
Robert Harold
The price is ฿2,995
฿3,339 total
includes taxes & fees
21 May - 22 May
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
3.0 star property
30.1 km from Sanctuary
8.6 out of 10, Excellent, (868 reviews)
"Staff very friendly. Fabulous breakfast. Clean and very nice hotel"
United States
michael
The price is ฿2,869
฿3,199 total
includes taxes & fees
27 May - 28 May
Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Sundial Beach Resort & Spa

Sundial Beach Resort & Spa
5.0 star property
Mid Island, 12.8 km from Sanctuary
8.6 out of 10, Excellent, (2,644 reviews)
"Great place! Very clean, great amenities."
United States
Karen
The price is ฿14,458
฿17,880 total
includes taxes & fees
7 Jun - 8 Jun
Sundial Beach Resort & Spa

MALU LANI Inn & Marina

MALU LANI Inn & Marina
3.5 star property
24.7 km from Sanctuary
10.0 out of 10, Exceptional, (6 reviews)
"Beautiful property, peaceful, clean rental. Super responsive owner and all the things you need. Perfect location for boaters. Loved this stay and would definitely rent again! "
United States
April
The price is ฿7,013
฿13,590 total
includes taxes & fees
19 May - 20 May
MALU LANI Inn & Marina

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
3.0 star property
22.9 km from Sanctuary
8.6 out of 10, Excellent, (1,008 reviews)
"Breakfast was good and parking excellent "
United States
Catherine
The price is ฿2,746
฿3,062 total
includes taxes & fees
18 May - 19 May
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Summerwind Studios

Summerwind Studios
2.0 star property
22.6 km from Sanctuary
8.2 out of 10, Very good, (15 reviews)
"The room was clean and had everything that I needed. The tv is too small it needs to be a 65'. The door to the other unit that is not in use needs taken out as the noises from the othe unit is like they are in the same roon with you. The lighting on the side of the building could be better, but all in all it was ok and I would return again. "
United States
Craig
The price is ฿1,900
฿3,159 total
includes taxes & fees
14 May - 15 May
Summerwind Studios

DiamondHead Beach Resort

DiamondHead Beach Resort
3.5 star property
22.3 km from Sanctuary
9.2 out of 10, Wonderful, (1,167 reviews)
"Great room, great staff and great beach! Really enjoyed the location as well. Would stay here again"
United States
Kristen
The price is ฿6,415
฿8,410 total
includes taxes & fees
17 May - 18 May
DiamondHead Beach Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Sanctuary

Find the best Sanctuary areas for the activities you enjoy most.

Mid Island

If you're spending some time in Mid Island, Periwinkle Way and Sanibel Island Southern Beach are top sights worth seeing.

West End

If you're spending some time in West End, J. N. Ding Darling National Wildlife Refuge and Bowman's Beach are top sights worth seeing.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Beachview Country Club Estates

While visiting Beachview Country Club Estates, you might make a stop by sights like Periwinkle Way and Sanibel Island Golf Club.

Shell Harbor

While Shell Harbor isn't home to many top sights, Sanibel Moorings Botanical Gardens and Sanibel Sea School are some notable places to visit nearby.

Top Sanctuary Hotel Reviews

Frequently asked questions

What is Sanctuary like?
Travellers are sure to enjoy a stay in Sanibel's Sanctuary neighbourhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels will I be able to find in the Sanctuary area?
With 10 Expedia hotels and other accommodation options in Sanctuary to choose from, this is a good starting point for exploring the greater Sanibel area.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to get the best deals available in Sanctuary.
What is there to do around this Sanibel neighbourhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

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