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Our top choices for Sanctuary hotels

The Nile

The Nile
2.0 star property
23.8 km from Sanctuary
The price is ฿8,050
฿13,806 total
includes taxes & fees
12 May - 13 May
The Nile

Sanibel Inn

Sanibel Inn
3.0 star property
East End, 13.8 km from Sanctuary
9.2 out of 10, Wonderful, (1,006 reviews)
"We enjoyed our stay with a relaxing day on the beach. Everyone was friendly & helpful and our room was very comfortable."
United States
Mary
The price is ฿12,258
฿15,714 total
includes taxes & fees
7 Jun - 8 Jun
Sanibel Inn

Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina
4.0 star property
20.4 km from Sanctuary
9.4 out of 10, Exceptional, (1,351 reviews)
"Excellent breakfast with a beautiful condo overlooking the beach"
United States
Amy
The price is ฿19,619
฿23,994 total
includes taxes & fees
18 May - 19 May
Pink Shell Beach Resort and Marina

Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
22 km from Sanctuary
8.6 out of 10, Excellent, (1,008 reviews)
"Place is quiet and right down the street from the beach"
United States
Bryan
The price is ฿2,975
฿3,317 total
includes taxes & fees
12 May - 13 May
Latitude 26 Waterfront Resort & Marina

DiamondHead Beach Resort

DiamondHead Beach Resort
3.5 star property
22.3 km from Sanctuary
9.2 out of 10, Wonderful, (1,166 reviews)
"Great room, great staff and great beach! Really enjoyed the location as well. Would stay here again"
United States
Kristen
The price is ฿6,415
฿8,410 total
includes taxes & fees
17 May - 18 May
DiamondHead Beach Resort

Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,879 reviews)
"Loved the room and the location, the grounds were beautiful and had a convenient beach access, very charming!"
United States
Hillary
The price is ฿8,340
฿10,104 total
includes taxes & fees
31 May - 1 Jun
Sanibel Island Beach Resort

Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
19.3 km from Sanctuary
8.8 out of 10, Excellent, (1,003 reviews)
"Wonderful location and accommodations!"
United States
Karen
The price is ฿3,317
฿3,698 total
includes taxes & fees
12 May - 13 May
Residence Inn by Marriott Fort Myers Sanibel

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
21.8 km from Sanctuary
9.0 out of 10, Wonderful, (1,471 reviews)
"Loved the resort and amenities"
United States
Steven
The price is ฿5,477
฿6,825 total
includes taxes & fees
14 May - 15 May
Lani Kai Beachfront Resort

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
23.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,452 reviews)
"Excellent location, friendly staff, clean comfortable rooms and walking distance to restaurants and bars. "
United States
Jacqueline
The price is ฿3,542
฿3,949 total
includes taxes & fees
25 May - 26 May
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa
4.0 star property
15.6 km from Sanctuary
8.6 out of 10, Excellent, (1,012 reviews)
"Our favorite place to stay!"
United States
Tammy
The price is ฿7,696
฿9,708 total
includes taxes & fees
9 Jun - 10 Jun
Marriott Sanibel Harbour Resort & Spa

Tween Waters Island Resort & Spa

Tween Waters Island Resort & Spa
3.0 star property
3.7 km from Sanctuary
8.6 out of 10, Excellent, (1,004 reviews)
"View from room was amazing. "
United States
Timothy
The price is ฿8,768
฿10,903 total
includes taxes & fees
13 May - 14 May
Tween Waters Island Resort & Spa

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
19.9 km from Sanctuary
8.2 out of 10, Very good, (1,148 reviews)
"Clean room, nice pool, near beaches, good breakfast."
United States
Kenneth
The price is ฿2,434
฿2,714 total
includes taxes & fees
9 Jun - 10 Jun
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

Allure Suites

Allure Suites
3.0 star property
27.2 km from Sanctuary
7.6 out of 10, Good, (1,006 reviews)
"Nice suite, dated but clean and comfortable, "
United States
Melvin
The price is ฿2,518
฿2,808 total
includes taxes & fees
12 May - 13 May
Allure Suites

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
3.0 star property
30.1 km from Sanctuary
8.6 out of 10, Excellent, (867 reviews)
"Best Fairfield we have stayed in."
United States
Martin
The price is ฿2,869
฿3,199 total
includes taxes & fees
27 May - 28 May
Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Homewood Suites by Hilton - Fort Myers

Homewood Suites by Hilton - Fort Myers
3.0 star property
30.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,012 reviews)
"Excellent breakfast, great pool and hot tub"
United States
David William
The price is ฿3,941
฿4,395 total
includes taxes & fees
7 Jun - 8 Jun
Homewood Suites by Hilton - Fort Myers

Sundial Beach Resort & Spa

Sundial Beach Resort & Spa
5.0 star property
Mid Island, 12.8 km from Sanctuary
8.6 out of 10, Excellent, (2,644 reviews)
"Great place! Very clean, great amenities."
United States
Karen
The price is ฿12,204
฿15,366 total
includes taxes & fees
31 May - 1 Jun
Sundial Beach Resort & Spa

Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers
3.0 star property
29.5 km from Sanctuary
8.8 out of 10, Excellent, (1,011 reviews)
"Nice room, comfortable stay and good breakfast."
United States
Tia
The price is ฿3,357
฿3,743 total
includes taxes & fees
11 Jun - 12 Jun
Hilton Garden Inn Ft Myers

Doubletree by Hilton Fort Myers at Bell Tower Shops

Doubletree by Hilton Fort Myers at Bell Tower Shops
4.0 star property
30.8 km from Sanctuary
8.8 out of 10, Excellent, (1,102 reviews)
"Great place to stay "
United States
Gabriela
The price is ฿3,421
฿3,815 total
includes taxes & fees
7 Jun - 8 Jun
Doubletree by Hilton Fort Myers at Bell Tower Shops

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
23.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,011 reviews)
"The room was clean and comfortable"
United States
Robert Harold
The price is ฿2,995
฿3,339 total
includes taxes & fees
21 May - 22 May
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
3.0 star property
22.9 km from Sanctuary
8.6 out of 10, Excellent, (1,007 reviews)
"Breakfast was good and parking excellent "
United States
Catherine
The price is ฿2,746
฿3,062 total
includes taxes & fees
18 May - 19 May
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Sanctuary

Find the best Sanctuary areas for the activities you enjoy most.

Mid Island

If you're spending some time in Mid Island, Periwinkle Way and Sanibel Island Southern Beach are top sights worth seeing.

West End

If you're spending some time in West End, J. N. Ding Darling National Wildlife Refuge and Bowman's Beach are top sights worth seeing.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Beachview Country Club Estates

While visiting Beachview Country Club Estates, you might make a stop by sights like Periwinkle Way and Sanibel Island Golf Club.

Shell Harbor

While Shell Harbor isn't home to many top sights, Sanibel Moorings Botanical Gardens and Sanibel Sea School are some notable places to visit nearby.

Top Sanctuary Hotel Reviews

Frequently asked questions

What is Sanctuary like?
Travellers are sure to enjoy a stay in Sanibel's Sanctuary neighbourhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels will I be able to find in the Sanctuary area?
With 10 Expedia hotels and other accommodation options in Sanctuary to choose from, this is a good starting point for exploring the greater Sanibel area.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to get the best deals available in Sanctuary.
What is there to do around this Sanibel neighbourhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

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