Search Hotels in Serra Mesa, San Diego

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Top Trending Hotels Near Serra Mesa, San Diego

Room, 1 King Bed with Sofa bed, Marina View | View from room
Sheraton San Diego Resort

Sheraton San Diego Resort

4.0 star property
10.1 km from Serra Mesa
8.2 out of 10, Very good, (3167)
"Great stay! "
United States
Melissa
The price is ฿2,999
฿4,596 total
includes taxes & fees
28 Dec - 29 Dec
Sheraton San Diego Resort
Standard Room, 1 King Bed, Non Smoking, Bay View | Premium bedding, pillow-top beds, in-room safe, desk
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3.0 star property
9.3 km from Serra Mesa
8.8 out of 10, Excellent, (711)
"Great staff, great location, great value. "
United States
Juan
The price is ฿3,127
฿3,626 total
includes taxes & fees
14 Dec - 15 Dec
The DEXTRO Little Italy, BW Premier Collection
Lobby
Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld

3.0 star property
9 km from Serra Mesa
7.4 out of 10, Good, (4093)
"Clean rooms and friendly staff."
United States
Aniket
The price is ฿2,697
฿3,101 total
includes taxes & fees
16 Dec - 17 Dec
Wyndham Garden San Diego Near SeaWorld
Terrace/patio
Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley

2.5 star property
6.4 km from Serra Mesa
8.8 out of 10, Excellent, (1267)
"Spacious and clean rooms, helpful staff"
United States
Gholam
The price is ฿3,153
฿3,624 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn San Diego/Mission Valley
3 outdoor pools, pool cabanas (surcharge), pool umbrellas
Sycuan Casino Resort

Sycuan Casino Resort

4.0 star property
29.1 km from Serra Mesa
9.2 out of 10, Wonderful, (1628)
"Nice hotel and friendly staff. Will definitely stay again ."
United States
Lorna
Sycuan Casino Resort
2 outdoor pools, open 6 AM to 10:00 PM, pool cabanas (surcharge)
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

4.0 star property
Marina District, 10.7 km from Serra Mesa
9.2 out of 10, Wonderful, (1934)
"Great hotel"
United States
Farzana
The price is ฿5,073
฿7,559 total
includes taxes & fees
13 Dec - 14 Dec
Marriott Marquis San Diego Marina
Courtyard
DoubleTree by Hilton San Diego - Del Mar

DoubleTree by Hilton San Diego - Del Mar

4.0 star property
Carmel Valley, 17.4 km from Serra Mesa
8.4 out of 10, Very good, (1850)
"The room had a great view of the pool and staff was very friendly! "
United States
eva
The price is ฿3,898
฿4,441 total
includes taxes & fees
4 Jan - 5 Jan 2026
DoubleTree by Hilton San Diego - Del Mar
Terrace/patio
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4.0 star property
9.9 km from Serra Mesa
8.4 out of 10, Very good, (6064)
"Always an amazing stay"
United States
Jana
The price is ฿4,312
฿5,924 total
includes taxes & fees
10 Dec - 11 Dec
Wyndham San Diego Bayside
Meeting facility
The Westin San Diego Bayview

The Westin San Diego Bayview

4.0 star property
10 km from Serra Mesa
8.6 out of 10, Excellent, (1046)
"Great room in a very convenient location"
Canada
Kristjan
The price is ฿4,313
฿5,926 total
includes taxes & fees
20 Dec - 21 Dec
The Westin San Diego Bayview
Reception
Kings Inn San Diego

Kings Inn San Diego

2.5 star property
6 km from Serra Mesa
8.8 out of 10, Excellent, (3568)
"Room was very clean, and the breakfast was good"
United States
Roxana
The price is ฿2,512
฿2,883 total
includes taxes & fees
17 Dec - 18 Dec
Kings Inn San Diego
Exterior
Hilton Garden Inn San Diego Old Town/SeaWorld Area

Hilton Garden Inn San Diego Old Town/SeaWorld Area

3.0 star property
Old Town San Diego, 7.4 km from Serra Mesa
8.6 out of 10, Excellent, (1294)
"Good location, the room was specious and clean. We really enjoyed our stay!"
United States
Yana
The price is ฿3,461
฿3,978 total
includes taxes & fees
19 Dec - 20 Dec
Hilton Garden Inn San Diego Old Town/SeaWorld Area
Outdoor pool, a heated pool
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3.0 star property
5.4 km from Serra Mesa
8.0 out of 10, Very good, (2420)
"Front desk staff was kind, knowledgeable and efficient "
United States
Elizabeth
The price is ฿2,820
฿3,242 total
includes taxes & fees
10 Dec - 11 Dec
Days Inn by Wyndham San Diego Hotel Circle
Standard Room, 2 Queen Beds | Pillow-top beds, individually decorated, individually furnished, desk
GreenTree Inn San Diego Mission Bay

GreenTree Inn San Diego Mission Bay

2.5 star property
Pacific Beach, 7.3 km from Serra Mesa
8.0 out of 10, Very good, (1841)
"The breakfast was the best part and the people also will wonderful staff wonderful also"
United States
Tempest
The price is ฿2,699
฿3,103 total
includes taxes & fees
14 Dec - 15 Dec
GreenTree Inn San Diego Mission Bay
Outdoor pool, pool umbrellas, pool loungers
Hampton Inn San Diego-Downtown

Hampton Inn San Diego-Downtown

2.5 star property
9.6 km from Serra Mesa
8.2 out of 10, Very good, (2264)
"Great stay, I recommend it"
United States
Furio
The price is ฿3,309
฿3,837 total
includes taxes & fees
25 Dec - 26 Dec
Hampton Inn San Diego-Downtown
Exterior
Comfort Inn San Diego Old Town

Comfort Inn San Diego Old Town

2.5 star property
Old Town San Diego, 7.9 km from Serra Mesa
8.2 out of 10, Very good, (1910)
"Efficient check in, clean rooms and great breakfast."
Canada
Wendy
The price is ฿3,132
฿3,600 total
includes taxes & fees
21 Dec - 22 Dec
Comfort Inn San Diego Old Town
Reception
Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina

3.0 star property
12.9 km from Serra Mesa
8.8 out of 10, Excellent, (1563)
"Nice hotel "
United States
Anthony
The price is ฿3,819
฿4,390 total
includes taxes & fees
4 Jan - 5 Jan 2026
Best Western Plus Island Palms Hotel & Marina
Outdoor pool, pool umbrellas, pool loungers
Handlery Hotel

Handlery Hotel

3.5 star property
5.7 km from Serra Mesa
8.2 out of 10, Very good, (2206)
"Staff was amazing and very accommodating. Always recommended staying here. "
United States
Taja
The price is ฿2,782
฿3,198 total
includes taxes & fees
22 Dec - 23 Dec
Handlery Hotel
Desk, laptop workspace, blackout curtains, iron/ironing board
SureStay Hotel by Best Western San Diego Pacific Beach

SureStay Hotel by Best Western San Diego Pacific Beach

2.5 star property
Pacific Beach, 7.3 km from Serra Mesa
8.0 out of 10, Very good, (1395)
"Perfect stay for a very good price. "
United States
Damon
The price is ฿2,526
฿2,853 total
includes taxes & fees
22 Dec - 23 Dec
SureStay Hotel by Best Western San Diego Pacific Beach
In-room safe, desk, blackout curtains, iron/ironing board
Bahia Resort Hotel

Bahia Resort Hotel

3.5 star property
Central Mission Beach, 10.7 km from Serra Mesa
8.6 out of 10, Excellent, (1806)
"Staff was very friendly hotel was very very clean! "
United States
Antonio
The price is ฿4,058
฿6,441 total
includes taxes & fees
5 Jan - 6 Jan 2026
Bahia Resort Hotel
Front of property
Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista

2.0 star property
18.6 km from Serra Mesa
7.2 out of 10, Good, (1973)
"Great stay"
United States
Eleazar
The price is ฿2,044
฿2,249 total
includes taxes & fees
11 Dec - 12 Dec
Hotel Palmeras Chula Vista
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Gaslamp Quarter featuring a bar, night scenes and street scenes

Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

Pacific Beach Park showing a beach

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Belmont Park featuring a park and rides

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach Pier and Dog Beach.

Top Serra Mesa Hotel Reviews

Hampton Inn & Suites by Hilton San Diego SeaWorld

Hampton Inn & Suites by Hilton San Diego SeaWorld

10/10 Excellent
"Very clean!"
Franco 3-night trip
Posted 3 days ago
Hampton Inn & Suites by Hilton San Diego SeaWorld

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Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels can I expect to find in the Serra Mesa area?
Expedia has 39 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.
What can I see and do in this San Diego neighbourhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.