Search Hotels in Serra Mesa, San Diego

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Our top choices for Serra Mesa hotels

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.8 km from Serra Mesa
9.4 out of 10, Exceptional, (1,964 reviews)
"Always a great stay"
United States
Jeanette
The price is ฿4,332
฿5,158 total
includes taxes & fees
9 Jun - 10 Jun
Sycuan Casino Resort

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
9 km from Serra Mesa
7.4 out of 10, Good, (4,248 reviews)
"Nice stay, clean room"
United States
Luis
The price is ฿3,888
฿4,469 total
includes taxes & fees
7 Jun - 8 Jun
Wyndham Garden San Diego Near SeaWorld

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
28.1 km from Serra Mesa
8.8 out of 10, Excellent, (1,294 reviews)
"Everything was very pleasant,the place was super clean, and the breakfast was delicious👍"
United States
Nancy
The price is ฿3,996
฿4,546 total
includes taxes & fees
21 Jun - 22 Jun
Best Western Americana Inn

Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
18.6 km from Serra Mesa
8.2 out of 10, Very good, (1,533 reviews)
"Laundry room was extremely clean breakfast pretty nice staff was excellent "
United States
Victoria
The price is ฿4,138
฿4,560 total
includes taxes & fees
28 Jun - 29 Jun
Comfort Inn Chula Vista San Diego South

La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
18.7 km from Serra Mesa
8.6 out of 10, Excellent, (1,635 reviews)
"Great place to stay at, would definitely stay there again."
United States
Jose
The price is ฿3,976
฿4,373 total
includes taxes & fees
14 Jun - 15 Jun
La Quinta Inn by Wyndham San Diego Chula Vista

Courtyard by Marriott San Diego Central

Courtyard by Marriott San Diego Central
3.0 star property
2.6 km from Serra Mesa
8.8 out of 10, Excellent, (1,014 reviews)
"Great hotel and I will stay there again. Good breakfast and very clean and safe."
United States
Natalie
The price is ฿5,451
฿6,266 total
includes taxes & fees
5 Jul - 6 Jul
Courtyard by Marriott San Diego Central

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
10.1 km from Serra Mesa
8.4 out of 10, Very good, (3,547 reviews)
"My family and I truly enjoyed our stay."
United States
Beverly A
The price is ฿5,201
฿7,631 total
includes taxes & fees
5 Jul - 6 Jul
Sheraton San Diego Resort

Days Inn by Wyndham San Diego-East/El Cajon

Days Inn by Wyndham San Diego-East/El Cajon
2.0 star property
17.7 km from Serra Mesa
7.8 out of 10, Good, (1,005 reviews)
"Rooms were cheap clean property was clean convenient close to where I was working"
United States
James
The price is ฿2,472
฿2,724 total
includes taxes & fees
8 Jun - 9 Jun
Days Inn by Wyndham San Diego-East/El Cajon

The Alcala Hotel Mission Valley/Seaworld

The Alcala Hotel Mission Valley/Seaworld
2.5 star property
6.6 km from Serra Mesa
8.2 out of 10, Very good, (162 reviews)
"Staff was great and rooms were nice."
United States
Brittney
The price is ฿3,272
฿3,761 total
includes taxes & fees
7 Jun - 8 Jun
The Alcala Hotel Mission Valley/Seaworld

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
7.9 km from Serra Mesa
9.2 out of 10, Wonderful, (1,071 reviews)
"Staff was so great nice rooms really great stay"
United States
Amelia
The price is ฿5,228
฿6,009 total
includes taxes & fees
7 Jun - 8 Jun
Holiday Inn Express San Diego Airport - Old Town by IHG

GreenTree Inn San Diego Mission Bay

GreenTree Inn San Diego Mission Bay
2.5 star property
Pacific Beach, 7.3 km from Serra Mesa
8.0 out of 10, Very good, (2,153 reviews)
"Great experience, will stay here again"
United States
Victoria
The price is ฿4,087
฿4,698 total
includes taxes & fees
7 Jun - 8 Jun
GreenTree Inn San Diego Mission Bay

Ramada by Wyndham San Diego Poway Miramar

Ramada by Wyndham San Diego Poway Miramar
2.0 star property
18.2 km from Serra Mesa
7.2 out of 10, Good, (1,016 reviews)
"Nice place to stay."
United States
Jacquie
The price is ฿4,190
฿4,609 total
includes taxes & fees
7 Jun - 8 Jun
Ramada by Wyndham San Diego Poway Miramar

Best Western San Diego/Miramar Hotel

Best Western San Diego/Miramar Hotel
2.5 star property
10.1 km from Serra Mesa
8.0 out of 10, Very good, (1,371 reviews)
"Great staff and comfortable room."
United States
Angela
The price is ฿4,034
฿4,637 total
includes taxes & fees
7 Jun - 8 Jun
Best Western San Diego/Miramar Hotel

California Suites Hotel

California Suites Hotel
2.0 star property
4.8 km from Serra Mesa
7.8 out of 10, Good, (2,606 reviews)
"Great place to stay. Nice staff, pretty affordable for the area and nice pool & spa"
United States
Kimberly
The price is ฿2,911
฿3,340 total
includes taxes & fees
7 Jun - 8 Jun
California Suites Hotel

Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station
2.5 star property
10.6 km from Serra Mesa
9.2 out of 10, Wonderful, (1,725 reviews)
"Good location, clean room and nice staff. A great place to stay."
United States
Patricia
The price is ฿5,599
฿6,436 total
includes taxes & fees
28 Jun - 29 Jun
Hampton Inn & Suites San Diego Airport Liberty Station

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
5.3 km from Serra Mesa
9.4 out of 10, Exceptional, (1,687 reviews)
"Lovely hotel, very aesthetic place"
United States
Roxana
The price is ฿8,135
฿9,351 total
includes taxes & fees
29 Jun - 30 Jun
Lafayette Hotel & Club

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
9.9 km from Serra Mesa
8.4 out of 10, Very good, (6,162 reviews)
"Enjoyed our stay."
United States
Debra
The price is ฿5,848
฿7,918 total
includes taxes & fees
8 Jun - 9 Jun
Wyndham San Diego Bayside

SpringHill Suites by Marriott San Diego Rancho Bernardo/Scripps Poway

SpringHill Suites by Marriott San Diego Rancho Bernardo/Scripps Poway
3.0 star property
15.2 km from Serra Mesa
8.8 out of 10, Excellent, (1,204 reviews)
"Great service and clean rooms. Happy with location and stay."
United States
Maria
The price is ฿5,848
฿6,722 total
includes taxes & fees
7 Jun - 8 Jun
SpringHill Suites by Marriott San Diego Rancho Bernardo/Scripps Poway

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.1 km from Serra Mesa
9.2 out of 10, Wonderful, (3,868 reviews)
"Great stay"
United States
Cameron
The price is ฿4,940
฿5,444 total
includes taxes & fees
10 Jun - 11 Jun
Best Western Plus Marina Gateway Hotel

Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
18.5 km from Serra Mesa
9.4 out of 10, Exceptional, (1,215 reviews)
"Very nice place to stay"
United States
Lingzhi
The price is ฿5,110
฿5,621 total
includes taxes & fees
7 Jun - 8 Jun
Holiday Inn Express San Diego South - Chula Vista by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and USS Midway Museum are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Top Serra Mesa Hotel Reviews

Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels can I expect to find in the Serra Mesa area?
Expedia has 38 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.
What can I see and do in this San Diego neighbourhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Sharp Learning Resource Center and Convoy District are also worth a stop.