Search Hotels in Serra Mesa, San Diego

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Our top choices for Serra Mesa hotels

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection
3.0 star property
9.3 km from Serra Mesa
9.0 out of 10, Wonderful, (1,027 reviews)
"Clean rooms and friendly staff"
United States
Topeka
The price is ฿3,657
฿4,240 total
includes taxes & fees
22 Feb - 23 Feb
The DEXTRO Little Italy, BW Premier Collection

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
9 km from Serra Mesa
7.4 out of 10, Good, (4,171 reviews)
"Good location friendly staff"
United States
Anya
The price is ฿2,806
฿3,225 total
includes taxes & fees
9 Feb - 10 Feb
Wyndham Garden San Diego Near SeaWorld

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
9.9 km from Serra Mesa
8.4 out of 10, Very good, (6,026 reviews)
"Great place to stay"
United States
David
The price is ฿4,797
฿6,659 total
includes taxes & fees
15 Feb - 16 Feb
Wyndham San Diego Bayside

Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle
3.0 star property
5.4 km from Serra Mesa
8.0 out of 10, Very good, (2,459 reviews)
"Very easy to check in and check out, room was clean and location was fantastic. "
United States
Melissa
The price is ฿2,519
฿2,895 total
includes taxes & fees
10 Feb - 11 Feb
Days Inn by Wyndham San Diego Hotel Circle

Comfort Inn San Diego Old Town

Comfort Inn San Diego Old Town
2.5 star property
Old Town San Diego, 7.9 km from Serra Mesa
8.2 out of 10, Very good, (1,962 reviews)
"Room was nice and clean, staff was very accomidating and friendly."
United States
Steve
The price is ฿2,774
฿3,189 total
includes taxes & fees
22 Feb - 23 Feb
Comfort Inn San Diego Old Town

Kings Inn San Diego

Kings Inn San Diego
2.5 star property
6 km from Serra Mesa
8.8 out of 10, Excellent, (3,632 reviews)
"Love the Kings Inn, always on our travel list!!"
United States
Linzee
Kings Inn San Diego

The Sofia Hotel

The Sofia Hotel
3.5 star property
10 km from Serra Mesa
8.6 out of 10, Excellent, (1,749 reviews)
"Great hotel "
United States
Alexander
The Sofia Hotel

Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina
4.0 star property
Mission Bay, 10.3 km from Serra Mesa
8.4 out of 10, Very good, (1,598 reviews)
"Balcony view is awesome, clean room, staff at counter and restaurant service was stunning."
United States
francisco
The price is ฿5,013
฿7,430 total
includes taxes & fees
26 Feb - 27 Feb
Hyatt Regency Mission Bay Spa and Marina

GreenTree Inn San Diego Mission Bay

GreenTree Inn San Diego Mission Bay
2.5 star property
Pacific Beach, 7.3 km from Serra Mesa
8.0 out of 10, Very good, (1,927 reviews)
"The staff was very nice and great location"
United States
Curtis
The price is ฿2,769
฿3,183 total
includes taxes & fees
12 Feb - 13 Feb
GreenTree Inn San Diego Mission Bay

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.8 km from Serra Mesa
9.2 out of 10, Wonderful, (1,715 reviews)
"Very clean resort. "
United States
Petrina
Sycuan Casino Resort

Paradise Point Resort & Spa

Paradise Point Resort & Spa
4.0 star property
Mission Bay, 9.9 km from Serra Mesa
8.8 out of 10, Excellent, (2,402 reviews)
"Clean rooms, friendly staff, and a beautiful view all around.. "
United States
Morgan
The price is ฿4,524
฿6,869 total
includes taxes & fees
1 Mar - 2 Mar
Paradise Point Resort & Spa

The Atwood Hotel San Diego - SeaWorld/Zoo

The Atwood Hotel San Diego - SeaWorld/Zoo
3.0 star property
5.8 km from Serra Mesa
8.0 out of 10, Very good, (1,857 reviews)
"Plenty of parking!"
United States
Juan
The Atwood Hotel San Diego - SeaWorld/Zoo

Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina
3.0 star property
12.9 km from Serra Mesa
9.0 out of 10, Wonderful, (1,581 reviews)
"Great place.very clean great for family would definitely stay there again."
United States
Joseph
The price is ฿4,489
฿5,160 total
includes taxes & fees
8 Mar - 9 Mar
Best Western Plus Island Palms Hotel & Marina

DoubleTree by Hilton San Diego - Del Mar

DoubleTree by Hilton San Diego - Del Mar
4.0 star property
Carmel Valley, 17.4 km from Serra Mesa
8.4 out of 10, Very good, (2,042 reviews)
"Nice hotel, staff is great."
United States
Felipe Ramirez
The price is ฿4,110
฿4,684 total
includes taxes & fees
1 Mar - 2 Mar
DoubleTree by Hilton San Diego - Del Mar

Best Western San Diego/Miramar Hotel

Best Western San Diego/Miramar Hotel
2.5 star property
10.1 km from Serra Mesa
7.8 out of 10, Good, (1,183 reviews)
"Clean room and great breakfast buffet."
United States
Danny Bryan
The price is ฿2,684
฿3,085 total
includes taxes & fees
16 Feb - 17 Feb
Best Western San Diego/Miramar Hotel

Bay Club Hotel & Marina

Bay Club Hotel & Marina
3.5 star property
12.6 km from Serra Mesa
9.2 out of 10, Wonderful, (3,369 reviews)
"We had great time and enjoyed our stay "
United States
sadra
The price is ฿4,001
฿4,599 total
includes taxes & fees
16 Feb - 17 Feb
Bay Club Hotel & Marina

Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego
3.0 star property
Gaslamp Quarter, 10.4 km from Serra Mesa
9.4 out of 10, Exceptional, (1,004 reviews)
"Great location and stay. "
United States
Simran
The price is ฿3,263
฿4,694 total
includes taxes & fees
22 Feb - 23 Feb
Staypineapple, Hotel Z, Gaslamp San Diego

Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista
2.0 star property
18.6 km from Serra Mesa
7.2 out of 10, Good, (2,131 reviews)
"Good stay, quiet,place was easy to find."
United States
Annie
The price is ฿2,096
฿2,306 total
includes taxes & fees
9 Feb - 10 Feb
Hotel Palmeras Chula Vista

Holiday Inn Express San Diego Downtown by IHG

Holiday Inn Express San Diego Downtown by IHG
2.5 star property
9.4 km from Serra Mesa
8.4 out of 10, Very good, (1,597 reviews)
"Lovely stay, friendly staff and great breakfast "
Canada
Louella
The price is ฿4,256
฿4,935 total
includes taxes & fees
1 Mar - 2 Mar
Holiday Inn Express San Diego Downtown by IHG

SureStay Hotel by Best Western San Diego Pacific Beach

SureStay Hotel by Best Western San Diego Pacific Beach
2.5 star property
Pacific Beach, 7.3 km from Serra Mesa
8.0 out of 10, Very good, (1,525 reviews)
"Room was nice, clean, staff was friendly, "
United States
philip
The price is ฿2,845
฿3,213 total
includes taxes & fees
9 Feb - 10 Feb
SureStay Hotel by Best Western San Diego Pacific Beach
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Dog Beach and Ocean Beach Farmers Market.

Top Serra Mesa Hotel Reviews

Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels can I expect to find in the Serra Mesa area?
Expedia has 38 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.
What can I see and do in this San Diego neighbourhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.