The Best Hotels in Otay Mesa West, San Diego - 2026 Updated Prices

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Our top choices for Otay Mesa West hotels

A spacious lobby with a fireplace, wooden furniture, and a chandelier.

1. Best Western Americana Inn

2.1 km from Otay Mesa West

Luis

฿4,247 total

includes taxes & fees

20 Sept - 21 Sept

A hotel room with a large bed, a desk, a chair, a painting, and a view of the city.

2. Best Western Plus Marina Gateway Hotel

10.5 km from Otay Mesa West

Alexander

฿5,219 total

includes taxes & fees

10 Sept - 11 Sept

A Holiday Inn Express building with a prominent entrance, palm trees, and a clear sky.

3. Holiday Inn Express San Diego South - Chula Vista by IHG

8 km from Otay Mesa West

Cathie

฿4,941 total

includes taxes & fees

10 Sept - 11 Sept

An outdoor patio area with seating and a bar.

4. Ayres Hotel San Diego South - Chula Vista

9.2 km from Otay Mesa West

Shan Shan

฿7,046 total

includes taxes & fees

1 Oct - 2 Oct

A breakfast bar with La Quinta branding, a coffee machine, and a waffle display.

5. La Quinta Inn by Wyndham San Diego Chula Vista

7.8 km from Otay Mesa West

Sharon

฿3,752 total

includes taxes & fees

20 Sept - 21 Sept

A hotel lobby with a patterned carpet, a reception desk, a sofa with cushions, and potted plants.

6. Comfort Inn Chula Vista San Diego South

7.9 km from Otay Mesa West

Katsuya

฿3,969 total

includes taxes & fees

20 Sept - 21 Sept

A modern hotel with a prominent 'Hercor Hotel' sign, multiple balconies, and a 'Urban Boutique' label.

7. Hercor Hotel - Urban Boutique

6.8 km from Otay Mesa West

Mahmoud

฿3,587 total

includes taxes & fees

27 Sept - 28 Sept

A retro-themed arcade with classic games, a foosball table, and a long communal table with stools.

8. The Rambler Hotel

8 km from Otay Mesa West

Tracy

฿4,726 total

includes taxes & fees

22 Sept - 23 Sept

9. SpringHill Suites by Marriott Chula Vista Eastlake

12.4 km from Otay Mesa West

Alfonso

฿7,138 total

includes taxes & fees

27 Sept - 28 Sept

A spacious lobby with a large seating area, a wooden ceiling, and large windows offering a view of the outdoor patio area.

10. Hampton Inn & Suites San Diego Airport Liberty Station

22.4 km from Otay Mesa West

David

฿6,820 total

includes taxes & fees

5 Oct - 6 Oct

A hotel complex with multiple buildings, a landscaped garden, and a body of water reflecting the sunset.

11. Homewood Suites by Hilton San Diego Airport/Liberty Station

22.7 km from Otay Mesa West

Orlyn

฿7,721 total

includes taxes & fees

29 Sept - 30 Sept

A hotel room with a bed, a desk with a chair, a nightstand, and a wall-mounted TV displaying a sunset scene.

12. Hotel Palmeras Chula Vista

7.8 km from Otay Mesa West

Idanesha

฿2,476 total

includes taxes & fees

9 Sept - 10 Sept

A balcony with wicker furniture overlooking a marina and a coastal cityscape.

13. Sheraton San Diego Resort

21.4 km from Otay Mesa West

Kathleen

฿8,053 total

includes taxes & fees

27 Sept - 28 Sept

A modern hotel room with a large bed, bedside tables, a desk, and a wardrobe.

14. Holiday Inn Express San Diego Airport - Old Town by IHG

22.4 km from Otay Mesa West

Faleoalii Iereneo

฿5,444 total

includes taxes & fees

22 Sept - 23 Sept

An outdoor dining area with a long table and chairs, a street view, and a building with a 'P' parking sign.

15. Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Gaslamp Quarter, 17.6 km from Otay Mesa West

RheaAnn

฿5,222 total

includes taxes & fees

10 Sept - 11 Sept

An outdoor lounge area with seating, a fire feature, and a pool in the background.

16. Town and Country San Diego

23.3 km from Otay Mesa West

Sol

฿9,268 total

includes taxes & fees

10 Sept - 11 Sept

A multi-level hotel lobby with numerous tables and chairs, a central seating area, and a staircase connecting the floors.

17. Embassy Suites by Hilton San Diego Bay Downtown

18.4 km from Otay Mesa West

Jennifer

฿8,596 total

includes taxes & fees

11 Sept - 12 Sept

A spacious living room with a large arched window, a red sofa, a coffee table, and a chandelier.

18. Lamplighter Inn & Suites at SDSU

21 km from Otay Mesa West

Bernadette

฿4,867 total

includes taxes & fees

7 Oct - 8 Oct

19. Hard Rock Hotel San Diego

Gaslamp Quarter, 17.5 km from Otay Mesa West

Juan

฿8,110 total

includes taxes & fees

28 Sept - 29 Sept

A cozy outdoor seating area with wicker furniture, a fire pit, and a bar with a city view.

20. Hilton San Diego Gaslamp Quarter

Gaslamp Quarter, 17.6 km from Otay Mesa West

Juan Pablo

฿8,543 total

includes taxes & fees

13 Sept - 14 Sept

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Where to stay in Otay Mesa West

Find the best Otay Mesa West areas for the activities you enjoy most.

A plaza with a traditional building, benches, and a large tree.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

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A pier at sunset with people sitting and standing, waves crashing below.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

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A roller coaster under construction with scaffolding and a ticket booth in the foreground.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

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Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

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A beach with palm trees, a hotel, and people enjoying the sand and water.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach and Dog Beach.

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Top Otay Mesa West Hotel Reviews

Wyndham San Diego Bayside

10/10 Excellent

"The hotel was clean and the service was good; we will return next time"

Sheraton San Diego Resort

8/10 Good

"Our stay was good, not what I expected, but decent. Our room had marina view, which was nice, but we were sent to another tower some what far from the main. The jacuzzi did not work and the pool was freezing cold. Our room needs to be updated, needs renovation, but the room looked clean. Parking is expensive too, plus resort fee on top of booking. Close to San Diego city zoo but 30 minutes away from safari San diego zoo."

Paradise Point Resort & Spa

10/10 Excellent

"What a great facility for families. The rooms are spacious and comfortable. The ammenities are wonderful for kids, with lots of things for them to do to stay entertained. The views are gorgeous, and the bayfront rooms allow easy access to the beach at any point. We'll definitely be back with family and friends."

Days Inn by Wyndham San Diego Hotel Circle

10/10 Excellent

"I had a lovely room with a view of the mountain and foliage. I really appreciated that. Also the windows opened, so I was able to let in some fresh air. That was nice. I was pleasantly surprised with the room, grateful for the gracious hospitality of the staff, and enjoyed my experience overall. Thank you!"

Frequently asked questions

What is Otay Mesa West like?

Otay Mesa West is a neighbourhood that travellers like for its cathedral.

If I need to cancel my hotel reservation in Otay Mesa West, will I receive a refund?

Yes! The majority of room reservations are refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to review top deals in Otay Mesa West.

What is there to do around this San Diego neighbourhood?

A few places to visit in the area around Otay Mesa West include San Ysidro Border Crossing, Las Americas Premium Outlets and Sesame Place San Diego. While you're out sightseeing in San Diego, make sure that you visit other sights such as Tijuana Customs - Garita El Chaparral or North Island Credit Union Amphitheatre.

How can I get around Otay Mesa West and the greater San Diego area?

Ready to get out and explore the city? Iris Avenue Trolley Station is the closest metro station.

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Our top choices for Otay Mesa West hotels

1. Best Western Americana Inn

2. Best Western Plus Marina Gateway Hotel

3. Holiday Inn Express San Diego South - Chula Vista by IHG

4. Ayres Hotel San Diego South - Chula Vista

5. La Quinta Inn by Wyndham San Diego Chula Vista

6. Comfort Inn Chula Vista San Diego South

7. Hercor Hotel - Urban Boutique

8. The Rambler Hotel

9. SpringHill Suites by Marriott Chula Vista Eastlake

10. Hampton Inn & Suites San Diego Airport Liberty Station

11. Homewood Suites by Hilton San Diego Airport/Liberty Station

12. Hotel Palmeras Chula Vista

13. Sheraton San Diego Resort

14. Holiday Inn Express San Diego Airport - Old Town by IHG

15. Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

16. Town and Country San Diego

17. Embassy Suites by Hilton San Diego Bay Downtown

18. Lamplighter Inn & Suites at SDSU

19. Hard Rock Hotel San Diego

20. Hilton San Diego Gaslamp Quarter

Where to stay in Otay Mesa West

Downtown San Diego

Pacific Beach

Mission Beach

Gaslamp Quarter

Ocean Beach

Top Otay Mesa West Hotel Reviews

Wyndham San Diego Bayside

Frequently asked questions

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