A marina with boats docked, a city skyline with high-rise buildings, and a sunset with pink and orange clouds.

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Check prices for these dates

This weekend
30 Oct - 1 Nov
Next weekend
6 Nov - 8 Nov

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Our top choices for Otay Mesa West hotels

A spacious lobby with a fireplace, wooden furniture, and a chandelier.

1. Best Western Americana Inn

Best Western Americana Inn
2.5 star property
2.1 km from Otay Mesa West
8.8 out of 10, Excellent, (1,421 reviews)
"The staff was wonderful and the room was clean! Breakfast had great options and all good. Recommend for a great affordable stay!"
United States
Rene
The price is ฿3,531
฿4,017 total
includes taxes & fees
22 Nov - 23 Nov
Best Western Americana Inn
A neatly arranged hotel room with a large bed, a desk, a chair, and a bedside table.

2. Valli Hi Motel

Valli Hi Motel
2.0 star property
2.2 km from Otay Mesa West
8.2 out of 10, Very good, (1,159 reviews)
"Great stay and good room."
United States
Christian
The price is ฿2,731
฿3,112 total
includes taxes & fees
1 Nov - 2 Nov
Valli Hi Motel
A Holiday Inn Express building with a prominent entrance, palm trees, and a clear sky.

3. Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
8 km from Otay Mesa West
9.4 out of 10, Exceptional, (1,634 reviews)
"Great stay"
United States
Daniel
The price is ฿5,766
฿6,343 total
includes taxes & fees
18 Nov - 19 Nov
Holiday Inn Express San Diego South - Chula Vista by IHG
A hotel room with two beds, a television, a desk, and a dresser.

4. La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
7.8 km from Otay Mesa West
8.8 out of 10, Excellent, (1,775 reviews)
"Enjoyed our stay"
United States
Nuwan
The price is ฿3,583
฿3,941 total
includes taxes & fees
29 Nov - 30 Nov
La Quinta Inn by Wyndham San Diego Chula Vista
A hotel lobby with a patterned carpet, a reception desk, a sofa with cushions, and potted plants.

5. Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
7.9 km from Otay Mesa West
8.4 out of 10, Very good, (1,711 reviews)
"The breakfast and the staff were great!"
United States
Xochitl
The price is ฿3,507
฿3,865 total
includes taxes & fees
29 Nov - 30 Nov
Comfort Inn Chula Vista San Diego South
An outdoor patio area with seating and a bar.

6. Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
9.2 km from Otay Mesa West
9.8 out of 10, Exceptional, (1,031 reviews)
"I was very impressed with this hotel. The rooms were comfortable and modern and the staff was warm and welcoming."
United States
Rosemary
The price is ฿5,948
฿6,555 total
includes taxes & fees
29 Nov - 30 Nov
Ayres Hotel San Diego South - Chula Vista
A modern hotel with a prominent 'Hercor Hotel' sign, multiple balconies, and a 'Urban Boutique' label.

7. Hercor Hotel - Urban Boutique

Hercor Hotel - Urban Boutique
3.0 star property
6.8 km from Otay Mesa West
8.8 out of 10, Excellent, (1,564 reviews)
"Great stay"
United States
fannie
The price is ฿3,754
฿4,137 total
includes taxes & fees
18 Nov - 19 Nov
Hercor Hotel - Urban Boutique
A retro-themed arcade with classic games, a foosball table, and a long communal table with stools.

8. The Rambler Hotel

The Rambler Hotel
3.0 star property
8 km from Otay Mesa West
9.0 out of 10, Wonderful, (2,204 reviews)
"Solid place to stay"
United States
Neal
The price is ฿4,013
฿4,643 total
includes taxes & fees
1 Nov - 2 Nov
The Rambler Hotel
A modern living room with a stone fireplace, sofas, a coffee table, and a view of the upper floor.

9. Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
10.4 km from Otay Mesa West
9.2 out of 10, Wonderful, (4,214 reviews)
"Great property, friendly staff and a restaurant with good food and live music next door. Had an excellent time!"
United States
Candas
The price is ฿4,522
฿4,983 total
includes taxes & fees
15 Nov - 16 Nov
Best Western Plus Marina Gateway Hotel
View from property

10. SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
12.4 km from Otay Mesa West
9.6 out of 10, Exceptional, (807 reviews)
"Great hotel and service"
United States
Joey
The price is ฿6,061
฿6,679 total
includes taxes & fees
15 Nov - 16 Nov
SpringHill Suites by Marriott Chula Vista Eastlake
A hotel room with a large bed, a desk with a chair, a nightstand, a mirror, and a blue-striped carpet.

11. Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel
2.5 star property
2.4 km from Otay Mesa West
8.0 out of 10, Very good, (2,019 reviews)
"Good hotel"
United States
Mario
The price is ฿3,697
฿4,074 total
includes taxes & fees
22 Nov - 23 Nov
Best Western Chula Vista/Otay Valley Hotel
An aerial view of a coastal resort with multiple buildings, marina, and a pier.

12. Loews Coronado Bay Resort

Loews Coronado Bay Resort
4.0 star property
9.6 km from Otay Mesa West
9.0 out of 10, Wonderful, (1,151 reviews)
"We really enjoyed our stay at Loews. The location was beautiful and the staff was super friendly and accommodating. Looking forward to visiting again!"
United States
Irene
The price is ฿6,564
฿8,929 total
includes taxes & fees
22 Nov - 23 Nov
Loews Coronado Bay Resort
A modern outdoor fire feature with a glass enclosure, surrounded by a white wall.

13. Holiday Inn Express & Suites San Diego - Mission Valley by IHG

Holiday Inn Express & Suites San Diego - Mission Valley by IHG
2.5 star property
22.9 km from Otay Mesa West
8.8 out of 10, Excellent, (1,010 reviews)
"Room was clean. Staff was friendly and helpful. Breakfast was basic but still really good."
United States
Lilli
The price is ฿4,215
฿4,950 total
includes taxes & fees
1 Nov - 2 Nov
Holiday Inn Express & Suites San Diego - Mission Valley by IHG
A hotel room with a bed, a desk with a chair, a nightstand, and a wall-mounted TV displaying a sunset scene.

14. Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista
2.0 star property
7.8 km from Otay Mesa West
7.4 out of 10, Good, (2,435 reviews)
"A modest and clean hotel, recommended, with reasonable prices."
United States
AHMAD
The price is ฿2,444
฿2,689 total
includes taxes & fees
1 Nov - 2 Nov
Hotel Palmeras Chula Vista
A swimming pool with palm trees and a mountain in the background.

15. Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
31.2 km from Otay Mesa West
9.4 out of 10, Exceptional, (2,204 reviews)
"Great stay!"
United States
Kimberly
The price is ฿3,067
฿3,778 total
includes taxes & fees
3 Nov - 4 Nov
Sycuan Casino Resort
An indoor swimming pool with lounge chairs and umbrellas, surrounded by palm trees and modern architecture.

16. Hilton San Diego Bayfront

Hilton San Diego Bayfront
4.0 star property
Marina District, 17 km from Otay Mesa West
8.8 out of 10, Excellent, (2,523 reviews)
"Great location!"
United States
Jason
The price is ฿5,704
฿8,263 total
includes taxes & fees
22 Nov - 23 Nov
Hilton San Diego Bayfront
A spacious lobby with a large seating area, a wooden ceiling, and large windows offering a view of the outdoor patio area.

17. Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station
2.5 star property
22.4 km from Otay Mesa West
9.2 out of 10, Wonderful, (1,731 reviews)
"Love to stay here, very nice accommodations, quiet, great service, the airport shuttle very convenient."
United States
MANUEL
The price is ฿4,949
฿5,689 total
includes taxes & fees
22 Nov - 23 Nov
Hampton Inn & Suites San Diego Airport Liberty Station
An outdoor seating area with wicker chairs and a fire feature.

18. Courtyard by Marriott San Diego Central

Courtyard by Marriott San Diego Central
3.0 star property
28.8 km from Otay Mesa West
8.8 out of 10, Excellent, (1,009 reviews)
"Great staff, clean rooms and excellent location"
United States
Ahmad
The price is ฿4,284
฿4,924 total
includes taxes & fees
22 Nov - 23 Nov
Courtyard by Marriott San Diego Central
A breakfast buffet area with a stone wall, a coffee station, and a fruit display.

19. Hampton Inn San Diego-Kearny Mesa

Hampton Inn San Diego-Kearny Mesa
2.5 star property
29.7 km from Otay Mesa West
9.2 out of 10, Wonderful, (1,009 reviews)
"Fantastic hotel with very friendly staff"
United States
Jeffrey
The price is ฿3,841
฿4,407 total
includes taxes & fees
8 Nov - 9 Nov
Hampton Inn San Diego-Kearny Mesa
An outdoor seating area with fire pits, lounge chairs, and a modern building in the background.

20. Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area

Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area
3.0 star property
23.5 km from Otay Mesa West
8.8 out of 10, Excellent, (1,748 reviews)
"Clean room, very friendly staff, great breakfast."
United States
Edith
The price is ฿5,704
฿6,556 total
includes taxes & fees
15 Nov - 16 Nov
Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Otay Mesa West

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A spacious lobby with a fireplace, wooden furniture, and a chandelier.
Best Western Americana Inn
2.5 star property
8.8
Excellent
1,421 reviews
View
An outdoor patio area with seating and a bar.
Ayres Hotel San Diego South - Chula Vista
3.0 star property
9.8
Exceptional
1,031 reviews
View
A Holiday Inn Express building with a prominent entrance, palm trees, and a clear sky.
Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
9.4
Exceptional
1,634 reviews
View
A neatly arranged hotel room with a large bed, a desk, a chair, and a bedside table.
Valli Hi Motel
2.0 star property
8.2
Very good
1,159 reviews
View
A hotel room with two beds, a television, a desk, and a dresser.
La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
8.8
Excellent
1,775 reviews
View

Hotels recommended for families in Otay Mesa West

A hotel room with a large bed, a desk with a chair, a nightstand, a mirror, and a blue-striped carpet.

Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel
2.5 star property
Otay
8.0 out of 10, Very good, (2,019)
The price is ฿3,697
฿4,074 total
includes taxes & fees
22 Nov - 23 Nov
Best Western Chula Vista/Otay Valley Hotel

Where to stay in Otay Mesa West

Find the best Otay Mesa West areas for the activities you enjoy most.
A large stadium with the sign "Cobo Park" and palm trees around it.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

A pier extending into the ocean with buildings at the end, under a partly cloudy sky.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

A theater marquee with ornate designs and the name "Gaslamp Quarter".

Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

A coastal cityscape with a long sandy beach, a pier, and dense urban buildings.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.

Top Otay Mesa West Hotel Reviews

Wyndham San Diego Bayside

Wyndham San Diego Bayside

10/10 Excellent
"Nice clean room, central located to walking activities. It's nice to have a view of the bay but not nice to look onto the dirty roof tops of the buildings in front of us. That I do not know if they can do anything about. On a nicer note we spoke with a lovely lady about different eating places we could walk to, she even gave up a coupon to eat at a few that were in front of the hotel, down the water front."
Pam 2-night trip
Posted 21 hours ago
Wyndham San Diego Bayside

Frequently asked questions

What is Otay Mesa West like?
Otay Mesa West is a neighbourhood that travellers like for its cathedral.
If I need to cancel my hotel reservation in Otay Mesa West, will I receive a refund?
Yes! The majority of room reservations are refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to review top deals in Otay Mesa West.
What is there to do around this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa West include San Ysidro Border Crossing, Las Americas Premium Outlets and Sesame Place San Diego. While you're out sightseeing in San Diego, make sure that you visit other sights such as Tijuana Customs - Garita El Chaparral or North Island Credit Union Amphitheatre.
How can I get around Otay Mesa West and the greater San Diego area?
Ready to get out and explore the city? Iris Avenue Trolley Station is the closest metro station.