A marina with boats docked, a city skyline with high-rise buildings, and a sunset with pink and orange clouds.

Search Hotels in Otay Mesa West, San Diego

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
30 Oct - 1 Nov
Next weekend
6 Nov - 8 Nov

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Otay Mesa West hotels

A modern kitchen area with a self-serve station, including a waffle maker, coffee machine, and various food items.

1. Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel
2.5 star property
2.4 km from Otay Mesa West
8.0 out of 10, Very good, (2,022 reviews)
"Good hotel"
United States
Mario
The price is ฿3,700
฿4,077 total
includes taxes & fees
8 Nov - 9 Nov
Best Western Chula Vista/Otay Valley Hotel
A neatly arranged hotel room with a large bed, a desk, a chair, and a bedside table.

2. Valli Hi Motel

Valli Hi Motel
2.0 star property
2.2 km from Otay Mesa West
8.2 out of 10, Very good, (1,163 reviews)
"Great stay and good room."
United States
Christian
The price is ฿2,733
฿3,114 total
includes taxes & fees
1 Nov - 2 Nov
Valli Hi Motel
A Holiday Inn Express building with a prominent entrance, palm trees, and a clear sky.

3. Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
8 km from Otay Mesa West
9.4 out of 10, Exceptional, (1,636 reviews)
"Great stay"
United States
Daniel
The price is ฿5,770
฿6,346 total
includes taxes & fees
18 Nov - 19 Nov
Holiday Inn Express San Diego South - Chula Vista by IHG
An outdoor patio area with seating and a bar.

4. Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
9.2 km from Otay Mesa West
9.8 out of 10, Exceptional, (1,033 reviews)
"I was very impressed with this hotel. The rooms were comfortable and modern and the staff was warm and welcoming."
United States
Rosemary
The price is ฿6,316
฿6,960 total
includes taxes & fees
29 Nov - 30 Nov
Ayres Hotel San Diego South - Chula Vista
A breakfast bar with La Quinta branding, a coffee machine, and a waffle display.

5. La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
7.8 km from Otay Mesa West
8.8 out of 10, Excellent, (1,780 reviews)
"Enjoyed our stay"
United States
Nuwan
The price is ฿3,585
฿3,943 total
includes taxes & fees
29 Nov - 30 Nov
La Quinta Inn by Wyndham San Diego Chula Vista
A hotel lobby with a patterned carpet, a reception desk, a sofa with cushions, and potted plants.

6. Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
7.9 km from Otay Mesa West
8.4 out of 10, Very good, (1,714 reviews)
"The breakfast and the staff were great!"
United States
Xochitl
The price is ฿3,509
฿3,867 total
includes taxes & fees
29 Nov - 30 Nov
Comfort Inn Chula Vista San Diego South
A modern hotel with a prominent 'Hercor Hotel' sign, multiple balconies, and a 'Urban Boutique' label.

7. Hercor Hotel - Urban Boutique

Hercor Hotel - Urban Boutique
3.0 star property
6.8 km from Otay Mesa West
8.8 out of 10, Excellent, (1,569 reviews)
"Great stay"
United States
fannie
The price is ฿3,756
฿4,139 total
includes taxes & fees
18 Nov - 19 Nov
Hercor Hotel - Urban Boutique
A retro-themed arcade with classic games, a foosball table, and a long communal table with stools.

8. The Rambler Hotel

The Rambler Hotel
3.0 star property
8 km from Otay Mesa West
9.0 out of 10, Wonderful, (2,204 reviews)
"Solid place to stay"
United States
Neal
The price is ฿4,013
฿4,643 total
includes taxes & fees
9 Nov - 10 Nov
The Rambler Hotel
Bar (on property)

9. Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
10.4 km from Otay Mesa West
9.2 out of 10, Wonderful, (4,217 reviews)
"Great property, friendly staff and a restaurant with good food and live music next door. Had an excellent time!"
United States
Candas
The price is ฿4,522
฿4,983 total
includes taxes & fees
8 Nov - 9 Nov
Best Western Plus Marina Gateway Hotel
View from property

10. SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
12.4 km from Otay Mesa West
9.6 out of 10, Exceptional, (807 reviews)
"Great hotel and service"
United States
Joey
The price is ฿6,064
฿6,683 total
includes taxes & fees
8 Nov - 9 Nov
SpringHill Suites by Marriott Chula Vista Eastlake
A spacious lobby with a fireplace, wooden furniture, and a chandelier.

11. Best Western Americana Inn

Best Western Americana Inn
2.5 star property
2.1 km from Otay Mesa West
8.8 out of 10, Excellent, (1,411 reviews)
"The staff was wonderful and the room was clean! Breakfast had great options and all good. Recommend for a great affordable stay!"
United States
Rene
The price is ฿3,533
฿4,019 total
includes taxes & fees
8 Nov - 9 Nov
Best Western Americana Inn
A hotel room with a bed, a desk with a chair, a nightstand, and a wall-mounted TV displaying a sunset scene.

12. Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista
2.0 star property
7.8 km from Otay Mesa West
7.4 out of 10, Good, (2,430 reviews)
"A modest and clean hotel, recommended, with reasonable prices."
United States
AHMAD
The price is ฿2,444
฿2,689 total
includes taxes & fees
12 Nov - 13 Nov
Hotel Palmeras Chula Vista
A modern interior with a long table and blue chairs, large windows with a view of palm trees and parked vehicles outside.

13. Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
11 km from Otay Mesa West
8.4 out of 10, Very good, (1,940 reviews)
"Staff was amazing and beds were sooo comfy"
United States
Helen
The price is ฿4,487
฿5,104 total
includes taxes & fees
29 Nov - 30 Nov
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
An aerial view of a coastal resort with multiple buildings, marina, and a pier.

14. Loews Coronado Bay Resort

Loews Coronado Bay Resort
4.0 star property
9.6 km from Otay Mesa West
9.0 out of 10, Wonderful, (1,153 reviews)
"We really enjoyed our stay at Loews. The location was beautiful and the staff was super friendly and accommodating. Looking forward to visiting again!"
United States
Irene
The price is ฿6,567
฿8,935 total
includes taxes & fees
22 Nov - 23 Nov
Loews Coronado Bay Resort
A swimming pool with palm trees and a mountain in the background.

15. Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
31.2 km from Otay Mesa West
9.4 out of 10, Exceptional, (2,207 reviews)
"Great stay!"
United States
Kimberly
The price is ฿3,069
฿3,781 total
includes taxes & fees
2 Nov - 3 Nov
Sycuan Casino Resort
An indoor swimming pool with lounge chairs and umbrellas, surrounded by palm trees and modern architecture.

16. Hilton San Diego Bayfront

Hilton San Diego Bayfront
4.0 star property
Marina District, 17 km from Otay Mesa West
8.8 out of 10, Excellent, (2,526 reviews)
"Great location!"
United States
Jason
The price is ฿5,707
฿8,268 total
includes taxes & fees
22 Nov - 23 Nov
Hilton San Diego Bayfront
A breakfast buffet area with a stone wall, a coffee station, and a fruit display.

17. Hampton Inn San Diego-Kearny Mesa

Hampton Inn San Diego-Kearny Mesa
2.5 star property
29.7 km from Otay Mesa West
9.2 out of 10, Wonderful, (1,001 reviews)
"Fantastic hotel with very friendly staff"
United States
Jeffrey
The price is ฿3,843
฿4,410 total
includes taxes & fees
22 Nov - 23 Nov
Hampton Inn San Diego-Kearny Mesa
A spacious lobby with a large seating area, a wooden ceiling, and large windows offering a view of the outdoor patio area.

18. Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station
2.5 star property
22.4 km from Otay Mesa West
9.2 out of 10, Wonderful, (1,732 reviews)
"Love to stay here, very nice accommodations, quiet, great service, the airport shuttle very convenient."
United States
MANUEL
The price is ฿4,952
฿5,693 total
includes taxes & fees
22 Nov - 23 Nov
Hampton Inn & Suites San Diego Airport Liberty Station
A modern bar area with wooden ceiling beams, bar stools, and a long counter.

19. Courtyard by Marriott San Diego Central

Courtyard by Marriott San Diego Central
3.0 star property
28.8 km from Otay Mesa West
8.8 out of 10, Excellent, (1,000 reviews)
"Great staff, clean rooms and excellent location"
United States
Ahmad
The price is ฿4,287
฿4,927 total
includes taxes & fees
22 Nov - 23 Nov
Courtyard by Marriott San Diego Central
A hotel courtyard with outdoor seating, palm trees, and a view of the ocean at dusk.

20. Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
19.2 km from Otay Mesa West
8.4 out of 10, Very good, (6,353 reviews)
"Close to sites and staff was very kind and helpful"
United States
Sarah
The price is ฿4,732
฿6,661 total
includes taxes & fees
22 Nov - 23 Nov
Wyndham San Diego Bayside
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Otay Mesa West

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A spacious lobby with a fireplace, wooden furniture, and a chandelier.
Best Western Americana Inn
2.5 star property
8.8
Excellent
1,411 reviews
View
A neatly arranged hotel room with a large bed, a desk, a chair, and a bedside table.
Valli Hi Motel
2.0 star property
8.2
Very good
1,163 reviews
View
A Holiday Inn Express building with a prominent entrance, palm trees, and a clear sky.
Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
9.4
Exceptional
1,636 reviews
View
A breakfast bar with La Quinta branding, a coffee machine, and a waffle display.
La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
8.8
Excellent
1,780 reviews
View
An outdoor patio area with seating and a bar.
Ayres Hotel San Diego South - Chula Vista
3.0 star property
9.8
Exceptional
1,033 reviews
View

Hotels recommended for families in Otay Mesa West

A modern kitchen area with a self-serve station, including a waffle maker, coffee machine, and various food items.

Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel
2.5 star property
Otay
8.0 out of 10, Very good, (2,022)
The price is ฿3,700
฿4,077 total
includes taxes & fees
8 Nov - 9 Nov
Best Western Chula Vista/Otay Valley Hotel

Where to stay in Otay Mesa West

Find the best Otay Mesa West areas for the activities you enjoy most.
A large stadium with the sign "Cobo Park" and palm trees around it.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

A pier extending into the ocean with buildings at the end, under a partly cloudy sky.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

A theater marquee with ornate designs and the name "Gaslamp Quarter".

Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

A coastal cityscape with a long sandy beach, a pier, and dense urban buildings.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.

Top Otay Mesa West Hotel Reviews

Best Western Seven Seas

Best Western Seven Seas

8/10 Good
"It was a pubic hair in the bathtub"
Connie 1-night trip
Posted less than an hour ago
Best Western Seven Seas

Frequently asked questions

What is Otay Mesa West like?
Otay Mesa West is a neighbourhood that travellers like for its cathedral.
If I need to cancel my hotel reservation in Otay Mesa West, will I receive a refund?
Yes! The majority of room reservations are refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to review top deals in Otay Mesa West.
What is there to do around this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa West include San Ysidro Border Crossing, Las Americas Premium Outlets and Sesame Place San Diego. While you're out sightseeing in San Diego, make sure that you visit other sights such as Tijuana Customs - Garita El Chaparral or North Island Credit Union Amphitheatre.
How can I get around Otay Mesa West and the greater San Diego area?
Ready to get out and explore the city? Iris Avenue Trolley Station is the closest metro station.