
Find hotels in O Brien, FL from ฿2,138
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Go beyond your typical stay in O Brien
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Check prices for these dates
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29 Aug - 30 AugTomorrow
30 Aug - 31 AugNext weekend
4 Sep - 6 SepIn two weeks
11 Sep - 13 SepOur top choices for O Brien hotels




1. Hampton Inn & Suites Lake City
Hampton Inn & Suites Lake CityLake City
tracy
฿3,748
฿4,216 total
includes taxes & fees
31 Aug - 1 Sept




2. Best Western Plus Lake City
Best Western Plus Lake CityLake City
William
฿2,663
฿2,996 total
includes taxes & fees
6 Sept - 7 Sept




3. Tru by Hilton Lake City
Tru by Hilton Lake CityLake City
Kelly
฿3,583
฿4,031 total
includes taxes & fees
6 Sept - 7 Sept




4. Comfort Suites Lake City
Comfort Suites Lake CityLake City
KHAJA
฿3,067
฿3,451 total
includes taxes & fees
13 Sept - 14 Sept




5. Home2 Suites by Hilton Lake City
Home2 Suites by Hilton Lake CityLake City
William
฿4,022
฿4,525 total
includes taxes & fees
6 Sept - 7 Sept




6. Fairfield Inn & Suites Lake City
Fairfield Inn & Suites Lake CityLake City
Thomas
฿3,373
฿3,794 total
includes taxes & fees
7 Sept - 8 Sept




7. La Quinta Inn & Suite by Wyndham Lake City
La Quinta Inn & Suite by Wyndham Lake CityLake City
Nadia
฿2,980
฿3,352 total
includes taxes & fees
30 Aug - 31 Aug




8. Super 8 by Wyndham Lake City
Super 8 by Wyndham Lake CityLake City
Mari
฿2,152
฿2,420 total
includes taxes & fees
24 Sept - 25 Sept




9. Holiday Inn Express & Suites Live Oak by IHG
Holiday Inn Express & Suites Live Oak by IHGLive Oak
Trisha
฿3,377
฿3,715 total
includes taxes & fees
27 Sept - 28 Sept




10. Americas Best Value Inn Lake City
Americas Best Value Inn Lake CityLake City
Larissa
฿2,219
฿2,496 total
includes taxes & fees
31 Aug - 1 Sept




11. Days Inn by Wyndham Lake City I-75
Days Inn by Wyndham Lake City I-75Lake City
Brizheet
฿2,078
฿2,337 total
includes taxes & fees
1 Sept - 2 Sept




12. Quality Inn Lake City
Quality Inn Lake CityLake City
Lucille
฿2,420
฿2,723 total
includes taxes & fees
28 Sept - 29 Sept




13. Econo Lodge Live Oak
Econo Lodge Live OakLive Oak
James
฿2,405
฿2,645 total
includes taxes & fees
31 Aug - 1 Sept




14. Holiday Inn & Suites Lake City by IHG
Holiday Inn & Suites Lake City by IHGLake City
Renee
฿3,278
฿3,688 total
includes taxes & fees
28 Sept - 29 Sept




15. Motel 6 – Lake City, Fl – Medical Center
Motel 6 – Lake City, Fl – Medical CenterLake City
Pennee
฿2,152
฿2,421 total
includes taxes & fees
30 Aug - 31 Aug




16. Regal Inn
Regal InnLake City
Samuel
฿2,039
฿2,294 total
includes taxes & fees
1 Sept - 2 Sept




17. Baymont by Wyndham Lake City I-75
Baymont by Wyndham Lake City I-75Lake City
Steve
฿1,900
฿2,138 total
includes taxes & fees
1 Sept - 2 Sept




18. Driftwood Inn
Driftwood InnLake City
Jamie
฿1,756
฿1,976 total
includes taxes & fees
30 Aug - 31 Aug




19. Suwannee River Retreat: Pet Friendly, Private Dock
Suwannee River Retreat: Pet Friendly, Private DockBranford
฿10,662
฿20,076 total
includes taxes & fees
31 Aug - 1 Sept




20. The Blanche
The BlancheLake City
Brandi
฿4,882
฿5,492 total
includes taxes & fees
31 Aug - 1 Sept
Learn more about O Brien
Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.
See all hotels in O Brien
Top O Brien Hotel Reviews
Fairfield Inn & Suites Lake City
10/10 Excellent
"It was a nice hotel that was close to food and the highway"
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
10/10 Excellent
"It was amazing, I loved this trip"
Days Inn by Wyndham Lake City I-10
10/10 Excellent
"Efficiet and cooperative staff. Clean room. Easy parking. Pleasant hotel."
Hampton Inn & Suites Alachua I-75
10/10 Excellent
"N/A"
Quality Inn Lake City
10/10 Excellent
"Very clean and quiet hotel. I will visit again when I am in the area."
Baymont by Wyndham Lake City I-75
10/10 Excellent
"Nice place"
More cheap stays in O Brien

Days Inn by Wyndham Lake City I-10
3430 N Us Highway 441 Lake City FL
฿1,946
฿2,189 total
1 Sept - 2 Sept
includes taxes & fees
7/10 Good! (1,000 reviews)

Quality Inn Lake City
285 Sw Commerce Dr Lake City FL
฿2,420
฿2,723 total
28 Sept - 29 Sept
includes taxes & fees

Best Western Plus Lake City
350 SW Florida Gateway Dr Lake City FL
฿2,663
฿2,996 total
6 Sept - 7 Sept
includes taxes & fees

Comfort Suites Lake City
3690 W Us Highway 90 Lake City FL
฿3,067
฿3,451 total
13 Sept - 14 Sept
includes taxes & fees

Hampton Inn & Suites Alachua I-75
15930 Northwest 163rd Lane Alachua FL
฿3,477
฿3,912 total
10 Sept - 11 Sept
includes taxes & fees
9.4/10 Exceptional! (552 reviews)

Tru by Hilton Lake City
284 NW Centurion Court Lake City FL
฿3,583
฿4,031 total
6 Sept - 7 Sept
includes taxes & fees
