Find hotels in O Brien, FL from ฿872
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Go beyond your typical stay in O Brien
Pet friendly
Check prices for these dates
Top 10 O Brien hotels and places to stay

High Springs Country Inn
High Springs Country Inn
8.0 out of 10, Very good, (6)
The price is ฿2,346
฿2,639 total
includes taxes & fees
28 Sept - 29 Sept

Postcard Cabins Gilchrist Springs
Postcard Cabins Gilchrist Springs
10.0 out of 10, Exceptional, (92)
The price is ฿3,196
฿4,758 total
includes taxes & fees
1 Sept - 2 Sept

Palms Garden Inn
Palms Garden Inn
7.4 out of 10, Good, (554)
The price is ฿2,097
฿2,359 total
includes taxes & fees
31 Aug - 1 Sept

Suwannee River Rendezvous
Suwannee River Rendezvous
8.4 out of 10, Very good, (17)
The price is ฿872
฿1,396 total
includes taxes & fees
2 Sept - 3 Sept

Hampton Inn & Suites Lake City
Hampton Inn & Suites Lake City
9.4 out of 10, Exceptional, (1006)
The price is ฿3,519
฿3,958 total
includes taxes & fees
7 Sept - 8 Sept

Vista Verde Farm Retreat
Vista Verde Farm Retreat
9.8 out of 10, Exceptional, (7)
The price is ฿3,486
฿6,123 total
includes taxes & fees
1 Sept - 2 Sept
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Learn more about O Brien
Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

Photo by Dr__Vlad
Open Photo by Dr__Vlad
Top O Brien Hotel Reviews
More cheap stays in O Brien
More cheap stays in O Brien

Tru by Hilton Lake City
284 NW Centurion Court, Lake City, FL
The price is ฿3,196 per night from 31 Aug to 1 Sept
฿3,196
฿3,595 total
31 Aug - 1 Sept
includes taxes & fees
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels Near O Brien, Florida
- Lake City Hotels
- Florida Panhandle Hotels
- High Springs Hotels
- Gulf Coast Hotels
- Alachua Hotels
- Perry Hotels
- Live Oak Hotels
- White Springs Hotels
- Newberry Hotels
- Fort White Hotels
- Central West Coast Florida Hotels
- Madison Hotels
- Old Town Hotels
- Southeastern United States Hotels
- Branford Hotels
- Jasper Hotels
- Mayo Hotels
- Northern Florida Hotels
- Lake Butler Hotels
- Trenton Hotels
Explore more hotels
More ways to book
Expedia's Latest Trends
Hotels
General
- Visit Freer
- Visit Forks
- Visit Panama City Beach
- Visit St. Augustine
- Visit Avalon
- Visit Destin
- Visit Montauk
- Visit Azusa
- Visit Stamford
- Visit South Lake Tahoe
- Visit Honolulu
- Visit West Palm Beach
- Visit Sequoia National Park
- Visit San Diego
- Visit Sandusky
- Visit West Point
- Visit Rainbow City
- Visit Mountain View
- Visit Palm Springs
- Visit Clearwater Beach
- Visit San Rafael
- Visit Cupertino
- Visit Miami Beach