Find hotels in O Brien, FL from ฿2,153
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29 Aug - 30 AugTomorrow
30 Aug - 31 AugNext weekend
4 Sep - 6 SepIn two weeks
11 Sep - 13 SepOur top choices for O Brien hotels
1. Hampton Inn & Suites Lake City
Hampton Inn & Suites Lake CityLake City
tracy
฿3,775
฿4,246 total
includes taxes & fees
30 Aug - 31 Aug
2. Best Western Plus Lake City
Best Western Plus Lake CityLake City
William
฿2,682
฿3,017 total
includes taxes & fees
31 Aug - 1 Sept
3. Tru by Hilton Lake City
Tru by Hilton Lake CityLake City
Kelly
฿3,609
฿4,060 total
includes taxes & fees
30 Aug - 31 Aug
4. Comfort Suites Lake City
Comfort Suites Lake CityLake City
KHAJA
฿3,067
฿3,451 total
includes taxes & fees
13 Sept - 14 Sept
5. Home2 Suites by Hilton Lake City
Home2 Suites by Hilton Lake CityLake City
William
฿4,051
฿4,558 total
includes taxes & fees
13 Sept - 14 Sept
6. Fairfield Inn & Suites Lake City
Fairfield Inn & Suites Lake CityLake City
Thomas
฿3,397
฿3,822 total
includes taxes & fees
6 Sept - 7 Sept
7. La Quinta Inn & Suite by Wyndham Lake City
La Quinta Inn & Suite by Wyndham Lake CityLake City
Nadia
฿2,980
฿3,352 total
includes taxes & fees
30 Aug - 31 Aug
8. Super 8 by Wyndham Lake City
Super 8 by Wyndham Lake CityLake City
฿2,167
฿2,438 total
includes taxes & fees
30 Aug - 31 Aug
9. Holiday Inn Express & Suites Live Oak by IHG
Holiday Inn Express & Suites Live Oak by IHGLive Oak
Trisha
฿3,377
฿3,715 total
includes taxes & fees
27 Sept - 28 Sept
10. Americas Best Value Inn Lake City
Americas Best Value Inn Lake CityLake City
Larissa
฿2,235
฿2,514 total
includes taxes & fees
30 Aug - 31 Aug
11. Days Inn by Wyndham Lake City I-75
Days Inn by Wyndham Lake City I-75Lake City
Brizheet
฿2,093
฿2,354 total
includes taxes & fees
30 Aug - 31 Aug
12. Quality Inn Lake City
Quality Inn Lake CityLake City
Lucille
฿2,420
฿2,723 total
includes taxes & fees
28 Sept - 29 Sept
13. Econo Lodge Live Oak
Econo Lodge Live OakLive Oak
James
฿2,550
฿2,805 total
includes taxes & fees
30 Aug - 31 Aug
14. Holiday Inn & Suites Lake City by IHG
Holiday Inn & Suites Lake City by IHGLake City
Renee
฿3,278
฿3,688 total
includes taxes & fees
28 Sept - 29 Sept
15. Motel 6 – Lake City, Fl – Medical Center
Motel 6 – Lake City, Fl – Medical CenterLake City
Pennee
฿2,152
฿2,421 total
includes taxes & fees
30 Aug - 31 Aug
16. Regal Inn
Regal InnLake City
Samuel
฿2,054
฿2,311 total
includes taxes & fees
31 Aug - 1 Sept
17. Baymont by Wyndham Lake City I-75
Baymont by Wyndham Lake City I-75Lake City
Steve
฿1,914
฿2,153 total
includes taxes & fees
30 Aug - 31 Aug
18. Driftwood Inn
Driftwood InnLake City
Jamie
฿1,756
฿1,976 total
includes taxes & fees
30 Aug - 31 Aug
19. Suwannee River Retreat: Pet Friendly, Private Dock
Suwannee River Retreat: Pet Friendly, Private DockBranford
฿10,662
฿20,076 total
includes taxes & fees
31 Aug - 1 Sept
20. The Blanche
The BlancheLake City
Brandi
฿4,917
฿5,532 total
includes taxes & fees
31 Aug - 1 Sept
Learn more about O Brien
Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.
See all hotels in O Brien
Top O Brien Hotel Reviews
Hampton Inn & Suites Alachua I-75
10/10 Excellent
"Pasamos una estancia maravillosa lo recomendamos 100%"
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
10/10 Excellent
"Only complaint was the coffee pot was not clean"
Fairfield Inn & Suites Lake City
10/10 Excellent
"It was a nice hotel that was close to food and the highway"
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
10/10 Excellent
"It was amazing, I loved this trip"
Days Inn by Wyndham Lake City I-10
10/10 Excellent
"Efficiet and cooperative staff. Clean room. Easy parking. Pleasant hotel."
Baymont by Wyndham Lake City I-75
10/10 Excellent
"Nice place"
More cheap stays in O Brien
Days Inn by Wyndham Lake City I-10
3430 N Us Highway 441 Lake City FL
฿1,960
฿2,205 total
30 Aug - 31 Aug
includes taxes & fees
7/10 Good! (1,000 reviews)
Quality Inn Lake City
285 Sw Commerce Dr Lake City FL
฿2,420
฿2,723 total
28 Sept - 29 Sept
includes taxes & fees
Best Western Plus Lake City
350 SW Florida Gateway Dr Lake City FL
฿2,682
฿3,017 total
31 Aug - 1 Sept
includes taxes & fees
Comfort Suites Lake City
3690 W Us Highway 90 Lake City FL
฿3,067
฿3,451 total
13 Sept - 14 Sept
includes taxes & fees
Hampton Inn & Suites Alachua I-75
15930 Northwest 163rd Lane Alachua FL
฿3,502
฿3,940 total
6 Sept - 7 Sept
includes taxes & fees
9.4/10 Exceptional! (553 reviews)
Tru by Hilton Lake City
284 NW Centurion Court Lake City FL
฿3,609
฿4,060 total
30 Aug - 31 Aug
includes taxes & fees
