A calm river with clear water, surrounded by dense trees and rocky banks.

Find hotels in O Brien, FL from ฿2,138

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29 Aug - 30 Aug
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30 Aug - 31 Aug
Next weekend
4 Sep - 6 Sep
In two weeks
11 Sep - 13 Sep

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Our top choices for O Brien hotels

A hotel pool area with lounge chairs and umbrellas, a pool with metal railings, and a building with multiple floors and large windows.
An outdoor patio area with tables and chairs, surrounded by a metal fence, and umbrellas providing shade.
A Hampton Inn & Suites hotel with a modern design, featuring a prominent red sign, a covered entrance, and a parking area.
A hotel with a blue and white facade, a covered entrance, and a parking lot.

1. Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
Lake City
United States
tracy
฿3,748
฿4,216 total
includes taxes & fees
31 Aug - 1 Sept
Hampton Inn & Suites Lake City
A spacious living area with a grey sofa, a coffee table, and a TV stand.
A hotel entrance with a covered walkway, palm trees, and a clear sky.
A modern kitchen with light wood cabinets, granite countertops, and stainless steel appliances. There are signs on the wall advertising different coffee brands.
A hotel room with a sofa, a small table, a lamp, and artwork on the wall.

2. Best Western Plus Lake City

Best Western Plus Lake City
Lake City
United States
William
฿2,663
฿2,996 total
includes taxes & fees
6 Sept - 7 Sept
Best Western Plus Lake City
A self-service beverage station with a variety of drinks, snacks, and a refrigerated section.
A modern hotel lobby with a central counter displaying snacks and beverages, two digital screens above the counter, and a seating area with a view of the lobby.
A modern interior with two red chairs and a small table, large windows, and hanging pendant lights.
A modern hotel with a flat roof, multiple windows, and a covered entrance.

3. Tru by Hilton Lake City

Tru by Hilton Lake City
Lake City
United States
Kelly
฿3,583
฿4,031 total
includes taxes & fees
6 Sept - 7 Sept
Tru by Hilton Lake City
A hotel room with a gray sofa, a bed with white linens, a desk with a chair, and a window with blinds.
A modern living room with a sectional sofa, a round coffee table, a hanging chair, and a flat-screen TV on a glass stand.
A modern hotel lobby with a fireplace, seating areas, and a bar.

4. Comfort Suites Lake City

Comfort Suites Lake City
Lake City
United States
KHAJA
฿3,067
฿3,451 total
includes taxes & fees
13 Sept - 14 Sept
Comfort Suites Lake City
An outdoor patio with a stone fire pit, grey cushioned seating, and wicker ottomans.
A modern hotel room with a bed, a desk with a computer, a TV, and a lamp.
A modern hotel lobby with a reception desk, seating areas, and a large screen.
A modern hotel with a two-story structure, a covered outdoor seating area, and a parking lot with marked spaces.

5. Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City
Lake City
United States
William
฿4,022
฿4,525 total
includes taxes & fees
6 Sept - 7 Sept
Home2 Suites by Hilton Lake City
An indoor swimming pool with clear water, surrounded by glass doors and windows, and a wooden deck area.
An outdoor patio area with a sectional sofa, chairs, a coffee table, and a fire pit.
A modern lounge area with a fireplace, comfortable seating, a dining table, and a large window offering a view.
A modern dining area with multiple tables and chairs, a kitchen in the background, and a 'Hello Fall' sign on the wall.

6. Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
Lake City
United States
Thomas
฿3,373
฿3,794 total
includes taxes & fees
7 Sept - 8 Sept
Fairfield Inn & Suites Lake City
A La Quinta hotel with a modern facade, multiple windows, and a well-lit entrance.
A hotel room with a large bed, a sofa, a desk, and a wall with a geometric pattern.
A modern kitchen area with a coffee station, including a coffee machine, cups, and a toaster.
A modern lobby with a large map mural, a wooden column, and a seating area with a yellow cushion.

7. La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
Lake City
United States
Nadia
฿2,980
฿3,352 total
includes taxes & fees
30 Aug - 31 Aug
La Quinta Inn & Suite by Wyndham Lake City
A hotel room with a large bed, a desk with a computer, a television, and a window with curtains.
A swimming pool with lounge chairs and umbrellas, surrounded by a brick building with balconies and palm trees.
A restaurant with a yellow accent wall, white tiled floor, and black and blue chairs.
An aerial view of a hotel with a swimming pool, parking lot, and surrounding greenery.

8. Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
Lake City
United States
Mari
฿2,152
฿2,420 total
includes taxes & fees
24 Sept - 25 Sept
Super 8 by Wyndham Lake City
A hotel with a covered entrance, a sign indicating it is a Holiday Inn Express, and a well-maintained lawn area.
A reception area with a counter, seating, and a fireplace.
A hotel room with a bed, a desk with a lamp, a television, and a microwave.
A hotel with a swimming pool, multiple windows, and a sign indicating no diving.

9. Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG
Live Oak
United States
Trisha
฿3,377
฿3,715 total
includes taxes & fees
27 Sept - 28 Sept
Holiday Inn Express & Suites Live Oak by IHG
A picnic table with a potted plant, located in a grassy area with a tree and a road in the background.
A hotel lobby with a reception desk, a clock, a plant, a water dispenser, and a coffee station.
A hotel lobby with a view of the street, a reception desk, and a large map on the wall.
A hotel room with two beds, a nightstand with a phone and remote, and a patterned curtain.

10. Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
Lake City
United States
Larissa
฿2,219
฿2,496 total
includes taxes & fees
31 Aug - 1 Sept
Americas Best Value Inn Lake City
A hotel room with two beds, a TV, a desk, and a painting of a sunset.
A swimming pool with lounge chairs, a small pool house, and a yellow multi-story building with balconies.
A kitchen with a black refrigerator and a microwave on a wooden shelf.
A reception area with a wooden counter, a clock, and a computer on a desk.

11. Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
Lake City
United States
Brizheet
฿2,078
฿2,337 total
includes taxes & fees
1 Sept - 2 Sept
Days Inn by Wyndham Lake City I-75
A spacious lobby with a high ceiling, a large window, a dining area with green chairs, and a black door leading outside.
A hotel dining area with tables and chairs, a reception desk, and a kitchen in the background.
A white building with multiple windows and a sign that reads 'Quality Inn.'
A hotel room with two beds, a desk, a chair, a painting on the wall, and a patterned carpet.

12. Quality Inn Lake City

Quality Inn Lake City
Lake City
United States
Lucille
฿2,420
฿2,723 total
includes taxes & fees
28 Sept - 29 Sept
Quality Inn Lake City
A hotel reception area with a reception desk, seating area, and a view of the parking lot.
A hotel room with two beds, a bedside table with a lamp, a phone, and a window with curtains.
A reception area with a wooden floor, a reception desk, a seating area with chairs, and a view through the glass doors to the outside.
A dining area with wooden chairs and tables, a coffee machine, and a counter with various items.

13. Econo Lodge Live Oak

Econo Lodge Live Oak
Live Oak
United States
James
฿2,405
฿2,645 total
includes taxes & fees
31 Aug - 1 Sept
Econo Lodge Live Oak
A multi-story hotel with a prominent entrance, palm trees, and a green-lit sign indicating the name.
An indoor swimming pool with clear lane markings, a lifeguard chair, and a changing room area.
A spacious lobby with multiple seating areas, a bar, and a large window with a view.
A fitness center with treadmills, elliptical machines, and a weight machine.

14. Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG
Lake City
United States
Renee
฿3,278
฿3,688 total
includes taxes & fees
28 Sept - 29 Sept
Holiday Inn & Suites Lake City by IHG

15. Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center
Lake City
United States
Pennee
฿2,152
฿2,421 total
includes taxes & fees
30 Aug - 31 Aug
Motel 6 – Lake City, Fl – Medical Center
A reception area with a stone wall, a blue accent wall, a clock, and a window with a view of the parking lot.
Two doors, one blue and one green, with numbers 105 and 103 respectively, against a brick wall.
A bathroom with a bathtub, a shower, and a toilet.
A modern bedroom with a wooden headboard, two bedside lamps, a patterned bedspread, and a blue door.

16. Regal Inn

Regal Inn
Lake City
United States
Samuel
฿2,039
฿2,294 total
includes taxes & fees
1 Sept - 2 Sept
Regal Inn
A reception area with a Baymont Inn & Suites sign, a reception desk, a glass-top table, and a door.
A breakfast bar with a coffee machine, a microwave, and a sign reading "Breakfast Corner." There are several wooden tables and chairs arranged around the bar.
A gazebo with a red roof and green walls, surrounded by trees and a pool.
A pool area with a fenced deck, palm trees, and a small building with a red roof.

17. Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75
Lake City
United States
Steve
฿1,900
฿2,138 total
includes taxes & fees
1 Sept - 2 Sept
Baymont by Wyndham Lake City I-75
A kitchen counter with a coffee maker, a 'Welcome' sign, and a vase of flowers.
A modern kitchen with a granite countertop, a built-in stove, and a large window with six panels.
A covered parking area with a Walmart store in the background.
A motel named Driftwood Inn with a clear blue sky, palm trees, and a parking lot.

18. Driftwood Inn

Driftwood Inn
Lake City
United States
Jamie
฿1,756
฿1,976 total
includes taxes & fees
30 Aug - 31 Aug
Driftwood Inn
A two-story building with a covered porch and a staircase leading to the upper level.

19. Suwannee River Retreat: Pet Friendly, Private Dock

Suwannee River Retreat: Pet Friendly, Private Dock
Branford
฿10,662
฿20,076 total
includes taxes & fees
31 Aug - 1 Sept
Suwannee River Retreat: Pet Friendly, Private Dock
A spacious living area with a large chandelier, a sofa set, a coffee table, and a patterned floor.
A spacious hotel lobby with high ceilings, chandeliers, and a central round table.
A spacious lobby with a large chandelier, two sofas, a glass coffee table, and a patterned carpet.
A storefront with a glass door and a brick wall. The sign above the door reads "The Blanche."

20. The Blanche

The Blanche
Lake City
United States
Brandi
฿4,882
฿5,492 total
includes taxes & fees
31 Aug - 1 Sept
The Blanche
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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
A calm river surrounded by trees reflecting in the water.

Top O Brien Hotel Reviews

Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City

10/10 Excellent
"It was a nice hotel that was close to food and the highway"
Kyle 1-night trip
Posted 23 hours ago
Fairfield Inn & Suites Lake City
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

10/10 Excellent
"It was amazing, I loved this trip"
Keren 2-night trip
Posted 2 days ago
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
Days Inn by Wyndham Lake City I-10

Days Inn by Wyndham Lake City I-10

10/10 Excellent
"Efficiet and cooperative staff. Clean room. Easy parking. Pleasant hotel."
Uri 1-night trip
Posted 3 days ago
Days Inn by Wyndham Lake City I-10
Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75

10/10 Excellent
"N/A"
Wren 3-night trip
Posted 5 days ago
Hampton Inn & Suites Alachua I-75
Quality Inn Lake City

Quality Inn Lake City

10/10 Excellent
"Very clean and quiet hotel. I will visit again when I am in the area."
Kia 1-night trip
Posted 5 days ago
Quality Inn Lake City
Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75

10/10 Excellent
"Nice place"
Steve 1-night trip
Posted 10 days ago
Baymont by Wyndham Lake City I-75

More cheap stays in O Brien

Days Inn by Wyndham Lake City I-10

Days Inn by Wyndham Lake City I-10

3430 N Us Highway 441 Lake City FL
฿1,946
฿2,189 total
1 Sept - 2 Sept
includes taxes & fees
7/10 Good! (1,000 reviews)
Days Inn by Wyndham Lake City I-10
Quality Inn Lake City

Quality Inn Lake City

285 Sw Commerce Dr Lake City FL
฿2,420
฿2,723 total
28 Sept - 29 Sept
includes taxes & fees
Quality Inn Lake City
Best Western Plus Lake City

Best Western Plus Lake City

350 SW Florida Gateway Dr Lake City FL
฿2,663
฿2,996 total
6 Sept - 7 Sept
includes taxes & fees
Best Western Plus Lake City
Comfort Suites Lake City

Comfort Suites Lake City

3690 W Us Highway 90 Lake City FL
฿3,067
฿3,451 total
13 Sept - 14 Sept
includes taxes & fees
Comfort Suites Lake City
Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75

15930 Northwest 163rd Lane Alachua FL
฿3,477
฿3,912 total
10 Sept - 11 Sept
includes taxes & fees
9.4/10 Exceptional! (552 reviews)
Hampton Inn & Suites Alachua I-75
Tru by Hilton Lake City

Tru by Hilton Lake City

284 NW Centurion Court Lake City FL
฿3,583
฿4,031 total
6 Sept - 7 Sept
includes taxes & fees
Tru by Hilton Lake City

Frequently asked questions

Where is the best place to stay in O Brien?
Best Western Plus Lake City, located 17.9 mi (28.8 km) from the heart of O Brien, is a top choice for your stay, based on our traveller data. Two other options for your trip to the area are Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and La Quinta Inn & Suite by Wyndham Lake City. See all available top hotels, or vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel bookings are refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
What are some accommodation options with pools in O Brien?
Best Western Plus Lake City: Provides a snack bar/deli, an indoor pool and buffet. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and La Quinta Inn & Suite by Wyndham Lake City are two additional hotels that feature an on-site pool. View all hotels with pools in O Brien.
How is it to stay in O Brien?
Visitors to O Brien will definitely find plenty to explore and enjoy. In O Brien, there are 9 hotels and other accommodation options to choose from. Find out more about O Brien.
What are the top places to visit in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River and Ichetucknee Springs State Park. You'll also find Troy Spring State Park and Lake City Mall in the area. Take a look at what more there is to see and do in Expedia's O Brien guide.
What's the seasonal weather in O Brien?
The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 14°C. Average annual precipitation for O Brien is 1278 mm.

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