An aerial view of a coastal area with a bridge connecting two land masses, a beach, and a clear blue sky.

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Check prices for these dates

Next weekend
23 Oct - 25 Oct
In two weeks
30 Oct - 1 Nov

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Our top choices for Murex Lakes hotels

A beach with a variety of seashells and pebbles.

1. Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 5.3 km from Murex Lakes
9.2 out of 10, Wonderful, (2,369 reviews)
"Great place in a great location, very much recommended"
United States
Eldad
The price is ฿5,983
฿7,603 total
includes taxes & fees
19 Oct - 20 Oct
Sanibel Island Beach Resort
A modern living room with a TV, dining table, and chairs. There is a balcony with a view of palm trees.

2. Casa Ybel Resort

Casa Ybel Resort
2.5 star property
Ybel, 3 km from Murex Lakes
8.8 out of 10, Excellent, (450 reviews)
"Lovely place."
United States
Heather
The price is ฿7,750
฿8,642 total
includes taxes & fees
18 Oct - 19 Oct
Casa Ybel Resort
A pool area with lounge chairs and umbrellas, a beach with umbrellas and lounge chairs, and palm trees.

3. Sundial Beach Resort & Spa

Sundial Beach Resort & Spa
5.0 star property
Mid Island, 4.8 km from Murex Lakes
8.6 out of 10, Excellent, (2,716 reviews)
"Love the resort and great access to beach"
United States
Lisa Renee
The price is ฿11,942
฿15,514 total
includes taxes & fees
18 Oct - 19 Oct
Sundial Beach Resort & Spa
A beach with a view of the ocean and a sunset.

4. Island Inn

Island Inn
3.5 star property
West End, 0.8 km from Murex Lakes
9.4 out of 10, Exceptional, (1,163 reviews)
"Great location"
United States
Nicole
The price is ฿9,349
฿10,425 total
includes taxes & fees
31 Oct - 1 Nov
Island Inn
A wooden boardwalk leading to a beach with clear skies and calm waters.

5. Shalimar Beach Resort

Shalimar Beach Resort
3.5 star property
West End, 1.5 km from Murex Lakes
9.8 out of 10, Exceptional, (108 reviews)
"Clean, quiet, perfect location. Easy access to the beach ⛱️."
United States
Mauricio
The price is ฿10,498
฿11,706 total
includes taxes & fees
20 Oct - 21 Oct
Shalimar Beach Resort
A pathway leading to a pool area with lounge chairs and umbrellas, surrounded by tropical plants and a thatched-roof structure.

6. Sanibel Inn

Sanibel Inn
3.0 star property
East End, 6.3 km from Murex Lakes
9.2 out of 10, Wonderful, (1,002 reviews)
"Property was clean and very friendly staff food and bar on property and restaurant amazing stay"
United States
William
The price is ฿10,134
฿13,424 total
includes taxes & fees
18 Oct - 19 Oct
Sanibel Inn
A pathway flanked by palm trees and wooden buildings with thatched roofs.

7. Kona Kai Motel

Kona Kai Motel
2.5 star property
Mid Island, 4.7 km from Murex Lakes
9.0 out of 10, Wonderful, (1,000 reviews)
"Newly renovated, excellent location, quiet and safe for solo travelers."
United States
Aurelia
The price is ฿5,385
฿6,184 total
includes taxes & fees
19 Oct - 20 Oct
Kona Kai Motel
Living area

8. The Anchor Inn

The Anchor Inn
2.0 star property
Mid Island, 5.4 km from Murex Lakes
9.8 out of 10, Exceptional, (80 reviews)
"Our room was cute and clean... perfect for our anniversary trip!"
United States
Ashton
The price is ฿4,757
฿5,805 total
includes taxes & fees
19 Oct - 20 Oct
The Anchor Inn
A large, clear swimming pool with multiple lounge areas and palm trees.

9. Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers
4.0 star property
14.7 km from Murex Lakes
9.0 out of 10, Wonderful, (2,675 reviews)
"Very nice place to stay in for the weekend"
United States
Jose
The price is ฿5,701
฿8,038 total
includes taxes & fees
18 Oct - 19 Oct
Margaritaville Beach Resort Fort Myers
An outdoor seating area with wicker chairs and a central table, surrounded by lush greenery and palm trees.

10. THE Palmview AND Sandpiper Inns

THE Palmview AND Sandpiper Inns
3.5 star property
Mid Island, 5.5 km from Murex Lakes
9.2 out of 10, Wonderful, (229 reviews)
"Nice and clean, has everything you need, in the kitchen particularly, 5 minute walk to the beach and the staff were lovely checking in every so often."
United Kingdom
Callie
The price is ฿8,032
฿10,819 total
includes taxes & fees
18 Oct - 19 Oct
THE Palmview AND Sandpiper Inns
A spacious living room with a grey sofa, striped armchair, and a woven coffee table. Large windows offer a view of a tropical garden.

11. Driftwood Inn

Driftwood Inn
4.0 star property
Mid Island, 5.4 km from Murex Lakes
10.0 out of 10, Exceptional, (11 reviews)
"This was our second stay at Driftwood Inn and we enjoyed it as much this time as the last! Property is immaculately cleaned, comfortable and has everything we need. The beach is a short walk away and the included cart, umbrellas and beach chairs make it easy to enjoy your time relaxing in the sun. Highly recommend this property for your beach time!"
United States
Heather
The price is ฿7,220
฿16,123 total
includes taxes & fees
18 Oct - 19 Oct
Driftwood Inn
A waterfront hotel with multiple buildings, a dock, and a calm body of water reflecting the structures.

12. Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa
4.0 star property
10.9 km from Murex Lakes
8.6 out of 10, Excellent, (1,000 reviews)
"I love everything about this hotel"
United States
Yunior
The price is ฿7,460
฿9,488 total
includes taxes & fees
1 Nov - 2 Nov
Marriott Sanibel Harbour Resort & Spa
A hotel pool area with multiple lounge chairs and umbrellas, surrounded by a fence and palm trees.

13. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
14.7 km from Murex Lakes
8.2 out of 10, Very good, (1,389 reviews)
"The staff was very helpful during my stay."
United States
Samantha
The price is ฿2,413
฿2,691 total
includes taxes & fees
26 Oct - 27 Oct
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
A spacious dining area with multiple tables and chairs, large windows, and a modern chandelier.

14. Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
14.1 km from Murex Lakes
8.8 out of 10, Excellent, (1,000 reviews)
"The hotel was in a great location, very clean and had great breakfast options."
United States
jennifer
The price is ฿2,874
฿3,205 total
includes taxes & fees
18 Oct - 19 Oct
Residence Inn by Marriott Fort Myers Sanibel
A swimming pool with a rock arch structure, a multi-story building with balconies, and palm trees in the background.

15. Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina
4.0 star property
13.9 km from Murex Lakes
9.4 out of 10, Exceptional, (1,479 reviews)
"It's nice place to stay"
United States
Mario
The price is ฿7,190
฿10,215 total
includes taxes & fees
15 Nov - 16 Nov
Pink Shell Beach Resort and Marina
A modern dining area with wooden flooring, white chairs, and large windows offering a view of the beach.

16. Best Western Plus Beach Resort

Best Western Plus Beach Resort
2.5 star property
14.2 km from Murex Lakes
9.4 out of 10, Exceptional, (1,003 reviews)
"The location was amazing. Right on the beach and close to restaurants."
United States
Radiana
The price is ฿7,241
฿8,074 total
includes taxes & fees
1 Nov - 2 Nov
Best Western Plus Beach Resort
A sign for Sunshine Island Inn with a palm tree and beach scene.

17. Sunshine Island Inn

Sunshine Island Inn
2.5 star property
East End, 7 km from Murex Lakes
9.0 out of 10, Wonderful, (309 reviews)
"Wonderful stay."
United States
Brooke
The price is ฿6,651
฿7,639 total
includes taxes & fees
18 Oct - 19 Oct
Sunshine Island Inn
A rustic outdoor bathroom with a wooden deck, a white sink, and various seashells scattered around.

18. Tarpon Tale Inn

Tarpon Tale Inn
3.0 star property
East End, 7.9 km from Murex Lakes
9.6 out of 10, Exceptional, (412 reviews)
"Makes you feel at home. Impeccably kept. Joe and Maureen give attention to details and think of guest convenience and hospitality. Excellent location. Steps from beach and little stores. Sanibel is gorgeous and chill, and so is Tarpon Tales Inn."
United States
Marianella
The price is ฿8,155
฿9,093 total
includes taxes & fees
18 Oct - 19 Oct
Tarpon Tale Inn
A beachfront hotel with a pool, beach, and ocean view.

19. DiamondHead Beach Resort

DiamondHead Beach Resort
3.5 star property
15.4 km from Murex Lakes
9.2 out of 10, Wonderful, (1,315 reviews)
"Would be willing to stay there again."
United States
Angela
The price is ฿6,758
฿8,839 total
includes taxes & fees
1 Nov - 2 Nov
DiamondHead Beach Resort
A balcony with a wooden table and chairs, a hanging chair, and a view of palm trees and a pool.

20. Off the Charts Inn & Out Island Resort

Off the Charts Inn & Out Island Resort
2.5 star property
8.1 km from Murex Lakes
9.6 out of 10, Exceptional, (164 reviews)
"Very comfortable and convenient location!"
United States
Lisa
The price is ฿5,999
฿7,807 total
includes taxes & fees
22 Oct - 23 Oct
Off the Charts Inn & Out Island Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Murex Lakes

Find the best Murex Lakes areas for the activities you enjoy most.
A coastal scene with a lighthouse, beach, and ocean.

Mid Island

If you're spending some time in Mid Island, Periwinkle Way and Sanibel Island Southern Beach are top sights worth seeing.

A coastal scene with a lighthouse, beach, and ocean.

West End

If you're spending some time in West End, J. N. Ding Darling National Wildlife Refuge and Bowman's Beach are top sights worth seeing.

A coastal scene with a lighthouse, beach, and ocean.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

A street lined with palm trees and a sign for Periwinkle Place Shops.

Beachview Country Club Estates

While visiting Beachview Country Club Estates, you might make a stop by sights like Periwinkle Way and Sanibel Island Golf Club.

A beach with clear turquoise water, a sandy shore, and a weathered driftwood structure.

Gulf Shores

When in Gulf Shores, you can plan a visit to Bowman's Beach and J. N. Ding Darling National Wildlife Refuge, some noteworthy sights in the nearby area.

Top Murex Lakes Hotel Reviews

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

8/10 Good
"Beach view, clean rooms. Restaurants need better food."
Kathy 2-night trip
Posted 1 hour ago
Lani Kai Beachfront Resort

Frequently asked questions

What's it like in Murex Lakes?
You'll be sure to have fun exploring Sanibel's Murex Lakes neighbourhood.
How many hotels can I expect to find in Murex Lakes?
If you're searching for places to stay in Sanibel, choose from one of Expedia's 17 hotels and other accommodation options in Murex Lakes.
If I need to cancel my hotel reservation in Murex Lakes, will I receive a refund?
Yes! Most hotel room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, it might still be possible to cancel it and receive a refund within 24 hours of booking. Add dates, click "Search", then use the "fully refundable" filter to review the best options available in Murex Lakes.
What is there to do around this Sanibel neighbourhood?
Sanibel Captiva Conservation Foundation, Bailey - Matthews Shell Museum and Sanibel Island Southern Beach are just a few of the places to visit in and around Murex Lakes. When you're sightseeing in Sanibel, Sanibel Historical Museum and Village and BIG Arts Center are also worth a stop.