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Search Hotels in Middletown, San Diego

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Check prices for these dates

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17 Dec - 18 Dec
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18 Dec - 19 Dec
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19 Dec - 21 Dec
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26 Dec - 28 Dec

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Our top choices for Middletown hotels

Exterior
City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
4.5 star property
Middletown
9.6 out of 10, Exceptional, (106)
"would definitely go back and stay there again "
United States
Kounwick
City24 Hotel Little Italy Mission Hills
Standard Room, 1 King Bed, Non Smoking, Bay View | Premium bedding, pillow-top beds, in-room safe, desk
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection
3.0 star property
2.2 km from Middletown
8.8 out of 10, Excellent, (742)
"Friendly staff and clean rooms. "
Canada
Justine
The price is ฿3,423
฿3,969 total
includes taxes & fees
24 Dec - 25 Dec
The DEXTRO Little Italy, BW Premier Collection
Outdoor pool, pool loungers
Hilton San Diego Bayfront

Hilton San Diego Bayfront

Hilton San Diego Bayfront
4.0 star property
Marina District, 4.2 km from Middletown
8.6 out of 10, Excellent, (1869)
"Enjoyed my stay"
United States
Brandon
The price is ฿3,303
฿5,373 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hilton San Diego Bayfront
Terrace/patio
Wyndham San Diego Bayside

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
2.3 km from Middletown
8.4 out of 10, Very good, (6030)
"Always an amazing stay"
United States
Jana
The price is ฿4,252
฿5,842 total
includes taxes & fees
21 Dec - 22 Dec
Wyndham San Diego Bayside
Room, 1 King Bed with Sofa bed, Marina View | View from room
Sheraton San Diego Resort

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
2.5 km from Middletown
8.4 out of 10, Very good, (3160)
"Great stay! "
United States
Melissa
The price is ฿3,343
฿4,975 total
includes taxes & fees
22 Dec - 23 Dec
Sheraton San Diego Resort
Outdoor pool, pool umbrellas, pool loungers
Hampton Inn San Diego-Downtown

Hampton Inn San Diego-Downtown

Hampton Inn San Diego-Downtown
2.5 star property
2.1 km from Middletown
8.2 out of 10, Very good, (2286)
"The room was great, the bed was comfortable."
United States
PAM
The price is ฿3,265
฿3,786 total
includes taxes & fees
5 Jan - 6 Jan 2026
Hampton Inn San Diego-Downtown
Premium bedding, pillow-top beds, desk, laptop workspace
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego
3.0 star property
Gaslamp Quarter, 3.6 km from Middletown
9.4 out of 10, Exceptional, (1000)
"Great location "
United States
Mohammad
The price is ฿2,803
฿4,159 total
includes taxes & fees
4 Jan - 5 Jan 2026
Staypineapple, Hotel Z, Gaslamp San Diego
Meeting facility
The Westin San Diego Bayview

The Westin San Diego Bayview

The Westin San Diego Bayview
4.0 star property
2.7 km from Middletown
8.6 out of 10, Excellent, (1065)
"I loved the hotel rooms bar area jacuzzi area everything was great it was in a pretty location will definitely come back "
United States
Alliyah
The price is ฿4,253
฿5,844 total
includes taxes & fees
24 Dec - 25 Dec
The Westin San Diego Bayview
Exterior
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego
4.0 star property
Marina District, 3.4 km from Middletown
9.0 out of 10, Wonderful, (2870)
"Great Location....tons of walking from the hotel Front desk were very nice and polite will be coming back for sure "
United States
Carlos
The price is ฿5,537
฿8,134 total
includes taxes & fees
18 Dec - 19 Dec
Manchester Grand Hyatt San Diego
Lobby
Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
4.1 km from Middletown
7.4 out of 10, Good, (4116)
"Room was very clean and staff very pleasant "
Canada
Brian
The price is ฿2,660
฿3,057 total
includes taxes & fees
24 Dec - 25 Dec
Wyndham Garden San Diego Near SeaWorld
Exterior
Comfort Inn San Diego Old Town

Comfort Inn San Diego Old Town

Comfort Inn San Diego Old Town
2.5 star property
Old Town San Diego, 2.1 km from Middletown
8.2 out of 10, Very good, (1908)
"Efficient check in, clean rooms and great breakfast."
Canada
Wendy
The price is ฿2,391
฿2,748 total
includes taxes & fees
4 Jan - 5 Jan 2026
Comfort Inn San Diego Old Town
2 outdoor pools, open 6 AM to 10:00 PM, pool cabanas (surcharge)
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina
4.0 star property
Marina District, 3.5 km from Middletown
9.2 out of 10, Wonderful, (1951)
"Amazing stay. Absolutely perfect "
United States
Wayne
The price is ฿5,002
฿7,454 total
includes taxes & fees
24 Dec - 25 Dec
Marriott Marquis San Diego Marina
Outdoor pool, open 7:00 AM to 10:00 PM, pool cabanas (surcharge)
San Diego Mission Bay Resort

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay, 5.4 km from Middletown
8.4 out of 10, Very good, (1311)
"Room was super clean and updated, location up against the bay was perfect. We really enjoyed our stay and want to come back soon!"
United States
Haley
The price is ฿3,934
฿5,941 total
includes taxes & fees
18 Dec - 19 Dec
San Diego Mission Bay Resort
Courtyard
DoubleTree by Hilton San Diego - Del Mar

DoubleTree by Hilton San Diego - Del Mar

DoubleTree by Hilton San Diego - Del Mar
4.0 star property
Carmel Valley, 22.6 km from Middletown
8.4 out of 10, Very good, (1890)
"Excellent location"
United States
Paolo
The price is ฿3,105
฿3,538 total
includes taxes & fees
4 Jan - 5 Jan 2026
DoubleTree by Hilton San Diego - Del Mar
Reception
Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina
3.0 star property
5.7 km from Middletown
8.8 out of 10, Excellent, (1560)
"Staff was great, easy check in and great location"
United States
Alysa
The price is ฿3,599
฿4,137 total
includes taxes & fees
4 Jan - 5 Jan 2026
Best Western Plus Island Palms Hotel & Marina
Terrace/patio
Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley
2.5 star property
2.2 km from Middletown
8.8 out of 10, Excellent, (1291)
"Hotel was very clean and the staff was very friendly"
United States
Norma
The price is ฿3,176
฿3,650 total
includes taxes & fees
5 Jan - 6 Jan 2026
Hampton Inn San Diego/Mission Valley
Lobby
Fairfield Inn & Suites by Marriott San Diego Pacific Beach

Fairfield Inn & Suites by Marriott San Diego Pacific Beach

Fairfield Inn & Suites by Marriott San Diego Pacific Beach
2.5 star property
Pacific Beach, 7.8 km from Middletown
9.0 out of 10, Wonderful, (801)
"good place to stay"
United States
Sisi
The price is ฿3,240
฿3,725 total
includes taxes & fees
22 Dec - 23 Dec
Fairfield Inn & Suites by Marriott San Diego Pacific Beach
Outdoor pool
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego
4.0 star property
Gaslamp Quarter, 3.8 km from Middletown
9.0 out of 10, Wonderful, (3158)
"Great stay"
United States
Laurence
The price is ฿5,351
฿7,651 total
includes taxes & fees
21 Dec - 22 Dec
Hard Rock Hotel San Diego
Reception
Kings Inn San Diego

Kings Inn San Diego

Kings Inn San Diego
2.5 star property
2.1 km from Middletown
8.8 out of 10, Excellent, (3579)
"Room was very clean, and the breakfast was good"
United States
Roxana
The price is ฿2,407
฿2,763 total
includes taxes & fees
21 Dec - 22 Dec
Kings Inn San Diego
Hot springs
The Atwood Hotel San Diego - SeaWorld/Zoo

The Atwood Hotel San Diego - SeaWorld/Zoo

The Atwood Hotel San Diego - SeaWorld/Zoo
3.0 star property
2.2 km from Middletown
8.0 out of 10, Very good, (1826)
"Clean and helpful staff, thank you !"
United States
Bora
The Atwood Hotel San Diego - SeaWorld/Zoo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Middletown

Find the best Middletown areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Gaslamp Quarter featuring a bar, night scenes and street scenes

Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

Pacific Beach Park showing a beach

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Belmont Park featuring a park and rides

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach Pier and Dog Beach.

Top Middletown Hotel Reviews

Pendry San Diego

Pendry San Diego

10/10 Excellent
"Clean room staff gently "
ALEJANDRO 1-night trip
Posted 2 days ago
Pendry San Diego

Frequently asked questions

What's it like in Middletown?
Middletown is a neighbourhood that travellers like for its live music, bars and theatres.
How many hotels can I expect to find in the Middletown area?
Expedia has 91 hotels and other accommodation options in Middletown to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Middletown, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of booking. Put your dates in and click on "Search", then use the "fully refundable" filter to view top deals in Middletown.
What are the top things to see and do in Middletown?
Favourite places to visit in the surrounding area include San Diego Zoo, Hotel Circle and Port of San Diego. While you're out sightseeing, Petco Park and Marston House are a couple of additional sights to visit in San Diego.
How can I get around Middletown and the greater San Diego area?
Ready to get out and explore the city? Middletown Station is the closest metro station.