Mesopotamia Packages (Flight + Hotel)

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Things to do in Mesopotamia

Shopping

In Mesopotamia, visit Shopping Sur, a vibrant mall offering a mix of local crafts and international brands. For a more authentic experience, explore the lively Mercado 4, where you can find unique souvenirs, handmade goods, and delicious local delicacies to take home.

Recreation

In Mesopotamia, Argentina, indulge in rejuvenating spa treatments at the tranquil Wellness Centre, where skilled therapists offer massages and holistic therapies. Explore lush landscapes through guided hikes or unwind with yoga sessions amidst nature, creating a perfect blend of relaxation and adventure in stunning surroundings.

Adventure

In Mesopotamia, explore the breathtaking Ibera Wetlands, home to diverse wildlife and stunning landscapes, ideal for kayaking and birdwatching. Visit the enchanting waterfalls of Saltos del Moconá, offering exhilarating hiking trails and opportunities for fishing, providing an unforgettable adventure in nature's splendour.

Nightlife

In Mesopotamia, Argentina, experience vibrant nightlife at local bars and clubs, particularly along Avenida Costanera and Calle San Martín. Enjoy live music, traditional Argentine tango, and delicious street food, creating an energetic atmosphere perfect for dancing and socialising with locals and fellow travellers.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Find the best attractions near Mesopotamia

Mesopotamia, Argentina, offers a range of attractions for travellers seeking outdoor adventure and scenic beauty, particularly within its national parks. Visitors can delve into the rich history of the ancient Mesopotamians, explore their numerous gods, and partake in the vibrant festivals that celebrate this fascinating culture. Whether you're an outdoor enthusiast or a history buff, Mesopotamia promises an enriching experience.

  • Portal Carambola: Nestled 22.5km from Mesopotamia, this national park offers breathtaking scenery and outdoor adventures. Experience lush landscapes, exciting trails, and vibrant wildlife, making it a perfect destination for nature enthusiasts and thrill-seekers alike.

Best time to go to Mesopotamia

The best time to visit Mesopotamia depends on your weather preferences. The hottest average temperature around Mesopotamia is in January and February. February is mostly sunny. The coolest average temperature around Mesopotamia is in May and July. July is mostly sunny.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January80.1°F (26.700000000000003°C)Light RainSunnyModerately HighAverage
February77.7°F (25.4°C)Light RainMostly Sunny
March72.9°F (22.700000000000003°C)Light RainMostly SunnyModerately HighAverage
April66.7°F (19.3°C)Light RainMostly SunnyAverageAverage
May59.5°F (15.3°C)Light RainMostly Sunny
June60.1°F (15.6°C)Light RainMostly Sunny
July53.4°F (11.9°C)Light RainMostly SunnyAverageSlightly High
August63.7°F (17.6°C)Light RainMostly SunnyAverageSlightly High
September60.6°F (15.9°C)Light RainMostly SunnyAverageAverage
October65.8°F (18.8°C)Light RainMostly SunnyAverageAverage
November72.3°F (22.4°C)Light RainSunnyModerately HighAverage
December77.0°F (25.0°C)Light RainSunnyAverageSlightly High

Tips to save on your trip to Mesopotamia

  • Combine your flights, hotels and car rentals on Expedia—bundling can result in significant savings.
  • Consider traveling during the off-peak season (typically ) for more affordable package holidays to Mesopotamia.
  • Use the Price per traveler filter on Expedia to find a package deal that suits your budget.
  • Check the VIP Access properties filter to discover outstanding hotels with added member perks at select properties.

Top hotels in Mesopotamia

O2 Hotel Gualeguaychú

O2 Hotel Gualeguaychú

2.5 out of 5
115 3 de Febrero Gualeguaychú Entre Ríos
Fully refundableReserve now, pay when you stay
The price is ฿1,469 per night from 31 Mar to 1 Apr
฿1,469
฿1,469 total
31 Mar - 1 Apr
7.8/10 Good! (77 reviews)
Si un huesped pregunta si se olvida algo en la habitacion tener la deliquicadesa de contestar por eso la calificaccion no me volveria a quedar

Reviewed on 23 Dec 2025

O2 Hotel Gualeguaychú
Marriott Corrientes Hotel

Marriott Corrientes Hotel

4.5 out of 5
Av Costanera Juan Pablo II y Lavalle Corrientes
Fully refundableReserve now, pay when you stay
The price is ฿4,235 per night from 10 Apr to 11 Apr
฿4,235
฿4,235 total
10 Apr - 11 Apr
10/10 Exceptional! (22 reviews)
Fantastic stay. Room was immaculate and hotel staff were very friendly and helpful. Great pool and beds were super comfortable.

Reviewed on 6 Feb 2026

Marriott Corrientes Hotel
Hathor Concordia

Hathor Concordia

3 out of 5
Ruta Nacional 14-km 264.5 Concordia Entre Rios
8.6/10 Excellent! (369 reviews)
AC did not work well, food was OK. Staff friendly. Good hotel for a stay on the road.

Reviewed on 22 Dec 2025

Get rates
Hathor Concordia
See all 512 properties in Mesopotamia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Parroquia Nuestra Señora de Itati

Basilica Nuestra Senora De Itati

Learn about the local history of Municipo de Itatí when you take a trip to Basilica Nuestra Senora De Itati.

Basilica Nuestra Senora De Itati

Termas de Chajarí

Enjoy an outing to Termas de Chajarí during your stay in Chajarí. Stroll along the lakeside or discover the area's hot springs.

Termas de Chajarí

Concordia Speedway

You can take time to visit Concordia Speedway during your travels to Concordia. Amble around the area's parks or experience its theatre scene.

Concordia Speedway

Frequently asked questions

Can I cancel my flight booking to Mesopotamia due to COVID-19?
If you haven't booked yet, glance over the terms and conditions of the airline you're considering. If you've already reserved your flight to Mesopotamia, make use of our Customer Service Portal. It will help determine which COVID-19 policies apply to your booking and provide advice on the next steps.
What's the best way to find cheap flights to Mesopotamia that have flexible change policies?
Search for your bargain flights to Mesopotamia, then tick the "No change fee" box directly underneath the "Flexible change policies" heading. It's that easy. We know that plans change and flexibility is essential, so you can book with confidence with Expedia.
What are some of the general tips for travellers to Mesopotamia during the COVID-19 outbreak?
If it's your first time travelling during the COVID-19 pandemic, you'll notice a range of new rules and restrictions in place. Take note of these tips and make your escape to Mesopotamia a smooth one:
  • Research if any travel restrictions apply to your destination and origin before booking. Also check if there are any requirements you'll have to follow on arrival, such as health testing.
  • Keep your face mask on even during airport screening. A TSA employee will require you to lower your mask temporarily to verify your identity.
  • Instead of handing a TSA employee your boarding pass, position it directly on the scanner yourself. When that's done, hold it up for inspection.
  • You're permitted to take one container of hand sanitizer up to 12 oz (350 ml) in your hand luggage. This will need to be taken out for screening.
  • Place any personal items (phone, wallet and keys for example) in your carry-on rather than a bin to minimize handling during screening.
  • Separate any food you have for screening. Food items often set off the alarm. Placing them in a clear plastic bag and into a bin reduces the need for a TSA employee to handle and inspect your belongings.

Which airlines fly to Mesopotamia?
Book your ticket with LATAM Airlines and then start putting together your Mesopotamia travel itinerary. This top airline provides 143 flights each month to Ministro Pistarini Intl. Airport (EZE), a major gateway.
How can I find cheap tickets to Mesopotamia?
One of the easiest ways to snare cheap tickets to Mesopotamia is to be flexible with your dates. Search for your flights, then click "flexible dates" above the results. It will bring up the cheapest prices for nearby days. The lowest price for a flight to Mesopotamia in the last seven days was . Booking ahead will generally help you get an even better deal.
How much is a flight to Mesopotamia?
You could have scored a return ticket to Mesopotamia from anywhere between and in the last seven days. For one-way trips leaving from (), the lowest amount paid during this period was just .
What are the most popular airports to fly into in Mesopotamia?
Book your flight to Ministro Pistarini Intl. Airport (EZE) and sample all that Mesopotamia has to offer. As the region's main entry point, around 850 flights land here each month.
When is the cheapest time to fly to Mesopotamia?
Leave for Mesopotamia early on in the week and you'll usually be rewarded more economical fares. Tuesday is typically the cheapest day to get on a plane, followed closely by Monday. If you'd like to avoid the most expensive flights, keep clear of Saturdays.
How much is a plane ticket to Mesopotamia?
Seats to Mesopotamia ranged from to in the last seven days. Normally, the earlier you make a reservation, the better the deal.
Which airlines with flights to Mesopotamia employ COVID-19 cleanliness policies?
In response to the global COVID-19 pandemic, airlines have adopted new precautionary measures to help their passengers and crew get back in the air. Here are some good examples:
  • Aerolineas Argentinas - this airline is known for conducting passenger temperature checks and cleaning with disinfectant.
  • LATAM Airlines - this airline is known for providing passenger masks and capped capacity flights.
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.