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25 Oct - 26 Oct
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26 Oct - 27 Oct
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30 Oct - 1 Nov
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6 Nov - 8 Nov

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Our top choices for Mayo Clinic hotels

A hotel room with two beds, a sofa, a chair, and a desk.
An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.
A modern restaurant with a counter, seating area, and a TV screen.
A modern lounge area with a sofa, chairs, and tables.

1. Home2 Suites by Hilton Rochester Mayo Clinic Area

Home2 Suites by Hilton Rochester Mayo Clinic Area
2.6 km from Mayo Clinic
United States
howard
฿3,702
฿4,262 total
includes taxes & fees
7 Nov - 8 Nov
Home2 Suites by Hilton Rochester Mayo Clinic Area
A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.
A modern lounge area with seating, a fireplace, and a bar area.
An outdoor patio area with wicker furniture, a central fire feature, and a stone building in the background.
A modern reception area with a brick-patterned wall, two reception desks, a flat-screen TV, and seating arrangements including a sofa and chairs.

2. Residence Inn by Marriott Rochester Mayo Clinic Area South

Residence Inn by Marriott Rochester Mayo Clinic Area South
2.4 km from Mayo Clinic
United States
Chee
฿4,457
฿5,131 total
includes taxes & fees
13 Nov - 14 Nov
Residence Inn by Marriott Rochester Mayo Clinic Area South
An outdoor patio area with a concrete floor, wooden fence, and string lights.
A Fairfield Inn & Suites hotel with a modern design, featuring a prominent entrance and a parking area.
A modern living room with a stone fireplace, a blue armchair, a round coffee table, and a large window offering a view of the outdoors.
A breakfast bar with a wooden counter, a coffee machine, and a refrigerator.

3. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys
Kutzky Park, 1.8 km from Mayo Clinic
United States
Brien
฿3,920
฿4,513 total
includes taxes & fees
6 Nov - 7 Nov
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys
A modern living room with a flat-screen TV, a fireplace, a sofa, a coffee table, and a view of a cityscape through large windows.
A hotel swimming pool with lounge chairs, a changing room, and a view of the cityscape.
A spacious lobby with modern furniture, a staircase, and large windows.
A modern hotel entrance with a glass facade, a covered entrance area, and a visible 'Hilton' sign.

4. Hilton Rochester Mayo Clinic Area

Hilton Rochester Mayo Clinic Area
Downtown Rochester, 0.3 km from Mayo Clinic
United States
Jennifer
฿5,998
฿6,905 total
includes taxes & fees
7 Nov - 8 Nov
Hilton Rochester Mayo Clinic Area
A spacious living area with a modern staircase, leather sofas, and contemporary lighting.
An outdoor seating area with blue sofas and wicker chairs, a wooden table, and green ottomans on a tiled patio.
A modern pool table in a spacious, well-lit room with large windows and a bar area.
A rooftop pool area with lounge chairs and umbrellas, surrounded by a modern building with a brick facade.

5. The Berkman

The Berkman
Folwell, 1.4 km from Mayo Clinic
United States
Suzette
฿6,418
฿7,463 total
includes taxes & fees
21 Nov - 22 Nov
The Berkman
A coffee shop interior with a wooden counter, menu boards, and seating area.
A hotel room with a bed, bedside table, and a window with curtains.
An outdoor seating area with tables and chairs, a neon sign, and flower arrangements.
Room

6. TownePlace Suites by Marriott Rochester Mayo Clinic Area

TownePlace Suites by Marriott Rochester Mayo Clinic Area
Kutzky Park, 0.4 km from Mayo Clinic
Canada
Cory
฿4,626
฿5,325 total
includes taxes & fees
6 Nov - 7 Nov
TownePlace Suites by Marriott Rochester Mayo Clinic Area
A modern indoor patio with a fire feature, seating, and large windows.
A modern living room with a fireplace, large windows, and a flat-screen TV mounted on the wall.
A modern hotel lobby with a large glass wall, a green wall mural, and a seating area with sofas and chairs.
A reception area with a curved reception desk, wooden shelving, and a green moss wall with the text "I ♥ EVEN".

7. EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG
Kutzky Park, 1 km from Mayo Clinic
United States
James
฿3,714
฿4,732 total
includes taxes & fees
6 Nov - 7 Nov
EVEN Hotel Rochester - Mayo Clinic Area by IHG
A modern living room with a fireplace, comfortable seating, and large windows.
A modern interior with a seating area, a bookshelf, and a view through large windows.
A modern hotel entrance with a glass facade, a staircase leading to the entrance, and a sign for Staybridge Suites.
A modern bar area with a long counter, bar stools, and a television screen mounted on the wall.

8. Staybridge Suites Rochester - Mayo Clinic Area by IHG

Staybridge Suites Rochester - Mayo Clinic Area by IHG
Kutzky Park, 1 km from Mayo Clinic
United States
Amanda
฿3,545
฿4,149 total
includes taxes & fees
25 Nov - 26 Nov
Staybridge Suites Rochester - Mayo Clinic Area by IHG
A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.
A hotel lobby with leather sofas, a stone fireplace, and a patterned carpet.
A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.
A compact laundry area with a washing machine, dryer, and a water fountain.

9. Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area
3.1 km from Mayo Clinic
United States
Ashley
฿2,213
฿2,548 total
includes taxes & fees
15 Nov - 16 Nov
Econo Lodge Mayo Clinic Area
An outdoor patio with a brick floor, stone fireplace, and wooden pergola.
A gym with exercise equipment, a clock, and a window with blinds.
A conference room with tables set for a meeting, a projector screen, and a view of the outside.
A modern hotel lobby with a stone wall fireplace, comfortable seating, and a chandelier.

10. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys
Kutzky Park, 1.4 km from Mayo Clinic
United States
Lin
฿3,702
฿4,262 total
includes taxes & fees
25 Nov - 26 Nov
Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys
A hotel with a stone facade, multiple windows, and a sign indicating it is Candlewood Suites.
A hotel lobby with a reception desk, seating area, and a large window.
A hotel room with a dining area, a sofa, a TV, and a bed.
A hotel gym with treadmills, elliptical machines, and free weights.

11. Candlewood Suites Rochester Mayo Clinic Area by IHG

Candlewood Suites Rochester Mayo Clinic Area by IHG
2.6 km from Mayo Clinic
United States
Kevin
฿3,613
฿4,159 total
includes taxes & fees
15 Nov - 16 Nov
Candlewood Suites Rochester Mayo Clinic Area by IHG
A Courtyard Marriott hotel with multiple floors, a brick facade, and illuminated signage.
A hotel room with a sofa, armchairs, a small kitchenette, a flat-screen TV, and a large window.
A modern kitchen with a built-in dishwasher, a coffee maker, a microwave, and a sink.
Miscellaneous

12. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
Kutzky Park, 1.4 km from Mayo Clinic
United States
MATTHEW
฿3,496
฿4,025 total
includes taxes & fees
6 Nov - 7 Nov
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.
A hotel room with a bed, a desk, a chair, a TV, and a bathroom visible through an open door.
A modern lounge area with seating arrangements, a reception desk, and a patterned wall.
A pool area with a table and chairs, a lifeguard chair, and a pool lift.

13. Hampton Inn Rochester-South

Hampton Inn Rochester-South
2.9 km from Mayo Clinic
United States
dennis
฿3,300
฿3,800 total
includes taxes & fees
1 Nov - 2 Nov
Hampton Inn Rochester-South
An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.
A modern dining area with round tables and chairs, a large painting on the wall, and a flat-screen TV mounted above a geometric-patterned wall.
A modern indoor pool area with lounge chairs and a pool.
A modern Hyatt House hotel with a prominent 'Hyatt House' sign, multiple floors, and a parking garage.

14. Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area
Downtown Rochester, 0.5 km from Mayo Clinic
United States
Arlan
฿4,288
฿4,937 total
includes taxes & fees
13 Nov - 14 Nov
Hyatt House Rochester/Mayo Clinic Area
A bedroom with a large bed, a TV on a dresser, and a view of the city through large windows.
A modern kitchen with wooden cabinets, a granite countertop, and a stainless steel stove.
A multi-story building with the sign 'Broadway Plaza' indicating a commercial or hotel property.
An indoor swimming pool with a clock on the wall, lounge chairs, and a lifeguard warning sign.

15. Broadway Plaza, Trademark Collection by Wyndham

Broadway Plaza, Trademark Collection by Wyndham
Downtown Rochester, 0.3 km from Mayo Clinic
United States
Jennifer
฿5,711
฿6,575 total
includes taxes & fees
7 Nov - 8 Nov
Broadway Plaza, Trademark Collection by Wyndham
A hotel entrance with a stone facade, a glass door, and a metal roof structure.
An outdoor patio area with brick walls, a large arched window, and outdoor seating.
A hotel room with a large bed, a TV, a bathroom with a sink and mirror, and a window with curtains.
A hotel lobby with striped armchairs, a sofa, a fireplace, and a clock on the wall.

16. Aspen Suites

Aspen Suites
1.2 km from Mayo Clinic
United States
Douangta
฿4,693
฿5,673 total
includes taxes & fees
22 Nov - 23 Nov
Aspen Suites
A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.
A reception area with a curved counter, ceiling lights, and a potted plant.
A long, narrow hotel corridor with a carpeted floor, light fixtures along the walls, and a ceiling with recessed lighting.
A hotel room with a bed, a sink, a microwave, and a window with curtains.

17. Brentwood Inn & Suites

Brentwood Inn & Suites
Downtown Rochester, 0.3 km from Mayo Clinic
United States
Elaine
฿4,052
฿4,665 total
includes taxes & fees
29 Oct - 30 Oct
Brentwood Inn & Suites
A spacious outdoor dining area with multiple tables and chairs, large windows, and a wooden ceiling structure.
A modern interior with a bar area, seating, and a large window.
A modern hotel building with a prominent sign for 'Hotel Indigo' and a 'Crave Drink' establishment.
A bar area with a central island, bar stools, and hanging pendant lights.

18. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG
Downtown Rochester, 0.4 km from Mayo Clinic
United States
Naomi
฿3,478
฿4,004 total
includes taxes & fees
14 Nov - 15 Nov
Hotel Indigo Rochester – Mayo Clinic Area by IHG
A spacious hotel lobby with multiple seating areas, including sofas and round tables, and a large dining area with yellow chairs.
A spacious lobby with a large seating area, a fireplace, and large windows providing natural light.
A grocery store with refrigerated and frozen sections, shelves stocked with snacks, and a variety of beverages.
A reception area with two counters, a patterned wall, and a wooden floor.

19. Hilton Garden Inn Rochester Downtown, MN

Hilton Garden Inn Rochester Downtown, MN
Downtown Rochester, 0.3 km from Mayo Clinic
United States
Richard
฿3,989
฿4,593 total
includes taxes & fees
7 Nov - 8 Nov
Hilton Garden Inn Rochester Downtown, MN
A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.
A hotel room with a large bed, bedside tables, a mirror, and a patterned carpet.
A hotel lobby with a patterned carpet, two beige armchairs, a small table, a clock, a fire extinguisher, and a staircase.
A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

20. Quality Inn & Suites Mayo Clinic Area

Quality Inn & Suites Mayo Clinic Area
2.6 km from Mayo Clinic
United States
Jessica
฿2,244
฿2,620 total
includes taxes & fees
14 Nov - 15 Nov
Quality Inn & Suites Mayo Clinic Area
View all properties

Compare popular hotels close to Mayo Clinic

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A hotel room with two beds, a sofa, a chair, and a desk.
Home2 Suites by Hilton Rochester Mayo Clinic Area
9.6
Exceptional
1,001 reviews
View
A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.
Residence Inn by Marriott Rochester Mayo Clinic Area South
9.6
Exceptional
319 reviews
View
An outdoor patio area with a concrete floor, wooden fence, and string lights.
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys
9.6
Exceptional
748 reviews
View
A modern living room with a flat-screen TV, a fireplace, a sofa, a coffee table, and a view of a cityscape through large windows.
Hilton Rochester Mayo Clinic Area
9.6
Exceptional
654 reviews
View
A spacious living area with a modern staircase, leather sofas, and contemporary lighting.
The Berkman
9.6
Exceptional
451 reviews
View

Top Mayo Clinic Hotel Reviews

AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

8/10 Good
"The room had some noise like water going thru some pipes during the early morning hours. Could be something due to the swimming pool. No sleep after that started."
John and Marilyn 1-night trip
Posted 7 hours ago
AmericInn by Wyndham Rochester Near Mayo Clinic
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

10/10 Excellent
"Staff was extremely helpful and knowledgeable. Restaurant was clean and food was great. Very close to everything and parking was easy and inexpensive."
Rebecca 3-night trip
Posted 21 hours ago
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

10/10 Excellent
"B"
Linda 1-night trip
Posted 23 hours ago
Hyatt House Rochester/Mayo Clinic Area
Brentwood Inn & Suites

Brentwood Inn & Suites

8/10 Good
"While the property is old, I found it very clean. Location is excellent. Bed was not great. Staff was incredibly accommodating."
Alicia 2-night trip
Posted 1 day ago
Brentwood Inn & Suites
Broadway Plaza, Trademark Collection by Wyndham

Broadway Plaza, Trademark Collection by Wyndham

10/10 Excellent
"The property had two bathrooms which was a nice surprise. The kitchen had a full size refrigerator, dishwasher, and laundry machine. The room also had a very pleasant air freshener smell and the bathroom had night lights so you didn'thave to turn on the bathroom's big light in during the night. Thank you for making our stay so pleasant."
Anonymous traveller 1-night trip
Posted 6 days ago
Broadway Plaza, Trademark Collection by Wyndham
Hilton Garden Inn Rochester Downtown, MN

Hilton Garden Inn Rochester Downtown, MN

10/10 Excellent
"The staff was very helpful. Our room was very clean. Loved how easy it was to get to the Mayo Clinic."
Kimberly 4-night trip
Posted 8 days ago
Hilton Garden Inn Rochester Downtown, MN

Frequently asked questions

What's the area like around Mayo Clinic?
Mayo Clinic is located in a welcoming area of Rochester known for its major shopping area. If you're looking for a convenient place to stay, take a look at the 153 hotels and other accommodation options you'll find within a mile.
What's the best place to stay close to Mayo Clinic?
Adjacent to Mayo Clinic, Kahler Grand Hotel is one of the top choices for your stay based on our traveller data, and this hotel offers 2 restaurants and an indoor pool. Other good options close by include Kahler Inn and Suites - Mayo Clinic Area and Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area.
How many hotels should I expect to find near Mayo Clinic?
Expedia has 153 hotels and other accommodation options within a mile from Mayo Clinic.
If I need to cancel the hotel reservation for my stay near Mayo Clinic, will I receive a refund?
Yes, most hotel bookings are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and receive a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to review the best deals near Mayo Clinic.
What can I see and do near Mayo Clinic?
You'll want to browse the exhibits at Mayowood Mansion and History Center of Olmsted County. Learn about local history at Assisi Heights and Plummer House. You can enjoy live performances at Rochester Civic Theater and Marcus Rochester Cinema.