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16 Oct - 17 Oct
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Our top choices for Mayo Clinic Florida hotels

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
A modern kitchen with a bar area, seating, and a view of the outdoors.
A multi-story hotel with a central entrance, surrounded by well-maintained lawns and palm trees.
A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
1.1 km from Mayo Clinic Florida
United States
Michaelanne
฿4,598
฿5,219 total
includes taxes & fees
23 Oct - 24 Oct
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
A modern kitchen with wooden cabinets, a built-in oven, and a coffee machine.
An outdoor patio with a pool, wooden pergola, and seating area.
A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.

2. TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
United States
gregory
฿4,122
฿4,679 total
includes taxes & fees
25 Oct - 26 Oct
TownePlace Suites by Marriott Jacksonville East
A modern restaurant with a bar area, wooden ceiling, and large windows.
A modern lobby with a central seating area, wooden shelving with decorative items, and a large pillar.
A covered outdoor seating area with chairs and sofas, a fountain, and a view of a lake and trees.
A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.

3. Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
0.8 km from Mayo Clinic Florida
United States
Patricia
฿5,669
฿6,434 total
includes taxes & fees
30 Oct - 31 Oct
Hilton Jacksonville at Mayo Clinic near Beaches
A lobby with a reception desk, seating area, and a staircase.
An indoor swimming pool with clear views of trees outside, a tiled floor, and a covered seating area.
A modern kitchen with a refrigerator, coffee machine, and a bakery display.
Lobby sitting area

4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.6 km from Mayo Clinic Florida
United States
frances
฿3,452
฿3,918 total
includes taxes & fees
14 Nov - 15 Nov
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
A hotel lobby with a bar area, seating arrangements, and a reception desk.
An outdoor patio with a brick wall, a round table with striped chairs, and two large umbrellas.
A gym with treadmills, elliptical machines, a bench press, and a rack of dumbbells.
A hotel pool area with a long, narrow pool, multiple lounge chairs, and a covered seating area.

5. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
United States
Patsy
฿3,978
฿4,514 total
includes taxes & fees
25 Oct - 26 Oct
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
An outdoor seating area with stone fire pit, wicker furniture, and potted plants.
A modern living room with two armchairs, a sofa, a coffee table, and a flat-screen TV mounted on the wall.
A modern hotel lobby with a flat-screen TV, a fireplace, comfortable seating, and a coffee bar.
A bar area with a long counter, multiple stools, and shelves stocked with bottles.

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
0.4 km from Mayo Clinic Florida
United States
Patricia
฿5,094
฿5,782 total
includes taxes & fees
31 Oct - 1 Nov
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
A round marble table with a magazine, a pair of glasses, and a coffee cup.
A cafe with a front desk, a coffee machine, and two chairs outside.
A backyard with a swimming pool, wooden deck, and outdoor furniture.
A living room with a sofa, a coffee table, a hanging light fixture, a framed picture, and a floor lamp.

7. Hotel Palms

Hotel Palms
7.8 km from Mayo Clinic Florida
฿6,391
฿7,253 total
includes taxes & fees
18 Oct - 19 Oct
Hotel Palms
A multi-story hotel with a modern design, featuring a covered entrance and a parking area with handicapped accessibility.
A beverage refrigerator stocked with various drinks, a small refrigerator, and a wall-mounted display with promotional items.
A coastal cityscape with a long beach, a large hotel with a curved facade, and a clear sky.
A hotel room with two beds, a desk, a chair, and a large window with a view.

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Southside, 7.7 km from Mayo Clinic Florida
United States
Aneudi
฿4,003
฿4,543 total
includes taxes & fees
29 Oct - 30 Oct
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
An outdoor patio area with seating, a fire pit, and a barbecue grill.
A modern living room with sofas, a coffee table, and a dining area.
A modern kitchen with wooden cabinets, a central island with jars, and a countertop with toasters.
A modern hotel with a sign reading "Towneplace Suites by Marriott" and a parking lot in front.

9. TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport
10.8 km from Mayo Clinic Florida
United States
irina
฿3,988
฿4,527 total
includes taxes & fees
15 Nov - 16 Nov
TownePlace Suites by Marriott® Jacksonville Mayport
A modern outdoor seating area with white wicker chairs, a glass fire pit with burning wood, and a view of palm trees and a building in the background.
A modern conference room with a long table, several chairs, and pendant lighting.
A pathway leading to a sunset over a beach with sand and grass.
A modern hotel lobby with a long reception desk, seating area, and large windows.

10. Element by Marriott Jacksonville Beach

Element by Marriott Jacksonville Beach
5.4 km from Mayo Clinic Florida
United States
Lisa
฿4,826
฿5,478 total
includes taxes & fees
1 Nov - 2 Nov
Element by Marriott Jacksonville Beach
A laptop on a wooden desk with a white mug, a spoon, and a smartphone.
Room
Terrace/patio
Lobby

11. Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
Deerwood, 7.8 km from Mayo Clinic Florida
United States
Camoya
฿4,070
฿4,619 total
includes taxes & fees
29 Oct - 30 Oct
Hyatt Studios Jacksonville/St Johns Town Center
A modern bar area with a central island, multiple seating options, and a variety of bottles displayed on shelves.
An outdoor seating area with white furniture and a well-maintained lawn, surrounded by large windows and a modern building facade.
A modern hotel building with a flat facade, large windows, and a sign reading "ACHTEL JACKSONVILLE".
A modern bar area with seating, a bar counter, and a view of the city through large windows.

12. AC Hotel Jacksonville St Johns Town Center

AC Hotel Jacksonville St Johns Town Center
Southside, 8.1 km from Mayo Clinic Florida
United States
Emily
฿5,999
฿6,809 total
includes taxes & fees
17 Oct - 18 Oct
AC Hotel Jacksonville St Johns Town Center
An outdoor seating area with a fire feature, chairs, and a table.
A gym with treadmills, dumbbells, and exercise balls, overlooking a swimming pool.
A modern bar area with a counter, bar stools, and a television screen.
A modern hotel room with two beds, a flat-screen TV, a desk, and a large window with a view of a building.

13. Hotel Indigo Jacksonville-Deerwood Park by IHG

Hotel Indigo Jacksonville-Deerwood Park by IHG
Southside, 10.8 km from Mayo Clinic Florida
United States
Carol
฿4,089
฿4,641 total
includes taxes & fees
12 Nov - 13 Nov
Hotel Indigo Jacksonville-Deerwood Park by IHG
A pool with a waterfall feature, surrounded by large rock formations.
A beachside bar with a long counter, multiple chairs, and a view of the ocean.
An outdoor seating area with round tables and blue chairs, shaded by blue umbrellas with a logo, in front of a building with balconies and palm trees.
A beachfront hotel with multiple balconies, a sandy beach, and ocean views.

14. Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront
6.3 km from Mayo Clinic Florida
United States
Hope
฿5,384
฿6,111 total
includes taxes & fees
8 Nov - 9 Nov
Hampton Inn Jacksonville Beach/Oceanfront
A self-service beverage station with a refrigerated display and a coffee machine.
A modern hotel reception area with a curved wooden reception desk, a digital display, and a view of the lobby.
A modern lounge area with seating, tables, and hanging lights.
A hotel room with two beds, a desk, a chair, a TV, and a large window with a view.

15. Tru By Hilton Jacksonville St Johns Town Center

Tru By Hilton Jacksonville St Johns Town Center
Southside, 8.7 km from Mayo Clinic Florida
United States
Josephine
฿3,669
฿4,165 total
includes taxes & fees
1 Nov - 2 Nov
Tru By Hilton Jacksonville St Johns Town Center
A modern bar area with wooden accents, a variety of beverages, and seating arrangements.
A patio area with a stone fire pit, outdoor furniture, and a brick floor.
A modern hotel lobby with a sofa set, armchairs, a coffee table, and a patterned carpet.
A multi-story hotel with a prominent entrance, a parking lot, and well-maintained landscaping.

16. Courtyard by Marriott Jacksonville I-295/East Beltway

Courtyard by Marriott Jacksonville I-295/East Beltway
Arlington, 13.2 km from Mayo Clinic Florida
United States
Chloie Marie
฿3,243
฿3,680 total
includes taxes & fees
22 Oct - 23 Oct
Courtyard by Marriott Jacksonville I-295/East Beltway
An outdoor patio with seating, a fire pit, and string lights.
A multi-story hotel with a modern design, featuring a large number of windows and a flat roof.
A modern bar area with a counter, bar stools, and a television screen. There are round tables with chairs in the dining area.
A modern living room with a dining area, a flat-screen TV, and a bookshelf.

17. Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
Southside, 8.6 km from Mayo Clinic Florida
United States
Becky
฿4,263
฿4,839 total
includes taxes & fees
18 Oct - 19 Oct
Hyatt Place Jacksonville / St. Johns Town Center
A hotel room with two beds, a desk with a computer, a chair, and a colorful carpet.
A coffee station with two espresso machines and a display of coffee products.
A hotel room with a microwave, coffee maker, and refrigerator on the counter. There is a door with a sign and a towel rack visible.
A pier extending into the ocean at sunset with birds flying above.

18. Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
4.6 km from Mayo Clinic Florida
United States
Bobby
฿3,821
฿4,337 total
includes taxes & fees
25 Oct - 26 Oct
Holiday Inn Express Jacksonville Beach by IHG
A spacious lobby with a reception desk, seating area, and large windows.
A bar area with wooden chairs, a round table, and a brick wall.
An indoor dining area with tables and chairs, a ceiling fan, and a view of the outdoors.
A multi-story hotel with a central entrance, large windows, and a well-lit facade.

19. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
8.5 km from Mayo Clinic Florida
United States
Madison
฿3,960
฿4,416 total
includes taxes & fees
11 Nov - 12 Nov
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
A hotel room with a dining area, two beds, a TV, and a kitchenette.
A hotel room with a dining area featuring a table, chairs, a television, a microwave, and a coffee maker.
A compact kitchen with dark cabinetry, a built-in refrigerator, a dining table with a chair, and a wall-mounted lamp.
Two people near a grill with a plate of food and a bottle.

20. Candlewood Suites Jacksonville - Mayport by IHG

Candlewood Suites Jacksonville - Mayport by IHG
9.2 km from Mayo Clinic Florida
United States
Joe
฿3,519
฿3,994 total
includes taxes & fees
25 Oct - 26 Oct
Candlewood Suites Jacksonville - Mayport by IHG
View all properties

Compare popular hotels close to Mayo Clinic Florida

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
9.4
Exceptional
608 reviews
View
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
TownePlace Suites by Marriott Jacksonville East
9.2
Wonderful
664 reviews
View
A modern restaurant with a bar area, wooden ceiling, and large windows.
Hilton Jacksonville at Mayo Clinic near Beaches
9.2
Wonderful
375 reviews
View
A lobby with a reception desk, seating area, and a staircase.
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
9.0
Wonderful
1,006 reviews
View
A hotel lobby with a bar area, seating arrangements, and a reception desk.
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
9.0
Wonderful
1,001 reviews
View

Top Mayo Clinic Florida Hotel Reviews

TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East

8/10 Good
"."
Shaneen 1-night trip
Posted 4 hours ago
TownePlace Suites by Marriott Jacksonville East
Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

10/10 Excellent
"The number one thing about our stay was the staff. John checked is in and everyone we interacted with was positive and helpful. They were generous with coffee and towels. When a little maintenance was needed, they were two quick to reply, the problem wasn't significant enough and we needed to rest. A wild party interrupted next door to us and I asked when quiet time started and at that time (10pm) the wild noise stopped. The TV was good, the balcony better, and the exercise room more than adequate. We did not eat on property but service is available. Thank you Margaritaville."
Patrick 4-night trip
Posted 15 hours ago
Margaritaville Jacksonville Beach
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

10/10 Excellent
"The Evening/Night staff was exceptional"
William 4-night trip
Posted 16 hours ago
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Frequently asked questions

What's the area like around Mayo Clinic Florida?
Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 44 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay close to Mayo Clinic Florida?
Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.
How many hotels are there near Mayo Clinic Florida?
Expedia has 44 hotels and other accommodation options within a mile from Mayo Clinic Florida.
If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.
What can I see and do near Mayo Clinic Florida?
You can catch a show at SeaWalk Pavillion, Players by the Sea and Blue Jay Listening Room. Spend some time exploring the the natural beauty of Huguenot Park, Oceanfront Park and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.