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Residence Inn By Marriott Jacksonville - Mayo Clinic Area

3.0 star property
Friendly staff welcome travelers to this Jacksonville retreat where they can soak up sunshine at the poolside bar or handle business in modern coworking spaces

Choose dates to view prices

Located in the heart of Jacksonville, Residence Inn By Marriott Jacksonville - Mayo Clinic Area offers warm hospitality with a free breakfast buffet. Guests can relax by the poolside bar, explore the garden, or use the coworking spaces and concierge services.

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Pet-friendly
  • Parking included
  • Free Wi-Fi
  • Air-conditioning
The current price is ฿5,152
฿5,847 total
includes taxes & fees
20 Mar - 21 Mar

Room options

Available filters for rooms
Showing 10 of 10 rooms

View all photos for Studio, 1 King Bed with Sofa bed, Corner

In-room safe, desk, laptop workspace, blackout curtains

Studio, 1 King Bed with Sofa bed, Corner

9.8 out of 10
Exceptional
(6 reviews)

Highlights

Separate dining area
Separate sitting area
Air conditioning
Heating
Connecting rooms available
Free rollaway/extra beds
Kitchen
Fridge
  • 50 sq m
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Studio Suite, 1 Bedroom, Corner

Studio Suite, 1 Bedroom, Corner | In-room safe, desk, laptop workspace, blackout curtains

Studio Suite, 1 Bedroom, Corner

10.0 out of 10
Exceptional
(3 reviews)

Highlights

Separate dining area
Separate sitting area
Air conditioning
Heating
Connecting rooms available
Kitchen
Fridge
Dishwasher
  • 60 sq m
  • 1 bedroom
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed

View all photos for Studio Suite, 1 King Bed with Sofa bed

Fridge, microwave, stovetop, dishwasher

Studio Suite, 1 King Bed with Sofa bed

9.6 out of 10
Exceptional
(85 reviews)

Highlights

Separate dining area
Separate sitting area
Air conditioning
Heating
Connecting rooms available
Free rollaway/extra beds
Kitchen
Fridge
  • 38 sq m
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Studio Suite, 1 Bedroom

Studio Suite, 1 Bedroom | Living room | 55-inch Smart TV with cable channels, TV, Netflix

Studio Suite, 1 Bedroom

9.8 out of 10
Exceptional
(17 reviews)

Highlights

Separate dining area
Separate sitting area
Air conditioning
Heating
Connecting rooms available
Kitchen
Fridge
Dishwasher
  • 52 sq m
  • 1 bedroom
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed

View all photos for Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Tub)

In-room safe, desk, laptop workspace, blackout curtains

Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Tub)

8.0 out of 10
Very good
(4 reviews)

Highlights

Separate dining area
Separate sitting area
Air conditioning
Heating
Connecting rooms available
Kitchen
Fridge
Dishwasher
  • 38 sq m
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Studio Suite, 1 King Bed with Sofa bed (Hearing Accessible)

In-room safe, desk, laptop workspace, blackout curtains

Studio Suite, 1 King Bed with Sofa bed (Hearing Accessible)

8.0 out of 10
Very good
(1 review)

Highlights

Separate dining area
Separate sitting area
Air conditioning
Heating
Connecting rooms available
Kitchen
Fridge
Dishwasher
  • 38 sq m
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Roll-In Shower)

In-room safe, desk, laptop workspace, blackout curtains

Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Roll-In Shower)

Highlights

Separate dining area
Separate sitting area
Air conditioning
Heating
Connecting rooms available
Kitchen
Fridge
Dishwasher
  • 38 sq m
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Studio Suite, 1 Bedroom (Hearing Accessible)

In-room safe, desk, laptop workspace, blackout curtains

Studio Suite, 1 Bedroom (Hearing Accessible)

8.0 out of 10
Very good
(1 review)

Highlights

Separate dining area
Separate sitting area
Air conditioning
Heating
Connecting rooms available
Kitchen
Fridge
Dishwasher
  • 52 sq m
  • 1 bedroom
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed

View all photos for Studio, 1 King Bed with Sofa bed, Corner (Hearing Accessible)

In-room safe, desk, laptop workspace, blackout curtains

Studio, 1 King Bed with Sofa bed, Corner (Hearing Accessible)

9.0 out of 10
Wonderful
(2 reviews)

Highlights

Separate dining area
Separate sitting area
Air conditioning
Heating
Connecting rooms available
Kitchen
Fridge
Dishwasher
  • 50 sq m
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Studio Suite, 1 Bedroom, Corner (Mobility/Hearing Access, Roll-In Shwr)

In-room safe, desk, laptop workspace, blackout curtains

Studio Suite, 1 Bedroom, Corner (Mobility/Hearing Access, Roll-In Shwr)

Highlights

Separate dining area
Separate sitting area
Air conditioning
Heating
Connecting rooms available
Kitchen
Fridge
Dishwasher
  • 60 sq m
  • 1 bedroom
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed

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About the area

Isle of Palms, a neighbourhood in Jacksonville, is home to Residence Inn By Marriott Jacksonville - Mayo Clinic Area. San Jose Episcopal Church and Ribault Monument are local landmarks, and some of the area's activities can be experienced at TPC Sawgrass and Harbor City Municipal Golf Course. Looking to enjoy an event or a game while in town? See what's happening at Jacksonville Beach Tennis Center or UNF Arena. Visit our Jacksonville travel guide
Map
4905 SAN PABLO ROAD SOUTH, Jacksonville, FL, 32224

What's nearby

  • Jacksonville_MayoClinicFlorida_6127706_04
    Mayo Clinic Florida
    17 min walk - 1.5 km
  • Jacksonville_UniversityofNorthFlorida_6127797_04
    University of North Florida
    6 min drive - 9.0 km
  • Jacksonville_StJohnsTownCenter_6127793_05
    St. Johns Town Center
    9 min drive - 12.3 km
  • Golf Course
    TPC Sawgrass
    12 min drive - 14.0 km
  • While attending the Florida Lighthouse Association's annual conference we visited two lighthouses on the Mayport Base. We beat the rain before heading back to the conference.
    Mayport Naval Station
    16 min drive - 17.9 km

Getting around

  • Jacksonville, FL (CRG-Jacksonville Executive at Craig)
    17 min drive

Restaurants

  • Culver’s
    4 min drive
  • Starbucks
    4 min drive
  • Circle K
    9 min walk
  • M Brothers at Mayo
    17 min walk
  • Starbucks
    3 min drive

About this property

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Hotel near St. Johns Town Center
A free breakfast buffet, a poolside bar and a free food/drink shopping service are just a few of the amenities provided at Residence Inn By Marriott Jacksonville - Mayo Clinic Area. In addition to a garden and dry cleaning/laundry services, guests can connect to free in-room WiFi.
Additional perks include:
  • An outdoor pool, along with sunloungers
  • Free self-parking
  • Express check-out, a ballroom and multilingual staff
  • Concierge services, smoke-free property and barbecues
  • Guest reviews say great things about the helpful staff
Room features
All 155 rooms boast comforts, such as laptop-compatible safes and laptop-friendly workspaces, in addition to perks, such as air conditioning and separate sitting areas. Guest reviews speak positively of the cleanliness rooms at the property.
Other conveniences in all rooms include:
  • Recycling and LED light bulbs
  • Bathrooms with baths or showers and free toiletries
  • 55-inch Smart TVs with Netflix, streaming services and premium channels
  • Separate sitting areas, separate dining areas and kitchens

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฿4,089 total
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Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transport

  • Free uncovered self parking on site
  • Limited on-site self parking
  • Wheelchair-accessible parking and van parking available

Food and drink

  • Free buffet breakfast available 6:30 AM to 9:00 AM on weekdays and 7:00 AM to 9:30 AM on weekends
  • A bar/lounge
  • A poolside bar
  • Coffee and tea in common areas

Things to do

  • 24-hour gym
  • Outdoor pool
  • TV in common areas

Family friendly

  • Grocery/convenience store
  • In-room kitchen
  • In-room microwave
  • In-room refrigerator
  • Laundry facilities
  • Outdoor pool
  • Separate in-room dining area

Conveniences

  • 24-hour front desk
  • Free newspapers in lobby
  • Grocery/convenience store
  • Laundry facilities
  • Luggage storage
  • Safe at front desk
  • Water dispenser

Guest services

  • Change of bedsheets (on request)
  • Concierge services
  • Dry cleaning/laundry service
  • Free grocery shopping service
  • Housekeeping (daily)
  • Multilingual staff
  • Wedding services

Business services

  • 2 meeting rooms
  • 2,678 square feet of conference space
  • 24-hour business centre
  • Computer station
  • Coworking space

Outdoors

  • Barbecue grill
  • Garden
  • Picnic area
  • Pool loungers

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Accessible bathtub
  • Assistive listening devices
  • Assistive listening devices in meeting rooms
  • Bathroom emergency pull cord
  • Braille/raised signage
  • Grab bar near toilet
  • Hand-held showerhead
  • Handrails in stairways
  • Height-adjustable showerhead
  • Lever door handles
  • Lift
  • Low-height bed
  • Low-height counter and sink
  • Low-height door lock
  • Low-height electrical sockets in bathroom
  • Low-height view port in door
  • Phone accessibility kit
  • Pool hoist on site
  • Raised toilet seat
  • Stair-free path to entrance
  • Vibrating pillow alarm
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessibility
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible business centre
  • Wheelchair-accessible concierge desk
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible path to lift
  • Wheelchair-accessible pool
  • Wheelchair-accessible public bathroom
  • Wheelchair-accessible registration desk
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible van parking
  • Wheelchair-width doorways

More

  • 1 building
  • 7 floors
  • At least 80% lighting from LEDs
  • Ballroom
  • Banquet hall
  • Biodegradable coffee stirrers available
  • Built in 2020
  • Communal living room
  • Comprehensive food waste policy
  • Comprehensive recycling policy
  • Double-glazed windows
  • Fireplace in lobby
  • No plastic coffee stirrers
  • Smoke-free property
  • Traditional architecture
  • Vegan dining options
  • Vegetarian breakfast available
  • Vegetarian dining options

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathtub or shower
  • Free toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Entertainment

  • 55-inch smart TV with premium cable channels
  • Netflix
  • Streaming services

Food and drink

  • Coffee/tea maker
  • Cookware, dishware, and utensils
  • Dishwasher
  • Hob
  • Kitchen
  • Microwave
  • Refrigerator
  • Separate dining area
  • Toaster

More

  • Air conditioning
  • Connecting rooms available
  • Desk
  • Energy-saving switches in guestrooms
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Laptop-compatible safe
  • LED lighting
  • Mobile key entry
  • Phone
  • Recycling
  • Separate sitting area
  • Water-efficient showers

Policies

Check-in

Check-in start time: 4:00 PM; check-in end time: 6:00 AM
Contactless check-in and check-out are available
Late check-in subject to availability
Minimum check-in age - 21

Check-out

Check-out before 11:00 AM
Contactless check-out
Express check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
If you are planning to arrive after 11:00 PM please contact the property in advance using the information on the booking confirmation
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets are allowed for an extra charge of USD 150 per accommodation, per stay
Service animals are welcome, and are exempt from fees
Welcoming dogs and cats only
2 total (up to 18 kg per pet)
Restrictions apply; for more information contact the property on the number on the booking confirmation

Children and extra beds

Children are welcome
Cots (infant beds) are not available

Payment types at the property

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Deposit: USD 125 per accommodation, per stay

We have included all charges provided to us by the property.

Optional extras

  • Pet fee: USD 150 per accommodation, per stay
  • Service animals are exempt from fees

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Cashless transactions are available
Safety features at this property include a carbon monoxide detector, a fire extinguisher, a smoke detector and window guards
This property affirms that it follows the cleaning and disinfection practices of Commitment to Clean (Marriott)

We should mention

Only registered guests are allowed in the guestrooms
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Property is also known as

Residence INN BY Marriott Jacksonville
Residence Inn by Marriott Jacksonville East
Residence Inn Jacksonville Mayo Clinic Area
Residence Inn By Marriott Jacksonville - Mayo Clinic Area Hotel

Frequently asked questions

Does Residence Inn By Marriott Jacksonville - Mayo Clinic Area have a pool?

Yes, this property has an outdoor pool.

How much does it cost to stay at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

As of 11 Mar 2026, prices found for a 1-night stay for 2 adults at Residence Inn By Marriott Jacksonville - Mayo Clinic Area on 20 Mar 2026 start from ฿5,152, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Is Residence Inn By Marriott Jacksonville - Mayo Clinic Area pet-friendly?

Yes, this property allows cats and dogs (limit 2 total) with a maximum weight of up to 18 kg per pet. There's a fee of USD 150 per accommodation, per stay. Service animals are exempt from fees. Some restrictions may apply, so please contact the property for more details.

How much is parking at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

Self-parking is free at this property.

What time is check-in at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

Check-in start time: 4:00 PM; check-in end time: 6:00 AM. Late check-in is available during limited hours.

What time is check-out at Residence Inn By Marriott Jacksonville - Mayo Clinic Area?

Checkout is at 11:00 AM.

Where is Residence Inn By Marriott Jacksonville - Mayo Clinic Area located?

Located in Isle of Palms, this hotel is 0.9 mi (1.5 km) from Mayo Clinic Florida and 1.7 mi (2.7 km) from Harbor City Municipal Golf Course. Windsor Commons Shopping Center and Windsor Parke Golf Club are also within 6 miles (10 km).

Can I cancel my reservation for free and receive a full refund?

Yes, this property offers free cancellation on selected room rates because flexibility matters! Please refer to the property cancellation policy on our site for more details about any exclusions or requirements.

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Reviews

Residence Inn By Marriott Jacksonville - Mayo Clinic Area Reviews

9.4

Exceptional

9.6

Cleanliness

9.0

Amenities

9.6

Staff & service

9.6

Property conditions & facilities
Rating 10 - Excellent. 371 out of 469 reviews
Rating 8 - Good. 68 out of 469 reviews
Rating 6 - Okay. 13 out of 469 reviews
Rating 4 - Poor. 13 out of 469 reviews
Rating 2 - Terrible. 4 out of 469 reviews

Reviews

10/10 Excellent

Stephen

Liked: Cleanliness, amenities, property conditions & facilities
Great room
Stayed 1 night in Feb 2026

8/10 Good

Kimberly

Liked: Cleanliness
Staff and amenities
Stayed 5 nights in Jan 2026

10/10 Excellent

Wayne

Liked: Cleanliness, amenities, property conditions & facilities
The staff was great at check in and the bar. Room was very clean, but the couch needed to be replaced.
Stayed 1 night in Jan 2026

10/10 Excellent

Kay

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Always comfortable, beautiful rooms, great beds, great service, spotless clean
Stayed 1 night in Oct 2025

10/10 Excellent

Joseph

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Clean, convenient to interstate, Mayo Hospital, 10 minutes from numerous restaurants and shopping. The staff was friendly.
Stayed 1 night in Dec 2025

10/10 Excellent

Carrie

Liked: Cleanliness, amenities, property conditions & facilities
The place was clean and staff was wonderful. Will be staying again!
Stayed 1 night in Jun 2025

10/10 Excellent

KENNETH

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Property was clean, fairly new, comfortable, and the staff was friendly and helpful.
Stayed 2 nights in Jul 2025

10/10 Excellent

Nadine

Liked: Cleanliness, amenities, property conditions & facilities
great stafff comfortable clean room and amenities
Stayed 2 nights in Jun 2025

10/10 Excellent

Kimberly

Liked: Cleanliness, amenities, property conditions & facilities
Yes room was clean!! We appreciate being able to add an additional nights stay, as we encountered an emergency overnight Stay at the hospital. Mayo Clinic patient.
Stayed 3 nights in Oct 2025

10/10 Excellent

Amit

Liked: Cleanliness, amenities, property conditions & facilities
We drove from WV and stopped after a long drive. The room was comfortable and check-in / checkout was efficient. Breakfast was good as well.
Stayed 2 nights in Jul 2025

10/10 Excellent

Patricia

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Great Stay!

This is a wonderful place to stay. It offers all of the services that you need. It is in a beautiful setting with great amenities.
Stayed 2 nights in Apr 2025

10/10 Excellent

Devon

Liked: Cleanliness, staff & service, property conditions & facilities
Absolutely enjoyed our stay. Room was really clean and very nice. Will definitely stay every time we come.
Stayed 1 night in Feb 2025

10/10 Excellent

SHERICE

Liked: Cleanliness, amenities, property conditions & facilities
Very nice. About 3.5 miles from the beach. Breakfast was amazing especially loved their coffee.
Stayed 2 nights in Jul 2025

10/10 Excellent

Craig

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Visiting Family

It was newer than expected facility and quite nice we had to swim in the pool easy in easy app great parking and the breakfast was exceptional we will be staying there again as we visit family in Jacksonville beach.
Stayed 2 nights in May 2025

10/10 Excellent

Stephen

Liked: Room comfort

Excellence in Hospitality

Mayo Clinic appointment; staff was professional in assisting with appointments vs hotel needs.
Stayed 1 night in Jul 2025

10/10 Excellent

DAWN

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Very nice property and staff
Stayed 1 night in Jun 2024

10/10 Excellent

Karen

Liked: Cleanliness, amenities, property conditions & facilities
Very convenient while visiting Mayo Jacksonville. Easy access from the highway and the morning breakfast was pretty good.
Stayed 2 nights in Dec 2024

10/10 Excellent

Pamela

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
The food, the environment, the staff, and quality was exceptional.
Stayed 2 nights in Sep 2024

10/10 Excellent

Joan

Liked: Cleanliness
Clean and friendly. Easy access to Mato and highway
Stayed 1 night in May 2025

10/10 Excellent

Mary Ellen

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Staff was very helpful and friendly. Mayo Clinic patients were made to feel welcome. We will stay again next trip to Mayo
Stayed 4 nights in Apr 2025

10/10 Excellent

Emmaruth

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
It’s very clean and roomy place . And it’s pretty quiet. Breakfast was very good and fresh. Could go back again and recommend to family and friends
Stayed 1 night in Apr 2025

10/10 Excellent

Roderick

Liked: Cleanliness, staff & service, property conditions & facilities
This is a great hotel, it’s very clean, new, and fresh. Will definitely stay there again.
Stayed 1 night in Jul 2024

10/10 Excellent

Helmuth

Liked: Cleanliness, staff & service, property conditions & facilities
We stayed there for 6 days. Our room was quiet, very clean, nice view to the woods. It was nice that they had a free shuttle to Mayo Clinic. The only problem was that one day we did’t had our room clean because the person in charge of doing it forgot. I have to go back to Mayo Clinic and my stay at the hotel was so good that I already made my reservation for the Residence Inn
Stayed 7 nights in Sep 2025

10/10 Excellent

Leslie

Loved how clean the hotel was and how close to Mayo Clinic
Stayed 6 nights in May 2024

10/10 Excellent

Samantha

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Family night out

The hotel was very nice. The rooms were clean, bed was comfortable, and the room was spacious. We would definitely stay here again.
Stayed 1 night in Jan 2025