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Check prices for these dates

Next weekend
29 May - 31 May
In two weeks
5 Jun - 7 Jun

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Our top choices for Matlacha Isles hotels

Room amenity

HomeTowne Studios by Red Roof Fort Myers

HomeTowne Studios by Red Roof Fort Myers
2.5 star property
21.7 km from Matlacha Isles
10.0 out of 10, Exceptional, (1 review)
"Clean room, pet friendly. My cat loved it! Very exceptional staff."
United States
Kaethe
The price is ฿2,054
฿2,290 total
includes taxes & fees
5 Jun - 6 Jun
HomeTowne Studios by Red Roof Fort Myers
3 restaurants; breakfast, lunch, dinner, and brunch served

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
23.2 km from Matlacha Isles
9.0 out of 10, Wonderful, (1,510 reviews)
"I really enjoyed my vacation here. I love the beachfront rooms."
United States
Christina
The price is ฿4,087
฿5,286 total
includes taxes & fees
26 May - 27 May
Lani Kai Beachfront Resort
Laptop workspace, blackout curtains, free WiFi, bed sheets

StudioRes by Marriott Fort Myers Airport

StudioRes by Marriott Fort Myers Airport
3.0 star property
29.5 km from Matlacha Isles
9.4 out of 10, Exceptional, (57 reviews)
"Excellent facility. Favorite place to stay"
United States
Daniel
The price is ฿2,466
฿2,750 total
includes taxes & fees
31 May - 1 Jun
StudioRes by Marriott Fort Myers Airport
Lobby

Comfort Suites Fort Myers East I-75

Comfort Suites Fort Myers East I-75
2.5 star property
24.8 km from Matlacha Isles
9.8 out of 10, Exceptional, (467 reviews)
"Great place to stay"
United States
Dennis
The price is ฿2,973
฿3,315 total
includes taxes & fees
14 Jun - 15 Jun
Comfort Suites Fort Myers East I-75
View from room

Pointe Estero Beach Resort

Pointe Estero Beach Resort
2.0 star property
28.6 km from Matlacha Isles
9.2 out of 10, Wonderful, (1,000 reviews)
"Love this place!!"
United States
Teneille
The price is ฿5,277
฿16,472 total
includes taxes & fees
31 May - 1 Jun
Pointe Estero Beach Resort
Exterior

The Bay Inn at Lani Kai

The Bay Inn at Lani Kai
3.0 star property
23.1 km from Matlacha Isles
7.6 out of 10, Good, (414 reviews)
"Great stay "
United States
Ashley Q.
The price is ฿3,516
฿4,647 total
includes taxes & fees
26 May - 27 May
The Bay Inn at Lani Kai
Exterior

Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina
4.0 star property
21.7 km from Matlacha Isles
9.4 out of 10, Exceptional, (1,369 reviews)
"Great stay!"
United States
John
The price is ฿8,792
฿11,952 total
includes taxes & fees
26 May - 27 May
Pink Shell Beach Resort and Marina
Sun deck

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
20.4 km from Matlacha Isles
8.8 out of 10, Excellent, (1,003 reviews)
"Amazing place to stay! "
United States
Kristen
The price is ฿2,959
฿3,299 total
includes taxes & fees
25 May - 26 May
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
Luxury Room | Bathroom | Towels, soap, shampoo, toilet paper

Park Motel

Park Motel
2.5 star property
Diplomat, 17.2 km from Matlacha Isles
9.2 out of 10, Wonderful, (46 reviews)
"Clean, quiet, very friendly and helpful staff, hot tub in room very relaxing."
United States
Kristeen
The price is ฿3,081
฿3,435 total
includes taxes & fees
5 Jun - 6 Jun
Park Motel
On the beach, sun-loungers, beach towels

Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
22.7 km from Matlacha Isles
9.2 out of 10, Wonderful, (1,914 reviews)
"This is the perfect place for a relaxing getaway!"
United States
Denise
The price is ฿8,135
฿9,887 total
includes taxes & fees
31 May - 1 Jun
Sanibel Island Beach Resort
Free daily full breakfast

Best Western Plus Beach Resort

Best Western Plus Beach Resort
2.5 star property
22.4 km from Matlacha Isles
9.4 out of 10, Exceptional, (1,001 reviews)
"Great hotel"
United States
Carol J
The price is ฿8,198
฿9,141 total
includes taxes & fees
10 Jun - 11 Jun
Best Western Plus Beach Resort
Exterior

American Inn Punta Gorda

American Inn Punta Gorda
2.5 star property
27.4 km from Matlacha Isles
7.6 out of 10, Good, (456 reviews)
"Located close to airport. Adequate for one night stay."
United States
Karen
The price is ฿2,282
฿2,556 total
includes taxes & fees
24 May - 25 May
American Inn Punta Gorda
Lobby

MainStay Suites Fort Myers East I-75

MainStay Suites Fort Myers East I-75
2.5 star property
24.7 km from Matlacha Isles
9.6 out of 10, Exceptional, (387 reviews)
"Great place to stay."
United States
Darrel
The price is ฿3,815
฿4,253 total
includes taxes & fees
31 May - 1 Jun
MainStay Suites Fort Myers East I-75
Deluxe Single Room | Living area | 55-inch Smart TV with cable channels, streaming services

The Anchor Inn

The Anchor Inn
2.0 star property
21.8 km from Matlacha Isles
9.8 out of 10, Exceptional, (38 reviews)
"We had a great time and would definitely stay there again!"
United States
William Edward
The price is ฿6,207
฿7,411 total
includes taxes & fees
7 Jun - 8 Jun
The Anchor Inn
Lobby

Extended Stay America Premier Suites - Fort Myers - Airport

Extended Stay America Premier Suites - Fort Myers - Airport
2.5 star property
23.6 km from Matlacha Isles
8.8 out of 10, Excellent, (992 reviews)
"very nice place to stay!"
United States
Natalia
The price is ฿1,940
฿2,163 total
includes taxes & fees
31 May - 1 Jun
Extended Stay America Premier Suites - Fort Myers - Airport
Floating Coconut Cottage Houseboat | Terrace/patio

Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
20.3 km from Matlacha Isles
8.6 out of 10, Excellent, (1,002 reviews)
"Nice and clean, friendly staff"
United States
Samuel
The price is ฿3,306
฿3,687 total
includes taxes & fees
25 May - 26 May
Latitude 26 Waterfront Resort & Marina
Exterior

Woodspring Suites Fort Myers - Cape Coral

Woodspring Suites Fort Myers - Cape Coral
2.5 star property
18.2 km from Matlacha Isles
7.6 out of 10, Good, (287 reviews)
"Staff was amazing and friendly. The mini kitchen was perfect for our short stay. Location was great. There really is nothing bad to say."
United States
Shari
The price is ฿2,576
฿2,872 total
includes taxes & fees
24 May - 25 May
Woodspring Suites Fort Myers - Cape Coral
On the beach, white sand, snorkelling, surfing

Shalimar Beach Resort

Shalimar Beach Resort
2.0 star property
24.4 km from Matlacha Isles
9.8 out of 10, Exceptional, (54 reviews)
"Lovely place to stay. Clean, quiet and right in the beach."
United States
Laura Elizabeth
The price is ฿11,379
฿12,687 total
includes taxes & fees
3 Jun - 4 Jun
Shalimar Beach Resort
1 King Bed Suite w/ Efficiency Non Smoking | Premium bedding, down duvets, desk, laptop workspace

Quality Inn Fort Myers Cape Coral

Quality Inn Fort Myers Cape Coral
2.0 star property
18.4 km from Matlacha Isles
7.6 out of 10, Good, (317 reviews)
"Clean room, nice breakfast and wonderful staff!"
United States
Christina
The price is ฿1,709
฿2,424 total
includes taxes & fees
29 May - 30 May
Quality Inn Fort Myers Cape Coral
Restaurant

Fairfield Inn & Suites by Marriott Cape Coral/North Fort Myers

Fairfield Inn & Suites by Marriott Cape Coral/North Fort Myers
3.0 star property
Hancock, 11.5 km from Matlacha Isles
9.4 out of 10, Exceptional, (803 reviews)
"Lovely place"
United States
Emily
The price is ฿3,575
฿3,986 total
includes taxes & fees
11 Jun - 12 Jun
Fairfield Inn & Suites by Marriott Cape Coral/North Fort Myers
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Matlacha Isles

Find the best Matlacha Isles areas for the activities you enjoy most.
Sunset on Fort Myers Beach

Pelican

While visiting Pelican, you might make a stop by sights like Tarpon Point and Chabad Jewish Center.

Aerial Drone View of Bay in Cape Coral, Florida with Mangroves and Real Estate in the Foreground and the Caloosahatchee River in the Background

Caloosahatchee

If you're spending some time in Caloosahatchee, Cape Coral Yacht Club Beach and Dolphin Marina are top sights worth seeing.

Colorfull sunset on Pine Island, Florida

Yacht Club

While Yacht Club isn't home to many top sights, Cape Coral Yacht Club Beach and Dolphin Marina are some notable places to visit nearby.

Fort Myers Beach

Hancock

While visiting Hancock, you might make a stop by sights like Four Mile Cove Ecological Preserve and Sun Splash Water Park.

This is the morning view of Pine Island Sound. Its pier juts out from the left side with wooden pylons standing up out of the water near the shore.

Burnt Store

When in Burnt Store, you can plan a visit to Burnt Store Marina and Royal Tee Golf Club, some noteworthy sights in the nearby area.

Top Matlacha Isles Hotel Reviews

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

10/10 Excellent
"Fantastic"
Artemi 2-night trip
Posted 1 hour ago
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

Frequently asked questions

What is Matlacha Isles like?
Travellers will be sure to find plenty to entertain them in Cape Coral's Matlacha Isles neighbourhood.
How many hotels will I be able to find in the Matlacha Isles area?
When you want to put your feet up after a day of exploring the sights in Cape Coral, you can choose from 17 Expedia hotels and other accommodation options in Matlacha Isles.
If I need to cancel my hotel reservation in Matlacha Isles, will I receive a refund?
Yes, the majority of room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and get a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to get the best deals in Matlacha Isles.
What are the top things to see and do in Matlacha Isles?
A few places to visit in the area around Matlacha Isles include Griffen American Center for Haitian Art, Lovegrove Gallery & Gardens and Royal Tee Golf Club. While you're out sightseeing in Cape Coral, make sure that you visit other sights such as Little Dead Key or Big Dead Key.