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Our top choices for Matlacha Isles hotels

Seahorse Cottages on Sanibel - Adults Only

Seahorse Cottages on Sanibel - Adults Only
3.0 star property
21.2 km from Matlacha Isles
9.6 out of 10, Exceptional, (82 reviews)
"The Room was very clean and convenient with access to the beach and a nice ice cream/coffee shop."
United States
Kreg A.
The price is ฿6,261
฿6,981 total
includes taxes & fees
25 Jan - 26 Jan
Seahorse Cottages on Sanibel - Adults Only

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
23.2 km from Matlacha Isles
9.0 out of 10, Wonderful, (1,148 reviews)
"The breakfast was good "
United States
Ileana
The price is ฿7,016
฿8,521 total
includes taxes & fees
27 Jan - 28 Jan
Lani Kai Beachfront Resort

Baymont by Wyndham Punta Gorda/Port Charlotte

Baymont by Wyndham Punta Gorda/Port Charlotte
2.5 star property
28.9 km from Matlacha Isles
8.4 out of 10, Very good, (1,167 reviews)
"The room was excellent and the staff were very friendly "
United States
Ronnie
The price is ฿3,635
฿4,071 total
includes taxes & fees
25 Jan - 26 Jan
Baymont by Wyndham Punta Gorda/Port Charlotte

Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park

Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park
2.0 star property
28 km from Matlacha Isles
8.0 out of 10, Very good, (1,551 reviews)
"Great little hotel. Rooms and common areas look like they were recently renovated, everything was very clean and the staff was great. Thanks for the excellent stay."
Canada
Geoffrey
The price is ฿2,789
฿3,110 total
includes taxes & fees
25 Jan - 26 Jan
Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park

Comfort Inn & Suites Fort Myers Airport

Comfort Inn & Suites Fort Myers Airport
2.5 star property
27.9 km from Matlacha Isles
8.8 out of 10, Excellent, (1,116 reviews)
"Comfortable rooms and beds, good breakfast and easy access to baseball parks."
United States
Javier
The price is ฿3,353
฿3,738 total
includes taxes & fees
25 Jan - 26 Jan
Comfort Inn & Suites Fort Myers Airport

Woodspring Suites Fort Myers - Cape Coral

Woodspring Suites Fort Myers - Cape Coral
2.5 star property
18.2 km from Matlacha Isles
7.2 out of 10, Good, (168 reviews)
"The service at the front desk was exceptional, the new manager is doing an amazing job!!"
United States
Sandro
The price is ฿2,786
฿3,107 total
includes taxes & fees
24 Jan - 25 Jan
Woodspring Suites Fort Myers - Cape Coral

Comfort Suites Fort Myers East I-75

Comfort Suites Fort Myers East I-75
2.5 star property
24.8 km from Matlacha Isles
9.6 out of 10, Exceptional, (386 reviews)
"Very nice receptionist, and the room is great! "
United States
Dawn
The price is ฿4,231
฿4,718 total
includes taxes & fees
1 Feb - 2 Feb
Comfort Suites Fort Myers East I-75

Quality Inn Fort Myers Cape Coral

Quality Inn Fort Myers Cape Coral
2.0 star property
18.4 km from Matlacha Isles
7.6 out of 10, Good, (215 reviews)
"Clean room and staff was excellent "
Canada
SURINDER
The price is ฿2,634
฿3,406 total
includes taxes & fees
25 Jan - 26 Jan
Quality Inn Fort Myers Cape Coral

Hampton Inn & Suites Fort Myers - Colonial Blvd

Hampton Inn & Suites Fort Myers - Colonial Blvd
2.5 star property
21 km from Matlacha Isles
9.4 out of 10, Exceptional, (1,000 reviews)
"Great place to stay, will be back!"
United States
Douglas
The price is ฿4,492
฿5,009 total
includes taxes & fees
1 Feb - 2 Feb
Hampton Inn & Suites Fort Myers - Colonial Blvd

Best Western Fort Myers Inn & Suites

Best Western Fort Myers Inn & Suites
2.5 star property
20.8 km from Matlacha Isles
8.8 out of 10, Excellent, (1,132 reviews)
"Clean room, old property and fresh, varied options for breakfast"
Canada
supriya
The price is ฿3,297
฿3,676 total
includes taxes & fees
25 Jan - 26 Jan
Best Western Fort Myers Inn & Suites

Knights Inn Punta Gorda

Knights Inn Punta Gorda
1.5 star property
28.5 km from Matlacha Isles
7.2 out of 10, Good, (956 reviews)
"Yes"
United States
John
The price is ฿2,850
฿3,192 total
includes taxes & fees
24 Jan - 25 Jan
Knights Inn Punta Gorda

Holiday Inn Express & Suites Fort Myers Airport by IHG

Holiday Inn Express & Suites Fort Myers Airport by IHG
2.5 star property
29 km from Matlacha Isles
9.6 out of 10, Exceptional, (1,003 reviews)
"The rooms were clean and coffee was great!"
United States
Kyle
The price is ฿4,508
฿5,026 total
includes taxes & fees
25 Jan - 26 Jan
Holiday Inn Express & Suites Fort Myers Airport by IHG

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
20.4 km from Matlacha Isles
8.8 out of 10, Excellent, (1,000 reviews)
"Great stay"
United States
Andrea
The price is ฿4,931
฿5,498 total
includes taxes & fees
26 Jan - 27 Jan
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
22.7 km from Matlacha Isles
9.2 out of 10, Wonderful, (1,552 reviews)
"Sweet staff, amazing beach access, pool, restaurant on site. Good value and great stay!"
United States
Freda
The price is ฿8,734
฿10,521 total
includes taxes & fees
25 Jan - 26 Jan
Sanibel Island Beach Resort

Comfort Inn Fort Myers Northeast

Comfort Inn Fort Myers Northeast
2.5 star property
25.8 km from Matlacha Isles
7.8 out of 10, Good, (683 reviews)
"Nice stay"
United States
Carole
The price is ฿3,852
฿4,295 total
includes taxes & fees
25 Jan - 26 Jan
Comfort Inn Fort Myers Northeast

Quality Suites Fort Myers I-75

Quality Suites Fort Myers I-75
2.5 star property
27.1 km from Matlacha Isles
8.2 out of 10, Very good, (1,002 reviews)
"Room was clean, front desk pleasant."
United States
Carol
The price is ฿3,176
฿3,541 total
includes taxes & fees
25 Jan - 26 Jan
Quality Suites Fort Myers I-75

Travelodge by Wyndham Fort Myers Airport

Travelodge by Wyndham Fort Myers Airport
2.0 star property
27.1 km from Matlacha Isles
7.4 out of 10, Good, (1,003 reviews)
"Was "
United States
Brian
The price is ฿2,085
฿2,325 total
includes taxes & fees
25 Jan - 26 Jan
Travelodge by Wyndham Fort Myers Airport

Hyatt Place Fort Myers/at The Forum

Hyatt Place Fort Myers/at The Forum
3.0 star property
24.7 km from Matlacha Isles
8.2 out of 10, Very good, (1,002 reviews)
"The check in staff was wonderful."
United States
Cynthia
The price is ฿4,508
฿5,026 total
includes taxes & fees
25 Jan - 26 Jan
Hyatt Place Fort Myers/at The Forum

Courtyard by Marriott Fort Myers Cape Coral

Courtyard by Marriott Fort Myers Cape Coral
3.0 star property
20.4 km from Matlacha Isles
8.2 out of 10, Very good, (1,000 reviews)
"Great service, would stay again "
United States
Matthew
The price is ฿3,916
฿4,367 total
includes taxes & fees
1 Feb - 2 Feb
Courtyard by Marriott Fort Myers Cape Coral

Boca Grande Hotel

Boca Grande Hotel
2.5 star property
28.8 km from Matlacha Isles
8.8 out of 10, Excellent, (592 reviews)
"The staff are exceptional. Victoria was so helpful and Margarita went above and beyond. I am a single woman travelling alone and felt very well taken care of. I would highly recommend this property."
United States
Diana
The price is ฿4,852
฿5,435 total
includes taxes & fees
26 Jan - 27 Jan
Boca Grande Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Matlacha Isles

Find the best Matlacha Isles areas for the activities you enjoy most.

Pelican

While visiting Pelican, you might make a stop by sights like Tarpon Point and Chabad Jewish Center.

Caloosahatchee

If you're spending some time in Caloosahatchee, Cape Coral Yacht Club Beach and Dolphin Marina are top sights worth seeing.

Yacht Club

While Yacht Club isn't home to many top sights, Cape Coral Yacht Club Beach and Dolphin Marina are some notable places to visit nearby.

Mariner

While visiting Mariner, you might make a stop by sights like Mike Greenwell's Bat-A-Ball & Family Fun Park and Yucca Pens Unit State Wildlife Management Area.

Hancock

While visiting Hancock, you might make a stop by sights like Four Mile Cove Ecological Preserve and Pine Island Shopping Center.

Top Matlacha Isles Hotel Reviews

Frequently asked questions

What is Matlacha Isles like?
Travellers will be sure to find plenty to entertain them in Cape Coral's Matlacha Isles neighbourhood.
How many hotels will I be able to find in the Matlacha Isles area?
When you want to put your feet up after a day of exploring the sights in Cape Coral, you can choose from 17 Expedia hotels and other accommodation options in Matlacha Isles.
If I need to cancel my hotel reservation in Matlacha Isles, will I receive a refund?
Yes, the majority of room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and get a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to get the best deals in Matlacha Isles.
What are the top things to see and do in Matlacha Isles?
A few places to visit in the area around Matlacha Isles include Griffen American Center for Haitian Art, Lovegrove Gallery & Gardens and Royal Tee Golf Club. While you're out sightseeing in Cape Coral, make sure that you visit other sights such as Little Dead Key or Big Dead Key.