What is Manatee Bay like?

You'll be sure to have fun exploring Saint James City's Manatee Bay neighbourhood.

How many hotels can I expect to find in Manatee Bay?

When you want to find places to stay in Saint James City, start by booking one of Expedia's 5 hotels and other accommodation options in Manatee Bay.

If I need to cancel my hotel reservation in Manatee Bay, will I receive a refund?

Yes, you'll find most hotel bookings are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best deals in Manatee Bay.

The Best Hotels in Manatee Bay, Saint James City - 2026 Updated Prices

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Our top choices for Manatee Bay hotels

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a window with curtains.

1. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

13.9 km from Manatee Bay

john

฿3,723 total

includes taxes & fees

30 Sept - 1 Oct

A modern dining area with a central island, multiple tables, and chairs.

2. Fairfield Inn & Suites by Marriott Cape Coral/North Fort Myers

20.1 km from Manatee Bay

Annette

฿4,042 total

includes taxes & fees

28 Sept - 29 Sept

An outdoor patio with wicker furniture, a fire feature, and string lights.

3. Hilton Garden Inn Ft Myers

19.8 km from Manatee Bay

Hoyle

฿3,246 total

includes taxes & fees

27 Sept - 28 Sept

A waterfront hotel with multiple buildings, a dock, and a calm body of water reflecting the structures.

4. Marriott Sanibel Harbour Resort & Spa

8.9 km from Manatee Bay

Charles

฿9,478 total

includes taxes & fees

18 Oct - 19 Oct

A spacious dining area with multiple tables and chairs, large windows, and a modern chandelier.

5. Residence Inn by Marriott Fort Myers Sanibel

11.8 km from Manatee Bay

jennifer

฿3,201 total

includes taxes & fees

27 Sept - 28 Sept

A modern hotel lobby with a seating area, a reception desk, and a dining area.

6. Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

12.4 km from Manatee Bay

Taylor

฿3,417 total

includes taxes & fees

11 Oct - 12 Oct

A balcony with a table and chairs, large windows, and a view of the sea.

7. The Westin Cape Coral Resort At Marina Village

8.3 km from Manatee Bay

Eric

฿6,952 total

includes taxes & fees

25 Oct - 26 Oct

A hotel pool area with multiple lounge chairs and umbrellas, surrounded by a fence and palm trees.

8. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

12.4 km from Manatee Bay

Jorge

฿2,816 total

includes taxes & fees

28 Sept - 29 Sept

A hotel with a modern design, featuring a prominent 'Best Western' sign, multiple parking spaces, and palm trees.

9. Best Western Fort Myers Inn & Suites

24.3 km from Manatee Bay

William

฿2,412 total

includes taxes & fees

27 Sept - 28 Sept

A balcony with a pool view, a table, and chairs.

10. OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

14.8 km from Manatee Bay

Roni

฿1,996 total

includes taxes & fees

30 Sept - 1 Oct

A Holiday Inn Express building with a modern design, featuring a flat facade and a covered entrance area.

11. Holiday Inn Express & Suites Fort Myers Airport by IHG

29.4 km from Manatee Bay

Brian

฿4,393 total

includes taxes & fees

30 Sept - 1 Oct

12. Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

20.8 km from Manatee Bay

Dianne

฿3,313 total

includes taxes & fees

27 Sept - 28 Sept

A turquoise building with a red door, surrounded by potted plants and flowers.

13. Angler's Inn

9.9 km from Manatee Bay

Paul

฿6,143 total

includes taxes & fees

28 Sept - 29 Sept

A beach with a variety of seashells and pebbles.

14. Sanibel Island Beach Resort

12 km from Manatee Bay

Jill

฿7,594 total

includes taxes & fees

4 Oct - 5 Oct

A hotel room with a bed, a desk, a chair, and a small table.

15. SpringHill Suites by Marriott Fort Myers Airport

28.2 km from Manatee Bay

Michael

฿4,058 total

includes taxes & fees

27 Sept - 28 Sept

A hotel with a covered entrance, palm trees, and a well-maintained garden.

16. Homewood Suites by Hilton - Fort Myers

21.3 km from Manatee Bay

Iris

฿4,121 total

includes taxes & fees

11 Oct - 12 Oct

A spacious lobby with a high ceiling, a seating area with a sofa and chairs, a small round table, and a decorative wall with artwork.

17. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

15.1 km from Manatee Bay

Robert

฿3,289 total

includes taxes & fees

28 Sept - 29 Sept

A row of turquoise Adirondack chairs with umbrellas, a wooden deck, and a marina in the background.

18. Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

14.5 km from Manatee Bay

Ana

฿3,090 total

includes taxes & fees

8 Oct - 9 Oct

A balcony with a wooden table and chairs, a hanging chair, and a view of palm trees and a pool.

19. Off the Charts Inn & Out Island Resort

4 km from Manatee Bay

Lisa

฿6,128 total

includes taxes & fees

29 Sept - 30 Sept

A hotel room with a bed, desk, chair, and a balcony with a view of the sea.

20. Best Western Fort Myers Waterfront

23.7 km from Manatee Bay

Adrian

฿3,449 total

includes taxes & fees

27 Sept - 28 Sept

View all properties

Top Manatee Bay Hotel Reviews

Lani Kai Beachfront Resort

10/10 Excellent

"We have been to this resort 3 times now and absolutely love it! The best part is all the amenities offered right there on the property. Resteraunts are all fabulous. Shops and other things were not all open all the time, as we were there during off season. Beach chair rentals available at a discounted rate for guests help the budget. The rooms have a beautiful decor and are very comfortable for the most part. (We had a very firm bed this time that could have used a mattress topper to make it more comfy) I am pretty sure we will go back a 4th time."

Sanibel Island Beach Resort

10/10 Excellent

"Our room was clean and tidy when we arrived and service came every other day for cleaning and linen change, etc. The staff was cordial and helpful every step of the way. The on-site restaurant was very good, particularly their grilled mahi-mahi and their onion rings! Other items on the menu were equally as good if not better than a couple of the local establishments. Our parking was convenient to our room, and our room was just a few steps from the pool and the beach. Our stay was a full week that, unfortunately, flew by way too fast!"