Lodging Image

Search Hotels in Main Street Fort Pierce, Fort Pierce

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Main Street Fort Pierce hotels

A hotel lobby with a large reception desk, multiple seating areas, and a patterned carpet.

1. Fairfield Inn & Suites by Marriott Fort Pierce

Fairfield Inn & Suites by Marriott Fort Pierce
3.0 star property
7.7 km from Main Street Fort Pierce
8.8 out of 10, Excellent, (1,003 reviews)
"Plenty of parking and cozy room."
United States
Katherine
The price is ฿3,105
฿3,478 total
includes taxes & fees
22 Oct - 23 Oct
Fairfield Inn & Suites by Marriott Fort Pierce
Exterior

2. Hampton Inn & Suites Ft. Pierce

Hampton Inn & Suites Ft. Pierce
2.5 star property
7.9 km from Main Street Fort Pierce
9.2 out of 10, Wonderful, (1,001 reviews)
"My weekend stay was a 10/10.I will definitely book my next stay here"
United States
Angela
The price is ฿3,248
฿3,637 total
includes taxes & fees
1 Nov - 2 Nov
Hampton Inn & Suites Ft. Pierce
A modern reception area with a long corridor, a reception desk, and a seating area with tables and chairs.

3. Holiday Inn Express Hotel & Suites Fort Pierce West by IHG

Holiday Inn Express Hotel & Suites Fort Pierce West by IHG
2.5 star property
8.3 km from Main Street Fort Pierce
9.0 out of 10, Wonderful, (902 reviews)
"I would definitely stay at this hotel again"
United States
Rodney
The price is ฿3,284
฿3,679 total
includes taxes & fees
15 Nov - 16 Nov
Holiday Inn Express Hotel & Suites Fort Pierce West by IHG
An outdoor seating area with fire feature, stone walls, and a view into the building.

4. Home2 Suites by Hilton Ft. Pierce I-95

Home2 Suites by Hilton Ft. Pierce I-95
3.0 star property
7.8 km from Main Street Fort Pierce
9.4 out of 10, Exceptional, (275 reviews)
"Nice little breakfast...very clean and easy check in and check out..."
United States
JERRY
The price is ฿3,960
฿4,435 total
includes taxes & fees
30 Oct - 31 Oct
Home2 Suites by Hilton Ft. Pierce I-95
A pool area with lounge chairs and a hot tub, surrounded by palm trees and a view of the ocean.

5. Hutchinson Island Hotel

Hutchinson Island Hotel
2.5 star property
3.1 km from Main Street Fort Pierce
8.2 out of 10, Very good, (1,374 reviews)
"Clean room nice staff and awesome view!! Will be staying there again soon!"
United States
Lana
The price is ฿3,675
฿4,763 total
includes taxes & fees
18 Oct - 19 Oct
Hutchinson Island Hotel
A spacious living area with a grey sofa, a blue sofa, and a wooden accent wall with a flat-screen TV.

6. La Quinta Inn & Suites by Wyndham Ft. Pierce

La Quinta Inn & Suites by Wyndham Ft. Pierce
3.0 star property
7.9 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,004 reviews)
"Very clean friendly staff good breakfast"
United States
riad
The price is ฿2,949
฿3,303 total
includes taxes & fees
25 Oct - 26 Oct
La Quinta Inn & Suites by Wyndham Ft. Pierce
A hotel entrance with a welcome sign, a black mat, and two potted plants.

7. At Home Inn

At Home Inn
2.5 star property
8.2 km from Main Street Fort Pierce
8.0 out of 10, Very good, (1,337 reviews)
"Room was clean. Staff was very helpful respectful and breakfast was sufficient"
United States
Ronald
The price is ฿1,917
฿2,148 total
includes taxes & fees
16 Nov - 17 Nov
At Home Inn
A hotel lobby with a reception desk, seating area, and a hallway leading to other rooms.

8. Days Inn & Suites by Wyndham Fort Pierce I-95

Days Inn & Suites by Wyndham Fort Pierce I-95
2.5 star property
7.8 km from Main Street Fort Pierce
7.4 out of 10, Good, (1,000 reviews)
"The staff was excellent"
United States
Carlton
The price is ฿1,980
฿2,218 total
includes taxes & fees
1 Nov - 2 Nov
Days Inn & Suites by Wyndham Fort Pierce I-95
A hotel room with a bed, a sofa, and a small table. There are framed pictures on the wall.

9. Comfort Suites Fort Pierce I-95

Comfort Suites Fort Pierce I-95
2.5 star property
7.7 km from Main Street Fort Pierce
7.8 out of 10, Good, (971 reviews)
"Clean rooms, friendly staff"
United States
Marina
The price is ฿2,787
฿3,122 total
includes taxes & fees
8 Nov - 9 Nov
Comfort Suites Fort Pierce I-95
A hotel lobby with a reception desk, a chandelier, a clock, and a sofa.

10. Sleep Inn Fort Pierce I-95

Sleep Inn Fort Pierce I-95
2.5 star property
7.9 km from Main Street Fort Pierce
7.6 out of 10, Good, (920 reviews)
"Staff was very friendly and rooms were clean"
United States
Charity
The price is ฿2,547
฿2,852 total
includes taxes & fees
1 Nov - 2 Nov
Sleep Inn Fort Pierce I-95
A hotel room with two beds, a television, a ceiling fan, and a view of the beach.

11. The Royal Inn Beach Hotel Hutchinson Island

The Royal Inn Beach Hotel Hutchinson Island
2.5 star property
3.8 km from Main Street Fort Pierce
7.2 out of 10, Good, (1,003 reviews)
"My go-to hotel when I need a place to get away!"
United States
Taylor
The price is ฿3,167
฿4,085 total
includes taxes & fees
18 Oct - 19 Oct
The Royal Inn Beach Hotel Hutchinson Island
A gym with treadmills, elliptical machines, and a red exercise ball.

12. Hampton Inn & Suites Port St. Lucie, West

Hampton Inn & Suites Port St. Lucie, West
2.5 star property
17.4 km from Main Street Fort Pierce
9.0 out of 10, Wonderful, (1,001 reviews)
"Very Helpful and Friendly staff, our room was super clean, and breakfast was great!"
United States
Ahim
The price is ฿3,248
฿3,637 total
includes taxes & fees
1 Nov - 2 Nov
Hampton Inn & Suites Port St. Lucie, West
A multi-story hotel with a modern design, featuring a prominent sign for 'Springhill Suites Marriott'.

13. SpringHill Suites Port St. Lucie

SpringHill Suites Port St. Lucie
3.0 star property
17.2 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,002 reviews)
"Loved our stay, great staff."
United States
Amy
The price is ฿3,439
฿3,851 total
includes taxes & fees
23 Oct - 24 Oct
SpringHill Suites Port St. Lucie
A Holiday Inn Express & Suites hotel with a modern design, featuring a prominent entrance, well-maintained landscaping, and a clear view of the sky.

14. Holiday Inn Express & Suites Port St. Lucie West by IHG

Holiday Inn Express & Suites Port St. Lucie West by IHG
2.5 star property
17.1 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,003 reviews)
"Great stay"
United States
AEON
The price is ฿3,687
฿4,129 total
includes taxes & fees
25 Oct - 26 Oct
Holiday Inn Express & Suites Port St. Lucie West by IHG
A modern living room with a fireplace, a dining area with bar stools, and a large TV mounted on the wall.

15. Hampton Inn & Suites Vero Beach Downtown

Hampton Inn & Suites Vero Beach Downtown
2.5 star property
22.1 km from Main Street Fort Pierce
9.2 out of 10, Wonderful, (1,000 reviews)
"Easy access and secure parking"
United States
Cameron
The price is ฿4,370
฿4,894 total
includes taxes & fees
1 Nov - 2 Nov
Hampton Inn & Suites Vero Beach Downtown
A clear blue swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a gazebo.

16. Best Western Port St. Lucie

Best Western Port St. Lucie
2.5 star property
14 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,005 reviews)
"Good place for a short stay"
United States
BRIAN
The price is ฿3,016
฿3,378 total
includes taxes & fees
1 Nov - 2 Nov
Best Western Port St. Lucie
A spacious lobby with a stone fireplace, comfortable seating, and a bar area.

17. Staybridge Suites Vero Beach by IHG

Staybridge Suites Vero Beach by IHG
3.0 star property
24.1 km from Main Street Fort Pierce
9.6 out of 10, Exceptional, (722 reviews)
"Perfect stay"
United States
Michelle
The price is ฿4,156
฿4,655 total
includes taxes & fees
1 Nov - 2 Nov
Staybridge Suites Vero Beach by IHG
A restaurant interior with a bar area, wooden flooring, and multiple seating arrangements.

18. Days Inn & Suites by Wyndham Fort Pierce Midtown

Days Inn & Suites by Wyndham Fort Pierce Midtown
2.0 star property
4.5 km from Main Street Fort Pierce
7.0 out of 10, Good, (1,000 reviews)
"Good value"
United States
Cynthia
The price is ฿2,194
฿2,457 total
includes taxes & fees
19 Oct - 20 Oct
Days Inn & Suites by Wyndham Fort Pierce Midtown
An outdoor patio area with a fire pit, red and black wicker furniture, and string lights.

19. Residence Inn by Marriott Port St. Lucie

Residence Inn by Marriott Port St. Lucie
3.0 star property
17.8 km from Main Street Fort Pierce
9.0 out of 10, Wonderful, (1,002 reviews)
"Great place to stay"
United States
Eduardo
The price is ฿3,687
฿4,129 total
includes taxes & fees
25 Oct - 26 Oct
Residence Inn by Marriott Port St. Lucie
A modern bar area with wooden tables and blue chairs, featuring black pendant lights and a large abstract mural on the wall.

20. TownePlace Suites by Marriott Port St. Lucie I-95

TownePlace Suites by Marriott Port St. Lucie I-95
3.0 star property
21.9 km from Main Street Fort Pierce
9.4 out of 10, Exceptional, (1,002 reviews)
"Location was convenient , staff was nice , hotel was clean"
United States
Demonica
The price is ฿3,881
฿4,346 total
includes taxes & fees
16 Nov - 17 Nov
TownePlace Suites by Marriott Port St. Lucie I-95
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Main Street Fort Pierce

Find the best Main Street Fort Pierce areas for the activities you enjoy most.
A coastal area with a narrow waterway, a beach, and residential buildings.

Lakewood Park

When in Lakewood Park, you can plan a visit to McKee Botanical Garden and Avalon State Park, some noteworthy sights in the nearby area.

Spanish Lakes Country Club Village

While Spanish Lakes Country Club Village isn't home to many top sights, Harbor Branch Ocean Discovery Center and McKee Botanical Garden are some notable places to visit nearby.

A calm lake reflecting trees and a clear sky.

Spanish Lakes Fairways

While there might not be top attractions in Spanish Lakes Fairways, you can explore the larger area and discover places like Lakewood Park Regional Park / Pool and Indrio Road Park / Schoolhouse.

A coastal city with a bay, mangrove islands, and a clear blue sky.

Meadowood

While Meadowood isn't home to many top sights, Endless Summer Vineyard & Winery and Al's Family Farms are some notable places to visit nearby.

A mosaic sign with 'Mainstreet Fort Pierce' written on it.

Panther Woods

While Panther Woods may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Endless Summer Vineyard & Winery and Al's Family Farms.

Top Main Street Fort Pierce Hotel Reviews

voco Sandpiper All-Inclusive Resort by IHG

voco Sandpiper All-Inclusive Resort by IHG

10/10 Excellent
"."
Mirlenis 2-night trip
Posted 2 hours ago
voco Sandpiper All-Inclusive Resort by IHG

Frequently asked questions

What is Main Street Fort Pierce like?
Main Street Fort Pierce is a neighbourhood that travellers like for its waterfront, art and shopping. Make sure that you visit Sunrise Theater and Fort Pierce Farmer's Market as part of your Main Street Fort Pierce travel plans.
How many hotels will I find in Main Street Fort Pierce?
Book one of Expedia's 7 hotels and other accommodation options in Main Street Fort Pierce and start exploring everything Fort Pierce has to offer.
If I need to cancel my hotel reservation in Main Street Fort Pierce, will I receive a refund?
Yes! Most room reservations are fully refundable if cancelled prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and get a refund within 24 hours of booking. Add dates, click "Search", then use the "fully refundable" filter to get the best options available in Main Street Fort Pierce.
What is there to do in this Fort Pierce neighbourhood?
Sights like Sunrise Theater and Official Highwaymen Art Gallery can be part of your cultural tour of Main Street Fort Pierce. Fort Pierce Farmer's Market and Fort Pierce City Marina are also a couple of places to visit in the neighbourhood. A few places to visit in the area around Main Street Fort Pierce include Manatee Education and Observation Center, House of Seven Gables and A.E. Backus Museum. Marina at Fort Pierce and Causeway Cove are also worth a visit when you're out sightseeing in Fort Pierce.