Search Hotels in Isle of Palms South, Jacksonville
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Our top choices for Isle of Palms South hotels
1. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic2.9 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,003 reviews)
"Great place to stay."
Patsy
The price is ฿4,238
฿4,810 total
includes taxes & fees
23 Aug - 24 Aug
2. TownePlace Suites by Marriott Jacksonville East
TownePlace Suites by Marriott Jacksonville East2.9 km from Isle of Palms South
9.2 out of 10, Wonderful, (649 reviews)
"Clean place"
Anonymous traveller
The price is ฿3,521
฿3,997 total
includes taxes & fees
6 Sept - 7 Sept
3. Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Residence Inn By Marriott Jacksonville - Mayo Clinic AreaIsle of Palms, 2 km from Isle of Palms South
9.4 out of 10, Exceptional, (584 reviews)
"Great stay"
Michaelanne
The price is ฿4,531
฿5,143 total
includes taxes & fees
29 Aug - 30 Aug
4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG3.7 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,018 reviews)
"Very helpful staff and nice view to the golf course."
Jorge
The price is ฿3,646
฿4,138 total
includes taxes & fees
13 Sept - 14 Sept
5. Hyatt Place Jacksonville / St. Johns Town Center
Hyatt Place Jacksonville / St. Johns Town Center9.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (1,170 reviews)
"New hotel , great location , nice deck overlooking the lake"
David
The price is ฿4,474
฿5,078 total
includes taxes & fees
1 Sept - 2 Sept
6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches1.5 km from Isle of Palms South
8.4 out of 10, Very good, (794 reviews)
"Nice hotel for the money."
Troy
The price is ฿5,038
฿5,718 total
includes taxes & fees
22 Aug - 23 Aug
7. Hilton Jacksonville at Mayo Clinic near Beaches
Hilton Jacksonville at Mayo Clinic near Beaches1.9 km from Isle of Palms South
9.4 out of 10, Exceptional, (322 reviews)
"Enjoyed my stay here we definitely come back!"
Mercedes
The price is ฿5,001
฿5,676 total
includes taxes & fees
7 Sept - 8 Sept
8. Margaritaville Jacksonville Beach
Margaritaville Jacksonville BeachOceanfront, 4.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (4,354 reviews)
"Lovely and beautiful place for the family."
Noelia
The price is ฿4,947
฿5,614 total
includes taxes & fees
18 Aug - 19 Aug
9. Sheraton Jacksonville Hotel
Sheraton Jacksonville Hotel10.5 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,003 reviews)
"Staff was very nice!"
Jone'
The price is ฿4,099
฿4,652 total
includes taxes & fees
21 Aug - 22 Aug
10. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass8.8 km from Isle of Palms South
9.2 out of 10, Wonderful, (1,018 reviews)
"Family of 5 stayed comfortably!
Very accommodating and friendly!
Room was clean, pool was also fun!"
Brooke
The price is ฿4,198
฿4,680 total
includes taxes & fees
30 Aug - 31 Aug
11. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area3.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,202 reviews)
"Clean and staff very attentive."
Hannah
The price is ฿3,916
฿4,445 total
includes taxes & fees
13 Sept - 14 Sept
12. Element by Marriott Jacksonville Beach
Element by Marriott Jacksonville BeachOceanfront, 4.4 km from Isle of Palms South
9.6 out of 10, Exceptional, (574 reviews)
"Best hotel ever 😊"
Tablo
The price is ฿4,773
฿5,417 total
includes taxes & fees
30 Aug - 31 Aug
13. Homewood Suites by Hilton Jacksonville-South/St. Johns Ctr.
Homewood Suites by Hilton Jacksonville-South/St. Johns Ctr.8.9 km from Isle of Palms South
8.6 out of 10, Excellent, (1,005 reviews)
"Everyone and everything was very nice as usual. We stayed last August 2025 for college move in and stayed this time too, August 2026. Excellent place and people!"
Angela
The price is ฿3,211
฿3,644 total
includes taxes & fees
30 Aug - 31 Aug
14. Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Holiday Inn Express & Suites Jacksonville - Town Center by IHG8.5 km from Isle of Palms South
9.6 out of 10, Exceptional, (1,003 reviews)
"Hotel was very well kept. Enjoyed the stay"
Satish
The price is ฿4,342
฿4,928 total
includes taxes & fees
23 Aug - 24 Aug
15. Best Western Oceanfront
Best Western OceanfrontOceanfront, 4.6 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,009 reviews)
"The location was great."
Shawna
The price is ฿4,375
฿4,965 total
includes taxes & fees
23 Aug - 24 Aug
16. Hyatt Studios Jacksonville/St Johns Town Center
Hyatt Studios Jacksonville/St Johns Town Center8.7 km from Isle of Palms South
9.4 out of 10, Exceptional, (173 reviews)
"Clean , convenient, wonderful staff."
Alicia
The price is ฿3,646
฿4,138 total
includes taxes & fees
1 Sept - 2 Sept
17. SpringHill Suites by Marriott Jacksonville
SpringHill Suites by Marriott Jacksonville11.9 km from Isle of Palms South
8.6 out of 10, Excellent, (1,002 reviews)
"Rooms were very clean and staff were extremely helpful."
James
The price is ฿3,613
฿4,100 total
includes taxes & fees
21 Aug - 22 Aug
18. Tru By Hilton Jacksonville St Johns Town Center
Tru By Hilton Jacksonville St Johns Town Center9.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (939 reviews)
"Love it here! Staff is so friendly, rooms are clean and comfortable. I stay here often as my preferred choice for work trips! Free parking is a PLUS!"
Tierra
The price is ฿3,629
฿4,118 total
includes taxes & fees
23 Aug - 24 Aug
19. Courtyard by Marriott Jacksonville I-295/East Beltway
Courtyard by Marriott Jacksonville I-295/East Beltway13.2 km from Isle of Palms South
9.2 out of 10, Wonderful, (734 reviews)
"Great hotel with clean rooms, friendly staff, and excellent service. I had a wonderful stay and would definitely return."
Virnilito Nambayan
The price is ฿3,071
฿3,485 total
includes taxes & fees
23 Aug - 24 Aug
20. Springhill Suites By Marriott Jacksonville Beach Oceanfront
Springhill Suites By Marriott Jacksonville Beach OceanfrontOceanfront, 4.7 km from Isle of Palms South
9.0 out of 10, Wonderful, (771 reviews)
"Wonderful property with a great location and friendly staff! I’ve stayed at many Jax beach properties and always go back to this one."
Elizabeth
The price is ฿5,606
฿6,363 total
includes taxes & fees
30 Aug - 31 Aug
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Isle of Palms South
Find the best Isle of Palms South areas for the activities you enjoy most.
Amelia City
While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.
Oceanfront
While visiting Oceanfront, you might make a stop by sights like Oceanfront Park and Northeast Florida Beaches.
Photo by Ryan Ketterman
Open Photo by Ryan Ketterman
Downtown Jacksonville
The picturesque St. Johns River meanders through the center of this hub of skyscrapers, cultural landmarks and exciting nightlife.
Southside
If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.
Sawgrass
Beaches and riverfront are just a few things travellers like about Sawgrass. A stop by Mickler Beach is also recommended if you've got time to explore the area.
Top Isle of Palms South Hotel Reviews
Scottish Inn Jacksonville Downtown
8/10 Good
