Search Hotels in Isle of Palms South, Jacksonville

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
12 Dec - 13 Dec
Tomorrow
13 Dec - 14 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Isle of Palms South hotels

Lobby
Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
4.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (3427)
"Staff were very friendly, the restaurant had amazing food and the view was perfect! Loved staying here! Would highly recommend!"
United States
Sydney
The price is ฿4,515
฿5,124 total
includes taxes & fees
15 Dec - 16 Dec
Margaritaville Jacksonville Beach
2 outdoor pools, open 7:00 AM to 9:00 PM, pool umbrellas, pool loungers
Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront
3.0 star property
5.1 km from Isle of Palms South
9.2 out of 10, Wonderful, (2584)
"We thoroughly enjoyed our stay! "
United States
Diane
The price is ฿3,306
฿3,753 total
includes taxes & fees
21 Dec - 22 Dec
Hampton Inn Jacksonville Beach/Oceanfront
Indoor pool, 2 outdoor pools, open 8:00 AM to 10:00 PM, pool umbrellas
The Villas of Amelia Island

The Villas of Amelia Island

The Villas of Amelia Island
4.0 star property
29.5 km from Isle of Palms South
8.4 out of 10, Very good, (1128)
"We have stayed at this property every year for the past decade. We have always enjoyed our time out here with family. Highly recommend catching morning sunrise from the beach. The vibe is very pleasant and accommodating, you will not be disapppointed. "
United States
Harsha
The price is ฿5,023
฿7,039 total
includes taxes & fees
21 Dec - 22 Dec
The Villas of Amelia Island
Lobby
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
3.0 star property
8.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (1014)
"We have stayed here in the past,excellent location. We especially enjoyed our food from Mulligan's..our waitress was exceptional. "
United States
Robert
The price is ฿3,630
฿4,048 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
Property amenity
Sheraton Jacksonville Hotel

Sheraton Jacksonville Hotel

Sheraton Jacksonville Hotel
4.0 star property
10.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (1001)
"Great stay and great customer service"
United States
Rebecca
The price is ฿2,824
฿3,205 total
includes taxes & fees
21 Dec - 22 Dec
Sheraton Jacksonville Hotel
Balcony
One Ocean Resort and Spa

One Ocean Resort and Spa

One Ocean Resort and Spa
4.5 star property
6.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (1001)
"Clean rooms and very nice staff "
United States
Arthur
The price is ฿4,403
฿6,018 total
includes taxes & fees
21 Dec - 22 Dec
One Ocean Resort and Spa
Exterior
Seahorse Oceanfront Inn

Seahorse Oceanfront Inn

Seahorse Oceanfront Inn
2.5 star property
6.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (602)
"Room was clean staff was friendly"
United States
Lisa
Seahorse Oceanfront Inn
Free daily continental breakfast
Fairfield Inn & Suites by Marriott Jacksonville Beach

Fairfield Inn & Suites by Marriott Jacksonville Beach

Fairfield Inn & Suites by Marriott Jacksonville Beach
2.5 star property
5.2 km from Isle of Palms South
8.6 out of 10, Excellent, (889)
"Great place to stay highly recommend it"
United States
Taryn
The price is ฿3,596
฿4,082 total
includes taxes & fees
21 Dec - 22 Dec
Fairfield Inn & Suites by Marriott Jacksonville Beach
BBQ/picnic Area
Salt Air Inn & Suites

Salt Air Inn & Suites

Salt Air Inn & Suites
2.5 star property
6.6 km from Isle of Palms South
9.8 out of 10, Exceptional, (407)
"A cute little gem with some of the best hospitality in the area. "
United States
Windy
Salt Air Inn & Suites
Sports facility
Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
3.0 star property
9.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (1000)
"Good location, friendly staff, clean "
United States
john
The price is ฿3,771
฿4,281 total
includes taxes & fees
23 Dec - 24 Dec
Hyatt Place Jacksonville / St. Johns Town Center
Bar (on property)
Springhill Suites By Marriott Jacksonville Beach Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront
4.0 star property
4.7 km from Isle of Palms South
9.0 out of 10, Wonderful, (619)
"Loved staying here. Great hotel. Very clean. The check-in process was smooth and Jay was awesome. I would recommend!"
United States
Kedric
The price is ฿4,809
฿5,459 total
includes taxes & fees
21 Dec - 22 Dec
Springhill Suites By Marriott Jacksonville Beach Oceanfront
Property amenity
Element Jacksonville Beach

Element Jacksonville Beach

Element Jacksonville Beach
3.0 star property
4.4 km from Isle of Palms South
9.6 out of 10, Exceptional, (521)
"The hotel was spotless as usual.The staff was fantastic incredible cleanliness"
United States
Robert
The price is ฿3,734
฿4,238 total
includes taxes & fees
21 Dec - 22 Dec
Element Jacksonville Beach
Terrace/patio
Aloft Jacksonville Tapestry Park

Aloft Jacksonville Tapestry Park

Aloft Jacksonville Tapestry Park
3.0 star property
11.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (1001)
"Clean room and nice staff"
United States
Shaquon
The price is ฿3,944
฿4,476 total
includes taxes & fees
19 Dec - 20 Dec
Aloft Jacksonville Tapestry Park
Outdoor pool, open 7:00 AM to 10:00 PM, pool umbrellas, pool loungers
Courtyard by Marriott Jacksonville Beach Oceanfront

Courtyard by Marriott Jacksonville Beach Oceanfront

Courtyard by Marriott Jacksonville Beach Oceanfront
3.0 star property
5.2 km from Isle of Palms South
8.6 out of 10, Excellent, (1000)
"Perfect time thanks again marriot"
United States
BRANDON
The price is ฿4,746
฿5,387 total
includes taxes & fees
22 Dec - 23 Dec
Courtyard by Marriott Jacksonville Beach Oceanfront
Exterior
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
2.5 star property
3.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (1003)
"Good location for exploring Ponte Vedra and Jacksonville Beach areas."
United States
Julianne
The price is ฿3,508
฿3,982 total
includes taxes & fees
19 Dec - 20 Dec
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Exterior
Tru by Hilton Jacksonville South Mandarin

Tru by Hilton Jacksonville South Mandarin

Tru by Hilton Jacksonville South Mandarin
2.5 star property
21.4 km from Isle of Palms South
9.0 out of 10, Wonderful, (1001)
"Excellent staff and hotel "
United States
Edward
The price is ฿2,820
฿3,200 total
includes taxes & fees
11 Jan - 12 Jan 2026
Tru by Hilton Jacksonville South Mandarin
Exterior
Casa Marina Hotel

Casa Marina Hotel

Casa Marina Hotel
3.0 star property
4.7 km from Isle of Palms South
8.4 out of 10, Very good, (1005)
"Great breakfast. Easy walk to beach. "
United States
Denise
Casa Marina Hotel
Terrace/patio
TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
3.0 star property
2.9 km from Isle of Palms South
9.2 out of 10, Wonderful, (547)
"Very good hotel"
United States
Careli
The price is ฿3,596
฿4,082 total
includes taxes & fees
11 Jan - 12 Jan 2026
TownePlace Suites by Marriott Jacksonville East
Exterior
Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG
2.5 star property
8.6 km from Isle of Palms South
9.6 out of 10, Exceptional, (1003)
"Nice refurbished rooms.. "
United States
David
The price is ฿4,038
฿4,583 total
includes taxes & fees
24 Dec - 25 Dec
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Lobby
Embassy Suites by Hilton Jacksonville Baymeadows

Embassy Suites by Hilton Jacksonville Baymeadows

Embassy Suites by Hilton Jacksonville Baymeadows
3.5 star property
14 km from Isle of Palms South
8.4 out of 10, Very good, (1282)
"Excellent place! "
United States
Amanda
The price is ฿3,761
฿4,268 total
includes taxes & fees
22 Dec - 23 Dec
Embassy Suites by Hilton Jacksonville Baymeadows
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Isle of Palms South

Find the best Isle of Palms South areas for the activities you enjoy most.
Photo by Ryan Ketterman
Open Photo by Ryan Ketterman

Downtown Jacksonville

The picturesque St. Johns River meanders through the center of this hub of skyscrapers, cultural landmarks and exciting nightlife.

Amelia City

While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.

Southside

If you're spending some time in Southside, St. Johns Town Center and Merill Road Shopping Center are top sights worth seeing.

Sawgrass

Beaches and riverfront are just a few things travellers like about Sawgrass. A stop by Mickler Beach is also recommended if you've got time to explore the area.

Cummer Museum of Art and Gardens featuring art and interior views as well as a couple
Photo by Visit Jacksonville
Open Photo by Visit Jacksonville

Northwest

While visiting Northwest, you might make a stop by sights like Cummer Museum of Art and Gardens and Jacksonville-Baldwin Rail Trail.

Top Isle of Palms South Hotel Reviews

Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic

10/10 Excellent
"It is a newly built hotel, so rooms wete in good condition. Staff was very friendly and respectful. Id you do not have car, it will be chellenging to go aroubd. "
Mousmee 3-night trip
Posted 2 days ago
Hilton Jacksonville At Mayo Clinic

Explore a world of travel with Expedia

Frequently asked questions

What is Isle of Palms South like?
Travellers will be sure to find plenty to entertain them in Jacksonville Beach's Isle of Palms South neighbourhood.
How many hotels can I expect to find in Isle of Palms South?
Expedia has 7 Isle of Palms South hotels and other accommodation options, and one might make a good home base for venturing out into the greater Jacksonville Beach area.
If I need to cancel my hotel reservation in Isle of Palms South, will I receive a refund?
Yes, the majority of hotel reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to view the best deals in Isle of Palms South.
What are the top things to see and do in Isle of Palms South?
Adventure Landing, Cradle Creek Preserve and Windsor Parke Golf Club are just a few of the places to visit in and around Isle of Palms South. Jacksonville Beach Golf Club and Windsor Commons Shopping Center are also worth a visit when you're out sightseeing in Jacksonville Beach.