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18 Sep - 20 Sep
Next weekend
25 Sep - 27 Sep

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Our top choices for Isle of Palms South hotels

Lobby

1. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
2.9 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,000 reviews)
"Great place to stay."
United States
Patsy
The price is ฿3,658
฿4,152 total
includes taxes & fees
4 Oct - 5 Oct
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Terrace/patio

2. TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
3.0 star property
2.9 km from Isle of Palms South
9.2 out of 10, Wonderful, (658 reviews)
"Great location close to the beach. Super well maintained facility. Everything was great!"
United States
gregory
The price is ฿4,143
฿4,703 total
includes taxes & fees
18 Oct - 19 Oct
TownePlace Suites by Marriott Jacksonville East
Lobby sitting area

3. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
3.7 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,007 reviews)
"clean rooms and great location!"
United States
Jami
The price is ฿3,095
฿3,513 total
includes taxes & fees
18 Oct - 19 Oct
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Lobby lounge

4. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
Isle of Palms, 2 km from Isle of Palms South
9.6 out of 10, Exceptional, (599 reviews)
"Great stay"
United States
Michaelanne
The price is ฿4,568
฿5,185 total
includes taxes & fees
18 Oct - 19 Oct
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Sports facility

5. Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
3.0 star property
9.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (1,164 reviews)
"Great staff, great breakfast, and very clean."
United States
Marty
The price is ฿4,233
฿4,805 total
includes taxes & fees
4 Oct - 5 Oct
Hyatt Place Jacksonville / St. Johns Town Center
Lobby

6. Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
Oceanfront, 4.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (4,477 reviews)
"Enjoyed our overnight stay"
United States
Melissa
The price is ฿4,967
฿5,637 total
includes taxes & fees
20 Sept - 21 Sept
Margaritaville Jacksonville Beach
Terrace/patio

7. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
3.0 star property
1.5 km from Isle of Palms South
8.4 out of 10, Very good, (797 reviews)
"The staff was very helpful and the parking easy and, in parts, quite shady. It was within easy walking distance of the Mayo Clinic!"
United States
Patricia
The price is ฿5,058
฿5,741 total
includes taxes & fees
26 Sept - 27 Sept
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
Breakfast, lunch and dinner served

8. Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
4.5 star property
1.9 km from Isle of Palms South
9.4 out of 10, Exceptional, (354 reviews)
"Excellent hotel and staff."
United States
Kristen
The price is ฿5,594
฿6,349 total
includes taxes & fees
17 Oct - 18 Oct
Hilton Jacksonville at Mayo Clinic near Beaches
Premium bedding, desk, iron/ironing board, free cots/infant beds

9. Holiday Inn Jacksonville E 295 Baymeadows by IHG

Holiday Inn Jacksonville E 295 Baymeadows by IHG
3.0 star property
9.6 km from Isle of Palms South
8.6 out of 10, Excellent, (999 reviews)
"Great Hotel"
United States
Josh
The price is ฿2,762
฿3,135 total
includes taxes & fees
18 Oct - 19 Oct
Holiday Inn Jacksonville E 295 Baymeadows by IHG
Lobby

10. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
3.0 star property
8.8 km from Isle of Palms South
9.2 out of 10, Wonderful, (1,004 reviews)
"Family of 5 stayed comfortably! Very accommodating and friendly! Room was clean, pool was also fun!"
United States
Brooke
The price is ฿3,921
฿4,371 total
includes taxes & fees
19 Oct - 20 Oct
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
Exterior

11. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
2.5 star property
3.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,228 reviews)
"Just wish the hotel have a restaurant or a bar."
United States
Hollye
The price is ฿3,932
฿4,463 total
includes taxes & fees
11 Oct - 12 Oct
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Desk, blackout curtains, iron/ironing board (on request)

12. Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
2.5 star property
8.7 km from Isle of Palms South
9.4 out of 10, Exceptional, (211 reviews)
"Very nice stay, they have grab and go breakfast as complimentary."
United States
Phi
The price is ฿3,661
฿4,155 total
includes taxes & fees
3 Oct - 4 Oct
Hyatt Studios Jacksonville/St Johns Town Center
Standard Room, 2 Queen Beds, Accessible (Accessible Tub) | In-room safe, desk, laptop workspace, blackout curtains

13. Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
3.0 star property
3.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (1,001 reviews)
"The staff was nice, and the breakfast was very good,"
United States
Jose
The price is ฿3,927
฿4,457 total
includes taxes & fees
13 Oct - 14 Oct
Holiday Inn Express Jacksonville Beach by IHG
Snack bar

14. Tru By Hilton Jacksonville St Johns Town Center

Tru By Hilton Jacksonville St Johns Town Center
2.5 star property
9.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (956 reviews)
"Everything was clean and well maintained. The breakfast was great as well."
United States
Jami
The price is ฿3,643
฿4,135 total
includes taxes & fees
27 Sept - 28 Sept
Tru By Hilton Jacksonville St Johns Town Center
Property amenity

15. Sheraton Jacksonville Hotel

Sheraton Jacksonville Hotel
4.0 star property
10.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (1,001 reviews)
"Good location"
United States
Jose
The price is ฿4,392
฿4,985 total
includes taxes & fees
20 Sept - 21 Sept
Sheraton Jacksonville Hotel
On the beach

16. Best Western Oceanfront

Best Western Oceanfront
3.0 star property
Oceanfront, 4.6 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,001 reviews)
"The location was great."
United States
Shawna
The price is ฿4,360
฿4,949 total
includes taxes & fees
20 Sept - 21 Sept
Best Western Oceanfront
Property amenity

17. Element by Marriott Jacksonville Beach

Element by Marriott Jacksonville Beach
3.0 star property
Oceanfront, 4.4 km from Isle of Palms South
9.6 out of 10, Exceptional, (584 reviews)
"Nice lodging a block from the beach. Great food nearby."
United States
Nick
The price is ฿5,079
฿5,764 total
includes taxes & fees
21 Sept - 22 Sept
Element by Marriott Jacksonville Beach
Exterior

18. Homewood Suites by Hilton Jacksonville-South/St. Johns Ctr.

Homewood Suites by Hilton Jacksonville-South/St. Johns Ctr.
3.0 star property
8.9 km from Isle of Palms South
8.6 out of 10, Excellent, (1,001 reviews)
"The room was very clean and I really enjoyed my stay and I look forward to future stays at this loc"
United States
Eddie
The price is ฿3,793
฿4,305 total
includes taxes & fees
18 Oct - 19 Oct
Homewood Suites by Hilton Jacksonville-South/St. Johns Ctr.
Lobby

19. Embassy Suites by Hilton Jacksonville Baymeadows

Embassy Suites by Hilton Jacksonville Baymeadows
3.5 star property
14 km from Isle of Palms South
8.4 out of 10, Very good, (1,503 reviews)
"The hotel was clean and staff was present and helpful"
United States
Shebra
The price is ฿3,930
฿4,460 total
includes taxes & fees
11 Oct - 12 Oct
Embassy Suites by Hilton Jacksonville Baymeadows
Bar (on property)

20. Courtyard by Marriott Jacksonville I-295/East Beltway

Courtyard by Marriott Jacksonville I-295/East Beltway
3.0 star property
13.2 km from Isle of Palms South
9.2 out of 10, Wonderful, (744 reviews)
"Lovely stay"
United States
Chloie Marie
The price is ฿3,649
฿4,142 total
includes taxes & fees
3 Oct - 4 Oct
Courtyard by Marriott Jacksonville I-295/East Beltway
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Isle of Palms South

Find the best Isle of Palms South areas for the activities you enjoy most.
A city skyline with modern skyscrapers, a prominent Wells Fargo building, and a blue bridge over a river.
Photo by Ryan Ketterman
Open Photo by Ryan Ketterman

Downtown Jacksonville

The picturesque St. Johns River meanders through the center of this hub of skyscrapers, cultural landmarks and exciting nightlife.

A coastal cityscape at dusk with a prominent clock tower, waterfront, and historic buildings.

Amelia City

While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.

A sunset over a beach with waves and a pier.

Oceanfront

While visiting Oceanfront, you might make a stop by sights like Oceanfront Park and Northeast Florida Beaches.

A city skyline at night with illuminated buildings and a bridge reflecting on the water.

Southside

If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.

A golf course with a pond, trees, and buildings in the background.

Sawgrass

Beaches and riverfront are just a few things travellers like about Sawgrass. A stop by Mickler Beach is also recommended if you've got time to explore the area.

Top Isle of Palms South Hotel Reviews

Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center

8/10 Good
"We arrived at about 7:00pm after all day on the road. The room we were given had not yet been cleaned. There were no more king rooms available, so due to the lateness of getting there took a double queen. The room was clean, so we just decided to keep that room for our stay of two nights. Over all the property was good."
Michael 2-night trip
Posted 1 hour ago
Hyatt Studios Jacksonville/St Johns Town Center

Frequently asked questions

What is Isle of Palms South like?
Travellers will be sure to find plenty to entertain them in Jacksonville Beach's Isle of Palms South neighbourhood.
How many hotels can I expect to find in Isle of Palms South?
Expedia has 7 Isle of Palms South hotels and other accommodation options, and one might make a good home base for venturing out into the greater Jacksonville Beach area.
If I need to cancel my hotel reservation in Isle of Palms South, will I receive a refund?
Yes, the majority of hotel reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to view the best deals in Isle of Palms South.
What are the top things to see and do in Isle of Palms South?
Cradle Creek Preserve, Windsor Parke Golf Club and Jacksonville Beach Golf Club are just a few of the places to visit in and around Isle of Palms South. Windsor Commons Shopping Center and Harbor City Municipal Golf Course are also worth a visit when you're out sightseeing in Jacksonville Beach.