Search Hotels in Isle of Palms, Jacksonville

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Our top choices for Isle of Palms hotels

Reception
Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
Isle of Palms
9.4 out of 10, Exceptional, (447)
"Great facility to stay."
United States
Gary
The price is ฿5,665
฿6,430 total
includes taxes & fees
2 Jan - 3 Jan 2026
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
On the beach, white sand, surfing, kayaking
Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
4.6 km from Isle of Palms
9.0 out of 10, Wonderful, (3447)
"Nice stay!"
United States
Mark
The price is ฿4,162
฿4,724 total
includes taxes & fees
7 Jan - 8 Jan 2026
Margaritaville Jacksonville Beach
2 outdoor pools, open 7:00 AM to 9:00 PM, pool umbrellas, pool loungers
Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront
3.0 star property
5 km from Isle of Palms
9.2 out of 10, Wonderful, (2618)
"The room was clean, staff was friendly and we loved the location. "
United States
Diane
The price is ฿4,152
฿4,713 total
includes taxes & fees
22 Jan - 23 Jan 2026
Hampton Inn Jacksonville Beach/Oceanfront
Property amenity
Sheraton Jacksonville Hotel

Sheraton Jacksonville Hotel

Sheraton Jacksonville Hotel
4.0 star property
10.7 km from Isle of Palms
9.2 out of 10, Wonderful, (1000)
"Great stay and great customer service"
United States
Rebecca
The price is ฿3,185
฿3,615 total
includes taxes & fees
1 Jan - 2 Jan 2026
Sheraton Jacksonville Hotel
Lobby
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
3.0 star property
8.8 km from Isle of Palms
9.0 out of 10, Wonderful, (1006)
"Friendly staff, easy check-in super clean room and facility. Location is excellent as well."
United States
Anthony
The price is ฿3,631
฿4,049 total
includes taxes & fees
25 Jan - 26 Jan 2026
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
Exterior
Fairfield Inn & Suites by Marriott Jacksonville Beach

Fairfield Inn & Suites by Marriott Jacksonville Beach

Fairfield Inn & Suites by Marriott Jacksonville Beach
2.5 star property
5 km from Isle of Palms
8.6 out of 10, Excellent, (892)
"Great place to stay highly recommend it"
United States
Taryn
The price is ฿3,482
฿3,952 total
includes taxes & fees
4 Jan - 5 Jan 2026
Fairfield Inn & Suites by Marriott Jacksonville Beach
Premium bedding, down duvets, pillow-top beds, minibar
World Golf Village Renaissance St. Augustine Resort

World Golf Village Renaissance St. Augustine Resort

World Golf Village Renaissance St. Augustine Resort
4.0 star property
31.6 km from Isle of Palms
8.6 out of 10, Excellent, (1001)
"Beautiful place and clean, Amazing staff, breakfast was excellent. However the bed and pillows HORRIBLE 😔 😟 🙁 😥. "
United States
Giseana
The price is ฿4,273
฿4,764 total
includes taxes & fees
18 Jan - 19 Jan 2026
World Golf Village Renaissance St. Augustine Resort
Outdoor pool, open 7:00 AM to 7:00 PM, pool umbrellas, pool loungers
One Ocean Resort and Spa

One Ocean Resort and Spa

One Ocean Resort and Spa
4.5 star property
6.7 km from Isle of Palms
8.8 out of 10, Excellent, (1002)
"Need to rethink having guests in middle of this major renovation. Refresh definitely needed. Wouldn’t stay here again until renovation is complete. Staff was accommodating. "
United States
karen
The price is ฿5,042
฿6,744 total
includes taxes & fees
12 Jan - 13 Jan 2026
One Ocean Resort and Spa
BBQ/picnic Area
Salt Air Inn & Suites

Salt Air Inn & Suites

Salt Air Inn & Suites
2.5 star property
6.5 km from Isle of Palms
9.8 out of 10, Exceptional, (415)
"Great stay , convenient locations , friendly staff and well priced "
United States
Grant
Salt Air Inn & Suites
On the beach, windsurfing
Springhill Suites By Marriott Jacksonville Beach Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront
4.0 star property
4.5 km from Isle of Palms
9.0 out of 10, Wonderful, (623)
"The room was great and the staff was exceptional. Would stay here again in a heartbeat. "
United States
Michael
The price is ฿5,222
฿5,927 total
includes taxes & fees
4 Jan - 5 Jan 2026
Springhill Suites By Marriott Jacksonville Beach Oceanfront
Exterior
Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG
2.5 star property
8.8 km from Isle of Palms
9.6 out of 10, Exceptional, (1005)
"Great hotel"
United States
Nima
The price is ฿4,146
฿4,706 total
includes taxes & fees
11 Jan - 12 Jan 2026
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
On the beach, beach shuttle
Casa Marina Hotel

Casa Marina Hotel

Casa Marina Hotel
3.0 star property
4.5 km from Isle of Palms
8.4 out of 10, Very good, (1001)
"Great breakfast. Easy walk to beach. "
United States
Denise
Casa Marina Hotel
Exterior
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
2.5 star property
3.7 km from Isle of Palms
9.0 out of 10, Wonderful, (1008)
"Good location for exploring Ponte Vedra and Jacksonville Beach areas."
United States
Julianne
The price is ฿3,860
฿4,382 total
includes taxes & fees
11 Jan - 12 Jan 2026
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Sports facility
Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
3.0 star property
9.7 km from Isle of Palms
9.2 out of 10, Wonderful, (1006)
"Breakfast was great. The selection was the best I have ever had in the US"
United States
Sandra
The price is ฿4,020
฿4,562 total
includes taxes & fees
9 Jan - 10 Jan 2026
Hyatt Place Jacksonville / St. Johns Town Center
Outdoor pool, open 8:00 AM to 8:00 PM, pool umbrellas, pool loungers
Seahorse Oceanfront Inn

Seahorse Oceanfront Inn

Seahorse Oceanfront Inn
2.5 star property
6.7 km from Isle of Palms
9.0 out of 10, Wonderful, (613)
"The location was ideal if you enjoy shopping eating and entertainment in walking distance ."
United States
Alethia
Seahorse Oceanfront Inn
Exterior
Home2 Suites by Hilton Jacksonville Airport

Home2 Suites by Hilton Jacksonville Airport

Home2 Suites by Hilton Jacksonville Airport
3.0 star property
31.3 km from Isle of Palms
8.6 out of 10, Excellent, (1006)
"Clean room and friendly staff"
United States
Marlene
The price is ฿3,756
฿4,263 total
includes taxes & fees
2 Jan - 3 Jan 2026
Home2 Suites by Hilton Jacksonville Airport
Reception
Tru by Hilton Jacksonville South Mandarin

Tru by Hilton Jacksonville South Mandarin

Tru by Hilton Jacksonville South Mandarin
2.5 star property
21.6 km from Isle of Palms
9.0 out of 10, Wonderful, (1007)
"Excellent staff and hotel "
United States
Edward
The price is ฿2,829
฿3,211 total
includes taxes & fees
11 Jan - 12 Jan 2026
Tru by Hilton Jacksonville South Mandarin
Exterior
Hotel Indigo Jacksonville-Deerwood Park by IHG

Hotel Indigo Jacksonville-Deerwood Park by IHG

Hotel Indigo Jacksonville-Deerwood Park by IHG
3.5 star property
11.8 km from Isle of Palms
9.2 out of 10, Wonderful, (1002)
"Very nice stay "
United States
Timmothy
The price is ฿3,608
฿4,095 total
includes taxes & fees
3 Jan - 4 Jan 2026
Hotel Indigo Jacksonville-Deerwood Park by IHG
Exterior
Holiday Inn Express & Suites Jacksonville Airport by IHG

Holiday Inn Express & Suites Jacksonville Airport by IHG

Holiday Inn Express & Suites Jacksonville Airport by IHG
2.5 star property
31.3 km from Isle of Palms
8.6 out of 10, Excellent, (1012)
"Clean room, great service, good breakfast options."
United States
KRITI KUMAR
The price is ฿3,292
฿3,736 total
includes taxes & fees
1 Jan - 2 Jan 2026
Holiday Inn Express & Suites Jacksonville Airport by IHG
On the beach
Best Western Oceanfront

Best Western Oceanfront

Best Western Oceanfront
3.0 star property
4.4 km from Isle of Palms
9.0 out of 10, Wonderful, (1003)
"Great location, clean, comfortable bed, friendly staff"
United States
Jeff
The price is ฿3,899
฿4,425 total
includes taxes & fees
6 Jan - 7 Jan 2026
Best Western Oceanfront
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Isle of Palms

Find the best Isle of Palms areas for the activities you enjoy most.
Photo by Ryan Ketterman
Open Photo by Ryan Ketterman

Downtown Jacksonville

The picturesque St. Johns River meanders through the center of this hub of skyscrapers, cultural landmarks and exciting nightlife.

Amelia City

While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.

Southside

If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.

Sawgrass

Beaches and riverfront are just a few things travellers like about Sawgrass. A stop by Mickler Beach is also recommended if you've got time to explore the area.

Cummer Museum of Art and Gardens featuring art and interior views as well as a couple
Photo by Visit Jacksonville
Open Photo by Visit Jacksonville

Northwest

While visiting Northwest, you might make a stop by sights like Cummer Museum of Art and Gardens and Jacksonville-Baldwin Rail Trail.

Top Isle of Palms Hotel Reviews

Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic

10/10 Excellent
"Very nice enjoyed visiting "
anjillica 1-night trip
Posted 11 hours ago
Hilton Jacksonville At Mayo Clinic

Frequently asked questions

What is Isle of Palms like?
Travellers are sure to enjoy a stay in Jacksonville Beach's Isle of Palms neighbourhood.
What's a favourite hotel to stay in Isle of Palms?
Based on Expedia customer reviews, Residence Inn By Marriott Jacksonville - Mayo Clinic Area is the highest ranked property in Isle of Palms. This hotel offers free breakfast and an outdoor pool.
How many hotels should I expect to find in Isle of Palms?
Expedia has 39 hotels and other accommodation options in Isle of Palms to choose from, making this an ideal home base for exploring the greater Jacksonville Beach area.
If I need to cancel my hotel reservation in Isle of Palms, will I receive a refund?
Yes! You'll find that most hotel room reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to view the best deals available in Isle of Palms.
What is there to do in this Jacksonville Beach neighbourhood?
A few places to visit in the area around Isle of Palms include Adventure Landing, Cradle Creek Preserve and Jacksonville Beach Golf Club. While you're out sightseeing in Jacksonville Beach, make sure that you visit other sights such as Windsor Parke Golf Club or Players by the Sea.