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Check availability on Guanajuato Spa Hotels

Our top choices for Guanajuato hotels with a spa

Sauna, hot tub, steam room, body treatments, hot stone massages
Villa Maria Cristina

Villa Maria Cristina

5.0 star property
De La Presa
9.4 out of 10, Exceptional, (389)
"Super clean great service very comfortable"
Canada
Benjamin
The price is ฿5,247
฿6,296 total
includes taxes & fees
4 Jan - 5 Jan 2026
Villa Maria Cristina
Outdoor pool
Antigua Trece Hotel Fusión

Antigua Trece Hotel Fusión

3.0 star property
Zona Centro
9.0 out of 10, Wonderful, (218)
"easy access to everything nearby would recommend staying here "
United States
Fernanda
Antigua Trece Hotel Fusión
Indoor pool, open 9 AM to 9 PM, pool loungers
Edelmira Hotel Boutique

Edelmira Hotel Boutique

4.0 star property
Zona Centro
9.0 out of 10, Wonderful, (848)
"Amazing stay, excellent location, friendly staff and great breakfast. "
United States
Elvia Daniella
Edelmira Hotel Boutique
Valenciana | Premium bedding, in-room safe, individually decorated
Casa Estrella Valenciana Hotel Boutique

Casa Estrella Valenciana Hotel Boutique

4.0 star property
Guanajuato
10.0 out of 10, Exceptional, (128)
"Stunning view, amazing food, cozy beds, and fantastic massages."
United States
Karla
Casa Estrella Valenciana Hotel Boutique
Front of property
Casa Florencia Hotel Boutique

Casa Florencia Hotel Boutique

3.5 star property
De La Presa
9.2 out of 10, Wonderful, (49)
"Excellent and well designed property. "
United States
Rodolfo
The price is ฿2,880
฿3,456 total
includes taxes & fees
18 Dec - 19 Dec
Casa Florencia Hotel Boutique
Indoor pool
Casa Kloster Hotel Boutique

Casa Kloster Hotel Boutique

4.5 star property
Zona Centro
9.2 out of 10, Wonderful, (163)
"Great beds and pillows. Friendly staff and wonderful breakfast."
Canada
Benjamin
Casa Kloster Hotel Boutique
Couples treatment room(s), sauna, body treatments, deep-tissue massages
1850 Hotel Boutique

1850 Hotel Boutique

4.0 star property
Zona Centro
9.6 out of 10, Exceptional, (802)
"Hotel was great "
United States
Marisela
The price is ฿4,939
฿5,926 total
includes taxes & fees
11 Dec - 12 Dec
1850 Hotel Boutique
Junior Room, 1 King Bed | Balcony
Hotel Suites Corazon Mexicano

Hotel Suites Corazon Mexicano

3.5 star property
Guanajuato
8.2 out of 10, Very good, (690)
"Stayed in room 210 and felt very uncomfortable with a window that was facing a 10+ foot wall. It was clean and spacious. The hotel is surrounded with mom and pop restaurants, pharmacy, supermarket and a beauty salon. Property is located approximately 20 minute walking distance from the city center."
United States
Steven
The price is ฿3,176
฿3,811 total
includes taxes & fees
8 Jan - 9 Jan 2026
Hotel Suites Corazon Mexicano
Couples treatment room(s), aromatherapy, deep-tissue massages
Casona San Cayetano Suites & Lofts & Spa by SCE

Casona San Cayetano Suites & Lofts & Spa by SCE

4.5 star property
Guanajuato
8.6 out of 10, Excellent, (15)
"Staff members were very helpful and friendly! Breakfast was a plus, delicious! Will definitely consider staying here on my next visit to Guanajuato. "
United States
Araceli
The price is ฿1,401
฿1,681 total
includes taxes & fees
11 Dec - 12 Dec
Casona San Cayetano Suites & Lofts & Spa by SCE
Couples treatment room(s), body treatments, hot stone massages
Nueve 25 Hotel Boutique

Nueve 25 Hotel Boutique

4.5 star property
Zona Centro
9.8 out of 10, Exceptional, (165)
"Location and hotel were perfect."
United States
Eduardo
Nueve 25 Hotel Boutique
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Guanajuato Hotel Reviews

Hotel Posada Santa Fe

Hotel Posada Santa Fe

10/10 Excellent
"The room was spacious and clean and comfortable. "
robin james 3-night trip
Posted 4 days ago
Hotel Posada Santa Fe

Frequently asked questions

Looking for a spa hotel in Guanajuato?
Treat yourself to some time in a luxurious spa hotel and you won't regret it. Travellers like the historical sites in Guanajuato. Take in the culture at the museums and cathedral during your stay. Hotels with spas are the perfect way to take a break from your routine and add a layer of luxury to your holiday.
What is the best spa hotel in Guanajuato?
Hotel Suites Corazon Mexicano is a top spa hotel featuring a fitness centre and a restaurant. Enjoy a couples treatment or sauna at Spa Muluki. Other popular spa hotels in Guanajuato include Nueve 25 Hotel Boutique and Edelmira Hotel Boutique.
How many spa hotels will I find in Guanajuato?
Among Expedia's 178 accommodation options in Guanajuato, there are 7 spa hotels.
What's there to see and do in Guanajuato?
Enjoy Guanajuato and visit Hidalgo Market, Alley of the Kiss and La Paz Square. If you have extra time while you're in the area, you might want to see Basilica of Our Lady of Guanajuato and Union Garden.
What is a Guanajuato spa hotel?
Spa hotels in Guanajuato provide lodging and have an on-site spa offering services including facials as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation and relaxation.