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Our top choices for East Side Pioneers hotels

Exterior
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
East Side Pioneers
8.8 out of 10, Excellent, (892)
"Room was clean and comfortable Staff courteous Comfortable beds Great restaurant"
United States
Matney
The price is ฿2,513
฿2,893 total
includes taxes & fees
1 Jan - 2 Jan 2026
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Presidential Suite, Multiple Beds | Living area | 55-inch LCD TV with satellite channels, TV
Hilton Rochester Mayo Clinic Area

Hilton Rochester Mayo Clinic Area

Hilton Rochester Mayo Clinic Area
3.5 star property
East Side Pioneers
9.6 out of 10, Exceptional, (546)
"Very courteous staff, loved the valet guy!"
United States
Jean
The price is ฿5,383
฿6,197 total
includes taxes & fees
2 Jan - 3 Jan 2026
Hilton Rochester Mayo Clinic Area
Two-Bedroom Apartment - Mobility Accessible/Non-Smoking | In-room safe, individually furnished, desk, laptop workspace
Broadway Plaza, Trademark Collection by Wyndham

Broadway Plaza, Trademark Collection by Wyndham

Broadway Plaza, Trademark Collection by Wyndham
3.0 star property
East Side Pioneers
9.2 out of 10, Wonderful, (167)
"Great staff, clean room, spacious kitchen and living room."
United States
silvia
The price is ฿4,864
฿5,600 total
includes taxes & fees
28 Dec - 29 Dec
Broadway Plaza, Trademark Collection by Wyndham
Reception
Hampton Inn Rochester-South

Hampton Inn Rochester-South

Hampton Inn Rochester-South
2.5 star property
3.3 km from East Side Pioneers
9.0 out of 10, Wonderful, (1011)
"We had a wonderful stay!"
United States
Sarah
The price is ฿2,584
฿2,974 total
includes taxes & fees
11 Jan - 12 Jan 2026
Hampton Inn Rochester-South
Exterior
Holiday Inn Express Rochester South - Mayo Area by IHG

Holiday Inn Express Rochester South - Mayo Area by IHG

Holiday Inn Express Rochester South - Mayo Area by IHG
2.5 star property
6.9 km from East Side Pioneers
8.8 out of 10, Excellent, (1004)
"Clean rooms, very friendly staff and just all around homey "
United States
Kathy
The price is ฿2,293
฿2,640 total
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express Rochester South - Mayo Area by IHG
Terrace/patio
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area
3.0 star property
Downtown Rochester, 1.3 km from East Side Pioneers
9.2 out of 10, Wonderful, (1005)
"Quick and easy check-in, walkable area and nice breakfast and accomodations. Would stay again!"
United States
Elizabeth
The price is ฿4,052
฿4,664 total
includes taxes & fees
23 Dec - 24 Dec
Hyatt House Rochester/Mayo Clinic Area
View from property
Kahler Grand Hotel

Kahler Grand Hotel

Kahler Grand Hotel
3.0 star property
Downtown Rochester, 1.3 km from East Side Pioneers
8.4 out of 10, Very good, (1839)
"It was just perfect!"
United States
Shannon
The price is ฿4,212
฿4,849 total
includes taxes & fees
24 Dec - 25 Dec
Kahler Grand Hotel
Courtyard
EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG
4.0 star property
Kutzky Park, 2.3 km from East Side Pioneers
9.4 out of 10, Exceptional, (963)
"Rooms are comfortable and staff was was so professional and helpful."
United States
William
The price is ฿3,423
฿4,004 total
includes taxes & fees
26 Dec - 27 Dec
EVEN Hotel Rochester - Mayo Clinic Area by IHG
Desk, blackout curtains, iron/ironing board, free cots/infant beds
AmericInn by Wyndham Rochester

AmericInn by Wyndham Rochester

AmericInn by Wyndham Rochester
2.0 star property
12.2 km from East Side Pioneers
8.8 out of 10, Excellent, (1002)
"Enjoyed our stay, rated breakfast as a erage as we did not try it."
United States
jeanne
The price is ฿2,376
฿2,735 total
includes taxes & fees
26 Dec - 27 Dec
AmericInn by Wyndham Rochester
Breakfast served
Hilton Garden Inn Rochester Downtown, MN

Hilton Garden Inn Rochester Downtown, MN

Hilton Garden Inn Rochester Downtown, MN
3.0 star property
Downtown Rochester, 1.1 km from East Side Pioneers
8.8 out of 10, Excellent, (853)
"Everything was wonderful! Helpful, friendly staff, great location, nice amenities."
United States
kristi
The price is ฿3,362
฿3,870 total
includes taxes & fees
2 Jan - 3 Jan 2026
Hilton Garden Inn Rochester Downtown, MN
Serves lunch, dinner and happy hour
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic
3.0 star property
3 km from East Side Pioneers
8.2 out of 10, Very good, (1146)
"Good price, room clean, descent breakfast. I have stayed here several time"
United States
Amy M
The price is ฿2,292
฿2,639 total
includes taxes & fees
26 Dec - 27 Dec
AmericInn by Wyndham Rochester Near Mayo Clinic
Front of property
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3.0 star property
7.3 km from East Side Pioneers
7.2 out of 10, Good, (1025)
"Staff was courteous and breakfast was well stocked."
United States
Doug
The price is ฿2,205
฿2,538 total
includes taxes & fees
25 Dec - 26 Dec
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Pub
TownePlace Suites by Marriott Rochester Mayo Clinic Area

TownePlace Suites by Marriott Rochester Mayo Clinic Area

TownePlace Suites by Marriott Rochester Mayo Clinic Area
3.0 star property
Downtown Rochester, 1.7 km from East Side Pioneers
9.6 out of 10, Exceptional, (481)
"Room was large, clean, beds were comfortable. Downstairs cafe and seating areas were very comfortable."
United States
Ann
The price is ฿3,989
฿4,592 total
includes taxes & fees
26 Dec - 27 Dec
TownePlace Suites by Marriott Rochester Mayo Clinic Area
Restaurant
Hampton Inn & Suites Rochester-North

Hampton Inn & Suites Rochester-North

Hampton Inn & Suites Rochester-North
2.5 star property
8.2 km from East Side Pioneers
9.2 out of 10, Wonderful, (1004)
"Pool was nice "
Canada
Jesse
The price is ฿2,807
฿3,232 total
includes taxes & fees
28 Dec - 29 Dec
Hampton Inn & Suites Rochester-North
Exterior
Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG
2.5 star property
Kutzky Park, 2.9 km from East Side Pioneers
8.8 out of 10, Excellent, (765)
"Clean room, friendly staff. The only minus is the lighting in the bathroom, way too dim. "
United States
Stacy
The price is ฿2,733
฿3,146 total
includes taxes & fees
25 Dec - 26 Dec
Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG
Free daily full breakfast
Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area
2.0 star property
3.4 km from East Side Pioneers
9.0 out of 10, Wonderful, (898)
"Good breakfast..shuttle service is excellent..super nice staff.."
United States
DALE K
The price is ฿2,123
฿2,444 total
includes taxes & fees
9 Jan - 10 Jan 2026
Econo Lodge Mayo Clinic Area
Exterior
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
3.0 star property
Kutzky Park, 2.7 km from East Side Pioneers
9.2 out of 10, Wonderful, (771)
"Clean room and housekeeping service was excellent"
United States
Dawn
The price is ฿2,638
฿3,037 total
includes taxes & fees
25 Dec - 26 Dec
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
Lobby sitting area
Brentwood Inn & Suites

Brentwood Inn & Suites

Brentwood Inn & Suites
2.5 star property
Downtown Rochester, 1.5 km from East Side Pioneers
8.8 out of 10, Excellent, (1007)
"Convenient, clean location and friendly staff"
United States
Kaushika
The price is ฿3,533
฿4,068 total
includes taxes & fees
23 Dec - 24 Dec
Brentwood Inn & Suites
Reception
Spark by Hilton Rochester South

Spark by Hilton Rochester South

Spark by Hilton Rochester South
3.0 star property
7 km from East Side Pioneers
9.4 out of 10, Exceptional, (326)
"Great place"
United States
Abidemi
The price is ฿2,215
฿2,550 total
includes taxes & fees
28 Dec - 29 Dec
Spark by Hilton Rochester South
Indoor pool, open 7:00 AM to 10:00 PM, pool loungers
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area
3.5 star property
Downtown Rochester, 1.4 km from East Side Pioneers
8.0 out of 10, Very good, (1522)
"Clean room, good room service and good breakfast."
United States
Donald
The price is ฿4,381
฿5,044 total
includes taxes & fees
23 Dec - 24 Dec
Kahler Inn and Suites - Mayo Clinic Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in East Side Pioneers

Find the best East Side Pioneers areas for the activities you enjoy most.
Rochester showing skyline and a city
Photo by Howard Lower Photography
Open Photo by Howard Lower Photography

Downtown Rochester

If you're spending some time in Downtown Rochester, Mayo Civic Center and Rochester Civic Theater are top sights worth seeing.

Kutzky Park

While there might not be top attractions in Kutzky Park, you can explore the larger area and discover places like Soldiers Field Veterans Memorial and Mayo Civic Center.

Rochester which includes a river or creek and forests
Photo by Chad Johnson
Open Photo by Chad Johnson

Historic Southwest

While visiting Historic Southwest, you might make a stop by sights like Soldiers Field Veterans Memorial and Plummer House.

Slatterly Park

While Slatterly Park isn't home to many top sights, Rochester Art Center and Soldiers Field Veterans Memorial are some notable places to visit nearby.

Folwell

Though Folwell may not have many top sights, you can venture to the surrounding area to see attractions like Soldiers Field Veterans Memorial and Apache Mall.

Top East Side Pioneers Hotel Reviews

Kahler Grand Hotel

Kahler Grand Hotel

10/10 Excellent
"Great place to stay downtown. "
LORETTA 1-night trip
Posted 3 days ago
Kahler Grand Hotel

Frequently asked questions

What's it like in East Side Pioneers?
Travellers are sure to enjoy a stay in Rochester's East Side Pioneers neighbourhood. Are you looking for East Side Pioneers travel tips? Make sure that you visit Rochester Art Center and Rochester Civic Theater while you're in the neighbourhood.
What's the best accommodation in East Side Pioneers?
Based on Expedia customer reviews, Hilton Rochester Mayo Clinic Area is the highest ranked property in East Side Pioneers. This hotel is a short 6-minute walk from Mayo Clinic, and it offers a full-service spa and 2 restaurants. Another favourite option in the neighbourhood is Hotel Indigo Rochester – Mayo Clinic Area by IHG.
How many hotels should I expect to find in East Side Pioneers?
If you're searching for places to stay in Rochester, choose from one of Expedia's 17 hotels and other accommodation options in East Side Pioneers.
If I need to cancel my hotel reservation in East Side Pioneers, will I receive a refund?
Yes! The majority of room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then use the filter option "fully refundable" to get the best deals in East Side Pioneers.
What can I see and do in this Rochester neighbourhood?
Spend some time exploring the natural setting of East Side Pioneers with a visit to Silver Lake Park and Mayo Park. You could also plan a visit to Rochester Art Center or Rochester Civic Theater while you're in the neighbourhood. A few places to visit in the area around East Side Pioneers include Mayo Civic Center, Rochester Public Library and Shops University Square. While you're out sightseeing, Plummer Building and Soldiers Field Veterans Memorial are a couple of additional sights to visit in Rochester.