Find hotels in East Prairie, MO from ฿1,745

Start date: Check-in selected.
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Top 10 East Prairie hotels and places to stay

Days Inn and Suites by Wyndham Sikeston

2.0 star property
7.2 out of 10, Good, (1002)
"The room was awesome and the building had a historical thing about it."
The price is ฿2,018
฿2,300 total
includes taxes & fees
15 Sept - 16 Sept
Days Inn and Suites by Wyndham Sikeston

Hampton Inn Sikeston

2.5 star property
8.8 out of 10, Excellent, (387)
"I liked everything about this property this is where i stay every time im in town "
The price is ฿3,408
฿3,859 total
includes taxes & fees
21 Sept - 22 Sept
Hampton Inn Sikeston

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 star property
8.6 out of 10, Excellent, (428)
"Close in eating and shopping "
The price is ฿3,368
฿3,814 total
includes taxes & fees
3 Oct - 4 Oct
Holiday Inn Express & Suites Sikeston Southwest by IHG

Best Western Plus Sikeston

2.5 star property
8.4 out of 10, Very good, (1004)
"Staff was friendly and room was very clean. A very comfortable stay"
The price is ฿2,699
฿3,076 total
includes taxes & fees
21 Sept - 22 Sept
Best Western Plus Sikeston

Super 8 by Wyndham Sikeston/Miner Area

2.0 star property
6.6 out of 10, (553)
"I enjoyed our stay"
The price is ฿1,905
฿2,172 total
includes taxes & fees
21 Sept - 22 Sept
Super 8 by Wyndham Sikeston/Miner Area

Sleep Inn at Discovery Park of America

2.5 star property
9.0 out of 10, Wonderful, (270)
"This place must be brand new, the pillows and bed were perfect, everything was spotlessly clean, and the complementary breakfast was wonderful!"
The price is ฿2,699
฿3,206 total
includes taxes & fees
28 Sept - 29 Sept
Sleep Inn at Discovery Park of America

Pear Tree Inn Sikeston

2.5 star property
9.4 out of 10, Exceptional, (1004)
"I love this hotel! Have stayed several times and will definitely stay again. The rooms are always very clean and the staff is so friendly and helpful. I highly recommend this hotel!"
The price is ฿2,470
฿2,839 total
includes taxes & fees
15 Sept - 16 Sept
Pear Tree Inn Sikeston

Super 8 by Wyndham Charleston/Sikeston East MO

2.0 star property
6.6 out of 10, (587)
"Rooms was clean "
The price is ฿1,827
฿2,028 total
includes taxes & fees
9 Sept - 10 Sept
Super 8 by Wyndham Charleston/Sikeston East MO

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 star property
8.4 out of 10, Very good, (676)
"Everything was nice"
The price is ฿1,940
฿2,212 total
includes taxes & fees
9 Sept - 10 Sept
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Hospitality House Union City I 69 / US 51

2.5 star property
6.8 out of 10, (330)
"Owners trying to clean up the drug activity and prostitution going on..otherwise place can be a decent place !"
The price is ฿1,745
฿2,073 total
includes taxes & fees
7 Oct - 8 Oct
Hospitality House Union City I 69 / US 51

Comfort Inn & Suites Sikeston I-55

2.5 star property
8.4 out of 10, Very good, (271)
"The facility was very nice. "
The price is ฿2,972
฿3,387 total
includes taxes & fees
21 Sept - 22 Sept
Comfort Inn & Suites Sikeston I-55

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1003)
"Great location "
The price is ฿2,887
฿3,319 total
includes taxes & fees
15 Sept - 16 Sept
Drury Inn & Suites Sikeston, MO

Quality Inn Union City US 51

2.5 star property
8.4 out of 10, Very good, (465)
"Nice place. Everything went as should and no hidden fees. "
The price is ฿2,154
฿2,558 total
includes taxes & fees
28 Sept - 29 Sept
Quality Inn Union City US 51

Quality Inn Cairo I-57

2.5 star property
6.6 out of 10, (266)
"The hotel is in need of some serious upkeep and cleaning. It is in fairly poor condition, but it the only hotel in town."
The price is ฿2,181
฿2,421 total
includes taxes & fees
6 Oct - 7 Oct
Quality Inn Cairo I-57

Fairfield Inn & Suites by Marriott Sikeston

2.5 star property
9.4 out of 10, Exceptional, (22)
"Nice hotel "
The price is ฿3,240
฿3,668 total
includes taxes & fees
21 Sept - 22 Sept
Fairfield Inn & Suites by Marriott Sikeston

Country Hearth Inn & Suites Union City

2.5 star property
8.6 out of 10, Excellent, (531)
"Very good!"
The price is ฿2,309
฿2,742 total
includes taxes & fees
9 Sept - 10 Sept
Country Hearth Inn & Suites Union City

Holiday Inn Express & Suites Union City by IHG

2.5 star property
9.4 out of 10, Exceptional, (290)
"There was absolutely nothing I didn't like. It was very clean, very quiet, beds were awesome, and breakfast was hot and fresh. "
The price is ฿3,689
฿4,381 total
includes taxes & fees
3 Oct - 4 Oct
Holiday Inn Express & Suites Union City by IHG

New Orleans Inn Portageville

2.5 star property
8.0 out of 10, Very good, (690)
"Very nice stay"
New Orleans Inn Portageville

Travel Inn

2.5 star property
5.6 out of 10, (110)
"Great place"
Travel Inn

TownePlace Suites by Marriott Sikeston

3.0 star property
8.4 out of 10, Very good, (5)
"I loved all of what this property had to offer "
The price is ฿4,170
฿4,722 total
includes taxes & fees
18 Sept - 19 Sept
TownePlace Suites by Marriott Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top East Prairie Hotel Reviews

More cheap stays in East Prairie

More cheap stays in East Prairie

Frequently asked questions

What's the best place for a stay in East Prairie?

Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay, based on our traveller data. Other good choices for your trip to the area are Best Western Plus Sikeston and Pear Tree Inn Sikeston. See all available top hotels, or vacation rentals in East Prairie.

If I need to cancel my hotel reservation in East Prairie, will I receive a refund?

Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.

How is it staying in East Prairie?

Visitors will definitely enjoy all that East Prairie has to offer. There are 30 hotels and other accommodation options in the surrounding area. Find out more about East Prairie.

What are the top places to visit in East Prairie?

The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Central Park and Sikeston Depot Museum in the area. Take a look at what more there is to see and do in Expedia's East Prairie guide.

What's the weather like in East Prairie?

The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.