East Prairie Holiday Rentals, Missouri: Private House Rentals

A tree-lined landscape with a river and fields.

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Our top choices for East Prairie hotels

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.

A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.

1. Drury Inn & Suites Sikeston, MO

Sikeston

Scott

฿3,138

฿3,608 total

includes taxes & fees

4 Oct - 5 Oct

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

A hotel lobby with a bar area, seating arrangements, and a large window providing natural light.

An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.

A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.

2. Hampton Inn Sikeston

Sikeston

John

฿3,395

฿3,844 total

includes taxes & fees

4 Oct - 5 Oct

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A conference room with a long table, multiple chairs, and a television screen on the wall.

An indoor swimming pool with a tiled floor, a lifeguard chair, and a pool ladder.

A Holiday Inn Express & Suites building with a covered entrance, multiple windows, and a parking lot.

3. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

Melissa

฿3,372

฿3,818 total

includes taxes & fees

18 Oct - 19 Oct

A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

A restaurant with wooden cabinets, a refrigerator, and a counter with various items. There are tables and chairs for dining.

A reception area with a counter, a flat-screen TV, and a window with blinds.

4. Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

William

฿1,987

฿2,205 total

includes taxes & fees

28 Sept - 29 Sept

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

5. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Allen

฿3,372

฿3,818 total

includes taxes & fees

4 Oct - 5 Oct

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

A hotel with a covered entrance, a sign indicating a restaurant, and a well-lit parking area.

A reception area with a wooden reception desk, a large painting on the wall, and a potted plant.

6. Best Western Plus Sikeston I-55

Sikeston

Shelley

฿2,911

฿3,318 total

includes taxes & fees

11 Oct - 12 Oct

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

A modern kitchen with stainless steel appliances, wooden cabinets, and a bright yellow accent wall.

A Travel Inn and Suites with a brick facade, a flat roof, and a welcoming entrance.

A reception area with a sign for 'Travel Inn and Suites' and a counter with a computer and a phone.

7. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

Sharika West

฿2,320

฿2,644 total

includes taxes & fees

28 Sept - 29 Sept

A building with a fountain and flower beds in front.

A modern kitchen with dark wooden cabinets, a central island, and a ceiling fan.

A hotel room with a beige sofa, two patterned armchairs, a ceiling fan, a flat-screen TV, and a window with curtains.

A hotel room with a large bed, two bedside tables with lamps, a chair, a small table, and a picture on the wall.

8. The Riverstone Hotel Charleston-Sikeston

Charleston

Jay

฿2,220

฿2,463 total

includes taxes & fees

29 Sept - 30 Sept

A modern hotel room with a large window, a gray sofa, a small round table, a white chair, and a bed.

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.

9. TownePlace Suites by Marriott Sikeston

Sikeston

Stacy

฿3,339

฿3,780 total

includes taxes & fees

4 Oct - 5 Oct

A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.

A spacious lobby with a central atrium, a piano, and a reception desk.

10. Days Inn and Suites by Wyndham Sikeston

Sikeston

David

฿2,214

฿2,523 total

includes taxes & fees

30 Sept - 1 Oct

A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.

A hotel lobby with a reception desk, seating area, and large windows offering a view of the outdoors.

A hot tub area with a tiled floor, a wooden deck surrounding the tub, and a view of the sky through large windows.

A living room with two sofas, a coffee table, a TV, and a cabinet.

11. Comfort Inn & Suites Sikeston I-55

Sikeston

Starlette

฿2,922

฿3,330 total

includes taxes & fees

25 Oct - 26 Oct

A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

A kitchen with wooden cabinets, a granite countertop, a built-in microwave, and a window with a view.

A motel with a sign reading "Eagle Inn" and a parking lot with several cars.

A bathroom with a sink, mirror, towel rack, shower, and toilet.

12. Eagle Inn Charleston

Charleston

Jackson

฿2,203

฿2,445 total

includes taxes & fees

28 Sept - 29 Sept

A hotel room with two beds, a desk, a chair, a TV, and a mirror.

A reception area with a sofa, a small table, a trash bin, a microwave, and a book display.

A bathroom with a bathtub, toilet, and shower curtain.

A reception area with a counter, a coffee machine, and seating.

13. Country Yard Inn and Suite

Sikeston

William

฿2,046

฿2,434 total

includes taxes & fees

28 Sept - 29 Sept

A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

A hotel room with a flat-screen TV, a microwave, a coffee maker, a dining table, and two sofas.

A hotel kitchen with a long counter, various appliances, and a tiled backsplash.

A motel with a covered entrance, multiple rooms, and a parking lot.

14. Super 8 by Wyndham Sikeston/Miner Area

Sikeston

William

฿1,907

฿2,174 total

includes taxes & fees

4 Oct - 5 Oct

A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.

A room with a brown leather sofa, a red chair, and a cityscape painting on the wall.

A modern kitchen with a stone backsplash, a dining area with red chairs, and a red accent wall with a framed picture.

A hotel with a central entrance, multiple parking spaces, and a well-lit facade.

15. Super 8 By Wyndham Marston

Marston

Rachel

฿1,925

฿2,199 total

includes taxes & fees

29 Sept - 30 Sept

A hotel lobby with a reception desk, seating area, and a large window.

A hotel lobby with a reception desk, two armchairs, a coffee table, and large windows with potted plants.

A hotel room with a desk, chair, television, and a lamp.

A hotel room with two beds, a desk with a computer, a television, and a window with curtains.

16. Quality Inn Cairo I-57

Cairo

Santiago

฿2,279

฿2,530 total

includes taxes & fees

9 Oct - 10 Oct

A fireplace with a framed painting above it, flanked by two vases of flowers.

A restaurant with yellow walls, a red carpet, a chandelier, a ceiling fan, and Christmas decorations.

A Country Hearth Inn with a red brick facade, a covered front porch, and a well-maintained lawn.

A reception desk with a wooden counter, a chandelier, and a plant on the right.

17. Country Hearth Inn & Suites Union City

Union City

Jade

฿2,009

฿2,386 total

includes taxes & fees

4 Oct - 5 Oct

A reception area with a reception desk, two blue armchairs, a round table, and a glass door leading outside.

A modern building with a covered entrance, a nameplate, and a landscaped area with shrubs and a street lamp.

An outdoor patio area with a blue sectional sofa, an orange ottoman, and black metal chairs.

A corridor with a vending machine displaying various beverages and a wall with hanging products.

18. Sleep Inn at Discovery Park of America

Union City

Ben

฿2,951

฿3,504 total

includes taxes & fees

11 Oct - 12 Oct

An outdoor seating area with a fire pit, cushioned chairs, and a metal fence.

A modern hotel lobby with multiple seating areas, a kitchen in the background, and large windows with curtains.

A Hampton Inn hotel with a modern design, featuring a well-lit entrance and a clear signage.

A hotel lobby with a long counter, multiple seating areas, and a modern chandelier.

19. Hampton Inn Union City

Union City

Clarence

฿3,945

฿4,684 total

includes taxes & fees

11 Oct - 12 Oct

A hotel room with a dark wooden desk, a television, a lamp, a chair, and a mirror on the wall.

A bathroom with a bathtub, a toilet, and a sink.

A parking space marked with a wheelchair accessibility symbol.

A building with multiple floors and a flat roof, surrounded by a grassy area with trees.

20. Reelfoot Lake Inn

Tiptonville

Larry

฿2,037

฿2,337 total

includes taxes & fees

6 Oct - 7 Oct

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Stay near popular East Prairie attractions

Big Oak Tree State Park

8.0/10 (20 reviews)

You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.

See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie

Top East Prairie Hotel Reviews

Hampton Inn Union City

10/10 Excellent

"Don’t need to change a thing. Great job!"

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

10/10 Excellent

"It has been updated somewhat but is still an older building. I don't think carpets are ever clean enough. The staff is always friendly and helpful. I love staying here."

Sleep Inn at Discovery Park of America

10/10 Excellent

"Nice and clean. Had a great stay!"

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Clean room and perfect stay. We have come to consistently appreciate Drury brand for a quality stay. We would definitely recommend this location for clean comfortable accommodations."

Hampton Inn Sikeston

10/10 Excellent

"Staff was great"

Super 8 by Wyndham Charleston/Sikeston East MO

10/10 Excellent

"Súper affordable pricing, and the property was clean and comfortable! Complimentary breakfast was a plus!"

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent

"This was a very good value. It has been the best hotel I've stayed at in awhile."

Holiday Inn Express & Suites Union City by IHG

8/10 Good

"Love the staff and the parking and the quiet"

The Riverstone Hotel Charleston-Sikeston

8/10 Good

"Overall it was excellant, other then the toilet running constantly... Pool could have been cleaner, considering the heat-wave they were having............."

More cheap stays in East Prairie

Super 8 by Wyndham Sikeston/Miner Area

2609 E Malone Ave Sikeston MO

฿1,907

฿2,174 total

4 Oct - 5 Oct

includes taxes & fees

Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St Charleston MO

฿1,987

฿2,205 total

28 Sept - 29 Sept

includes taxes & fees

6.8/10 (669 reviews)

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

฿2,214

฿2,523 total

30 Sept - 1 Oct

includes taxes & fees

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

฿2,911

฿3,318 total

11 Oct - 12 Oct

includes taxes & fees

Sleep Inn at Discovery Park of America

1111 BLue Heron Lane Union City TN

฿2,951

฿3,504 total

11 Oct - 12 Oct

includes taxes & fees

9.2/10 Wonderful! (436 reviews)

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

฿3,395

฿3,844 total

4 Oct - 5 Oct

includes taxes & fees

9/10 Wonderful! (624 reviews)

Frequently asked questions

What's the best place for a stay in East Prairie?

Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay, based on our traveller data. Other good choices for your trip to the area are Days Inn and Suites by Wyndham Sikeston and Best Western Plus Sikeston I-55. See all available top hotels, or vacation rentals in East Prairie.

If I need to cancel my hotel reservation in East Prairie, will I receive a refund?

Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.

How is it staying in East Prairie?

Visitors will definitely enjoy all that East Prairie has to offer. There are 36 hotels and other accommodation options in the surrounding area. Find out more about East Prairie.

What are the top places to visit in East Prairie?

The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Columbus-Belmont State Park and Fort Defiance State Park in the area. Take a look at what more there is to see and do in Expedia's East Prairie guide.

What's the weather like in East Prairie?

The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.

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Book Hotels in East Prairie on Expedia.com

Find hotels in East Prairie, MO from ฿2,174

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in East Prairie

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for East Prairie hotels

1. Drury Inn & Suites Sikeston, MO

2. Hampton Inn Sikeston

3. Holiday Inn Express & Suites Sikeston Southwest by IHG

4. Super 8 by Wyndham Charleston/Sikeston East MO

5. Fairfield Inn & Suites by Marriott Sikeston

6. Best Western Plus Sikeston I-55

7. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8. The Riverstone Hotel Charleston-Sikeston

9. TownePlace Suites by Marriott Sikeston

10. Days Inn and Suites by Wyndham Sikeston

11. Comfort Inn & Suites Sikeston I-55

12. Eagle Inn Charleston

13. Country Yard Inn and Suite

14. Super 8 by Wyndham Sikeston/Miner Area

15. Super 8 By Wyndham Marston

16. Quality Inn Cairo I-57

17. Country Hearth Inn & Suites Union City

18. Sleep Inn at Discovery Park of America

19. Hampton Inn Union City

20. Reelfoot Lake Inn

Stay near popular East Prairie attractions

Big Oak Tree State Park

Learn more about East Prairie

Top East Prairie Hotel Reviews

Hampton Inn Union City

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sleep Inn at Discovery Park of America

Drury Inn & Suites Sikeston, MO

Hampton Inn Sikeston

Super 8 by Wyndham Charleston/Sikeston East MO

Days Inn and Suites by Wyndham Sikeston

Holiday Inn Express & Suites Union City by IHG

The Riverstone Hotel Charleston-Sikeston

More cheap stays in East Prairie

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Charleston/Sikeston East MO

Days Inn and Suites by Wyndham Sikeston

Best Western Plus Sikeston I-55

Sleep Inn at Discovery Park of America

Hampton Inn Sikeston

Frequently asked questions

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