A tree-lined landscape with a river and fields.

Find hotels in East Prairie, MO from ฿2,043

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Our top choices for East Prairie hotels

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,004 reviews)
"Great place!"
United States
Jennifer
The price is ฿3,705
฿4,259 total
includes taxes & fees
15 Jul - 16 Jul
Drury Inn & Suites Sikeston, MO

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very good, (778 reviews)
"Great stay with Great people, very clean and welcoming"
United States
Mircea
The price is ฿1,892
฿2,043 total
includes taxes & fees
5 Jul - 6 Jul
New Orleans Inn Portageville

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (643 reviews)
"Clean rooms,"
United States
Karl
The price is ฿1,986
฿2,204 total
includes taxes & fees
5 Jul - 6 Jul
Super 8 by Wyndham Charleston/Sikeston East MO

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (418 reviews)
"It was not at all what I expected. The website showed a very good hotel. It was awful. I would not paid even $40/ night if I knew how awful it is. I felt bad for the ladies working on front desk."
United States
Soheila
The price is ฿2,503
฿2,778 total
includes taxes & fees
29 Jun - 30 Jun
The Riverstone Hotel Charleston-Sikeston

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (583 reviews)
"Staff were great at Check in, room was clean, breakfast was good."
United States
Brandi
The price is ฿3,531
฿3,998 total
includes taxes & fees
9 Jul - 10 Jul
Hampton Inn Sikeston

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (473 reviews)
"Only stayed one night, no complaints"
United States
Zachary
The price is ฿3,505
฿3,968 total
includes taxes & fees
26 Jul - 27 Jul
Holiday Inn Express & Suites Sikeston Southwest by IHG

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (793 reviews)
"I love it there."
United States
Sharika West
The price is ฿2,586
฿2,948 total
includes taxes & fees
29 Jun - 30 Jun
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (96 reviews)
"Great stay, kind staff, very clean property."
United States
Joni
The price is ฿3,371
฿3,817 total
includes taxes & fees
5 Jul - 6 Jul
Fairfield Inn & Suites by Marriott Sikeston

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (401 reviews)
"The room was clean, the breakfast was good. We enjoyed our stay."
United States
David
The price is ฿3,139
฿3,728 total
includes taxes & fees
1 Jul - 2 Jul
Sleep Inn at Discovery Park of America

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.2 out of 10, Very good, (65 reviews)
"Clean room, The receptionist very friendly, good parking."
United States
Temera
The price is ฿2,764
฿3,157 total
includes taxes & fees
29 Jun - 30 Jun
Super 8 By Wyndham Marston

Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (1,004 reviews)
"Very convenient and staff was great."
United States
jeanne
The price is ฿2,830
฿3,225 total
includes taxes & fees
26 Jul - 27 Jul
Best Western Plus Sikeston I-55

Reelfoot Lake Inn

Reelfoot Lake Inn
2.0 star property
Tiptonville
7.2 out of 10, Good, (499 reviews)
"The lake view was beautiful and staff was amazing"
United States
Richard
The price is ฿2,327
฿2,670 total
includes taxes & fees
29 Jun - 30 Jun
Reelfoot Lake Inn

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (572 reviews)
"It was great "
United States
Jade
The price is ฿1,997
฿2,372 total
includes taxes & fees
1 Jul - 2 Jul
Country Hearth Inn & Suites Union City

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,001 reviews)
"Business friendly, clean room staff very friendly, accommodating."
United States
Janice
The price is ฿2,270
฿2,587 total
includes taxes & fees
13 Jul - 14 Jul
Days Inn and Suites by Wyndham Sikeston

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (186 reviews)
"Friendly staff, comfortable bed."
United States
James
The price is ฿3,777
฿4,485 total
includes taxes & fees
5 Jul - 6 Jul
Hampton Inn Union City

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (332 reviews)
"I enjoy myself and I will recommend anybody to stay.."
United States
Faye
The price is ฿3,605
฿4,281 total
includes taxes & fees
11 Jul - 12 Jul
Holiday Inn Express & Suites Union City by IHG

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.2 out of 10, Very good, (528 reviews)
"Breakfast was filling and fresh. Short overnight stay which completely met our needs First level room with convenient vehicle parking right outside the door which made moving luggage painless. "
United States
Lisa
The price is ฿2,355
฿2,796 total
includes taxes & fees
16 Jul - 17 Jul
Quality Inn Union City US 51

Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (140 reviews)
"Enjoyed our stay. All the appliances worked and our air conditioner kept us cool! Will definitely stay here again!"
United States
Sheryl
The price is ฿2,037
฿2,424 total
includes taxes & fees
30 Jun - 1 Jul
Country Yard Inn and Suite

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
7.0 out of 10, Good, (654 reviews)
"Staff is great rooms clean no bugs and bed was comfortable "
United States
James
The price is ฿2,103
฿2,397 total
includes taxes & fees
26 Jul - 27 Jul
Super 8 by Wyndham Sikeston/Miner Area

Travel Inn Marston I-55 by Hotel O

Travel Inn Marston I-55 by Hotel O
2.5 star property
Marston
6.0 out of 10, (125 reviews)
"Quiet safe area."
United States
Frank
The price is ฿1,752
฿2,177 total
includes taxes & fees
29 Jun - 30 Jun
Travel Inn Marston I-55 by Hotel O
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

A tree-lined landscape with a river and fields.

Top East Prairie Hotel Reviews

More cheap stays in East Prairie

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay, based on our traveller data. Other good choices for your trip to the area are Days Inn and Suites by Wyndham Sikeston and Hampton Inn Sikeston. See all available top hotels, or vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
How is it staying in East Prairie?
Visitors will definitely enjoy all that East Prairie has to offer. There are 33 hotels and other accommodation options in the surrounding area. Find out more about East Prairie.
What are the top places to visit in East Prairie?
The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Central Park and Sikeston Depot Museum in the area. Take a look at what more there is to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.