Find hotels in East Prairie, MO from ฿1,528

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24 Dec - 25 Dec
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26 Dec - 28 Dec
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Our top choices for East Prairie hotels

Suite, 2 Queen Beds, Non Smoking | Individually furnished, desk, laptop workspace, blackout curtains
MainStay Suites Union City, TN

MainStay Suites Union City, TN

MainStay Suites Union City, TN
2.5 star property
Union City
8.6 out of 10, Excellent, (42)
Hiking trails surround this welcoming hotel with free breakfast and parking. The 24-hour fitness centre and health club keep exercise routines on track, while in-room refrigerators and microwaves add convenience for extended stays.
"Perfect, staff was very helpful."
United States
Marcos
The price is ฿2,768
฿3,288 total
includes taxes & fees
29 Dec - 30 Dec
MainStay Suites Union City, TN
Lobby
Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (320)
Located in Union City, this hotel offers convenient access to Discovery Park of America. Enjoy free breakfast, WiFi, and parking. Jump into the indoor pool or get active in the 24-hour fitness centre, making your Tennessee adventure complete.
"Wonderful breakfast, awesome room"
United States
Kimberly
The price is ฿2,492
฿2,959 total
includes taxes & fees
2 Jan - 3 Jan 2026
Sleep Inn at Discovery Park of America
Free daily buffet breakfast
Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (310)
Experience comfort in the entertainment district of Union City at this welcoming hotel. Start your day with free breakfast before exploring nearby Discovery Park of America. After sightseeing, unwind in the indoor pool or maintain your routine at the 24-hour fitness centre.
"Rooms were spotless and comfortable. The bathroom had all the amenities. Great view. Awesome buffet breakfast to wake up to. "
United States
Rickey Smith
The price is ฿2,924
฿3,472 total
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Express & Suites Union City by IHG
Seasonal outdoor pool
Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51
2.5 star property
Union City
6.8 out of 10, (370)
Business travellers love this Union City hotel with a seasonal outdoor pool and on-site restaurant. Enjoy complimentary breakfast, WiFi, and parking. The helpful staff receives excellent reviews, and nearby County Market Place and Reelfoot Shopping Centre offer local attractions.
"Easy to check in.. Clean Room..Lots of food options near by.. "
United States
Pooran
The price is ฿1,692
฿2,010 total
includes taxes & fees
22 Jan - 23 Jan 2026
Hospitality House Union City I 69 / US 51
Reception
Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (548)
Discover convenience at this friendly Union City motel, where free breakfast and parking enhance every stay. Explore County Market Place and Reelfoot Shopping Centre nearby. Guests consistently praise the clean rooms and helpful staff.
"Clean rooms, helpful and polite staff"
United States
Jennifer
The price is ฿2,239
฿2,659 total
includes taxes & fees
25 Dec - 26 Dec
Country Hearth Inn & Suites Union City
Terrace/patio
Hampton Inn Union City

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (165)
Located near County Market Place and Reelfoot Shopping Centre, this welcoming hotel offers a free breakfast and convenient parking. Take a morning swim in the indoor pool after enjoying the complimentary meal. The helpful staff earns consistent praise from guests.
"Clean room, nice breakfast"
United States
STUART
The price is ฿3,188
฿3,786 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn Union City
Lobby
Quality Inn Union City US 51

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very good, (488)
Unwind at this Union City hotel offering a seasonal outdoor pool and hot tub for relaxation. Just a short distance from County Market Place and Reelfoot Shopping Centre, guests enjoy free breakfast, WiFi, and parking.
"The Staff for sure is what keeps me coming back! Plus the rooms are very clean!"
United States
Walter
The price is ฿2,090
฿2,482 total
includes taxes & fees
11 Jan - 12 Jan 2026
Quality Inn Union City US 51
Lobby
Quality Inn Cairo I-57

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (274)
Start your day with complimentary full breakfast before exploring nearby attractions. This hotel provides free WiFi and parking, making it an ideal base for visiting Fort Defiance State Park and Ballard Wildlife Management Area.
"Break fast was excellent "
United States
Uma
The price is ฿2,206
฿2,448 total
includes taxes & fees
17 Jan - 18 Jan 2026
Quality Inn Cairo I-57
Desk, iron/ironing board, free WiFi, alarm clocks
Eagle Inn Charleston

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (105)
Discover relaxation at this Charleston motel offering complimentary WiFi and parking. The on-site health club provides fitness options after exploring local attractions. Cape Girardeau Municipal Airport is just a 43-minute drive away.
"Middle of nowhere hotel was ok"
United States
David
The price is ฿1,882
฿2,088 total
includes taxes & fees
25 Dec - 26 Dec
Eagle Inn Charleston
Front of property – evening/night
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (613)
This Charleston motel offers complimentary on-the-go breakfast and WiFi for a hassle-free stay. Guests appreciate the helpful staff and free parking. Located within driving distance of Cape Girardeau Municipal Airport for easy regional access.
"Staff was great! Room was nice. "
United States
Lana
The price is ฿1,932
฿2,144 total
includes taxes & fees
19 Jan - 20 Jan 2026
Super 8 by Wyndham Charleston/Sikeston East MO
Handicap Room | Blackout curtains, iron/ironing board, free WiFi, bed sheets
Reelfoot Lake Inn

Reelfoot Lake Inn

Reelfoot Lake Inn
2.0 star property
Tiptonville
7.2 out of 10, Good, (461)
"Bed bugs in two separate rooms, wouldn’t refund my room"
United States
Jacquelynn
The price is ฿2,169
฿2,489 total
includes taxes & fees
27 Dec - 28 Dec
Reelfoot Lake Inn
Iron/ironing board, free WiFi, bed sheets
Country Yard Inn and Suite

Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (121)
This Sikeston motel offers a convenient base for exploring nearby Central Park and Sikeston Depot Museum. Enjoy thoughtful amenities like free WiFi and parking alongside 24-hour front desk service for assistance anytime.
"Great spot en route home from Mississippi. Staff put me in a room that ended up being in a quiet section of the hotel. Great sleep."
United States
Andrew
The price is ฿1,662
฿1,978 total
includes taxes & fees
25 Dec - 26 Dec
Country Yard Inn and Suite
1 bedroom, desk, laptop workspace, blackout curtains
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1002)
This tranquil Sikeston hotel offers complimentary on-the-go breakfast and WiFi, plus convenient access to Central Park and Sikeston Depot Museum. Guests appreciate the helpful staff, clean rooms, and free parking, with a fitness centre for morning workouts.
"A great stay in every aspect. "
United States
Gertrude
The price is ฿1,957
฿2,230 total
includes taxes & fees
20 Jan - 21 Jan 2026
Days Inn and Suites by Wyndham Sikeston
Free daily full breakfast
Best Western Plus Sikeston

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very good, (1009)
Located in Sikeston, this hotel offers an indoor pool for relaxing swims after a day of exploring. Near Central Park and the Sikeston Depot Museum, guests praise the delicious free breakfast and attentive service.
"Great stay, everything was clean and comfortable. "
United States
Charles
The price is ฿2,353
฿2,682 total
includes taxes & fees
29 Dec - 30 Dec
Best Western Plus Sikeston
Property amenity
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1000)
Located just off the highway near Sikeston dining and shopping, this hotel offers both indoor and outdoor pools for year-round swimming. Guests praise the peaceful atmosphere, helpful staff, and complimentary breakfast, parking, and WiFi.
"This our favorite place to stop for a good night sleep. "
United States
Eileen
The price is ฿2,799
฿3,218 total
includes taxes & fees
28 Dec - 29 Dec
Drury Inn & Suites Sikeston, MO
Exterior
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (722)
Enjoy tranquil accommodation at this welcoming Sikeston hotel where helpful staff receive consistent praise. Located near Central Park and Sikeston Depot Museum, guests appreciate the quiet atmosphere, clean rooms, and daily continental breakfast.
"Room was good as usual. This is 4th stay over past 5 years. Only issue I had on this stay was the orange juice from breakfast options. "
United States
Todd
The price is ฿1,726
฿1,967 total
includes taxes & fees
20 Jan - 21 Jan 2026
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Exterior
Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (282)
Experience refreshing comfort at this Sikeston hotel with an indoor swimming pool and fitness centre. Near Central Park and Sikeston Depot Museum, travellers appreciate the helpful staff, complimentary WiFi, and free parking for a convenient, stress-free stay.
"Room was clean, breakfast was very good. "
United States
Connie
The price is ฿2,750
฿3,134 total
includes taxes & fees
22 Jan - 23 Jan 2026
Comfort Inn & Suites Sikeston I-55
Lobby
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1002)
Escape to this serene retreat with both indoor and outdoor pools for year-round enjoyment. The fitness centre keeps your routine intact while complimentary breakfast energises your day exploring nearby Central Park and Sikeston Depot Museum.
"Everything was clean, staff was friendly "
United States
Matthew
The price is ฿2,333
฿2,682 total
includes taxes & fees
29 Dec - 30 Dec
Pear Tree Inn Sikeston
Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (450)
Take a refreshing dip in the indoor pool or maintain your routine at the fitness centre. Free breakfast, WiFi, and parking enhance your stay. Central Park and Sikeston Depot Museum are just moments away from this welcoming retreat.
"clean room, comfy bedding, nice staff, convenient location "
United States
Alexa
The price is ฿3,035
฿3,437 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn Sikeston
Room, 1 King Bed, Accessible, Non Smoking | Desk, laptop workspace, blackout curtains, free WiFi
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
6.8 out of 10, (568)
Start your day with complimentary breakfast at this Sikeston hotel. Enjoy free WiFi and parking while staying minutes from Central Park and the Sikeston Depot Museum. Cape Girardeau Municipal Airport is just a 29-minute drive away.
"Awesomeness "
United States
Rick
The price is ฿1,848
฿2,106 total
includes taxes & fees
13 Jan - 14 Jan 2026
Super 8 by Wyndham Sikeston/Miner Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Big Oak Tree State Park

3.8/5 (8 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
Bridge over Mississippi River, New Orleans in background

Top East Prairie Hotel Reviews

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

10/10 Excellent
"Very clean environment. Staff is very nice and friendly. Will not mind staying here again in future. "
Rahveen 2-night trip
Posted 10 days ago
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

More cheap stays in East Prairie

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

100 Matthews Lane Sikeston MO
The price is ฿1,726 per night from 20 Jan to 21 Jan
฿1,726
฿1,967 total
20 Jan - 21 Jan 2026
includes taxes & fees
8.4/10 Very Good! (720 reviews)

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay, based on our traveller data. Other good choices for your trip to the area are Hampton Inn Sikeston and Best Western Plus Sikeston. See all available top hotels, or vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
How is it staying in East Prairie?
Visitors will definitely enjoy all that East Prairie has to offer. There are 33 hotels and other accommodation options in the surrounding area. Find out more about East Prairie.
What are the top places to visit in East Prairie?
The picturesque setting of Mississippi River and Big Oak Tree State Park exemplify the area's natural beauty. You'll also find Central Park and Sikeston Depot Museum in the area. Take a look at what more there is to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.