Find hotels in Southern Illinois, IL from ฿2,062
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Southern Illinois
Pet friendly
Condo
Family friendly
Cottage
Waterpark
Apartment
Check prices for these dates
Tonight
22 Aug - 23 AugTomorrow
23 Aug - 24 AugNext weekend
28 Aug - 30 AugIn two weeks
4 Sep - 6 SepOur top choices for Southern Illinois hotels
1. Drury Plaza Hotel Mt. Vernon
Drury Plaza Hotel Mt. VernonMount Vernon
Kirstyn
฿3,626
฿4,090 total
includes taxes & fees
30 Aug - 31 Aug
2. Holiday Inn Express & Suites Mount Vernon by IHG
Holiday Inn Express & Suites Mount Vernon by IHGMount Vernon
Angela D
฿3,626
฿4,090 total
includes taxes & fees
20 Sept - 21 Sept
3. Comfort Suites Mount Vernon
Comfort Suites Mount VernonMount Vernon
Erica
฿3,996
฿4,500 total
includes taxes & fees
30 Aug - 31 Aug
4. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake
Fairfield Inn & Suites by Marriott Mt. Vernon Rend LakeMount Vernon
Blake
฿3,561
฿4,017 total
includes taxes & fees
30 Aug - 31 Aug
5. DoubleTree by Hilton Mt. Vernon
DoubleTree by Hilton Mt. VernonMount Vernon
Samuel
฿4,200
฿4,727 total
includes taxes & fees
4 Sept - 5 Sept
6. Super 8 by Wyndham Mt. Vernon IL
Super 8 by Wyndham Mt. Vernon ILMount Vernon
Matthew W,
฿2,293
฿2,611 total
includes taxes & fees
23 Aug - 24 Aug
7. Hampton Inn & Suites Effingham
Hampton Inn & Suites EffinghamEffingham
Kate
฿3,992
฿4,430 total
includes taxes & fees
6 Sept - 7 Sept
8. SureStay Hotel by Best Western Whittington Rend Lake
SureStay Hotel by Best Western Whittington Rend LakeWhittington
Vinay
฿2,646
฿2,936 total
includes taxes & fees
6 Sept - 7 Sept
9. Best Western Plus Centralia Hotel & Suites
Best Western Plus Centralia Hotel & SuitesCentralia
Corey
฿4,868
฿5,451 total
includes taxes & fees
23 Aug - 24 Aug
10. Days Inn by Wyndham Mount Vernon
Days Inn by Wyndham Mount VernonMount Vernon
Norberto
฿2,360
฿2,685 total
includes taxes & fees
26 Aug - 27 Aug
11. Drury Inn & Suites Marion
Drury Inn & Suites MarionMarion
Tara
฿3,463
฿4,155 total
includes taxes & fees
30 Aug - 31 Aug
12. Holiday Inn Express & Suites Vandalia by IHG
Holiday Inn Express & Suites Vandalia by IHGVandalia
Scott
฿3,594
฿3,916 total
includes taxes & fees
20 Sept - 21 Sept
13. La Quinta Inn & Suites by Wyndham Effingham
La Quinta Inn & Suites by Wyndham EffinghamEffingham
Alexis
฿3,277
฿3,670 total
includes taxes & fees
30 Aug - 31 Aug
14. Quality Inn Effingham North
Quality Inn Effingham NorthEffingham
Sierra
฿2,499
฿2,774 total
includes taxes & fees
6 Sept - 7 Sept
15. Best Western Delta Inn
Best Western Delta InnEffingham
Chris
฿2,888
฿3,234 total
includes taxes & fees
30 Aug - 31 Aug
16. Comfort Inn & Suites Greenville I-70
Comfort Inn & Suites Greenville I-70Greenville
Alan
฿3,243
฿3,599 total
includes taxes & fees
30 Aug - 31 Aug
17. Ramada by Wyndham Vandalia
Ramada by Wyndham VandaliaVandalia
Harold
฿2,646
฿2,884 total
includes taxes & fees
30 Aug - 31 Aug
18. Baymont by Wyndham Effingham
Baymont by Wyndham EffinghamEffingham
Amy
฿2,360
฿2,620 total
includes taxes & fees
30 Aug - 31 Aug
19. Best Western Plus MidAmerica Hotel
Best Western Plus MidAmerica HotelMascoutah
Justin
฿3,435
฿3,915 total
includes taxes & fees
30 Aug - 31 Aug
20. Home2 Suites By Hilton Effingham
Home2 Suites By Hilton EffinghamEffingham
Tim
฿4,260
฿4,770 total
includes taxes & fees
6 Sept - 7 Sept
Holiday Rentals in Southern Illinois
Cottage
Harrisburg Home w/ Private Yard + Screened Porch!
Harrisburg Home w/ Private Yard + Screened Porch!Harrisburg
"We love how accommodating, helpful and responsive Hollie and Clayton were. The rental had everything we needed and then some. Very clean, cozy and comfortable. We chose this location, because it was close to the different parks and trails we had visited. Thank you, Hollie and Clayton, for being such gracious hosts."
Cottage
Peaceful Robinson Home w/ Yard, Near Golf Courses!
Peaceful Robinson Home w/ Yard, Near Golf Courses!Robinson
Cottage
Country Home Near EIU & Lake Charleston!
Country Home Near EIU & Lake Charleston!Charleston
"Property was very clean and beautifully decorated in a farmhouse style. Very cozy and comfortable! Came stocked with everything you would need. We had fun at nearby Aikman Wildlife Adventure in Arcola, Kayaking in Lake Charleston, hiking in Fox Ridge State Park a visit to Amish country in Arthur, IL. The kitchen, living and dining room were very spacious! The bathroom was very tiny so if staying with 4 adults - be prepared for this. Also there was a strange odor right outside the front entry...
Apartment
Murphysboro Retreat w/ Deck Near Kinkaid Lake!
Murphysboro Retreat w/ Deck Near Kinkaid Lake!Murphysboro
"This is a very clean and nice apartment within a very close drive to the Kinkaid boat launch. Easy to locate and can fit a car with a boat in tow no problem. This spot was also much more quiet than the campground or RV spots nearby. They have a great porch and a grill and we didn’t bring something for it which made me sad. "
Cottage
Illinois Vacation Rental Home: Pets Welcome
Illinois Vacation Rental Home: Pets WelcomePalestine
Cottage
Cozy Anna Home Near Southern Illinois Attractions!
Cozy Anna Home Near Southern Illinois Attractions!Anna
"Good communication with the owners. Nice perks such as coffee, tea, and hygiene items."
Cottage
Mins to Local Attractions: Pet Friendly w/ Yard!
Mins to Local Attractions: Pet Friendly w/ Yard!Casey
"Property was very clean and quiet, will definitely schedule for next family reunion."
Cottage
Beautiful Makanda Cabin in Shawnee National Forest
Beautiful Makanda Cabin in Shawnee National ForestMakanda
"It was very peaceful and relaxing. "
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Southern Illinois attractions
Garden of the Gods Recreation Area
9.8/10 (63 reviews)
See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.
O'Fallon Family Sports Park
8.6/10 (137 reviews)
This sports complex features premium turf fields, splash pads, and fishing ponds in a family-friendly setting. Watch tournaments or enjoy the scenic walking trail that winds around natural areas.
World Wide Technology Raceway
9.0/10 (2 reviews)
Catch an event at World Wide Technology Raceway during your trip to St. Louis. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
Harrah's Metropolis
8.0/10 (310 reviews)
This riverside casino offers over 600 slot machines and 17 table games along the scenic Ohio River. Join the rewards programme to maximise your experience while enjoying Southern classics at the on-site restaurants.
Learn more about Southern Illinois
Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.
See all hotels in Southern Illinois
Photo by Southernmost Illinois Tourism Bureau
Top Southern Illinois Hotel Reviews
Drury Plaza Hotel Mt. Vernon
10/10 Excellent
"Restaurant was open late! Very nice place to stay."
Country Inn & Suites by Radisson, Effingham, IL
8/10 Good
"Someone was smoking weed. We could smell it when we came back in the evening from supper. Not on our floor, but the elevator stunk. The carpet felt damp,"
Best Western St. Louis Fairview Heights
10/10 Excellent
"Everything is great 👍 clean rooms food is great the staff is very nice 👌 best place to stay in O'Fallon Illinois."
Motel 6 Caseyville, IL - Caseyville Il
10/10 Excellent
"Great place to stay it was clean and staff was helpful!"
Drury Inn & Suites St. Louis Fairview Heights
10/10 Excellent
"Easy parking, dinner and breakfast great"
Country Inn & Suites by Radisson, Fairview Heights, IL
10/10 Excellent
"Me and my sister had a good time. We enjoyed our stay. We ready to go back again and just got home."
Baymont by Wyndham Effingham
10/10 Excellent
"All good"
Holiday Inn Express & Suites Mount Vernon by IHG
10/10 Excellent
"Pool was very small, too small for our normal pool exercise routine."
Comfort Inn Edwardsville - St. Louis
8/10 Good
"Breakfast was vary goods Well stocked"
More cheap stays in Southern Illinois
Super 8 by Wyndham O'Fallon
1100 Eastgate Dr O'Fallon IL
฿1,794
฿2,062 total
24 Aug - 25 Aug
includes taxes & fees
6.6/10 (1,081 reviews)
Baymont by Wyndham Effingham
1811 W Fayette Avenue Effingham IL
฿2,360
฿2,620 total
30 Aug - 31 Aug
includes taxes & fees
8.2/10 Very good! (1,009 reviews)
Best Western St. Louis Fairview Heights
150 Ludwig Dr Fairview Heights IL
฿2,611
฿2,950 total
30 Aug - 31 Aug
includes taxes & fees
7.4/10 Good! (96 reviews)
Baymont by Wyndham Marion
2608 W Main St Marion IL
฿2,676
฿3,210 total
24 Aug - 25 Aug
includes taxes & fees
8.4/10 Very good! (1,092 reviews)
Holiday Inn Express Metropolis by IHG
2179 East 5th Street Metropolis IL
฿3,234
฿3,589 total
20 Sept - 21 Sept
includes taxes & fees
8.8/10 Excellent! (1,018 reviews)
Comfort Suites Mount Vernon
404 South 44th Street Mount Vernon IL
฿3,996
฿4,500 total
30 Aug - 31 Aug
includes taxes & fees
9/10 Wonderful! (1,077 reviews)
