Photo by Southernmost Illinois Tourism Bureau

Find hotels in Southern Illinois, IL from ฿1,824
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Southern Illinois
Check prices for these dates
Our top choices for Southern Illinois hotels

Holiday Inn Express & Suites Effingham by IHG
Holiday Inn Express & Suites Effingham by IHGEffingham
9.4 out of 10, Exceptional, (1,002 reviews)
The price is ฿3,210
฿3,595 total
includes taxes & fees
1 Mar - 2 Mar

Country Inn & Suites by Radisson, Effingham, IL
Country Inn & Suites by Radisson, Effingham, ILEffingham
8.8 out of 10, Excellent, (1,002 reviews)
The price is ฿2,776
฿3,081 total
includes taxes & fees
22 Mar - 23 Mar

La Quinta Inn & Suites by Wyndham Effingham
La Quinta Inn & Suites by Wyndham EffinghamEffingham
9.2 out of 10, Wonderful, (1,005 reviews)
The price is ฿3,014
฿3,376 total
includes taxes & fees
1 Mar - 2 Mar

Innkeeper Motel
Innkeeper MotelHamel
7.0 out of 10, Good, (4 reviews)
The price is ฿1,960
฿2,175 total
includes taxes & fees
23 Feb - 24 Feb

Quality Inn Effingham North
Quality Inn Effingham NorthEffingham
8.4 out of 10, Very good, (1,002 reviews)
The price is ฿2,473
฿2,745 total
includes taxes & fees
8 Mar - 9 Mar

Quality Inn & Suites Vandalia near I-70 and Hwy 51
Quality Inn & Suites Vandalia near I-70 and Hwy 51Vandalia
8.4 out of 10, Very good, (1,001 reviews)
The price is ฿1,955
฿2,131 total
includes taxes & fees
25 Feb - 26 Feb

Drury Plaza Hotel Mt. Vernon
Drury Plaza Hotel Mt. VernonMount Vernon
9.6 out of 10, Exceptional, (1,662 reviews)
The price is ฿3,483
฿3,928 total
includes taxes & fees
15 Mar - 16 Mar

Ramada by Wyndham Vandalia
Ramada by Wyndham VandaliaVandalia
7.8 out of 10, Good, (819 reviews)
The price is ฿2,115
฿2,305 total
includes taxes & fees
23 Feb - 24 Feb

Comfort Suites Effingham Central
Comfort Suites Effingham CentralEffingham
8.8 out of 10, Excellent, (586 reviews)
The price is ฿3,001
฿3,361 total
includes taxes & fees
22 Mar - 23 Mar

Best Western Delta Inn
Best Western Delta InnEffingham
9.2 out of 10, Wonderful, (1,010 reviews)
The price is ฿2,588
฿2,898 total
includes taxes & fees
8 Mar - 9 Mar

Holiday Inn Express & Suites Vandalia by IHG
Holiday Inn Express & Suites Vandalia by IHGVandalia
8.8 out of 10, Excellent, (791 reviews)
The price is ฿3,639
฿3,966 total
includes taxes & fees
1 Mar - 2 Mar

Super 8 by Wyndham Carbondale
Super 8 by Wyndham CarbondaleCarbondale
7.4 out of 10, Good, (1,005 reviews)
The price is ฿2,022
฿2,325 total
includes taxes & fees
1 Mar - 2 Mar

Holiday Inn Effingham by IHG
Holiday Inn Effingham by IHGEffingham
9.0 out of 10, Wonderful, (663 reviews)
The price is ฿2,837
฿3,176 total
includes taxes & fees
28 Feb - 1 Mar

Hampton Inn & Suites Effingham
Hampton Inn & Suites EffinghamEffingham
9.6 out of 10, Exceptional, (713 reviews)
The price is ฿3,881
฿4,307 total
includes taxes & fees
28 Feb - 1 Mar

Drury Inn & Suites Marion
Drury Inn & Suites MarionMarion
9.4 out of 10, Exceptional, (1,003 reviews)
The price is ฿3,079
฿3,694 total
includes taxes & fees
13 Mar - 14 Mar

Home2 Suites By Hilton Effingham
Home2 Suites By Hilton EffinghamEffingham
9.8 out of 10, Exceptional, (38 reviews)
The price is ฿3,800
฿4,256 total
includes taxes & fees
28 Feb - 1 Mar

Baymont by Wyndham Effingham
Baymont by Wyndham EffinghamEffingham
8.0 out of 10, Very good, (1,004 reviews)
The price is ฿2,221
฿2,465 total
includes taxes & fees
3 Mar - 4 Mar

Ramada by Wyndham Effingham
Ramada by Wyndham EffinghamEffingham
7.6 out of 10, Good, (1,002 reviews)
The price is ฿1,924
฿2,154 total
includes taxes & fees
28 Feb - 1 Mar

Days Inn by Wyndham Effingham
Days Inn by Wyndham EffinghamEffingham
6.0 out of 10, (1,001 reviews)
The price is ฿1,719
฿1,924 total
includes taxes & fees
16 Mar - 17 Mar

Best Western U. S. Inn
Best Western U. S. InnNashville
8.6 out of 10, Excellent, (402 reviews)
The price is ฿2,737
฿2,983 total
includes taxes & fees
24 Feb - 25 Feb
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Holiday Rentals in Southern Illinois
Cottage

Cozy Anna Home Near Southern Illinois Attractions!
Cozy Anna Home Near Southern Illinois Attractions!Anna
10.0 out of 10, Exceptional, (1 review)
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Southern Illinois attractions
Learn more about Southern Illinois
Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

Photo by Southernmost Illinois Tourism Bureau
Open Photo by Southernmost Illinois Tourism Bureau
Top Southern Illinois Hotel Reviews

Comfort Suites Fairview Heights - St. Louis
10/10 Excellent
More cheap stays in Southern Illinois

Super 8 by Wyndham O'Fallon
1100 Eastgate Dr O'Fallon IL
The price is ฿1,586 per night from 1 Mar to 2 Mar
฿1,586
฿1,824 total
1 Mar - 2 Mar
includes taxes & fees
7/10 Good! (1,005 reviews)
































































































