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Top Trending Hotels Near Serra Mesa, San Diego

Wyndham San Diego Bayside
Terrace/patio

Wyndham San Diego Bayside

4.0 star property
8.4 out of 10, Very good, (5989)
"Enjoyed our stay very much."
The price is ฿4,974
฿6,715 total
includes taxes & fees
13 Oct - 14 Oct
Wyndham San Diego Bayside
Hard Rock Hotel San Diego
Outdoor pool

Hard Rock Hotel San Diego

4.0 star property
9.0 out of 10, Wonderful, (2999)
"Great stay"
The price is ฿5,876
฿8,319 total
includes taxes & fees
31 Oct - 1 Nov
Hard Rock Hotel San Diego
Palihotel San Diego Gaslamp Quarter
Rooftop terrace

Palihotel San Diego Gaslamp Quarter

4.0 star property
8.8 out of 10, Excellent, (1901)
"Staff was great location was great"
The price is ฿4,087
฿4,738 total
includes taxes & fees
13 Oct - 14 Oct
Palihotel San Diego Gaslamp Quarter
Ramada Suites by Wyndham San Diego/Hotel Circle Area
Outdoor pool

Ramada Suites by Wyndham San Diego/Hotel Circle Area

2.5 star property
6.2 out of 10, (1023)
"Clean room, friendly staff"
The price is ฿2,445
฿2,811 total
includes taxes & fees
29 Oct - 30 Oct
Ramada Suites by Wyndham San Diego/Hotel Circle Area
Loews Coronado Bay Resort
Exterior

Loews Coronado Bay Resort

4.0 star property
8.8 out of 10, Excellent, (1043)
"Beautiful quiet hotel."
The price is ฿6,506
฿8,709 total
includes taxes & fees
26 Oct - 27 Oct
Loews Coronado Bay Resort
Best Western Plus Marina Gateway Hotel
Suite, 2 Queen Beds, Non Smoking, Refrigerator (with Sofabed) | Premium bedding, in-room safe, desk, laptop workspace

Best Western Plus Marina Gateway Hotel

3.5 star property
9.2 out of 10, Wonderful, (3320)
"Nice place to stay !"
The price is ฿4,396
฿4,844 total
includes taxes & fees
2 Nov - 3 Nov
Best Western Plus Marina Gateway Hotel
Gaslamp Plaza Suites
Lobby

Gaslamp Plaza Suites

3.5 star property
8.8 out of 10, Excellent, (1010)
"Had a great stay "
The price is ฿3,531
฿4,016 total
includes taxes & fees
13 Oct - 14 Oct
Gaslamp Plaza Suites
The Horton Grand, Downtown/Gaslamp Quarter
Serves dinner and happy hour

The Horton Grand, Downtown/Gaslamp Quarter

3.5 star property
9.0 out of 10, Wonderful, (2593)
"Great location and friendly staff"
The Horton Grand, Downtown/Gaslamp Quarter
El Cordova Hotel on Coronado Island
Lobby

El Cordova Hotel on Coronado Island

3.5 star property
8.8 out of 10, Excellent, (1006)
"Cute and unique hotel！"
El Cordova Hotel on Coronado Island
The Sofia Hotel
Front of property

The Sofia Hotel

3.5 star property
8.4 out of 10, Very good, (1612)
"I loved the stay here, highly recommended "
The Sofia Hotel
The Bristol Hotel San Diego
Property entrance

The Bristol Hotel San Diego

3.5 star property
8.4 out of 10, Very good, (1395)
"Very nice staff from check in, clean rooms, quiet and comfortable. "
The Bristol Hotel San Diego
Legacy Resort Hotel & Spa
Garden

Legacy Resort Hotel & Spa

4.0 star property
9.2 out of 10, Wonderful, (2892)
"Great stay overall"
The price is ฿4,229
฿4,861 total
includes taxes & fees
23 Oct - 24 Oct
Legacy Resort Hotel & Spa
Days Inn by Wyndham San Diego Hotel Circle
Outdoor pool, a heated pool

Days Inn by Wyndham San Diego Hotel Circle

3.0 star property
8.0 out of 10, Very good, (2364)
"We loved our stay, great price, very clean and excellent location! "
The price is ฿3,207
฿3,686 total
includes taxes & fees
13 Oct - 14 Oct
Days Inn by Wyndham San Diego Hotel Circle
La Pensione Hotel
Exterior

La Pensione Hotel

3.0 star property
8.6 out of 10, Excellent, (1880)
"Very happy with our stay "
La Pensione Hotel
The Dana on Mission Bay
2 outdoor pools, a heated pool, pool loungers

The Dana on Mission Bay

3.5 star property
8.8 out of 10, Excellent, (3776)
"Great stay"
The price is ฿4,418
฿5,732 total
includes taxes & fees
26 Oct - 27 Oct
The Dana on Mission Bay
Staypineapple, Hotel Z, Gaslamp San Diego
Premium bedding, pillow-top beds, desk, blackout curtains

Staypineapple, Hotel Z, Gaslamp San Diego

3.0 star property
9.4 out of 10, Exceptional, (1003)
"Great staff and clean rooms"
The price is ฿4,862
฿6,582 total
includes taxes & fees
29 Oct - 30 Oct
Staypineapple, Hotel Z, Gaslamp San Diego
Days Inn by Wyndham San Diego-East/El Cajon
Standard Room, 1 King Bed, Smoking | Desk, laptop workspace, iron/ironing board, free WiFi

Days Inn by Wyndham San Diego-East/El Cajon

2.0 star property
7.6 out of 10, Good, (1007)
"Place was nice and comfy. Decent stay at a very genuine price. "
The price is ฿2,616
฿2,882 total
includes taxes & fees
19 Oct - 20 Oct
Days Inn by Wyndham San Diego-East/El Cajon
Hotel Palmeras Chula Vista
Front of property

Hotel Palmeras Chula Vista

2.0 star property
7.0 out of 10, Good, (1891)
"Quiet area all around nice place to stay !!!"
The price is ฿2,357
฿2,592 total
includes taxes & fees
2 Nov - 3 Nov
Hotel Palmeras Chula Vista
Sycuan Casino Resort
3 outdoor pools, pool cabanas (surcharge), pool umbrellas

Sycuan Casino Resort

4.0 star property
9.2 out of 10, Wonderful, (1565)
"Great resort!"
Sycuan Casino Resort
Kings Inn San Diego
Reception

Kings Inn San Diego

2.5 star property
8.8 out of 10, Excellent, (3455)
"Great place to stay!"
The price is ฿2,650
฿3,041 total
includes taxes & fees
13 Oct - 14 Oct
Kings Inn San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Gaslamp Quarter featuring a bar, night scenes and street scenes

Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

Pacific Beach Park showing a beach

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Belmont Park featuring a park and rides

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach Pier and Dog Beach.

Top Serra Mesa Hotel Reviews

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

10/10 Excellent
"Staff are super nice and helpful. The location is close to everything. We definitely going to stay here again. "
Thu 2-night trip
Posted 4 days ago
The DEXTRO Little Italy, BW Premier Collection

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Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels can I expect to find in the Serra Mesa area?
Expedia has 35 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.
What can I see and do in this San Diego neighbourhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.