Search Hotels in Serra Mesa, San Diego

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Our top choices for Serra Mesa hotels

Berkshire Motor Hotel

Berkshire Motor Hotel
2.5 star property
North Park, 5.3 km from Serra Mesa
8.4 out of 10, Very good, (1,000 reviews)
"Clean, very chill easy check in"
United States
Susana
The price is ฿2,872
฿3,238 total
includes taxes & fees
15 Mar - 16 Mar
Berkshire Motor Hotel

Urban Boutique Hotel

Urban Boutique Hotel
3.0 star property
Little Italy, 9.3 km from Serra Mesa
8.6 out of 10, Excellent, (1,275 reviews)
"Great location, clean rooms, friendly staff"
United States
Beth
Urban Boutique Hotel

Gaslamp Plaza Suites

Gaslamp Plaza Suites
3.5 star property
Gaslamp Quarter, 10 km from Serra Mesa
9.0 out of 10, Wonderful, (1,026 reviews)
"Clean quiet friendly helpful staff convenient location will stay there again"
United States
David
The price is ฿3,961
฿4,505 total
includes taxes & fees
5 Apr - 6 Apr
Gaslamp Plaza Suites

GreenTree Inn San Diego Mission Bay

GreenTree Inn San Diego Mission Bay
2.5 star property
Pacific Beach, 7.3 km from Serra Mesa
8.0 out of 10, Very good, (1,965 reviews)
"Great stay"
United States
Lizeth
The price is ฿3,303
฿3,796 total
includes taxes & fees
16 Mar - 17 Mar
GreenTree Inn San Diego Mission Bay

La Pensione Hotel

La Pensione Hotel
3.0 star property
Little Italy, 9.3 km from Serra Mesa
8.6 out of 10, Excellent, (1,929 reviews)
"Great location and staff "
United States
morgan
La Pensione Hotel

Heritage Inn San Diego

Heritage Inn San Diego
2.0 star property
9.1 km from Serra Mesa
7.4 out of 10, Good, (1,316 reviews)
"Clean room, staff was great during check in and checking out. "
United States
Amber
The price is ฿1,931
฿2,219 total
includes taxes & fees
29 Mar - 30 Mar
Heritage Inn San Diego

Ash&9th

Ash&9th
2.0 star property
9.4 km from Serra Mesa
8.2 out of 10, Very good, (407 reviews)
"Great location… stuff was really friendly "
United States
Aurora
The price is ฿2,501
฿2,845 total
includes taxes & fees
7 Apr - 8 Apr
Ash&9th

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
9 km from Serra Mesa
7.4 out of 10, Good, (4,181 reviews)
"Good location friendly staff"
United States
Anya
The price is ฿3,101
฿3,564 total
includes taxes & fees
22 Mar - 23 Mar
Wyndham Garden San Diego Near SeaWorld

SureStay Hotel by Best Western San Diego Pacific Beach

SureStay Hotel by Best Western San Diego Pacific Beach
2.5 star property
Pacific Beach, 7.3 km from Serra Mesa
8.0 out of 10, Very good, (1,557 reviews)
"Room was nice, clean, staff was friendly, "
United States
philip
The price is ฿3,337
฿3,769 total
includes taxes & fees
29 Mar - 30 Mar
SureStay Hotel by Best Western San Diego Pacific Beach

Comfort Inn Sea World Area

Comfort Inn Sea World Area
3.5 star property
8.2 km from Serra Mesa
8.6 out of 10, Excellent, (3,470 reviews)
"Nice beds and breakfast, really convenient "
Canada
Margarita
The price is ฿3,258
฿3,745 total
includes taxes & fees
5 Apr - 6 Apr
Comfort Inn Sea World Area

The Sofia Hotel

The Sofia Hotel
3.5 star property
10 km from Serra Mesa
8.6 out of 10, Excellent, (1,795 reviews)
"Great hotel "
United States
Alexander
The Sofia Hotel

The Beau Hotel Gaslamp Quarter San Diego

The Beau Hotel Gaslamp Quarter San Diego
3.0 star property
Gaslamp Quarter, 9.9 km from Serra Mesa
9.0 out of 10, Wonderful, (640 reviews)
"Clean room, friendly staff, great location."
United States
Bruce
The price is ฿4,851
฿5,518 total
includes taxes & fees
6 Apr - 7 Apr
The Beau Hotel Gaslamp Quarter San Diego

Westgate Hotel

Westgate Hotel
4.5 star property
9.9 km from Serra Mesa
9.2 out of 10, Wonderful, (1,002 reviews)
"Great stay"
United States
ESMERALDA
Westgate Hotel

Sea Harbor Hotel

Sea Harbor Hotel
2.0 star property
12.2 km from Serra Mesa
8.6 out of 10, Excellent, (1,020 reviews)
"Super clean rooms and a great location "
United States
Mark
Sea Harbor Hotel

The Bristol Hotel San Diego

The Bristol Hotel San Diego
3.5 star property
9.9 km from Serra Mesa
8.6 out of 10, Excellent, (1,519 reviews)
"Great stay, great location, great staff."
United States
Jodie
The Bristol Hotel San Diego

Comfort Inn San Diego Airport At The Harbor

Comfort Inn San Diego Airport At The Harbor
3.5 star property
11.9 km from Serra Mesa
7.8 out of 10, Good, (1,350 reviews)
"Great room, clean property and courteous staff"
United States
Reginald D.
The price is ฿3,605
฿4,072 total
includes taxes & fees
23 Mar - 24 Mar
Comfort Inn San Diego Airport At The Harbor

La Quinta Inn & Suites by Wyndham San Diego Mission Bay

La Quinta Inn & Suites by Wyndham San Diego Mission Bay
3.0 star property
North Pacific Beach, 7.4 km from Serra Mesa
8.0 out of 10, Very good, (1,490 reviews)
"Great staff, clean rooms "
United States
Hala
The price is ฿3,823
฿4,395 total
includes taxes & fees
5 Apr - 6 Apr
La Quinta Inn & Suites by Wyndham San Diego Mission Bay

Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley
2.5 star property
6.4 km from Serra Mesa
8.6 out of 10, Excellent, (1,456 reviews)
"Great breakfast-comfortable rooms-helpful staff-great location for events"
United States
bill
The price is ฿3,967
฿4,560 total
includes taxes & fees
5 Apr - 6 Apr
Hampton Inn San Diego/Mission Valley

Best Western Yacht Harbor Hotel

Best Western Yacht Harbor Hotel
2.5 star property
11.8 km from Serra Mesa
8.4 out of 10, Very good, (1,767 reviews)
"Well stay again love the location"
United States
Lynette
The price is ฿3,322
฿3,812 total
includes taxes & fees
29 Mar - 30 Mar
Best Western Yacht Harbor Hotel

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
3.0 star property
Gaslamp Quarter, 10.6 km from Serra Mesa
9.0 out of 10, Wonderful, (1,291 reviews)
"Clean room, friendly staff, great location Very affordable rate Good breakfast variety "
United States
Mary
The price is ฿4,588
฿5,320 total
includes taxes & fees
2 Apr - 3 Apr
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach and Dog Beach.

Top Serra Mesa Hotel Reviews

Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels can I expect to find in the Serra Mesa area?
Expedia has 38 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.
What can I see and do in this San Diego neighbourhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.