Find hotels in Santo Tomé from ฿1,680

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Our top choices for Santo Tomé hotels

Hotel Puerto Amarras

Hotel Puerto Amarras
3.5 star property
Santa Fe
8.0 out of 10, Very good, (75)
Located in Santa Fe near Ribera Shopping and Museo Etnográfico, this hotel features an outdoor pool and fitness centre. Enjoy massages or facials, savour Regional cuisine at Dos Aguas restaurant, or unwind at the bar after exploring local attractions.

"Good location and recommended spot in the city. Surrounded by water is a beautiful location to stay. The room was a very nice surprise: is huge!! It was a perfect stop over in the road trip!"
United States
Emilio
The price is ฿2,885
฿2,885 total
28 Dec - 29 Dec
Hotel Puerto Amarras

Maran Suites & Towers - Hotel & Spa

Maran Suites & Towers - Hotel & Spa
3.5 star property
Parana
9.2 out of 10, Wonderful, (31)
Set in Parana near Urquiza Park, this hotel offers a full-service spa featuring massages, aromatherapy, and reflexology. Guests enjoy the on-site fitness centre, bar, and café, plus free breakfast and WiFi for added convenience.

"Great location and friendly, accommodating staff. "
United States
Michael
The price is ฿3,212
฿3,212 total
28 Dec - 29 Dec
Maran Suites & Towers - Hotel & Spa

InterTower Hotel

InterTower Hotel
4.0 star property
Santa Fe
8.8 out of 10, Excellent, (213)
Discover international cuisine at Giulio restaurant while taking in scenic vistas from the rooftop terrace. This spa hotel offers deep-tissue massages and reflexology treatments, plus an outdoor pool and fitness centre, all near popular museums.

"Excelent place to stay."
United States
Angel
The price is ฿2,983
฿2,983 total
28 Dec - 29 Dec
InterTower Hotel

Castelar Hotel Santa Fe

Castelar Hotel Santa Fe
3.0 star property
Santa Fe
7.4 out of 10, Good, (92)
Experience this Santa Fe hotel with an outdoor pool for cooling off after exploring nearby Museo Del Colegio De Medicos. Grab a bite at the café or unwind with drinks at the bar, all while enjoying free breakfast daily.

"Great area for walking and dining. Friendly and helpful staff. "
Canada
Claude
The price is ฿1,987
฿1,987 total
27 Dec - 28 Dec
Castelar Hotel Santa Fe

Agustín 1 Apart

Agustín 1 Apart
4.0 star property
Parana
9.0 out of 10, Wonderful, (4)
Located near Plaza de Mayo and Museu De Sitio, this aparthotel offers espresso makers and spa services on site. The comfortable accommodation feature premium bedding, and Paraná Station is just a 19-minute walk away for convenient city exploration.

"Meu problema foi só a garagem, o apartamento é ótimo, limpeza estava impecável."
Brazil
Jose rodrigo kallas
The price is ฿1,680
฿1,680 total
19 Jan - 20 Jan 2026
Agustín 1 Apart

Los Silos Hotel

Los Silos Hotel
4.0 star property
Santa Fe
9.2 out of 10, Wonderful, (28)
"Unique, interesting, and very nice. Staff was outstanding. We will be back soon"
United States
Russell
The price is ฿3,358
฿3,358 total
4 Jan - 5 Jan 2026
Los Silos Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

What's the best place to stay in Santo Tomé?
Hotel de Campo Colon is one of the top choices for your stay based on our traveller data. This hotel offers a full-service spa and free breakfast. Other good options for your stay in the area are InterTower Hotel and Los Silos Hotel. See all available top hotels, or vacation rentals in Santo Tomé.
If I need to cancel my hotel reservation in Santo Tomé, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your check-in date. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Santo Tomé.
How is it staying in Santo Tomé?
Visitors can enjoy all that Santo Tomé has to offer, including its museums. There are 64 hotels and other accommodation options in the surrounding area. Find out more about Santo Tomé.
What are the top places to visit in Santo Tomé?
A couple of favourite places to visit are El Museo Etnografico y Colonial Juan de Garay and Museo De Arte Contemporaneo. You'll also find Brigadier General Estanislao Lopez Stadium and Plaza 25 de Mayo in the area. Take a look at what more there is to see and do in Expedia's Santo Tomé guide.
What's the weather like in Santo Tomé?
The hottest months are usually January and December, with an average temperature of 25°C, while the coldest months are July and June, with an average of 14°C. Average annual precipitation for Santo Tomé is 1226 mm.