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Our top choices for Sanctuary hotels

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
23.9 km from Sanctuary
9.2 out of 10, Wonderful, (1,528 reviews)
"This hotel was really nice and clean."
United States
Lilian
The price is ฿3,273
฿3,650 total
includes taxes & fees
21 Jun - 22 Jun
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

OYO Waterfront Hotel - Cape Coral/Fort Myers, FL
2.5 star property
25.2 km from Sanctuary
5.8 out of 10, (1,008 reviews)
"Although the hotel is not new, it is currently being renovated and well maintained. We had a great experience and highly recommend it. The staff were very kind, friendly, and always willing to help. We really enjoyed our stay and would gladly return."
United States
Roger
The price is ฿1,755
฿1,957 total
includes taxes & fees
28 Jun - 29 Jun
OYO Waterfront Hotel - Cape Coral/Fort Myers, FL

Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina
4.0 star property
20.4 km from Sanctuary
9.4 out of 10, Exceptional, (1,397 reviews)
"Great stay!"
United States
John
Pink Shell Beach Resort and Marina

Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (2,001 reviews)
"Great place to stay! This was our second time staying here and we will be back again!"
United States
Madison
The price is ฿8,151
฿9,906 total
includes taxes & fees
17 Jun - 18 Jun
Sanibel Island Beach Resort

Sanibel Inn

Sanibel Inn
3.0 star property
East End, 13.8 km from Sanctuary
9.2 out of 10, Wonderful, (1,013 reviews)
"Wonderful place to stay! Unfortunately the weather wasn’t perfect but the weekend was great and the restaurant was delicious!"
United States
Tracy
The price is ฿12,162
฿15,203 total
includes taxes & fees
25 Jun - 26 Jun
Sanibel Inn

Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
19.3 km from Sanctuary
8.8 out of 10, Excellent, (1,018 reviews)
"I would stay here again good breakfast nice heated pool good distance to beaches"
United States
Cheryl
The price is ฿3,110
฿3,467 total
includes taxes & fees
21 Jun - 22 Jun
Residence Inn by Marriott Fort Myers Sanibel

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral
3.0 star property
30.1 km from Sanctuary
8.8 out of 10, Excellent, (883 reviews)
"Friendly staff. Free parking in a safe area.. Excellent location"
United States
Maria
The price is ฿2,917
฿3,252 total
includes taxes & fees
21 Jun - 22 Jun
Fairfield Inn & Suites by Marriott Ft. Myers/Cape Coral

Tween Waters Island Resort & Spa

Tween Waters Island Resort & Spa
3.0 star property
3.7 km from Sanctuary
8.6 out of 10, Excellent, (1,008 reviews)
"Such a fun place and location"
United States
Jennifer S
The price is ฿9,663
฿11,920 total
includes taxes & fees
11 Jul - 12 Jul
Tween Waters Island Resort & Spa

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
21.8 km from Sanctuary
9.0 out of 10, Wonderful, (1,604 reviews)
"Easy parking and good location with friendly staff"
United States
Joseph
The price is ฿4,684
฿5,953 total
includes taxes & fees
21 Jun - 22 Jun
Lani Kai Beachfront Resort

Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
22 km from Sanctuary
8.6 out of 10, Excellent, (1,011 reviews)
"Nice and clean, friendly staff"
United States
Samuel
The price is ฿3,360
฿3,746 total
includes taxes & fees
15 Jun - 16 Jun
Latitude 26 Waterfront Resort & Marina

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
23.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,020 reviews)
"Great location"
United States
Kenneth A.
The price is ฿2,848
฿3,175 total
includes taxes & fees
13 Jul - 14 Jul
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
3.0 star property
22.9 km from Sanctuary
8.6 out of 10, Excellent, (1,018 reviews)
"The stay was great. The A/C worked wonderfully"
United States
Larisa
The price is ฿2,980
฿3,323 total
includes taxes & fees
15 Jul - 16 Jul
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers
3.0 star property
29.5 km from Sanctuary
8.8 out of 10, Excellent, (1,021 reviews)
"Nice room, comfortable stay and good breakfast."
United States
Tia
The price is ฿3,290
฿3,668 total
includes taxes & fees
30 Jun - 1 Jul
Hilton Garden Inn Ft Myers

Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa
4.0 star property
15.6 km from Sanctuary
8.6 out of 10, Excellent, (1,019 reviews)
"We had a great experience and would definitely stay here again. Highly recommended for families looking for a relaxing and enjoyable vacation."
United States
NAYLA
The price is ฿6,259
฿8,124 total
includes taxes & fees
2 Jul - 3 Jul
Marriott Sanibel Harbour Resort & Spa

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
19.9 km from Sanctuary
8.2 out of 10, Very good, (1,203 reviews)
"I have stayed here many times it is clean, reasonably priced and local to the island"
United States
Gabriel
The price is ฿3,211
฿3,581 total
includes taxes & fees
21 Jun - 22 Jun
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

Allure Suites

Allure Suites
3.0 star property
27.2 km from Sanctuary
7.6 out of 10, Good, (1,009 reviews)
"Hotel was fine. Needs remodeling"
United States
Brian
The price is ฿2,226
฿2,482 total
includes taxes & fees
17 Jun - 18 Jun
Allure Suites

Sundial Beach Resort & Spa

Sundial Beach Resort & Spa
5.0 star property
Mid Island, 12.8 km from Sanctuary
8.6 out of 10, Excellent, (2,654 reviews)
"Excellent stay and amenities for families. "
United States
Megan
The price is ฿14,698
฿18,176 total
includes taxes & fees
6 Jul - 7 Jul
Sundial Beach Resort & Spa

DiamondHead Beach Resort

DiamondHead Beach Resort
3.5 star property
22.3 km from Sanctuary
9.2 out of 10, Wonderful, (1,225 reviews)
"Diamondhead is our home away from home when visiting Ft Myers Beach."
United States
Joseph
The price is ฿6,140
฿8,124 total
includes taxes & fees
24 Jun - 25 Jun
DiamondHead Beach Resort

Best Western Plus Beach Resort

Best Western Plus Beach Resort
2.5 star property
20.9 km from Sanctuary
9.4 out of 10, Exceptional, (1,009 reviews)
"Clean room, nice breakfast and right on the beach. Also within walking distance of restaurants & shops. Would definitely stay again!"
United States
AARON
The price is ฿7,044
฿7,855 total
includes taxes & fees
15 Jun - 16 Jun
Best Western Plus Beach Resort

Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers
4.0 star property
21.6 km from Sanctuary
9.0 out of 10, Wonderful, (2,205 reviews)
"Perfect place for a vacation."
United States
Donna
The price is ฿7,336
฿9,822 total
includes taxes & fees
28 Jun - 29 Jun
Margaritaville Beach Resort Fort Myers
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Sanctuary

Find the best Sanctuary areas for the activities you enjoy most.

Mid Island

If you're spending some time in Mid Island, Sanibel Island Southern Beach and Periwinkle Way are top sights worth seeing.

West End

If you're spending some time in West End, Sanibel Island Southern Beach and J. N. Ding Darling National Wildlife Refuge are top sights worth seeing.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Southern Beach and Sanibel Island Northern Beach.

Beachview Country Club Estates

While visiting Beachview Country Club Estates, you might make a stop by sights like Periwinkle Way and Sanibel Island Golf Club.

Gulf Shores

When in Gulf Shores, you can plan a visit to Bowman's Beach and J. N. Ding Darling National Wildlife Refuge, some noteworthy sights in the nearby area.

Top Sanctuary Hotel Reviews

Frequently asked questions

What is Sanctuary like?
Travellers are sure to enjoy a stay in Sanibel's Sanctuary neighbourhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels will I be able to find in the Sanctuary area?
With 10 Expedia hotels and other accommodation options in Sanctuary to choose from, this is a good starting point for exploring the greater Sanibel area.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to get the best deals available in Sanctuary.
What is there to do around this Sanibel neighbourhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

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