Search Hotels in Sanctuary, Sanibel

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Our top choices for Sanctuary hotels

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
21.8 km from Sanctuary
9.0 out of 10, Wonderful, (1,432 reviews)
"Absolutely beautiful place! Staff is friendly and the rooms are so nicely decorated. Will stay again. "
United States
Sherry
The price is ฿6,085
฿7,503 total
includes taxes & fees
11 May - 12 May
Lani Kai Beachfront Resort

The Bay Inn at Lani Kai

The Bay Inn at Lani Kai
3.0 star property
21.8 km from Sanctuary
7.6 out of 10, Good, (395 reviews)
"So clean. Best view on the island. Staff was helpful. Check out the Bay Inn across the street. Sister hotel just as nice and a little more budget friendly. "
United States
Jan
The price is ฿3,405
฿4,514 total
includes taxes & fees
30 Apr - 1 May
The Bay Inn at Lani Kai

Pointe Estero Beach Resort

Pointe Estero Beach Resort
2.0 star property
27.3 km from Sanctuary
9.2 out of 10, Wonderful, (1,002 reviews)
"Beautiful beach view, friendly staff and lots of beach space for our family to enjoy!"
United States
Daniel
The price is ฿5,211
฿16,266 total
includes taxes & fees
12 May - 13 May
Pointe Estero Beach Resort

Golf Getaway: Cape Coral Condo 1 Mi to River!

Golf Getaway: Cape Coral Condo 1 Mi to River!
3.0 star property
29.2 km from Sanctuary
The price is ฿1,771
฿10,545 total
includes taxes & fees
28 Apr - 29 Apr
Golf Getaway: Cape Coral Condo 1 Mi to River!

The Palmetto Inn

The Palmetto Inn
3.0 star property
31.2 km from Sanctuary
8.2 out of 10, Very good, (117 reviews)
"Wonderful location in the center of Boca Grande. Easy walk to beachside. "
United States
Maria
The price is ฿5,634
฿6,282 total
includes taxes & fees
29 Apr - 30 Apr
The Palmetto Inn

1 Island Hideaway

1 Island Hideaway
3.0 star property
24.3 km from Sanctuary
8.6 out of 10, Excellent, (32 reviews)
"Clean and modern apartment and we stayed on first floor. Walking distance to beach with hot tub and pool. Not really walking distance to bars/restaurants so probably best to have a car. Worth the price."
United States
Howard
The price is ฿6,407
฿14,288 total
includes taxes & fees
5 May - 6 May
1 Island Hideaway

Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina
4.0 star property
20.4 km from Sanctuary
9.4 out of 10, Exceptional, (1,329 reviews)
"We loved our stay at the Pink Shell. Perfect for families. Wish we could have stayed longer. "
United States
Jeanine
The price is ฿9,620
฿12,844 total
includes taxes & fees
28 May - 29 May
Pink Shell Beach Resort and Marina

Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
22 km from Sanctuary
8.6 out of 10, Excellent, (1,006 reviews)
"Place is quiet and right down the street from the beach"
United States
Bryan
The price is ฿3,116
฿3,475 total
includes taxes & fees
28 Apr - 29 Apr
Latitude 26 Waterfront Resort & Marina

Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,827 reviews)
"Beautiful place to stay with access to the beach"
United States
Jonathan
The price is ฿7,405
฿9,061 total
includes taxes & fees
17 May - 18 May
Sanibel Island Beach Resort

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
21.5 km from Sanctuary
8.8 out of 10, Excellent, (1,005 reviews)
"Very nice place to stay. Was quiet and convenient to the beach and shops and I enjoyed my stay."
United States
Nancy
The price is ฿3,332
฿3,716 total
includes taxes & fees
29 Apr - 30 Apr
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Matlacha Tiny Village

Matlacha Tiny Village
3.0 star property
18.8 km from Sanctuary
8.8 out of 10, Excellent, (286 reviews)
"Super cute place!! Super clean and comfortable."
United States
Francesca
The price is ฿3,689
฿8,943 total
includes taxes & fees
29 Apr - 30 Apr
Matlacha Tiny Village

Summerwind Studios

Summerwind Studios
2.0 star property
22.6 km from Sanctuary
8.2 out of 10, Very good, (15 reviews)
"Very clean and roomy. Quiet neighborhood. Loves the shower; so relaxing. Only complaint is that we could have used some drinking glasses. I would stay here again. "
United States
Micki
The price is ฿1,900
฿3,159 total
includes taxes & fees
14 May - 15 May
Summerwind Studios

TriLuxe Inn & Studios

TriLuxe Inn & Studios
2.0 star property
22.7 km from Sanctuary
8.2 out of 10, Very good, (23 reviews)
"Great mattress, enjoyed the recliners, we prefer no doors on the closet making it fast & easy to access our wardrobe, liked the Roku TV, liked the induction stove top and drainer for washing our dishes daily as opposed to having a dishwasher. "
United States
Bobbi
The price is ฿1,900
฿3,159 total
includes taxes & fees
14 May - 15 May
TriLuxe Inn & Studios

Heated Pool, 3 Mi to Dtwn: Cape Coral Escape!

Heated Pool, 3 Mi to Dtwn: Cape Coral Escape!
3.0 star property
20.2 km from Sanctuary
The price is ฿2,511
฿11,151 total
includes taxes & fees
9 May - 10 May
Heated Pool, 3 Mi to Dtwn: Cape Coral Escape!

The Anchor Inn

The Anchor Inn
2.0 star property
Mid Island, 12.8 km from Sanctuary
10.0 out of 10, Exceptional, (28 reviews)
"The property was beautiful, everything was in perfect condition, would definitely go back!!"
United States
Jennifer
The price is ฿7,218
฿8,531 total
includes taxes & fees
28 Apr - 29 Apr
The Anchor Inn

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
19.9 km from Sanctuary
8.2 out of 10, Very good, (1,124 reviews)
"Clean room, nice pool, near beaches, good breakfast."
United States
Kenneth
The price is ฿2,447
฿2,728 total
includes taxes & fees
11 May - 12 May
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

Flamingo Inn

Flamingo Inn
3.0 star property
26.9 km from Sanctuary
7.8 out of 10, Good, (1,003 reviews)
"Great location, neighbors were noisy"
United States
Richard
The price is ฿2,737
฿5,165 total
includes taxes & fees
2 May - 3 May
Flamingo Inn

Shalimar Beach Resort

Shalimar Beach Resort
2.0 star property
West End, 10.3 km from Sanctuary
9.8 out of 10, Exceptional, (48 reviews)
"Loved this property! Everything was perfect!"
United States
Holly
The price is ฿11,236
฿12,528 total
includes taxes & fees
29 Apr - 30 Apr
Shalimar Beach Resort

MALU LANI Inn & Marina

MALU LANI Inn & Marina
3.5 star property
24.7 km from Sanctuary
10.0 out of 10, Exceptional, (5 reviews)
"Beautiful property, peaceful, clean rental. Super responsive owner and all the things you need. Perfect location for boaters. Loved this stay and would definitely rent again! "
United States
April
The price is ฿7,012
฿13,588 total
includes taxes & fees
28 Apr - 29 Apr
MALU LANI Inn & Marina

DiamondHead Beach Resort

DiamondHead Beach Resort
3.5 star property
22.3 km from Sanctuary
9.2 out of 10, Wonderful, (1,148 reviews)
"Great food, large drink selection, comfortable beds & we loved the beach area!!!!!"
United States
Stephanie
The price is ฿6,974
฿9,033 total
includes taxes & fees
4 May - 5 May
DiamondHead Beach Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Sanctuary

Find the best Sanctuary areas for the activities you enjoy most.

Mid Island

If you're spending some time in Mid Island, Periwinkle Way and Sanibel Island Southern Beach are top sights worth seeing.

West End

If you're spending some time in West End, J. N. Ding Darling National Wildlife Refuge and Bowman's Beach are top sights worth seeing.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Beachview Country Club Estates

While visiting Beachview Country Club Estates, you might make a stop by sights like Periwinkle Way and Sanibel Island Golf Club.

Shell Harbor

While Shell Harbor isn't home to many top sights, Sanibel Moorings Botanical Gardens and Sanibel Sea School are some notable places to visit nearby.

Top Sanctuary Hotel Reviews

Frequently asked questions

What is Sanctuary like?
Travellers are sure to enjoy a stay in Sanibel's Sanctuary neighbourhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.
How many hotels will I be able to find in the Sanctuary area?
When you want to find places to stay in Sanibel, start by booking one of Expedia's 9 hotels and other accommodation options in Sanctuary.
If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to get the best deals available in Sanctuary.
What is there to do around this Sanibel neighbourhood?
J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.

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