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Our top choices for Otay Mesa West hotels

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
31.2 km from Otay Mesa West
9.4 out of 10, Exceptional, (2,013 reviews)
"Room was very clean, staff was so helpful! Room with the balcony is so worth it!"
United States
Kristen
The price is ฿4,142
฿4,957 total
includes taxes & fees
5 Aug - 6 Aug
Sycuan Casino Resort

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
11 km from Otay Mesa West
8.2 out of 10, Very good, (1,794 reviews)
"Clean, friendly staff, great breakfast!!"
United States
Flor
The price is ฿4,506
฿5,126 total
includes taxes & fees
9 Aug - 10 Aug
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Motel 6 El Cajon, CA - San Diego

Motel 6 El Cajon, CA - San Diego
2.0 star property
26.3 km from Otay Mesa West
7.4 out of 10, Good, (1,708 reviews)
The price is ฿2,586
฿2,850 total
includes taxes & fees
14 Jul - 15 Jul
Motel 6 El Cajon, CA - San Diego

Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
9.2 km from Otay Mesa West
9.8 out of 10, Exceptional, (1,100 reviews)
"Nice place good food for breakfast 👍"
United States
Paul
The price is ฿6,909
฿7,614 total
includes taxes & fees
2 Aug - 3 Aug
Ayres Hotel San Diego South - Chula Vista

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
10.5 km from Otay Mesa West
9.2 out of 10, Wonderful, (3,933 reviews)
"Great stay"
United States
Cameron
The price is ฿6,115
฿6,738 total
includes taxes & fees
2 Aug - 3 Aug
Best Western Plus Marina Gateway Hotel

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
2.1 km from Otay Mesa West
8.8 out of 10, Excellent, (1,329 reviews)
"The breakfast was great, the staff was helpful, and the room was clean and spacious!"
United States
Christopher
The price is ฿4,176
฿4,750 total
includes taxes & fees
2 Aug - 3 Aug
Best Western Americana Inn

Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station
2.5 star property
22.4 km from Otay Mesa West
9.2 out of 10, Wonderful, (1,719 reviews)
"Breakfast was great. Room was very nice, great area convenient to everything. "
United States
Erica
The price is ฿5,735
฿6,592 total
includes taxes & fees
3 Aug - 4 Aug
Hampton Inn & Suites San Diego Airport Liberty Station

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
21.4 km from Otay Mesa West
8.4 out of 10, Very good, (3,561 reviews)
"Great stay"
United States
Karen
The price is ฿6,976
฿9,707 total
includes taxes & fees
2 Aug - 3 Aug
Sheraton San Diego Resort

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay, 26.8 km from Otay Mesa West
8.6 out of 10, Excellent, (1,520 reviews)
"We have stayed here before, good location, clean rooms, great staff."
United States
Lance
The price is ฿10,314
฿13,620 total
includes taxes & fees
9 Aug - 10 Aug
San Diego Mission Bay Resort

WoodSpring Suites Santee - San Diego Northeast

WoodSpring Suites Santee - San Diego Northeast
2.5 star property
29.1 km from Otay Mesa West
8.4 out of 10, Very good, (151 reviews)
"This property has all amenities travelers would need; including clean room, accessible laundry facility, complimentary parking and wonderful friendly staff."
United States
Lorenzo Gregorio
The price is ฿4,306
฿4,736 total
includes taxes & fees
12 Jul - 13 Jul
WoodSpring Suites Santee - San Diego Northeast

Old Town Inn

Old Town Inn
2.5 star property
23.7 km from Otay Mesa West
9.2 out of 10, Wonderful, (1,897 reviews)
"Clean room and great breakfast."
United States
Michael
The price is ฿6,011
฿6,897 total
includes taxes & fees
29 Jul - 30 Jul
Old Town Inn

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
22.4 km from Otay Mesa West
9.2 out of 10, Wonderful, (1,079 reviews)
"Very good hotel at the price with good choice of breakfast."
United States
Tirthankar
The price is ฿5,875
฿6,752 total
includes taxes & fees
20 Jul - 21 Jul
Holiday Inn Express San Diego Airport - Old Town by IHG

Carlton Oaks Lodge, an Ascend Collection Hotel

Carlton Oaks Lodge, an Ascend Collection Hotel
3.0 star property
29.7 km from Otay Mesa West
8.2 out of 10, Very good, (1,002 reviews)
"Loved the restaurant!!"
United States
Krista
The price is ฿3,321
฿4,754 total
includes taxes & fees
19 Jul - 20 Jul
Carlton Oaks Lodge, an Ascend Collection Hotel

California Suites Hotel

California Suites Hotel
2.0 star property
30.6 km from Otay Mesa West
7.8 out of 10, Good, (2,710 reviews)
"The location was excellent near the beaches and the shopping malls and the restaurants."
United States
Jamal
The price is ฿3,004
฿3,447 total
includes taxes & fees
12 Jul - 13 Jul
California Suites Hotel

Days Inn by Wyndham San Diego-East/El Cajon

Days Inn by Wyndham San Diego-East/El Cajon
2.0 star property
27 km from Otay Mesa West
7.8 out of 10, Good, (1,010 reviews)
"Rooms were cheap clean property was clean convenient close to where I was working"
United States
James
The price is ฿3,672
฿4,046 total
includes taxes & fees
10 Aug - 11 Aug
Days Inn by Wyndham San Diego-East/El Cajon

Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel
2.5 star property
2.4 km from Otay Mesa West
8.0 out of 10, Very good, (1,863 reviews)
"The stay was great, and breakfast was delicious"
United States
Katie
The price is ฿4,227
฿4,658 total
includes taxes & fees
9 Aug - 10 Aug
Best Western Chula Vista/Otay Valley Hotel

Best Western Plus Hacienda Hotel Old Town

Best Western Plus Hacienda Hotel Old Town
3.0 star property
Old Town San Diego, 23.5 km from Otay Mesa West
8.4 out of 10, Very good, (2,085 reviews)
"Clean room, staff were amazing and location was great!"
United States
Joy
The price is ฿5,314
฿6,108 total
includes taxes & fees
28 Jul - 29 Jul
Best Western Plus Hacienda Hotel Old Town

Valli Hi Motel

Valli Hi Motel
2.5 star property
2.2 km from Otay Mesa West
8.4 out of 10, Very good, (1,035 reviews)
"Great place to stay."
United States
Allan
The price is ฿3,004
฿3,423 total
includes taxes & fees
27 Jul - 28 Jul
Valli Hi Motel

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
21.3 km from Otay Mesa West
9.4 out of 10, Exceptional, (1,800 reviews)
"Great experience, staff was excellent food was delicious.. definitely recommend the hotel!"
United States
Lisa
The price is ฿9,613
฿11,049 total
includes taxes & fees
20 Jul - 21 Jul
Lafayette Hotel & Club

Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
7.9 km from Otay Mesa West
8.2 out of 10, Very good, (1,597 reviews)
"The room was comfortable and conveniently located. Breakfast was great for the cost of our stay."
United States
Arsenia P
The price is ฿4,256
฿4,690 total
includes taxes & fees
9 Aug - 10 Aug
Comfort Inn Chula Vista San Diego South
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa West

Find the best Otay Mesa West areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Seaport Village are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Top Otay Mesa West Hotel Reviews

Frequently asked questions

What is Otay Mesa West like?
Otay Mesa West is a neighbourhood that travellers like for its cathedral.
If I need to cancel my hotel reservation in Otay Mesa West, will I receive a refund?
Yes! The majority of room reservations are refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to review top deals in Otay Mesa West.
What is there to do around this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa West include San Ysidro Border Crossing, Las Americas Premium Outlets and Sesame Place San Diego. While you're out sightseeing in San Diego, make sure that you visit other sights such as Tijuana Customs - Garita El Chaparral or North Island Credit Union Amphitheatre.
How can I get around Otay Mesa West and the greater San Diego area?
Ready to get out and explore the city? Iris Avenue Trolley Station is the closest metro station.