Find hotels in O Brien, FL from ฿2,060

Start date: Check-in selected.
To Date
End date: Check-out

    Change your mind

    Book hotels with free cancellation

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
13 Oct - 14 Oct
Tomorrow
14 Oct - 15 Oct
This weekend
17 Oct - 19 Oct
Next weekend
24 Oct - 26 Oct

Filter by

Guest rating
Guest rating
Star rating

Top 10 O Brien hotels and places to stay

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Exterior
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
3.5 star property
9.4 out of 10, Exceptional, (1014)
"Clean rooms, helpful staff, great breakfast"
The price is ฿3,374
฿3,796 total
includes taxes & fees
19 Oct - 20 Oct
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Americas Best Value Inn Alachua
Desk, blackout curtains, iron/ironing board, rollaway beds
Americas Best Value Inn Alachua
2.0 star property
4.8 out of 10, (588)
"Staff very helpful and property clean"
The price is ฿1,883
฿2,118 total
includes taxes & fees
14 Oct - 15 Oct
Americas Best Value Inn Alachua
Hampton Inn & Suites Alachua I-75
Breakfast area
Hampton Inn & Suites Alachua I-75
2.5 star property
9.4 out of 10, Exceptional, (460)
"It's a new clean and nice hotel "
The price is ฿3,753
฿4,222 total
includes taxes & fees
20 Oct - 21 Oct
Hampton Inn & Suites Alachua I-75
La Quinta Inn & Suite by Wyndham Lake City
Exterior
La Quinta Inn & Suite by Wyndham Lake City
2.5 star property
8.8 out of 10, Excellent, (1014)
"We have stayed here multiple times, always convenient and our choice when passing through Lake City "
The price is ฿3,089
฿3,476 total
includes taxes & fees
19 Oct - 20 Oct
La Quinta Inn & Suite by Wyndham Lake City
High Springs Country Inn
Double Room, Non Smoking | Laptop workspace, free WiFi
High Springs Country Inn
2.0 star property
8.6 out of 10, Excellent, (12)
"Great remodel of a retro motel."
The price is ฿2,207
฿2,483 total
includes taxes & fees
16 Oct - 17 Oct
High Springs Country Inn
Best Western Plus Lake City
Lobby
Best Western Plus Lake City
2.5 star property
9.2 out of 10, Wonderful, (1016)
"Good breakfast, very clean room, great decor and overall a nice play to stay."
The price is ฿2,636
฿2,966 total
includes taxes & fees
23 Oct - 24 Oct
Best Western Plus Lake City
Courtyard By Marriott Lake City
Fireplace
Courtyard By Marriott Lake City
3.0 star property
9.6 out of 10, Exceptional, (149)
"Nice place for a weekend trip to the springs close by.Would definitely stay here again."
The price is ฿3,204
฿3,604 total
includes taxes & fees
26 Oct - 27 Oct
Courtyard By Marriott Lake City
Comfort Suites Lake City
Pillow-top beds, desk, laptop workspace, iron/ironing board
Comfort Suites Lake City
2.5 star property
9.6 out of 10, Exceptional, (1008)
"Amazing place to stay"
The price is ฿3,221
฿3,624 total
includes taxes & fees
19 Oct - 20 Oct
Comfort Suites Lake City
Baymont by Wyndham Lake City
Outdoor pool
Baymont by Wyndham Lake City
2.5 star property
5.0 out of 10, (1007)
"Just a perfect place to take a break while traveling. Clean,comfortable and a great staff. "
The price is ฿1,890
฿2,126 total
includes taxes & fees
14 Oct - 15 Oct
Baymont by Wyndham Lake City
Quality Inn Lake City
Outdoor pool, pool loungers
Quality Inn Lake City
2.5 star property
7.8 out of 10, Good, (935)
"Very nice place, would definitely stay there again!"
The price is ฿2,612
฿2,939 total
includes taxes & fees
12 Nov - 13 Nov
Quality Inn Lake City
Days Inn by Wyndham Lake City I-10
Free daily on-the-go breakfast
Days Inn by Wyndham Lake City I-10
2.0 star property
6.8 out of 10, (1001)
"All was good. Staff was great."
The price is ฿1,831
฿2,060 total
includes taxes & fees
14 Oct - 15 Oct
Days Inn by Wyndham Lake City I-10
Tru by Hilton Lake City
Exterior
Tru by Hilton Lake City
2.5 star property
9.2 out of 10, Wonderful, (1011)
"Good hotel"
The price is ฿3,563
฿4,009 total
includes taxes & fees
14 Oct - 15 Oct
Tru by Hilton Lake City
Quality Inn White Springs Suwanee
Standard Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout curtains, iron/ironing board
Quality Inn White Springs Suwanee
2.5 star property
7.2 out of 10, Good, (586)
"Clean room Friendly staff"
The price is ฿2,223
฿2,445 total
includes taxes & fees
3 Nov - 4 Nov
Quality Inn White Springs Suwanee
Americas Best Value Inn Lake City
BBQ/picnic Area
Americas Best Value Inn Lake City
2.0 star property
8.8 out of 10, Excellent, (1006)
"Friendly staff. Clean and comfortable rooms!"
The price is ฿2,207
฿2,483 total
includes taxes & fees
14 Oct - 15 Oct
Americas Best Value Inn Lake City
Fairfield Inn & Suites Lake City
Lobby
Fairfield Inn & Suites Lake City
2.5 star property
9.0 out of 10, Wonderful, (133)
"Friendly staff"
The price is ฿2,779
฿3,126 total
includes taxes & fees
28 Oct - 29 Oct
Fairfield Inn & Suites Lake City
Hampton Inn & Suites Lake City
Lobby
Hampton Inn & Suites Lake City
2.5 star property
9.4 out of 10, Exceptional, (1012)
"It was a great stay "
The price is ฿3,400
฿3,825 total
includes taxes & fees
19 Oct - 20 Oct
Hampton Inn & Suites Lake City
BlueGem Motel
Reception
BlueGem Motel
2.0 star property
9.2 out of 10, Wonderful, (376)
"Great place to stay."
The price is ฿3,240
฿3,645 total
includes taxes & fees
16 Oct - 17 Oct
BlueGem Motel
Super 8 by Wyndham Lake City
Exterior
Super 8 by Wyndham Lake City
2.0 star property
7.2 out of 10, Good, (647)
"Very friendly staff, delicious breakfast and dinner, clean pool, spacious room. Best hotel in the last 4 years within same price range"
The price is ฿2,195
฿2,470 total
includes taxes & fees
15 Oct - 16 Oct
Super 8 by Wyndham Lake City
Days Inn by Wyndham Lake City I-75
Pillow-top beds, in-room safe, desk, blackout curtains
Days Inn by Wyndham Lake City I-75
2.0 star property
7.4 out of 10, Good, (1008)
"The staff was nice and check in was easy"
The price is ฿2,195
฿2,470 total
includes taxes & fees
9 Nov - 10 Nov
Days Inn by Wyndham Lake City I-75
Holiday Inn & Suites Lake City by IHG
Exterior
Holiday Inn & Suites Lake City by IHG
3.0 star property
8.6 out of 10, Excellent, (1007)
"Great place to stay friendly staff clean rooms"
The price is ฿2,851
฿3,207 total
includes taxes & fees
19 Oct - 20 Oct
Holiday Inn & Suites Lake City by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
Photo by Dr__Vlad
Open Photo by Dr__Vlad

Top O Brien Hotel Reviews

Courtyard By Marriott Lake City

Courtyard By Marriott Lake City

10/10 Excellent
"Clean new hotel "
Amy 1-night trip
Posted 8 days ago
Courtyard By Marriott Lake City
Postcard Cabins Gilchrist Springs

Postcard Cabins Gilchrist Springs

10/10 Excellent
"Great place "
Joey 1-night trip
Posted 10 days ago
Postcard Cabins Gilchrist Springs

More cheap stays in O Brien

Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG

6694 Us Highway 129, Live Oak, FL
The price is ฿3,635 per night from 19 Oct to 20 Oct
฿3,635
฿3,999 total
19 Oct - 20 Oct
includes taxes & fees
8.2/10 Very Good! (751 reviews)

Frequently asked questions

Where is the best place to stay in O Brien?
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG, located 29.9 mi (48.2 km) from the heart of O Brien, is a top choice for your stay, based on our traveller data. Two other options for your trip to the area are Best Western Plus Lake City and Postcard Cabins Gilchrist Springs. See all available top hotels, or vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel bookings are refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
What are some accommodation options with pools in O Brien?
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG: Features buffet, an outdoor pool and complimentary high-speed (wired) Internet access. Best Western Plus Lake City and La Quinta Inn & Suite by Wyndham Lake City are two additional hotels that feature an on-site pool. View all hotels with pools in O Brien.
How is it to stay in O Brien?
Visitors to O Brien will definitely find plenty to explore and enjoy. In O Brien, there are 9 hotels and other accommodation options to choose from. Find out more about O Brien.
What are the top places to visit in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River and Ichetucknee Springs State Park. You'll also find Wes Skiles Peacock Springs State Park and Lafayette Blue Springs State Park in the area. Take a look at what more there is to see and do in Expedia's O Brien guide.
What's the seasonal weather in O Brien?
The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 14°C. Average annual precipitation for O Brien is 1278 mm.

Explore a world of travel with Expedia