The Best Hotels in North Clayton, St. Louis - 2026 Updated Prices

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Where to stay in North Clayton

Find the best North Clayton areas for the activities you enjoy most.

The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Old Courthouse to Gateway Arch National Park – discover Downtown St. Louis, a destination also famous for its historic sites.

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A gazebo by a calm pond with autumn foliage and clear skies.

Clayton

Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

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A historic building with a green dome and adjacent modern high-rise buildings.

Central West End

Enjoy this relaxed area, the ultimate destination for a lazy afternoon. Browse unique stores, admire artworks and sip coffee at sidewalk tables shaded by trees.

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A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

St. Charles Historic District is known for its ample dining options, and you can make a stop by Historic Main Street and Missouri River while in the area.

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A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

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Top North Clayton Hotel Reviews

Hyatt Regency St. Louis at The Arch

8/10 Good

"The location is fantastic. I had an amazing view of the Arch directly outside my window, the staff was extremely helpful and friendly, and the bar downstairs was also a great spot. Unfortunately, the hotel itself was disappointing. My room was a nice size, but it felt old, dark, and in serious need of an update. Even with the incredible Arch view, the window had a cloudy white film between the panes AND dead bugs along it, which really took away from the view. Also, NO full-length mirror anywhere! In a room this size, I don't understand how that's possible. I literally had to stand on the toilet to see the bottom half of my outfit in the bathroom mirror. The bathroom itself could also use updating. The water pressure was okay, but the shower head was not great. One other heads-up: guest packages are handled by the FedEx location inside the hotel, which charges $4 PER PACKAGE for pickup. Amazon split my order into two packages, so I unexpectedly paid $8. I definitely would've made other arrangements had I known. Overall, you can't beat the location and the staff was wonderful, but the rooms need some serious TLC to match what I'd expect from a Hyatt Regency."

Drury Plaza Hotel St. Louis Union Station

10/10 Excellent

"Fantastic stay at the Drury Inn St. Louis at Union Station. The location is excellent, especially if you’re in town for an event downtown. The hotel was clean, comfortable, and incredibly convenient, and the staff was friendly and welcoming from check-in to checkout. One of the biggest standouts with Drury is the value. Between the complimentary breakfast, evening food and drinks, and the overall quality of the stay, you really feel like you’re getting more than what you paid for. The room was comfortable, everything was well maintained, and the hotel had a great atmosphere. Being right by Union Station and close to the major downtown attractions made getting around St. Louis incredibly easy. I’ve stayed in plenty of hotels while traveling, and this was easily one of the better experiences. I would absolutely stay here again and would recommend it to anyone visiting St. Louis. Five stars all the way."

Frequently asked questions

What is North Clayton like?

Travellers to St. Louis's North Clayton neighbourhood will be sure to enjoy a stay here.

What's a favourite place to stay in North Clayton?

Based on our traveller data, Hampton Inn & Suites Clayton/St. Louis-Galleria Area is one of the top choices for your stay in North Clayton. This hotel offers free breakfast and an indoor pool.

How many hotels will I find in the North Clayton area?

If you're searching for places to stay in St. Louis, choose from one of Expedia's 11 hotels and other accommodation options in North Clayton.

If I need to cancel my hotel reservation in North Clayton, will I receive a refund?

Yes, the majority of hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you have a reservation that's non-refundable, you may still be able to cancel and be given a refund within 24 hours of booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to view the best deals available in North Clayton.

What is there to do in this St. Louis neighbourhood?

St. Louis Zoo, Shaw Park Tennis Center and Saint Louis Galleria Mall are just a few of the places to visit in and around North Clayton. While you're out sightseeing, Heman Park Tennis Center and Tao Tennis Center are a couple of additional sights to visit in St. Louis.

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Our top choices for North Clayton hotels

1. Hampton Inn & Suites Clayton/St. Louis-Galleria Area

2. Drury Plaza Hotel St. Louis Brentwood

3. SpringHill Suites St. Louis Brentwood

4. Clayton Plaza Hotel & Extended Stay

5. The Knight Center at Washington University

6. Moonrise Hotel

7. Hampton Inn & Suites St. Louis at Forest Park

8. Hampton Inn By Hilton St Louis Airport

9. The Cheshire

10. Hyatt Select St. Louis Airport

11. Wingate by Wyndham St. Louis Airport

12. Drury Inn & Suites St. Louis Airport

13. Home2 Suites by Hilton St. Louis/Forest Park

14. Pear Tree Inn St. Louis Airport

15. Best Western Plus St. Louis West-Westport

16. Renaissance St. Louis Airport Hotel

17. Fairfield Inn & Suites St Louis Westport

18. Holiday Inn St Louis SW - Route 66 by IHG

19. La Quinta Inn & Suites by Wyndham St Louis Route 66

20. Courtyard by Marriott St Louis Creve Coeur

Where to stay in North Clayton

Downtown St. Louis

Clayton

Central West End

St. Charles Historic District

Creve Coeur

Top North Clayton Hotel Reviews

Hyatt Regency St. Louis at The Arch

Frequently asked questions

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