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Our top choices for Mayo Clinic Florida hotels

Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic
4.5 star property
0.8 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (160 reviews)
"Great place to stay"
United States
Judy
The price is ฿6,033
฿6,848 total
includes taxes & fees
20 Mar - 21 Mar
Hilton Jacksonville At Mayo Clinic

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
1.1 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (468 reviews)
"Clean room, amazing staff great location "
United States
Darlene
The price is ฿5,992
฿6,801 total
includes taxes & fees
19 Mar - 20 Mar
Residence Inn By Marriott Jacksonville - Mayo Clinic Area

TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
3.0 star property
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (585 reviews)
"Comfortable room, very nice staff. Great location."
United States
Andrew
The price is ฿3,756
฿4,264 total
includes taxes & fees
16 Mar - 17 Mar
TownePlace Suites by Marriott Jacksonville East

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1,002 reviews)
"Enjoyed the complimentary breakfast. "
United States
Andrew
The price is ฿3,539
฿4,016 total
includes taxes & fees
22 Mar - 23 Mar
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
2.6 km from Mayo Clinic Florida
8.8 out of 10, Excellent, (1,006 reviews)
"Staff was nice and room was clean "
United States
Charles
The price is ฿4,036
฿4,581 total
includes taxes & fees
28 Mar - 29 Mar
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
3.0 star property
0.4 km from Mayo Clinic Florida
8.4 out of 10, Very good, (765 reviews)
"Great location "
United States
Josiah Christine
The price is ฿6,116
฿6,942 total
includes taxes & fees
20 Mar - 21 Mar
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Element Jacksonville Beach

Element Jacksonville Beach
3.0 star property
5.4 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (539 reviews)
"Great place (and location)!"
United States
Dale
The price is ฿4,191
฿4,757 total
includes taxes & fees
22 Mar - 23 Mar
Element Jacksonville Beach

Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG
2.5 star property
Southside, 7.7 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (1,005 reviews)
"Great location, friendly staff, nice rooms, great breakfast."
United States
Michelle
The price is ฿3,787
฿4,299 total
includes taxes & fees
2 Apr - 3 Apr
Holiday Inn Express & Suites Jacksonville - Town Center by IHG

The Hotel Palms

The Hotel Palms
3.5 star property
7.8 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (294 reviews)
"stayed here for an event and it was awesome"
United States
clayton
The price is ฿5,868
฿6,660 total
includes taxes & fees
2 Apr - 3 Apr
The Hotel Palms

TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport
3.0 star property
10.8 km from Mayo Clinic Florida
9.8 out of 10, Exceptional, (81 reviews)
"New, clean room and nice breakfast."
United States
Gregory
The price is ฿3,881
฿4,405 total
includes taxes & fees
29 Mar - 30 Mar
TownePlace Suites by Marriott® Jacksonville Mayport

The Lodge and Club at Ponte Vedra Beach

The Lodge and Club at Ponte Vedra Beach
5.0 star property
6.3 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (688 reviews)
"Clean room, excellent service and only steps from the ocean. The facility could use some TLC but, all in all, a wonderful place to stay. We’ll be back for sure. "
United States
Robert
The price is ฿18,596
฿21,635 total
includes taxes & fees
3 Mar - 4 Mar
The Lodge and Club at Ponte Vedra Beach

Ponte Vedra Inn & Club

Ponte Vedra Inn & Club
5.0 star property
6.3 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (815 reviews)
"Amazing. Loved it "
United States
Carol
The price is ฿20,148
฿23,366 total
includes taxes & fees
3 Mar - 4 Mar
Ponte Vedra Inn & Club

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
2.5 star property
4.2 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1,033 reviews)
"Clean room, good breakfast and location"
United States
Jesus
The price is ฿4,048
฿4,594 total
includes taxes & fees
22 Mar - 23 Mar
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

AC Hotel Jacksonville St Johns Town Center

AC Hotel Jacksonville St Johns Town Center
2.5 star property
Southside, 8.1 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (180 reviews)
"Staff was excellent...highly recommend this Hotel"
Canada
Robert
The price is ฿7,109
฿8,069 total
includes taxes & fees
8 Mar - 9 Mar
AC Hotel Jacksonville St Johns Town Center

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
5.9 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (3,706 reviews)
"Yes room was spotless and staff was amazing!"
United States
Martina
The price is ฿4,722
฿5,360 total
includes taxes & fees
4 Mar - 5 Mar
Margaritaville Jacksonville Beach

Best Western Oceanfront

Best Western Oceanfront
3.0 star property
5.7 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1,011 reviews)
"Great location, breakfast was delicious "
United States
Paul
The price is ฿3,725
฿4,228 total
includes taxes & fees
22 Mar - 23 Mar
Best Western Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront
4.0 star property
5.8 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (644 reviews)
"The hotel was great! Very clean room and staff were very courteous and professional"
United States
Mike
The price is ฿6,054
฿6,871 total
includes taxes & fees
22 Mar - 23 Mar
Springhill Suites By Marriott Jacksonville Beach Oceanfront

Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
3.0 star property
4.6 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1,002 reviews)
"Hotel was clean, breakfast was perfect."
United States
Kurt
The price is ฿4,067
฿4,616 total
includes taxes & fees
16 Mar - 17 Mar
Holiday Inn Express Jacksonville Beach by IHG

Four Points by Sheraton Jacksonville Beachfront

Four Points by Sheraton Jacksonville Beachfront
3.0 star property
5.6 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1,001 reviews)
"Beds very comfortable. Check-in seamless. I loved my stay."
United States
Pizza
The price is ฿5,774
฿6,554 total
includes taxes & fees
22 Mar - 23 Mar
Four Points by Sheraton Jacksonville Beachfront

Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
3.0 star property
Southside, 8.6 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1,002 reviews)
"very friendly staff!! i love staying here!!"
United States
Evani
The price is ฿4,222
฿4,792 total
includes taxes & fees
2 Apr - 3 Apr
Hyatt Place Jacksonville / St. Johns Town Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels close to Mayo Clinic Florida

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Breakfast, lunch, dinner served; American cuisine
Hilton Jacksonville At Mayo Clinic
4.5 star property
9.4
Exceptional
160 reviews
View
Lobby lounge
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
9.4
Exceptional
468 reviews
View
Terrace/patio
TownePlace Suites by Marriott Jacksonville East
3.0 star property
9.2
Wonderful
585 reviews
View
Lobby
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
9.0
Wonderful
1,002 reviews
View
Lobby sitting area
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
8.8
Excellent
1,006 reviews
View

Top Mayo Clinic Florida Hotel Reviews

Hotels near other Mayo Clinic Florida attractions

Frequently asked questions

What's the area like around Mayo Clinic Florida?
Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 47 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay close to Mayo Clinic Florida?
Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville At Mayo Clinic and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.
How many hotels are there near Mayo Clinic Florida?
Expedia has 47 hotels and other accommodation options within a mile from Mayo Clinic Florida.
If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.
What can I see and do near Mayo Clinic Florida?
You can catch a show at Players by the Sea, SeaWalk Pavillion and SeaWalk Pavillion. Spend some time exploring the the natural beauty of Huguenot Park, Oceanfront Park and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.