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Our top choices for Mayo Clinic Florida hotels

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
1.1 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (528 reviews)
"Great place to stay!"
United States
Chad
The price is ฿5,298
฿6,013 total
includes taxes & fees
6 Jun - 7 Jun
Residence Inn By Marriott Jacksonville - Mayo Clinic Area

TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
3.0 star property
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (621 reviews)
"The staff was very helpful and very friendly. I will definitely be booking this hotelagain."
United States
Erica
The price is ฿4,063
฿4,612 total
includes taxes & fees
14 Jun - 15 Jun
TownePlace Suites by Marriott Jacksonville East

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1,003 reviews)
"Location: many business and restaurants to choose from and beach just down the road: staff very professional and knowledgeable and friendly and accommodating"
United States
Debra
The price is ฿3,564
฿4,045 total
includes taxes & fees
21 Jun - 22 Jun
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
2.6 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1,009 reviews)
"Breakfast was a hit and the pool is the best hotel pool we've seen in a long time!!"
United States
Patsy
The price is ฿3,948
฿4,482 total
includes taxes & fees
28 Jun - 29 Jun
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
3.0 star property
0.4 km from Mayo Clinic Florida
8.4 out of 10, Very good, (776 reviews)
"Enjoyed our stay"
United States
Alan
The price is ฿4,941
฿5,608 total
includes taxes & fees
6 Jun - 7 Jun
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
3.0 star property
4.6 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1,006 reviews)
"Super nice staff, quiet room - great stay!!"
United States
Sean
The price is ฿4,063
฿4,612 total
includes taxes & fees
14 Jun - 15 Jun
Holiday Inn Express Jacksonville Beach by IHG

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
2.5 star property
4.2 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1,129 reviews)
"Great place to stay"
United States
Jeffrey
The price is ฿4,393
฿4,986 total
includes taxes & fees
18 Jun - 19 Jun
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Best Western Oceanfront

Best Western Oceanfront
3.0 star property
5.7 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1,011 reviews)
"Great location, very nice staff"
United States
Maria
The price is ฿5,169
฿5,866 total
includes taxes & fees
15 Jun - 16 Jun
Best Western Oceanfront

Ponte Vedra Inn & Club

Ponte Vedra Inn & Club
5.0 star property
6.3 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (822 reviews)
"Beautiful room looking at the ocean, staff super helpful, property immaculate."
United Kingdom
Michael
The price is ฿16,220
฿19,027 total
includes taxes & fees
28 Jun - 29 Jun
Ponte Vedra Inn & Club

The Hotel Palms Courtyard

The Hotel Palms Courtyard
3.5 star property
7.8 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (302 reviews)
"Clean, room was very nice, staff was helpful"
United States
Angela
The price is ฿6,179
฿7,013 total
includes taxes & fees
24 Jun - 25 Jun
The Hotel Palms Courtyard

The Lodge and Club at Ponte Vedra Beach

The Lodge and Club at Ponte Vedra Beach
5.0 star property
6.3 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (695 reviews)
"Very nice resort! Staff is friendly, clean and great restaurants outside."
United States
Raymond
The price is ฿14,594
฿17,215 total
includes taxes & fees
7 Jun - 8 Jun
The Lodge and Club at Ponte Vedra Beach

Fairfield Inn & Suites by Marriott Jacksonville Beach

Fairfield Inn & Suites by Marriott Jacksonville Beach
3.0 star property
6.3 km from Mayo Clinic Florida
8.6 out of 10, Excellent, (943 reviews)
"Perfect location at a great price and a nice breakfast, nice staff, clean and updated"
United States
Sue
The price is ฿4,388
฿4,980 total
includes taxes & fees
7 Jun - 8 Jun
Fairfield Inn & Suites by Marriott Jacksonville Beach

Four Points by Sheraton Jacksonville Beachfront

Four Points by Sheraton Jacksonville Beachfront
3.0 star property
5.6 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1,002 reviews)
"Very nice property and staff"
United States
BONINA
The price is ฿6,891
฿7,821 total
includes taxes & fees
21 Jun - 22 Jun
Four Points by Sheraton Jacksonville Beachfront

Casa Marina Hotel

Casa Marina Hotel
3.0 star property
5.9 km from Mayo Clinic Florida
8.4 out of 10, Very good, (1,001 reviews)
"What a classic, well-staffed gem of history in a most beautiful beachfront setting! Nothing compares with a Penthouse martini while watching the sunset’s colors."
United States
Sharone
The price is ฿4,827
฿5,478 total
includes taxes & fees
3 Jun - 4 Jun
Casa Marina Hotel

Dune House Hotel & Spa

Dune House Hotel & Spa
4.5 star property
8 km from Mayo Clinic Florida
8.8 out of 10, Excellent, (1,000 reviews)
"We all had an enjoyable week at DH I spite of renovations it was good! Staff very friendly and ALL available to answer any questions!"
United States
Dawn
The price is ฿7,144
฿9,507 total
includes taxes & fees
24 Jun - 25 Jun
Dune House Hotel & Spa

Courtyard by Marriott Jacksonville Beach Oceanfront

Courtyard by Marriott Jacksonville Beach Oceanfront
3.0 star property
6.4 km from Mayo Clinic Florida
8.6 out of 10, Excellent, (1,006 reviews)
"Well maintained property, clean rooms, beautiful views and not overly crowded."
United States
Bonnie
The price is ฿6,200
฿7,037 total
includes taxes & fees
16 Jun - 17 Jun
Courtyard by Marriott Jacksonville Beach Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront
3.0 star property
6.3 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (2,667 reviews)
"Good breakfast and great amenities with the pool, beach and tiki barand grill. "
United States
Hillary
The price is ฿5,896
฿6,692 total
includes taxes & fees
16 Jun - 17 Jun
Hampton Inn Jacksonville Beach/Oceanfront

Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG
2.5 star property
Southside, 7.7 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (1,005 reviews)
"Great place to stay"
United States
Clyde
The price is ฿4,046
฿4,593 total
includes taxes & fees
2 Jul - 3 Jul
Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
3.0 star property
8.5 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1,000 reviews)
"Very enjoyable stay!"
United States
Kristin
The price is ฿4,265
฿4,755 total
includes taxes & fees
29 Jun - 30 Jun
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Sheraton Jacksonville Hotel

Sheraton Jacksonville Hotel
4.0 star property
Deerwood, 9.6 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1,001 reviews)
"Loved the hotel and staff"
United States
Leticia
The price is ฿4,290
฿4,869 total
includes taxes & fees
18 Jun - 19 Jun
Sheraton Jacksonville Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels close to Mayo Clinic Florida

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Lobby lounge
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
9.4
Exceptional
528 reviews
View
Terrace/patio
TownePlace Suites by Marriott Jacksonville East
3.0 star property
9.2
Wonderful
621 reviews
View
Lobby sitting area
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
9.0
Wonderful
1,009 reviews
View
Lobby
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
9.0
Wonderful
1,003 reviews
View
Terrace/patio
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
3.0 star property
8.4
Very good
776 reviews
View

Top Mayo Clinic Florida Hotel Reviews

Frequently asked questions

What's the area like around Mayo Clinic Florida?
Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 46 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay close to Mayo Clinic Florida?
Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville At Mayo Clinic and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.
How many hotels are there near Mayo Clinic Florida?
Expedia has 46 hotels and other accommodation options within a mile from Mayo Clinic Florida.
If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.
What can I see and do near Mayo Clinic Florida?
You can catch a show at SeaWalk Pavillion, Wilson Center For the Arts and Players by the Sea. Spend some time exploring the the natural beauty of Huguenot Park, Oceanfront Park and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.