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Our top choices for Mayo Clinic Florida hotels

Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic
4.5 star property
0.8 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (246 reviews)
"Excellent room, amenities, restaurant and plentiful breakfast selection. Will definitely stay again."
United States
Tammy
The price is ฿5,305
฿6,021 total
includes taxes & fees
27 Jun - 28 Jun
Hilton Jacksonville At Mayo Clinic

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
1.1 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (528 reviews)
"Great place to stay!"
United States
Chad
The price is ฿5,298
฿6,013 total
includes taxes & fees
6 Jun - 7 Jun
Residence Inn By Marriott Jacksonville - Mayo Clinic Area

TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
3.0 star property
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (621 reviews)
"The staff was very helpful and very friendly. I will definitely be booking this hotelagain."
United States
Erica
The price is ฿4,063
฿4,612 total
includes taxes & fees
14 Jun - 15 Jun
TownePlace Suites by Marriott Jacksonville East

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1,003 reviews)
"Location: many business and restaurants to choose from and beach just down the road: staff very professional and knowledgeable and friendly and accommodating"
United States
Debra
The price is ฿3,564
฿4,045 total
includes taxes & fees
21 Jun - 22 Jun
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
2.6 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1,007 reviews)
"Breakfast was a hit and the pool is the best hotel pool we've seen in a long time!!"
United States
Patsy
The price is ฿3,770
฿4,279 total
includes taxes & fees
21 Jun - 22 Jun
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
3.0 star property
0.4 km from Mayo Clinic Florida
8.4 out of 10, Very good, (775 reviews)
"Enjoyed our stay"
United States
Alan
The price is ฿4,941
฿5,608 total
includes taxes & fees
6 Jun - 7 Jun
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Element by Marriott Jacksonville Beach

Element by Marriott Jacksonville Beach
3.0 star property
5.4 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (558 reviews)
"Best hotel ever 😊"
United States
Tablo
The price is ฿5,233
฿5,940 total
includes taxes & fees
18 Jun - 19 Jun
Element by Marriott Jacksonville Beach

The Hotel Palms Poolside

The Hotel Palms Poolside
2.5 star property
7.8 km from Mayo Clinic Florida
9.8 out of 10, Exceptional, (479 reviews)
"Very clean and quiet, even with the festival in AB. Felt very safe. Loved the pool area!"
United States
Liza
The price is ฿5,870
฿6,662 total
includes taxes & fees
2 Jun - 3 Jun
The Hotel Palms Poolside

Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
2.5 star property
Deerwood, 7.8 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (60 reviews)
"Great location and awesome staff"
United States
Beth
The price is ฿4,117
฿4,672 total
includes taxes & fees
6 Jun - 7 Jun
Hyatt Studios Jacksonville/St Johns Town Center

Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG
2.5 star property
Southside, 7.7 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (1,004 reviews)
"Great place to stay"
United States
Clyde
The price is ฿4,031
฿4,575 total
includes taxes & fees
29 Jun - 30 Jun
Holiday Inn Express & Suites Jacksonville - Town Center by IHG

The Hotel Palms Courtyard

The Hotel Palms Courtyard
3.5 star property
7.8 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (301 reviews)
"Clean, room was very nice, staff was helpful"
United States
Angela
The price is ฿6,179
฿7,013 total
includes taxes & fees
2 Jun - 3 Jun
The Hotel Palms Courtyard

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
2.5 star property
4.2 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1,125 reviews)
"Great place to stay"
United States
Jeffrey
The price is ฿3,951
฿4,484 total
includes taxes & fees
21 Jun - 22 Jun
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

The Lodge and Club at Ponte Vedra Beach

The Lodge and Club at Ponte Vedra Beach
5.0 star property
6.3 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (695 reviews)
"Very nice resort! Staff is friendly, clean and great restaurants outside."
United States
Raymond
The price is ฿14,594
฿17,215 total
includes taxes & fees
7 Jun - 8 Jun
The Lodge and Club at Ponte Vedra Beach

Ponte Vedra Inn & Club

Ponte Vedra Inn & Club
5.0 star property
6.3 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (822 reviews)
"Beautiful room looking at the ocean, staff super helpful, property immaculate."
United Kingdom
Michael
The price is ฿16,220
฿19,027 total
includes taxes & fees
14 Jun - 15 Jun
Ponte Vedra Inn & Club

TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport
3.0 star property
10.8 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (104 reviews)
"Great staff and breakfast!"
United States
Kandi
The price is ฿4,648
฿5,276 total
includes taxes & fees
7 Jun - 8 Jun
TownePlace Suites by Marriott® Jacksonville Mayport

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
5.9 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (4,012 reviews)
"Very nice staff and beautiful property"
United States
Marley
The price is ฿6,114
฿6,940 total
includes taxes & fees
4 Jun - 5 Jun
Margaritaville Jacksonville Beach

AC Hotel Jacksonville St Johns Town Center

AC Hotel Jacksonville St Johns Town Center
2.5 star property
Southside, 8.1 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (203 reviews)
"Great stay! Highly recommend and tons to do in the area."
United States
Adam
The price is ฿5,818
฿6,604 total
includes taxes & fees
4 Jun - 5 Jun
AC Hotel Jacksonville St Johns Town Center

Best Western Oceanfront

Best Western Oceanfront
3.0 star property
5.7 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1,009 reviews)
"Great location, very nice staff"
United States
Maria
The price is ฿5,148
฿5,843 total
includes taxes & fees
28 Jun - 29 Jun
Best Western Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront
4.0 star property
5.8 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (707 reviews)
"Breakfast was fantastic loved how big the rooms were "
United States
Jonatan
The price is ฿6,051
฿6,867 total
includes taxes & fees
28 Jun - 29 Jun
Springhill Suites By Marriott Jacksonville Beach Oceanfront

Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
3.0 star property
4.6 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1,005 reviews)
"Super nice staff, quiet room - great stay!!"
United States
Sean
The price is ฿4,063
฿4,612 total
includes taxes & fees
14 Jun - 15 Jun
Holiday Inn Express Jacksonville Beach by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels close to Mayo Clinic Florida

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Breakfast, lunch and dinner served
Hilton Jacksonville At Mayo Clinic
4.5 star property
9.4
Exceptional
246 reviews
View
Lobby lounge
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
9.4
Exceptional
528 reviews
View
Terrace/patio
TownePlace Suites by Marriott Jacksonville East
3.0 star property
9.2
Wonderful
621 reviews
View
Lobby
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
9.0
Wonderful
1,003 reviews
View
Lobby sitting area
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
9.0
Wonderful
1,007 reviews
View

Top Mayo Clinic Florida Hotel Reviews

Frequently asked questions

What's the area like around Mayo Clinic Florida?
Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 46 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay close to Mayo Clinic Florida?
Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville At Mayo Clinic and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.
How many hotels are there near Mayo Clinic Florida?
Expedia has 46 hotels and other accommodation options within a mile from Mayo Clinic Florida.
If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.
What can I see and do near Mayo Clinic Florida?
You can catch a show at SeaWalk Pavillion, Wilson Center For the Arts and Players by the Sea. Spend some time exploring the the natural beauty of Huguenot Park, Oceanfront Park and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.