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Check prices for these dates

This weekend
5 Jun - 7 Jun
Next weekend
12 Jun - 14 Jun

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Our top choices for Matlacha Isles hotels

Reception

HomeTowne Studios by Red Roof Fort Myers

HomeTowne Studios by Red Roof Fort Myers
2.5 star property
21.7 km from Matlacha Isles
10.0 out of 10, Exceptional, (3 reviews)
"Great stay and staff"
United States
Kimberly
The price is ฿2,048
฿2,283 total
includes taxes & fees
7 Jun - 8 Jun
HomeTowne Studios by Red Roof Fort Myers
Lobby

Comfort Suites Fort Myers East I-75

Comfort Suites Fort Myers East I-75
2.5 star property
24.8 km from Matlacha Isles
9.8 out of 10, Exceptional, (477 reviews)
"Great place to stay"
United States
Dennis
The price is ฿2,855
฿3,184 total
includes taxes & fees
28 Jun - 29 Jun
Comfort Suites Fort Myers East I-75
Laptop workspace, blackout curtains, free WiFi, bed sheets

StudioRes by Marriott Fort Myers Airport

StudioRes by Marriott Fort Myers Airport
3.0 star property
29.5 km from Matlacha Isles
9.4 out of 10, Exceptional, (60 reviews)
"Excellent facility. Favorite place to stay"
United States
Daniel
The price is ฿2,459
฿2,742 total
includes taxes & fees
7 Jun - 8 Jun
StudioRes by Marriott Fort Myers Airport
Interior

Holiday Inn Express & Suites Fort Myers Airport by IHG

Holiday Inn Express & Suites Fort Myers Airport by IHG
2.5 star property
29 km from Matlacha Isles
9.6 out of 10, Exceptional, (1,057 reviews)
"Very nice stay"
United States
James
The price is ฿3,283
฿3,660 total
includes taxes & fees
30 Jun - 1 Jul
Holiday Inn Express & Suites Fort Myers Airport by IHG
Lobby

Extended Stay America Premier Suites - Fort Myers - Airport

Extended Stay America Premier Suites - Fort Myers - Airport
2.5 star property
23.6 km from Matlacha Isles
8.8 out of 10, Excellent, (1,006 reviews)
"very nice place to stay!"
United States
Natalia
The price is ฿1,930
฿2,152 total
includes taxes & fees
7 Jun - 8 Jun
Extended Stay America Premier Suites - Fort Myers - Airport
3 restaurants; breakfast, lunch, dinner and brunch served

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
23.2 km from Matlacha Isles
9.0 out of 10, Wonderful, (1,556 reviews)
"Love that all the rooms are ocean view and hotel is centrally located"
United States
Ryan
The price is ฿5,168
฿6,487 total
includes taxes & fees
8 Jun - 9 Jun
Lani Kai Beachfront Resort
Luxury Room | Bathroom | Towels, soap, shampoo, toilet paper

Park Motel

Park Motel
2.5 star property
Diplomat, 17.2 km from Matlacha Isles
9.2 out of 10, Wonderful, (46 reviews)
"Clean, quiet, very friendly and helpful staff, hot tub in room very relaxing."
United States
Kristeen
The price is ฿3,072
฿3,425 total
includes taxes & fees
2 Jun - 3 Jun
Park Motel
1 King Bed Suite w/ Efficiency Non Smoking | Premium bedding, down duvets, desk, laptop workspace

Quality Inn Fort Myers Cape Coral

Quality Inn Fort Myers Cape Coral
2.0 star property
18.4 km from Matlacha Isles
7.6 out of 10, Good, (324 reviews)
"Clean room, nice breakfast and wonderful staff!"
United States
Christina
The price is ฿1,610
฿2,285 total
includes taxes & fees
22 Jun - 23 Jun
Quality Inn Fort Myers Cape Coral
Lobby

Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park

Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park
2.0 star property
28 km from Matlacha Isles
8.0 out of 10, Very good, (1,683 reviews)
"We really enjoyed our stay at the hotel. "
United States
Coreen
The price is ฿2,253
฿2,512 total
includes taxes & fees
2 Jun - 3 Jun
Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park
Restaurant

Fairfield Inn & Suites by Marriott Cape Coral/North Fort Myers

Fairfield Inn & Suites by Marriott Cape Coral/North Fort Myers
3.0 star property
Hancock, 11.5 km from Matlacha Isles
9.4 out of 10, Exceptional, (808 reviews)
"Lovely place"
United States
Emily
The price is ฿3,426
฿3,820 total
includes taxes & fees
14 Jun - 15 Jun
Fairfield Inn & Suites by Marriott Cape Coral/North Fort Myers
Free daily buffet breakfast

Hampton Inn Fort Myers-Airport & I-75

Hampton Inn Fort Myers-Airport & I-75
3.5 star property
26.8 km from Matlacha Isles
9.0 out of 10, Wonderful, (1,002 reviews)
"Great place to stay."
United States
Vanaja
The price is ฿3,177
฿3,543 total
includes taxes & fees
7 Jun - 8 Jun
Hampton Inn Fort Myers-Airport & I-75
Suite, 1 King Bed, Non Smoking | Desk, laptop workspace, iron/ironing board, free WiFi

Comfort Inn Fort Myers Northeast

Comfort Inn Fort Myers Northeast
2.5 star property
25.8 km from Matlacha Isles
7.8 out of 10, Good, (737 reviews)
"Perfect location to continue my trip."
United States
Ronald
The price is ฿2,339
฿2,608 total
includes taxes & fees
28 Jun - 29 Jun
Comfort Inn Fort Myers Northeast
Lobby

Quality Suites Fort Myers I-75

Quality Suites Fort Myers I-75
2.5 star property
27.1 km from Matlacha Isles
8.4 out of 10, Very good, (1,005 reviews)
"Perfect stay "
United States
Israel
The price is ฿2,050
฿2,286 total
includes taxes & fees
28 Jun - 29 Jun
Quality Suites Fort Myers I-75
Property entrance

Holiday Inn Express & Suites Punta Gorda by IHG

Holiday Inn Express & Suites Punta Gorda by IHG
2.5 star property
28.8 km from Matlacha Isles
9.4 out of 10, Exceptional, (1,007 reviews)
"Overall great hotel"
United States
Jimmy
The price is ฿3,120
฿3,495 total
includes taxes & fees
21 Jun - 22 Jun
Holiday Inn Express & Suites Punta Gorda by IHG
Lobby

Baymont by Wyndham Punta Gorda/Port Charlotte

Baymont by Wyndham Punta Gorda/Port Charlotte
2.5 star property
28.9 km from Matlacha Isles
8.4 out of 10, Very good, (1,225 reviews)
"Room was clean and comfortable! Breakfast was excellent."
United States
Donna
The price is ฿2,282
฿2,556 total
includes taxes & fees
14 Jun - 15 Jun
Baymont by Wyndham Punta Gorda/Port Charlotte
Free daily buffet breakfast

Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
18.1 km from Matlacha Isles
8.8 out of 10, Excellent, (1,005 reviews)
"Wonderful location and accommodations!"
United States
Karen
The price is ฿3,348
฿3,733 total
includes taxes & fees
3 Jun - 4 Jun
Residence Inn by Marriott Fort Myers Sanibel
View from room

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
18.3 km from Matlacha Isles
8.2 out of 10, Very good, (1,188 reviews)
"Clean room, staff, good breakfast, easy parking"
United States
Jose
The price is ฿2,834
฿3,160 total
includes taxes & fees
15 Jun - 16 Jun
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
Property amenity

TownePlace Suites by Marriott Fort Myers Gulf Coast

TownePlace Suites by Marriott Fort Myers Gulf Coast
3.0 star property
29.9 km from Matlacha Isles
9.2 out of 10, Wonderful, (210 reviews)
"The staff was very friendly and accommodating. Room very clean."
United States
Cynthia
The price is ฿3,478
฿3,878 total
includes taxes & fees
12 Jun - 13 Jun
TownePlace Suites by Marriott Fort Myers Gulf Coast
Reception

Americas Best Value Inn Ft. Myers

Americas Best Value Inn Ft. Myers
3.0 star property
19.3 km from Matlacha Isles
7.6 out of 10, Good, (1,243 reviews)
"The rooms are really nice and affordable and I was pleased...."
United States
James
The price is ฿2,183
฿2,434 total
includes taxes & fees
2 Jun - 3 Jun
Americas Best Value Inn Ft. Myers
Exterior

Best Western Fort Myers Inn & Suites

Best Western Fort Myers Inn & Suites
2.5 star property
20.8 km from Matlacha Isles
8.8 out of 10, Excellent, (1,212 reviews)
"Breakfast was wonderful, staff was very friendly."
United States
Todd
The price is ฿2,311
฿2,577 total
includes taxes & fees
28 Jun - 29 Jun
Best Western Fort Myers Inn & Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Matlacha Isles

Find the best Matlacha Isles areas for the activities you enjoy most.
Sunset on Fort Myers Beach

Pelican

While visiting Pelican, you might make a stop by sights like Tarpon Point and Chabad Jewish Center.

Aerial Drone View of Bay in Cape Coral, Florida with Mangroves and Real Estate in the Foreground and the Caloosahatchee River in the Background

Caloosahatchee

If you're spending some time in Caloosahatchee, Cape Coral Yacht Club Beach and Dolphin Marina are top sights worth seeing.

Colorfull sunset on Pine Island, Florida

Yacht Club

While Yacht Club isn't home to many top sights, Cape Coral Yacht Club Beach and Dolphin Marina are some notable places to visit nearby.

Fort Myers Beach

Hancock

While visiting Hancock, you might make a stop by sights like Four Mile Cove Ecological Preserve and Pine Island Shopping Center.

This is the morning view of Pine Island Sound. Its pier juts out from the left side with wooden pylons standing up out of the water near the shore.

Burnt Store

When in Burnt Store, you can plan a visit to Burnt Store Marina and Royal Tee Golf Club, some noteworthy sights in the nearby area.

Top Matlacha Isles Hotel Reviews

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

6/10 Okay
"The room had a little bit sewer smell to it,I stayed in the first floor.Last time I stayed there the room was in the second floor and it was the best experience I ever had in a hotel"
Emanuel 3-night trip
Posted 1 hour ago
Lani Kai Beachfront Resort

Frequently asked questions

What is Matlacha Isles like?
Travellers will be sure to find plenty to entertain them in Cape Coral's Matlacha Isles neighbourhood.
How many hotels will I be able to find in the Matlacha Isles area?
When you want to put your feet up after a day of exploring the sights in Cape Coral, you can choose from 17 Expedia hotels and other accommodation options in Matlacha Isles.
If I need to cancel my hotel reservation in Matlacha Isles, will I receive a refund?
Yes, the majority of room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and get a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to get the best deals in Matlacha Isles.
What are the top things to see and do in Matlacha Isles?
A few places to visit in the area around Matlacha Isles include Griffen American Center for Haitian Art, Lovegrove Gallery & Gardens and Royal Tee Golf Club. While you're out sightseeing in Cape Coral, make sure that you visit other sights such as Little Dead Key or Big Dead Key.