The Best Hotels in Jefferson, San Antonio - 2026 Updated Prices

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Our top choices for Jefferson hotels

A Holiday Inn Express reception desk with a modern design, featuring a large illuminated sign, a reception area, and a potted plant.

1. Holiday Inn Express San Antonio-Airport by IHG

8.2 km from Jefferson

Lori

฿4,069 total

includes taxes & fees

29 Nov - 30 Nov

2. Hyatt Place San Antonio - Riverwalk

Downtown San Antonio, 6.5 km from Jefferson

Allen

฿4,808 total

includes taxes & fees

22 Nov - 23 Nov

A modern lobby with a sofa, patterned chairs, a central ottoman, and a chandelier.

3. Drury Plaza Hotel San Antonio Airport

8.2 km from Jefferson

Erica

฿4,571 total

includes taxes & fees

17 Nov - 18 Nov

A modern lobby with seating areas, a stone accent wall, and a wooden ceiling.

4. Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

Uptown Central, 8.4 km from Jefferson

Elsa

฿3,170 total

includes taxes & fees

17 Nov - 18 Nov

A spacious indoor lobby with a central water feature, surrounded by seating areas and greenery.

5. Embassy Suites San Antonio Riverwalk-Downtown

Downtown San Antonio, 5.8 km from Jefferson

Ludmila

฿5,619 total

includes taxes & fees

22 Nov - 23 Nov

A spacious lobby with a central staircase, seating area, and large windows.

6. San Antonio Marriott Northwest Medical Center

Medical Center District, 4.9 km from Jefferson

Hsiao Tung

฿3,482 total

includes taxes & fees

5 Dec - 6 Dec

A hotel with a red-roofed entrance, multiple floors, and a visible flag.

7. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

Medical Center District, 6.3 km from Jefferson

Gilbert

฿3,561 total

includes taxes & fees

9 Nov - 10 Nov

An outdoor patio area with stone pillars, a round table, and chairs.

8. Wyndham Garden San Antonio Airport

Uptown Central, 8.4 km from Jefferson

Johnny

฿3,374 total

includes taxes & fees

17 Nov - 18 Nov

A balcony with a view of a canal, surrounded by greenery and a stone bridge.

9. Omni La Mansion del Rio

Downtown San Antonio, 6.1 km from Jefferson

jenny

฿6,510 total

includes taxes & fees

24 Nov - 25 Nov

A modern hotel with a prominent sign reading "LA QUINTA".

10. La Quinta Inn & Suites by Wyndham San Antonio Seaworld/LAFB

9.8 km from Jefferson

Lakesha

฿4,305 total

includes taxes & fees

8 Nov - 9 Nov

A modern indoor pool area with glass railings, seating, and a bar area with screens.

11. Hyatt Regency San Antonio Riverwalk

Downtown San Antonio, 6.2 km from Jefferson

Donna M

฿7,569 total

includes taxes & fees

22 Nov - 23 Nov

A modern hotel with a stone facade, a reflective water feature, and a bridge connecting different sections.

12. Drury Plaza Hotel San Antonio Riverwalk

Downtown San Antonio, 6.1 km from Jefferson

Felicia

฿5,156 total

includes taxes & fees

15 Nov - 16 Nov

A spacious lobby with multiple seating areas, a central coffee table, and a view of the upper floors.

13. Drury Inn & Suites San Antonio Northwest Medical Center

Medical Center District, 8.1 km from Jefferson

Samuel

฿3,625 total

includes taxes & fees

15 Nov - 16 Nov

A modern bar area with wooden bar counters, black bar stools, and pendant lighting.

14. Courtyard by Marriott Medical Center San Antonio

Medical Center District, 7.1 km from Jefferson

Francisca

฿3,589 total

includes taxes & fees

13 Nov - 14 Nov

A multi-level hotel atrium with a central courtyard, outdoor seating, and a swimming pool.

15. Estancia del Norte San Antonio, Tapestry Collection by Hilton

7.9 km from Jefferson

Lauro

฿5,064 total

includes taxes & fees

29 Nov - 30 Nov

A spacious courtyard with a central fire feature, surrounded by lounge chairs and potted plants.

16. Hotel Valencia Riverwalk, Valencia Collection

Downtown San Antonio, 5.9 km from Jefferson

Derrick

฿5,500 total

includes taxes & fees

22 Nov - 23 Nov

A reception area with a modern design, featuring a reception desk, a digital screen, and a view of an old building through a stone archway.

17. La Quinta Inn & Suites by Wyndham San Antonio Downtown

Arsenal, 6.1 km from Jefferson

Natasha

฿3,596 total

includes taxes & fees

24 Nov - 25 Nov

A spacious lobby with a modern design, featuring a large seating area with sofas and armchairs, a patterned rug, and a reception desk.

18. Comfort Inn and Suites Near Medical Center

2.6 km from Jefferson

Amy

฿2,332 total

includes taxes & fees

17 Nov - 18 Nov

A spacious hotel lobby with high ceilings, modern chandeliers, and a mix of seating options including tables and chairs.

19. Hampton Inn & Suites San Antonio Lackland AFB SeaWorld

Far West Side, 11.7 km from Jefferson

France

฿4,028 total

includes taxes & fees

22 Nov - 23 Nov

A rooftop pool area with a hot tub, lounge chairs, and potted plants.

20. Hotel Contessa

Downtown San Antonio, 6.3 km from Jefferson

Pablo

฿7,146 total

includes taxes & fees

23 Nov - 24 Nov

View all properties

Compare popular hotels in Jefferson

Property	Property class	Guest rating
La Quinta Inn & Suites by Wyndham San Antonio Seaworld/LAFB	3.0 star property	9.2 Wonderful 1,168 reviews	View
Courtyard by Marriott Medical Center San Antonio	3.0 star property	8.8 Excellent 1,001 reviews	View
Candlewood Suites San Antonio Lackland AFB Area by IHG	2.5 star property	9.2 Wonderful 974 reviews	View
Drury Inn & Suites San Antonio Northwest Medical Center	3.0 star property	9.2 Wonderful 1,522 reviews	View
Holiday Inn Express San Antonio-Airport by IHG	2.5 star property	9.4 Exceptional 1,005 reviews	View

Where to stay in Jefferson

Find the best Jefferson areas for the activities you enjoy most.

A boat tour on a canal with a bridge in the background.

Downtown San Antonio

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

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A riverside walkway adorned with colorful umbrellas and festive lights.

Uptown Central

If you're spending some time in Uptown Central, Marion Koogler McNay Art Museum and Alamo Quarry Market are top sights worth seeing.

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A riverside walkway with colorful umbrellas, a stone bridge, and historic buildings.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

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A cityscape with a prominent tower, a large body of water, and a sunset.

Medical Center District

While Medical Center District isn't home to many top sights, Wonderland of the Americas Mall and Huebner Oaks are some notable places to visit nearby.

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A historic stone building with a central arched doorway, a flagpole with a flag, and a paved courtyard.

Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Crystal Ice Palace are top sights worth seeing.

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Top Jefferson Hotel Reviews

La Quinta Inn & Suites by Wyndham San Antonio Downtown

Downtown San Antonio

10/10 Excellent

David

A circular stone fire pit with two wooden benches, surrounded by a stone patio and string lights.

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Far West Side

10/10 Excellent

Grant

Courtyard by Marriott Medical Center San Antonio

Medical Center District

10/10 Excellent

Andrew

Drury Plaza Hotel San Antonio Riverwalk

Downtown San Antonio

10/10 Excellent

Fabulous location, friendly staff, huge room. Did decline housekeeping for one day, but didn’t get it for either, not a huge issue but communication maybe? Breakfast had a good choice (apart from this morning when by 945am everything had been cleared apart from cold hardboiled eggs and cheese) Evening ‘canopies’ is a full on meal - over our 3 evenings there were nachos, fajitas, hot dogs, pasta, jacket potatoes and includes 3 alcoholic drinks if you want them. Right on the RiverWalk made it...

Sarah

A lobby with marble floors, teal chairs, and a central elevator.

Hotel Gibbs Downtown Riverwalk

Downtown San Antonio

10/10 Excellent

Phillip

Omni La Mansion del Rio

Downtown San Antonio

10/10 Excellent

laura Kathryn

Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

Uptown Central

10/10 Excellent

Angus

A multi-story hotel with a brick facade, large windows, and a green entrance canopy.

Element by Marriott San Antonio Riverwalk

Downtown San Antonio

10/10 Excellent

Amir

A hotel with a modern facade, multiple windows, and a well-lit entrance.

Candlewood Suites San Antonio Lackland AFB Area by IHG

San Antonio

8/10 Good

Margaret

Frequently Asked Questions

What is Jefferson like?

Travellers to San Antonio's Jefferson neighbourhood will be sure to enjoy a stay here. Consider a visit to Woodlawn Lake Park as part of your Jefferson travel plans.

How many hotels should I expect to find in Jefferson?

Expedia has 42 hotels and other accommodation options in Jefferson to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Jefferson, will I receive a refund?

Yes! Most hotel reservations are fully refundable as long as you cancel before the hotel’s cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a reservation that's non-refundable, you may still be able to cancel and get a refund within a 24-hour period of booking. Add dates, click "Search", then you can use the "fully refundable" filter to review the top deals on offer in Jefferson.

What are the top things to see and do in Jefferson?

Woodlawn Lake Park is an attraction you might want to check out while you're in Jefferson. While you're out sightseeing in San Antonio, make sure that you visit other sights such as Woodlawn Theater or The Starlighter.

Search Hotels in Jefferson, San Antonio

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Our top choices for Jefferson hotels

1. Holiday Inn Express San Antonio-Airport by IHG

2. Hyatt Place San Antonio - Riverwalk

3. Drury Plaza Hotel San Antonio Airport

4. Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

5. Embassy Suites San Antonio Riverwalk-Downtown

6. San Antonio Marriott Northwest Medical Center

7. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

8. Wyndham Garden San Antonio Airport

9. Omni La Mansion del Rio

10. La Quinta Inn & Suites by Wyndham San Antonio Seaworld/LAFB

11. Hyatt Regency San Antonio Riverwalk

12. Drury Plaza Hotel San Antonio Riverwalk

13. Drury Inn & Suites San Antonio Northwest Medical Center

14. Courtyard by Marriott Medical Center San Antonio

15. Estancia del Norte San Antonio, Tapestry Collection by Hilton

16. Hotel Valencia Riverwalk, Valencia Collection

17. La Quinta Inn & Suites by Wyndham San Antonio Downtown

18. Comfort Inn and Suites Near Medical Center

19. Hampton Inn & Suites San Antonio Lackland AFB SeaWorld

20. Hotel Contessa

Compare popular hotels in Jefferson

Where to stay in Jefferson

Downtown San Antonio

Uptown Central

Far West Side

Medical Center District

Northwest Side

Top Jefferson Hotel Reviews

La Quinta Inn & Suites by Wyndham San Antonio Downtown

10/10 Excellent

Frequently Asked Questions

What is Jefferson like?

How many hotels should I expect to find in Jefferson?

If I need to cancel my hotel reservation in Jefferson, will I receive a refund?

What are the top things to see and do in Jefferson?