Search Hotels in Isle of Palms South, Jacksonville
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Our top choices for Isle of Palms South hotels
1. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic2.9 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,004 reviews)
"Great location. 10 mins from the beach access. Nice clean hotel. Will stay again."
keilyn
The price is ฿3,833
฿4,350 total
includes taxes & fees
26 Jul - 27 Jul
2. TownePlace Suites by Marriott Jacksonville East
TownePlace Suites by Marriott Jacksonville East2.9 km from Isle of Palms South
9.2 out of 10, Wonderful, (640 reviews)
"This is always a great place to stay especially because it’s close to the Mayo Clinic …a five minute drive"
Miriam
The price is ฿4,001
฿4,542 total
includes taxes & fees
2 Aug - 3 Aug
3. Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Residence Inn By Marriott Jacksonville - Mayo Clinic AreaIsle of Palms, 2 km from Isle of Palms South
9.4 out of 10, Exceptional, (562 reviews)
"Great place to stay!"
Chad
The price is ฿4,812
฿5,461 total
includes taxes & fees
7 Aug - 8 Aug
4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG3.7 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,005 reviews)
"Only stayed one night, however I will stay again!"
Wanda
The price is ฿3,327
฿3,776 total
includes taxes & fees
26 Jul - 27 Jul
5. Hyatt Place Jacksonville / St. Johns Town Center
Hyatt Place Jacksonville / St. Johns Town Center9.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (1,129 reviews)
"Would stay again! Great area too!!"
Alicia Ann
The price is ฿5,347
฿6,068 total
includes taxes & fees
23 Jul - 24 Jul
6. Hilton Jacksonville At Mayo Clinic
Hilton Jacksonville At Mayo Clinic1.9 km from Isle of Palms South
9.4 out of 10, Exceptional, (288 reviews)
"Great hotel and very convenient to Mayo."
Margaret
The price is ฿5,847
฿6,636 total
includes taxes & fees
26 Jul - 27 Jul
7. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches1.5 km from Isle of Palms South
8.4 out of 10, Very good, (787 reviews)
"Nice hotel for the money."
Troy
The price is ฿5,111
฿5,801 total
includes taxes & fees
25 Jul - 26 Jul
8. Margaritaville Jacksonville Beach
Margaritaville Jacksonville BeachOceanfront, 4.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (4,185 reviews)
"Great location!"
JOHN
The price is ฿5,656
฿6,420 total
includes taxes & fees
2 Aug - 3 Aug
9. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass8.8 km from Isle of Palms South
9.2 out of 10, Wonderful, (1,003 reviews)
"Very polite and helpful staff, very clean and comfortable room, very nice location."
Rodney
The price is ฿4,384
฿4,888 total
includes taxes & fees
26 Jul - 27 Jul
10. Sheraton Jacksonville Hotel
Sheraton Jacksonville Hotel10.5 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,005 reviews)
"Great breakfast"
ericca
The price is ฿4,159
฿4,720 total
includes taxes & fees
24 Jul - 25 Jul
11. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area3.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,180 reviews)
"Excellent access to multiple places with ample parking, good breakfast options and clean rooms."
Roberto
The price is ฿4,088
฿4,640 total
includes taxes & fees
9 Aug - 10 Aug
12. Element by Marriott Jacksonville Beach
Element by Marriott Jacksonville BeachOceanfront, 4.4 km from Isle of Palms South
9.6 out of 10, Exceptional, (571 reviews)
"Best hotel ever 😊"
Tablo
The price is ฿5,985
฿6,793 total
includes taxes & fees
23 Jul - 24 Jul
13. Best Western Oceanfront
Best Western OceanfrontOceanfront, 4.6 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,004 reviews)
"Nice place and good location."
Erik
The price is ฿5,380
฿6,106 total
includes taxes & fees
9 Aug - 10 Aug
14. Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Holiday Inn Express & Suites Jacksonville - Town Center by IHG8.5 km from Isle of Palms South
9.6 out of 10, Exceptional, (1,002 reviews)
"Good hotel would stay again"
Anthony
The price is ฿3,735
฿4,239 total
includes taxes & fees
6 Aug - 7 Aug
15. Hyatt Studios Jacksonville/St Johns Town Center
Hyatt Studios Jacksonville/St Johns Town Center8.7 km from Isle of Palms South
9.6 out of 10, Exceptional, (131 reviews)
"I really like this location and would definitely stay here again."
Althia
The price is ฿3,699
฿4,198 total
includes taxes & fees
14 Aug - 15 Aug
16. Homewood Suites by Hilton Jacksonville-South/St. Johns Ctr.
Homewood Suites by Hilton Jacksonville-South/St. Johns Ctr.8.9 km from Isle of Palms South
8.6 out of 10, Excellent, (1,002 reviews)
"It was such a nice stay with everything we needed and more"
Carter
The price is ฿3,833
฿4,350 total
includes taxes & fees
26 Jul - 27 Jul
17. Holiday Inn Jacksonville E 295 Baymeadows by IHG
Holiday Inn Jacksonville E 295 Baymeadows by IHG9.6 km from Isle of Palms South
8.6 out of 10, Excellent, (1,003 reviews)
"The front desk, staff and the staff Doing the breakfast were awesome. We will definitely stay there again."
Fred
The price is ฿3,170
฿3,597 total
includes taxes & fees
23 Jul - 24 Jul
18. Springhill Suites By Marriott Jacksonville Beach Oceanfront
Springhill Suites By Marriott Jacksonville Beach OceanfrontOceanfront, 4.7 km from Isle of Palms South
9.0 out of 10, Wonderful, (748 reviews)
"Great location, room was nice and we really enjoyed the pool and restaurant. Staff was helpful and can’t beat beachfront location."
STEPHEN
The price is ฿6,117
฿6,942 total
includes taxes & fees
9 Aug - 10 Aug
19. Four Points by Sheraton Jacksonville Beachfront
Four Points by Sheraton Jacksonville BeachfrontOceanfront, 4.5 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,001 reviews)
"Very nice property and staff"
BONINA
The price is ฿6,557
฿7,442 total
includes taxes & fees
9 Aug - 10 Aug
20. Courtyard by Marriott Jacksonville Beach Oceanfront
Courtyard by Marriott Jacksonville Beach OceanfrontOceanfront, 5.2 km from Isle of Palms South
8.6 out of 10, Excellent, (1,003 reviews)
"Great location, great staff."
Donna
The price is ฿5,974
฿6,780 total
includes taxes & fees
9 Aug - 10 Aug
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Isle of Palms South
Find the best Isle of Palms South areas for the activities you enjoy most.
Amelia City
While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.
Photo by Ryan Ketterman
Open Photo by Ryan Ketterman
Downtown Jacksonville
The picturesque St. Johns River meanders through the center of this hub of skyscrapers, cultural landmarks and exciting nightlife.
Oceanfront
While visiting Oceanfront, you might make a stop by sights like Oceanfront Park and Northeast Florida Beaches.
Southside
If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.
American Beach
If you're spending some time in American Beach, American Beach and Spanish Quarter Village are top sights worth seeing.
Top Isle of Palms South Hotel Reviews
Margaritaville Jacksonville Beach
10/10 Excellent
