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17 Jul - 19 Jul
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24 Jul - 26 Jul

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Our top choices for Isle of Palms South hotels

Exterior

Holiday Inn Express Jacksonville - Blount Island by IHG

Holiday Inn Express Jacksonville - Blount Island by IHG
2.5 star property
20.2 km from Isle of Palms South
8.8 out of 10, Excellent, (1,001 reviews)
The price is ฿3,072
฿3,486 total
includes taxes & fees
30 Jul - 31 Jul
Holiday Inn Express Jacksonville - Blount Island by IHG
Sports facility

Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
3.0 star property
9.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (1,115 reviews)
"Would stay again! Great area too!!"
United States
Alicia Ann
The price is ฿5,341
฿6,062 total
includes taxes & fees
19 Jul - 20 Jul
Hyatt Place Jacksonville / St. Johns Town Center
Double Room, 2 Queen Beds, Non Smoking | In-room dining

San Marco Inn East

San Marco Inn East
3.0 star property
19.5 km from Isle of Palms South
8.4 out of 10, Very good, (1,446 reviews)
"Great room, clean and nice."
United States
Joel K
The price is ฿2,311
฿2,623 total
includes taxes & fees
19 Jul - 20 Jul
San Marco Inn East
Lobby

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
2.9 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,003 reviews)
"Great location. 10 mins from the beach access. Nice clean hotel. Will stay again."
United States
keilyn
The price is ฿3,966
฿4,501 total
includes taxes & fees
2 Aug - 3 Aug
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Lobby

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
Oceanfront, 4.8 km from Isle of Palms South
8.8 out of 10, Excellent, (4,169 reviews)
"Great location!"
United States
JOHN
The price is ฿5,651
฿6,413 total
includes taxes & fees
2 Aug - 3 Aug
Margaritaville Jacksonville Beach
41-inch Smart TV with cable channels

Weekly Inn

Weekly Inn
2.0 star property
14.7 km from Isle of Palms South
7.6 out of 10, Good, (1,368 reviews)
"Very comfortable and clean."
United States
Laporsha
The price is ฿1,632
฿1,853 total
includes taxes & fees
16 Aug - 17 Aug
Weekly Inn
Lobby

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
3.0 star property
8.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,014 reviews)
"Very polite and helpful staff, very clean and comfortable room, very nice location."
United States
Rodney
The price is ฿4,435
฿4,945 total
includes taxes & fees
15 Aug - 16 Aug
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
Lobby

Wyndham Garden Jacksonville

Wyndham Garden Jacksonville
3.0 star property
15.3 km from Isle of Palms South
7.8 out of 10, Good, (1,955 reviews)
"Great location"
United States
Richard
The price is ฿2,691
฿3,054 total
includes taxes & fees
19 Jul - 20 Jul
Wyndham Garden Jacksonville
Exterior

Hyatt Regency Jacksonville

Hyatt Regency Jacksonville
4.0 star property
22.1 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,711 reviews)
"Staff was excellent!!"
United States
Sabrina
The price is ฿6,047
฿6,931 total
includes taxes & fees
9 Aug - 10 Aug
Hyatt Regency Jacksonville
Reception

Midtown Lodge

Midtown Lodge
2.5 star property
18.9 km from Isle of Palms South
8.0 out of 10, Very good, (701 reviews)
"The staff wss friendly, rooms are old but updated and clean. Water pressure is good and the beds are comfortable. The rooms are also very quiet."
United States
Toni
The price is ฿2,176
฿2,470 total
includes taxes & fees
30 Jul - 31 Jul
Midtown Lodge
Lobby sitting area

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
3.7 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,010 reviews)
The price is ฿3,323
฿3,772 total
includes taxes & fees
16 Aug - 17 Aug
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Exterior

Tru by Hilton Jacksonville South Mandarin

Tru by Hilton Jacksonville South Mandarin
2.5 star property
21.4 km from Isle of Palms South
9.2 out of 10, Wonderful, (1,001 reviews)
"We stay here several times a year for a least a week when visiting relatives. Great breakfast, friendly staff and super clean rooms!"
United States
Mark
The price is ฿3,002
฿3,408 total
includes taxes & fees
2 Aug - 3 Aug
Tru by Hilton Jacksonville South Mandarin
Lobby

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
Isle of Palms, 2 km from Isle of Palms South
9.4 out of 10, Exceptional, (558 reviews)
"Great place to stay!"
United States
Chad
The price is ฿4,685
฿5,317 total
includes taxes & fees
2 Aug - 3 Aug
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Reception

Hampton Inn Jacksonville East Regency Square

Hampton Inn Jacksonville East Regency Square
2.5 star property
12.8 km from Isle of Palms South
8.8 out of 10, Excellent, (1,000 reviews)
"Very nice stay"
United States
Anthony
The price is ฿3,002
฿3,408 total
includes taxes & fees
9 Aug - 10 Aug
Hampton Inn Jacksonville East Regency Square
Premium bedding, desk, blackout curtains, iron/ironing board

La Quinta Inn & Suites by Wyndham Jacksonville Mandarin

La Quinta Inn & Suites by Wyndham Jacksonville Mandarin
3.0 star property
21.1 km from Isle of Palms South
7.6 out of 10, Good, (549 reviews)
"The hotel was clean and staff was proficient."
United States
Maxine
The price is ฿2,453
฿2,784 total
includes taxes & fees
28 Jul - 29 Jul
La Quinta Inn & Suites by Wyndham Jacksonville Mandarin
Free daily continental breakfast

Baymont by Wyndham Jacksonville/Butler Blvd

Baymont by Wyndham Jacksonville/Butler Blvd
2.5 star property
16.2 km from Isle of Palms South
8.2 out of 10, Very good, (1,418 reviews)
"Everything was perfect here I’ll definitely be back"
United States
Kelly
The price is ฿2,227
฿2,527 total
includes taxes & fees
16 Aug - 17 Aug
Baymont by Wyndham Jacksonville/Butler Blvd
Exterior

Holiday Inn Jacksonville E 295 Baymeadows by IHG

Holiday Inn Jacksonville E 295 Baymeadows by IHG
3.0 star property
9.6 km from Isle of Palms South
8.6 out of 10, Excellent, (1,001 reviews)
"The front desk, staff and the staff Doing the breakfast were awesome. We will definitely stay there again."
United States
Fred
The price is ฿3,166
฿3,593 total
includes taxes & fees
22 Jul - 23 Jul
Holiday Inn Jacksonville E 295 Baymeadows by IHG
Lobby lounge

Courtyard by Marriott Jacksonville Flagler Center

Courtyard by Marriott Jacksonville Flagler Center
3.0 star property
17.7 km from Isle of Palms South
8.8 out of 10, Excellent, (1,000 reviews)
"Out whole stay was great. The room was quiet, ac was awesome, we were able to watch fireworks from our third floor room. Everything was top notch, will definitely be back!!"
United States
Jennifer
The price is ฿3,397
฿3,856 total
includes taxes & fees
23 Jul - 24 Jul
Courtyard by Marriott Jacksonville Flagler Center
Terrace/patio

Aloft by Marriott Jacksonville Tapestry Park

Aloft by Marriott Jacksonville Tapestry Park
3.0 star property
11.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,000 reviews)
"Great hotel. Attentive staff. Room was spotless. Lounge area was great to hang out in. Close to restaurants and retail. 10/10"
United States
Siddique
The price is ฿4,500
฿5,108 total
includes taxes & fees
23 Jul - 24 Jul
Aloft by Marriott Jacksonville Tapestry Park
On the beach

Best Western Oceanfront

Best Western Oceanfront
3.0 star property
Oceanfront, 4.6 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,003 reviews)
"Nice place and good location."
United States
Erik
The price is ฿5,374
฿6,100 total
includes taxes & fees
9 Aug - 10 Aug
Best Western Oceanfront
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Isle of Palms South

Find the best Isle of Palms South areas for the activities you enjoy most.
A coastal cityscape at dusk with a prominent clock tower, waterfront, and historic buildings.

Amelia City

While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.

A city skyline with modern skyscrapers, a prominent Wells Fargo building, and a blue bridge over a river.
Photo by Ryan Ketterman
Open Photo by Ryan Ketterman

Downtown Jacksonville

The picturesque St. Johns River meanders through the center of this hub of skyscrapers, cultural landmarks and exciting nightlife.

Oceanfront

While visiting Oceanfront, you might make a stop by sights like Oceanfront Park and Northeast Florida Beaches.

A city skyline at night with illuminated buildings and a bridge reflecting on the water.

Southside

If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.

A sunset over a beach with fallen trees and a distant shoreline.

American Beach

If you're spending some time in American Beach, American Beach and Spanish Quarter Village are top sights worth seeing.

Top Isle of Palms South Hotel Reviews

Hyatt Regency Jacksonville

Hyatt Regency Jacksonville

10/10 Excellent
"We enjoyed our stay. Very convenient location and looking forward to returning!"
Juanita 3-night trip
Posted 5 hours ago
Hyatt Regency Jacksonville

Frequently asked questions

What is Isle of Palms South like?
Travellers will be sure to find plenty to entertain them in Jacksonville Beach's Isle of Palms South neighbourhood.
How many hotels can I expect to find in Isle of Palms South?
Expedia has 7 Isle of Palms South hotels and other accommodation options, and one might make a good home base for venturing out into the greater Jacksonville Beach area.
If I need to cancel my hotel reservation in Isle of Palms South, will I receive a refund?
Yes, the majority of hotel reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to view the best deals in Isle of Palms South.
What are the top things to see and do in Isle of Palms South?
Cradle Creek Preserve, Windsor Parke Golf Club and Jacksonville Beach Golf Club are just a few of the places to visit in and around Isle of Palms South. Windsor Commons Shopping Center and Harbor City Municipal Golf Course are also worth a visit when you're out sightseeing in Jacksonville Beach.