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Check prices for these dates

This weekend
23 Oct - 25 Oct
Next weekend
30 Oct - 1 Nov

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Our top choices for Isle of Palms South hotels

A hotel lobby with a bar area, seating arrangements, and a reception desk.

1. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
2.9 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,005 reviews)
"Loved the room, and the little cheese omelets at breakfast were good!"
United States
Kerry
The price is ฿3,967
฿4,502 total
includes taxes & fees
25 Oct - 26 Oct
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
A lobby with a reception desk, seating area, and a staircase.

2. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
3.7 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,008 reviews)
"wonderful breakfast and friendly staff"
United States
frances
The price is ฿3,510
฿3,983 total
includes taxes & fees
30 Oct - 31 Oct
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
A spacious living area with a high ceiling, a fireplace, and a bar area in the background.

3. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
Isle of Palms, 2 km from Isle of Palms South
9.4 out of 10, Exceptional, (610 reviews)
"Great stay"
United States
Michaelanne
The price is ฿4,569
฿5,186 total
includes taxes & fees
24 Oct - 25 Oct
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
A modern restaurant with a bar area, wooden ceiling, and large windows.

4. Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
4.5 star property
1.9 km from Isle of Palms South
9.2 out of 10, Wonderful, (380 reviews)
"Very nice stay!"
United States
Patricia
The price is ฿5,625
฿6,385 total
includes taxes & fees
8 Nov - 9 Nov
Hilton Jacksonville at Mayo Clinic near Beaches
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.

5. TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
3.0 star property
2.9 km from Isle of Palms South
9.2 out of 10, Wonderful, (666 reviews)
"Great location close to the beach. Super well maintained facility. Everything was great!"
United States
gregory
The price is ฿4,245
฿4,818 total
includes taxes & fees
1 Nov - 2 Nov
TownePlace Suites by Marriott Jacksonville East
An outdoor seating area with stone fire pit, wicker furniture, and potted plants.

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
3.0 star property
1.5 km from Isle of Palms South
8.4 out of 10, Very good, (799 reviews)
"The staff was very helpful and the parking easy and, in parts, quite shady. It was within easy walking distance of the Mayo Clinic!"
United States
Patricia
The price is ฿5,080
฿5,766 total
includes taxes & fees
24 Oct - 25 Oct
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
A modern outdoor seating area with white wicker chairs, a glass fire pit with burning wood, and a view of palm trees and a building in the background.

7. Element by Marriott Jacksonville Beach

Element by Marriott Jacksonville Beach
3.0 star property
Oceanfront, 4.4 km from Isle of Palms South
9.6 out of 10, Exceptional, (592 reviews)
"The staff was very helpful to watch my dogs in their stroller while I got breakfast, and it was a wonderful breakfast."
United States
Lisa
The price is ฿4,813
฿5,463 total
includes taxes & fees
1 Nov - 2 Nov
Element by Marriott Jacksonville Beach
A beach with a sandy shore, waves, and buildings in the background.

8. Best Western Oceanfront

Best Western Oceanfront
3.0 star property
Oceanfront, 4.6 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,009 reviews)
"Great stay, very convenient for short beach stay."
United States
Stephanie
The price is ฿4,362
฿4,950 total
includes taxes & fees
20 Oct - 21 Oct
Best Western Oceanfront
Pool

9. Four Points by Sheraton Jacksonville Beachfront

Four Points by Sheraton Jacksonville Beachfront
3.0 star property
Oceanfront, 4.5 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,000 reviews)
"Great location, room was spacious and comfortable"
United States
Rachel
The price is ฿5,938
฿6,739 total
includes taxes & fees
8 Nov - 9 Nov
Four Points by Sheraton Jacksonville Beachfront
A terrace with wooden tables and chairs, overlooking a beach and a pier.

10. Springhill Suites By Marriott Jacksonville Beach Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront
4.0 star property
Oceanfront, 4.7 km from Isle of Palms South
9.0 out of 10, Wonderful, (811 reviews)
"Excellent room and customer service."
United States
MELISSA
The price is ฿5,654
฿6,417 total
includes taxes & fees
25 Oct - 26 Oct
Springhill Suites By Marriott Jacksonville Beach Oceanfront
A covered entrance with a dark tiled floor, white columns, and a green bench.

11. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
2.5 star property
3.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,242 reviews)
"Great location"
United States
William Garita
The price is ฿4,006
฿4,547 total
includes taxes & fees
25 Oct - 26 Oct
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
A hotel room with two beds, a desk with a computer, a chair, and a colorful carpet.

12. Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
3.0 star property
3.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (1,004 reviews)
"Great place to stay"
United States
Bobby
The price is ฿3,810
฿4,325 total
includes taxes & fees
25 Oct - 26 Oct
Holiday Inn Express Jacksonville Beach by IHG
A spacious lobby with a glass floor, a reception desk, and a view of the ocean.

13. Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
Oceanfront, 4.8 km from Isle of Palms South
8.8 out of 10, Excellent, (4,610 reviews)
"It was a great stay"
United States
Mariella
The price is ฿4,926
฿5,591 total
includes taxes & fees
1 Nov - 2 Nov
Margaritaville Jacksonville Beach
A modern dining area with wooden tables and chairs, pendant lighting, and artwork on the walls.

14. Fairfield Inn & Suites by Marriott Jacksonville Beach

Fairfield Inn & Suites by Marriott Jacksonville Beach
3.0 star property
Oceanfront, 5.2 km from Isle of Palms South
8.6 out of 10, Excellent, (995 reviews)
"Checking in excellent and very smooth. Food is good and the staffs are very professional and helpful."
United States
Stella
The price is ฿4,233
฿4,805 total
includes taxes & fees
1 Nov - 2 Nov
Fairfield Inn & Suites by Marriott Jacksonville Beach
A self-service beverage station with a refrigerated display and a coffee machine.

15. Tru By Hilton Jacksonville St Johns Town Center

Tru By Hilton Jacksonville St Johns Town Center
2.5 star property
9.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (973 reviews)
"Room was nice size. Breakfast was nice!"
United States
Josephine
The price is ฿3,659
฿4,153 total
includes taxes & fees
8 Nov - 9 Nov
Tru By Hilton Jacksonville St Johns Town Center
A balcony with a view of the beach, a wooden walkway, and a chair.

16. Courtyard by Marriott Jacksonville Beach Oceanfront

Courtyard by Marriott Jacksonville Beach Oceanfront
3.0 star property
Oceanfront, 5.2 km from Isle of Palms South
8.4 out of 10, Very good, (1,005 reviews)
"Great accommodations."
United States
John
The price is ฿5,521
฿6,266 total
includes taxes & fees
25 Oct - 26 Oct
Courtyard by Marriott Jacksonville Beach Oceanfront
A white building with a red-tiled roof, a covered patio area, and a view of the ocean.

17. Casa Marina Hotel

Casa Marina Hotel
3.0 star property
Oceanfront, 4.8 km from Isle of Palms South
8.4 out of 10, Very good, (1,000 reviews)
"Everything was good, personnel was nice an helpful the place is close to a nice area"
United States
Jimmy
The price is ฿5,415
฿6,146 total
includes taxes & fees
20 Oct - 21 Oct
Casa Marina Hotel
An outdoor patio with seating, a fire pit, and string lights.

18. Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
3.0 star property
9.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (1,184 reviews)
"Nice hotel"
United States
Becky
The price is ฿4,252
฿4,825 total
includes taxes & fees
22 Oct - 23 Oct
Hyatt Place Jacksonville / St. Johns Town Center
A laptop on a wooden desk with a white mug, a spoon, and a smartphone.

19. Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
2.5 star property
8.7 km from Isle of Palms South
9.4 out of 10, Exceptional, (229 reviews)
"Wonderful stay!"
United States
Mandy
The price is ฿3,677
฿4,173 total
includes taxes & fees
28 Oct - 29 Oct
Hyatt Studios Jacksonville/St Johns Town Center
An outdoor patio area with seating, a fire pit, and a barbecue grill.

20. TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport
3.0 star property
9.8 km from Isle of Palms South
9.6 out of 10, Exceptional, (127 reviews)
"Nice place"
United States
irina
The price is ฿3,977
฿4,514 total
includes taxes & fees
15 Nov - 16 Nov
TownePlace Suites by Marriott® Jacksonville Mayport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Isle of Palms South

Find the best Isle of Palms South areas for the activities you enjoy most.
A city skyline with modern skyscrapers, a prominent Wells Fargo building, and a blue bridge over a river.
Photo by Ryan Ketterman
Open Photo by Ryan Ketterman

Downtown Jacksonville

The picturesque St. Johns River meanders through the center of this hub of skyscrapers, cultural landmarks and exciting nightlife.

A coastal cityscape at dusk with a prominent clock tower, waterfront, and historic buildings.

Amelia City

While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.

A sunset over a beach with waves and a pier.

Oceanfront

While visiting Oceanfront, you might make a stop by sights like Oceanfront Park and Northeast Florida Beaches.

A city skyline at night with illuminated buildings and a bridge reflecting on the water.

Southside

If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.

A beach with waves, a grassy dune, and a row of buildings in the distance.

American Beach

If you're spending some time in American Beach, American Beach and Spanish Quarter Village are top sights worth seeing.

Top Isle of Palms South Hotel Reviews

Holiday Inn Express Jacksonville South Bartram Prk by IHG

Holiday Inn Express Jacksonville South Bartram Prk by IHG

10/10 Excellent
"The hotel is super clean and the breakfast is top notch. Great quality food at a great hotel for a reasonable price always."
John 4-night trip
Posted 12 hours ago
Holiday Inn Express Jacksonville South Bartram Prk by IHG

Frequently asked questions

What is Isle of Palms South like?
Travellers will be sure to find plenty to entertain them in Jacksonville Beach's Isle of Palms South neighbourhood.
How many hotels can I expect to find in Isle of Palms South?
Expedia has 7 Isle of Palms South hotels and other accommodation options, and one might make a good home base for venturing out into the greater Jacksonville Beach area.
If I need to cancel my hotel reservation in Isle of Palms South, will I receive a refund?
Yes, the majority of hotel reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to view the best deals in Isle of Palms South.
What are the top things to see and do in Isle of Palms South?
Cradle Creek Preserve, Windsor Parke Golf Club and Jacksonville Beach Golf Club are just a few of the places to visit in and around Isle of Palms South. Windsor Commons Shopping Center and Harbor City Municipal Golf Course are also worth a visit when you're out sightseeing in Jacksonville Beach.