Search Hotels in Isle of Palms, Jacksonville
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check prices for these dates
Our top choices for Isle of Palms hotels
1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Residence Inn By Marriott Jacksonville - Mayo Clinic AreaIsle of Palms
9.4 out of 10, Exceptional, (566 reviews)
"I stayed at this hotel for 3 days. It was super clean and comfortable to stay the night for vacation."
Devonta
The price is ฿4,450
฿5,051 total
includes taxes & fees
8 Aug - 9 Aug
2. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic3 km from Isle of Palms
9.0 out of 10, Wonderful, (1,002 reviews)
"Great location. 10 mins from the beach access. Nice clean hotel. Will stay again."
keilyn
The price is ฿3,834
฿4,351 total
includes taxes & fees
16 Aug - 17 Aug
3. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG3.9 km from Isle of Palms
9.0 out of 10, Wonderful, (1,019 reviews)
"Very helpful staff and nice view to the golf course."
Jorge
The price is ฿3,239
฿3,676 total
includes taxes & fees
16 Aug - 17 Aug
4. TownePlace Suites by Marriott Jacksonville East
TownePlace Suites by Marriott Jacksonville East3 km from Isle of Palms
9.2 out of 10, Wonderful, (642 reviews)
"This is always a great place to stay especially because it’s close to the Mayo Clinic …a five minute drive"
Miriam
The price is ฿4,010
฿4,551 total
includes taxes & fees
9 Aug - 10 Aug
5. Hilton Jacksonville At Mayo Clinic
Hilton Jacksonville At Mayo Clinic2.1 km from Isle of Palms
9.4 out of 10, Exceptional, (298 reviews)
"Great hotel and very convenient to Mayo."
Margaret
The price is ฿5,489
฿6,230 total
includes taxes & fees
14 Aug - 15 Aug
6. Margaritaville Jacksonville Beach
Margaritaville Jacksonville BeachOceanfront, 4.6 km from Isle of Palms
8.8 out of 10, Excellent, (4,260 reviews)
"Excellent place to stay"
stephen
The price is ฿5,658
฿6,421 total
includes taxes & fees
6 Aug - 7 Aug
7. Sheraton Jacksonville Hotel
Sheraton Jacksonville Hotel10.7 km from Isle of Palms
9.0 out of 10, Wonderful, (1,006 reviews)
"The property was very clean and well maintained will stay there for any future stays."
keren
The price is ฿4,160
฿4,721 total
includes taxes & fees
31 Jul - 1 Aug
8. Element by Marriott Jacksonville Beach
Element by Marriott Jacksonville BeachOceanfront, 4.2 km from Isle of Palms
9.6 out of 10, Exceptional, (573 reviews)
"Best hotel ever 😊"
Tablo
The price is ฿5,987
฿6,795 total
includes taxes & fees
2 Aug - 3 Aug
9. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass8.7 km from Isle of Palms
9.2 out of 10, Wonderful, (1,016 reviews)
"Very polite and helpful staff, very clean and comfortable room, very nice location."
Rodney
The price is ฿4,546
฿5,069 total
includes taxes & fees
23 Aug - 24 Aug
10. Best Western Oceanfront
Best Western OceanfrontOceanfront, 4.4 km from Isle of Palms
9.0 out of 10, Wonderful, (1,012 reviews)
"Great place overall!!"
Harkirat
The price is ฿4,735
฿5,375 total
includes taxes & fees
20 Aug - 21 Aug
11. Homewood Suites by Hilton Jacksonville-South/St. Johns Ctr.
Homewood Suites by Hilton Jacksonville-South/St. Johns Ctr.9.1 km from Isle of Palms
8.6 out of 10, Excellent, (1,008 reviews)
"The room was very clean and I really enjoyed my stay and I look forward to future stays at this loc"
Eddie
The price is ฿3,840
฿4,359 total
includes taxes & fees
9 Aug - 10 Aug
12. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area3.7 km from Isle of Palms
9.0 out of 10, Wonderful, (1,196 reviews)
"Attentive and friendly staff, good location, generous breakfast"
Dagmar Maria
The price is ฿4,038
฿4,583 total
includes taxes & fees
9 Aug - 10 Aug
13. Holiday Inn Express Jacksonville Beach by IHG
Holiday Inn Express Jacksonville Beach by IHG3.3 km from Isle of Palms
9.2 out of 10, Wonderful, (1,007 reviews)
"Great staff and location"
Tiffany
The price is ฿3,704
฿4,204 total
includes taxes & fees
13 Aug - 14 Aug
14. Holiday Inn Jacksonville E 295 Baymeadows by IHG
Holiday Inn Jacksonville E 295 Baymeadows by IHG9.8 km from Isle of Palms
8.6 out of 10, Excellent, (1,005 reviews)
"The front desk, staff and the staff Doing the breakfast were awesome. We will definitely stay there again."
Fred
The price is ฿3,170
฿3,598 total
includes taxes & fees
1 Aug - 2 Aug
15. Aloft by Marriott Jacksonville Tapestry Park
Aloft by Marriott Jacksonville Tapestry Park12 km from Isle of Palms
9.0 out of 10, Wonderful, (1,005 reviews)
"Always enjoy this brand and this stay was no exception. Lovely and modern decor! So clean & super friendly staff! Comfortable beds and great shower! They offered a late check-out just because we arrived after midnight! Our dog enjoy his stay too!"
Debra
The price is ฿4,507
฿5,116 total
includes taxes & fees
31 Jul - 1 Aug
16. Tru By Hilton Jacksonville St Johns Town Center
Tru By Hilton Jacksonville St Johns Town Center9.7 km from Isle of Palms
9.2 out of 10, Wonderful, (931 reviews)
"Love it here! Staff is so friendly, rooms are clean and comfortable. I stay here often as my preferred choice for work trips! Free parking is a PLUS!"
Tierra
The price is ฿3,689
฿4,187 total
includes taxes & fees
9 Aug - 10 Aug
17. Springhill Suites By Marriott Jacksonville Beach Oceanfront
Springhill Suites By Marriott Jacksonville Beach OceanfrontOceanfront, 4.5 km from Isle of Palms
9.0 out of 10, Wonderful, (754 reviews)
"Great location, room was nice and we really enjoyed the pool and restaurant. Staff was helpful and can’t beat beachfront location."
STEPHEN
The price is ฿6,261
฿7,106 total
includes taxes & fees
17 Aug - 18 Aug
18. Fairfield Inn & Suites by Marriott Jacksonville Beach
Fairfield Inn & Suites by Marriott Jacksonville BeachOceanfront, 5 km from Isle of Palms
8.6 out of 10, Excellent, (964 reviews)
"Very close to the beach, plenty of restaurants and shopping within a close distance. We will definitely be back there!"
Xaviera
The price is ฿4,832
฿5,484 total
includes taxes & fees
2 Aug - 3 Aug
19. Courtyard by Marriott Jacksonville I-295/East Beltway
Courtyard by Marriott Jacksonville I-295/East Beltway13.3 km from Isle of Palms
9.2 out of 10, Wonderful, (722 reviews)
"Great hotel with clean rooms, friendly staff, and excellent service. I had a wonderful stay and would definitely return."
Virnilito Nambayan
The price is ฿3,402
฿3,861 total
includes taxes & fees
16 Aug - 17 Aug
20. Dune House Hotel & Spa
Dune House Hotel & Spa6.7 km from Isle of Palms
8.8 out of 10, Excellent, (1,012 reviews)
"The Dune House is beautiful and the staff is so friendly! Will definitely be going back!"
Jennifer
The price is ฿6,074
฿8,340 total
includes taxes & fees
4 Aug - 5 Aug
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Isle of Palms
Find the best Isle of Palms areas for the activities you enjoy most.
Photo by Ryan Ketterman
Open Photo by Ryan Ketterman
Downtown Jacksonville
The picturesque St. Johns River meanders through the center of this hub of skyscrapers, cultural landmarks and exciting nightlife.
Oceanfront
While visiting Oceanfront, you might make a stop by sights like Oceanfront Park and Northeast Florida Beaches.
Amelia City
While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.
Southside
If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.
Sawgrass
Beaches and riverfront are just a few things travellers like about Sawgrass. A stop by Mickler Beach is also recommended if you've got time to explore the area.
