Upstate South Carolina Packages (Flight + Hotel)

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Where to stay in Upstate South Carolina

Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
A pedestrian bridge with colorful lights, surrounded by trees and a distant building.

Greenville Downtown

3 out of top 10 points of interest in this area

The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.

Find hotels in Greenville Downtown

Top hotels in Upstate South Carolina

Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites

2.5 out of 5
831 Congaree Rd Greenville SC
Fully refundableReserve now, pay when you stay
The price is ฿2,946 per night from 8 Nov to 9 Nov
฿2,946
฿3,240 total
8 Nov - 9 Nov
includes taxes & fees
9.2/10 Wonderful! (1,597 reviews)
"Beds were not as comfortable as used to in a hotel. Second day we had no service to our room. Did not get to room until quite late (Saturday evening when rates are the highest) and was shocked towels etc were not replaced - very disappointing If they were truly short staffed how long would it have ..."

Reviewed on 31 Oct 2026

Best Western Plus Greenville I-385 Inn & Suites
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

3.5 out of 5
851 Congaree Rd Greenville SC
Fully refundable
The price is ฿2,939 per night from 29 Nov to 30 Nov
฿2,939
฿3,330 total
29 Nov - 30 Nov
includes taxes & fees
8.6/10 Excellent! (1,003 reviews)
"The staff was professional, and the hotel was clean and conveniently located near downtown Greenville, with easy access to shopping and restaurants. The only drawback was the scent in the lobby, which was a little strong for my taste. Overall, a great place to stay!"

Reviewed on 31 Oct 2026

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

3.5 out of 5
670 Verdae Blvd Greenville SC
Fully refundableReserve now, pay when you stay
The price is ฿3,296 per night from 23 Nov to 24 Nov
฿3,296
฿3,734 total
23 Nov - 24 Nov
includes taxes & fees
9/10 Wonderful! (1,442 reviews)
"Staff was great, proximity to the golf course was awesome. Unfortunately there were roaches in the room"

Reviewed on 30 Oct 2026

Embassy Suites Greenville Golf Resort & Conference Center
See all 3,099 properties in Upstate South Carolina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)
Take a campus tour or just explore the area of Clemson University during your travels in Clemson. Experience the area's theatre scene or attend a football match.
See properties

What to do in Upstate South Carolina

Greenville: 2-Hour Dessert Tour

Greenville: 2-Hour Dessert Tour

฿3,005
per adult
Greenville: 2-Hour Dessert Tour
Saturday Evening Craft Cocktail Tour

Saturday Evening Craft Cocktail Tour

฿3,506
per adult
100% of travellers recommend
Saturday Evening Craft Cocktail Tour
Greenville Haunted Bar Tour

Greenville Haunted Bar Tour

฿1,169
per adult
100% of travellers recommend
Greenville Haunted Bar Tour
See all activities in Upstate South Carolina

Frequently asked questions

How much does a Upstate South Carolina holiday package cost?
From as low as . Yes, you read that right. Our Upstate South Carolina holiday packages are the best way to stretch your budget. Bundle your preferred hotels, flights and rental car and get to know this top destination.
How do I get a cheap travel package to Upstate South Carolina?
Our Upstate South Carolina holiday packages mean plenty of savings for the savvy explorer. For the best deal, simply combine your hotel, flights and extras (such as activities) into one neat package. But great bargains are only the start of your next awesome adventure. Book with Expedia and you'll have more than 550 airlines and 1,000,000 hotels around the world to choose from. No matter your style, there's a package with your name on it.
Where should I stay in Upstate South Carolina?
Falls Park on the Reedy is one of the key things that draws people to Upstate South Carolina, so it makes perfect sense that many opt to stay in Greenville.
What are the top hotels in Upstate South Carolina?
When it comes to hotels in Greenville, Best Western Plus Greenville I-385 Inn & Suites and Comfort Inn Greenville - Haywood Mall are two terrific options. If you're heading to Seneca, Quality Inn Seneca US-123 and Tru by Hilton Seneca Clemson will make you feel at home.
How far in advance should I book my Upstate South Carolina holiday?
While prices fluctuate, we generally suggest booking your seats as soon as possible. Most international airfares are available on Expedia up to 12 months in advance. If circumstances have left you booking late, you might still be in luck. Cheap journeys to Upstate South Carolina occasionally appear just weeks before departure.
What does an Expedia Upstate South Carolina travel package include?
With Expedia, you can choose any combination of flights, hotels and car rentals to build your ideal Upstate South Carolina travel package. Once you've made your booking, you can add on the fun stuff like sightseeing tours and activities. Remember — the more you bundle, the more dollars you'll save!
What should I know before booking a Upstate South Carolina travel package?
Design deals that suit your budget with an Expedia package. Hotels, flights, rental cars — we're a one-stop shop for all of them. You'll save big bucks just by bundling your bookings. Whether you're embarking on an adventure in the snow or getting some sun on a warm beach, your dream getaway is just a few clicks away.
Can I choose my airline with a Upstate South Carolina Expedia holiday package?
Yes — that's one of the best things about an Expedia holiday package. You can mix and match your flights, hotels and more. We have more than 550 airline partners throughout the world, so you have lots of choice when putting together your Upstate South Carolina getaway.
If I'm not able to travel, can I cancel my Upstate South Carolina holiday package?
Yes, you can cancel your Upstate South Carolina booking if your plans have changed. Whether you'll incur a fee or not depends on your hotel, airline or car rental company. It may be possible to change or cancel for free if you booked in the last 24 hours. Visit our Customer Service Portal to learn more.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.