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Find hotels in Upstate South Carolina, SC from ฿2,122

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Our top choices for Upstate South Carolina hotels

Free daily full breakfast
Holiday Inn Express Gaffney by IHG

Holiday Inn Express Gaffney by IHG

Holiday Inn Express Gaffney by IHG
2.5 star property
Gaffney
8.6 out of 10, Excellent, (424)
"Great place to stay"
United States
Timothy
The price is ฿2,421
฿2,639 total
includes taxes & fees
5 Jan - 6 Jan 2026
Holiday Inn Express Gaffney by IHG
Terrace/patio
Home2 Suites by Hilton Anderson Downtown

Home2 Suites by Hilton Anderson Downtown

Home2 Suites by Hilton Anderson Downtown
3.0 star property
Anderson
9.4 out of 10, Exceptional, (219)
"Great hotel. "
United States
scott
The price is ฿4,342
฿4,820 total
includes taxes & fees
3 Jan - 4 Jan 2026
Home2 Suites by Hilton Anderson Downtown
Free daily buffet breakfast
Hampton Inn Spartanburg-North I-85

Hampton Inn Spartanburg-North I-85

Hampton Inn Spartanburg-North I-85
2.5 star property
Spartanburg
8.8 out of 10, Excellent, (1001)
"The staff was courteous in the room was spotless!"
United States
Kimberly
The price is ฿2,418
฿2,684 total
includes taxes & fees
9 Jan - 10 Jan 2026
Hampton Inn Spartanburg-North I-85
Aerial view
Lakeside Lodge Clemson

Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
Seneca
9.0 out of 10, Wonderful, (1000)
"Great place to stay. "
United States
Gene
The price is ฿3,383
฿4,199 total
includes taxes & fees
28 Dec - 29 Dec
Lakeside Lodge Clemson
Desk, laptop workspace, blackout curtains, iron/ironing board
Hyatt Place Greenville Downtown

Hyatt Place Greenville Downtown

Hyatt Place Greenville Downtown
3.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (1000)
"I have stayed here several times and it is always clean and comfortable, also the staff is very nice. "
United States
Melissa
The price is ฿3,414
฿3,755 total
includes taxes & fees
3 Jan - 4 Jan 2026
Hyatt Place Greenville Downtown
Free daily on-the-go breakfast
Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123
2.5 star property
Downtown
8.0 out of 10, Very good, (665)
"Friendly check in, clean room."
United States
connie
The price is ฿2,281
฿2,694 total
includes taxes & fees
4 Jan - 5 Jan 2026
Quality Inn Seneca Clemson Area US-123
Exterior
Aloft Greenville Downtown

Aloft Greenville Downtown

Aloft Greenville Downtown
3.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (1002)
"Always a great place to stay. "
United States
Daniel
The price is ฿3,888
฿4,277 total
includes taxes & fees
4 Jan - 5 Jan 2026
Aloft Greenville Downtown
Free daily continental breakfast
Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites
2.5 star property
Greenville
9.0 out of 10, Wonderful, (1423)
"Clean room, great selection for breakfast, easy check in and check out"
United States
Angelica
The price is ฿2,638
฿2,902 total
includes taxes & fees
28 Dec - 29 Dec
Best Western Plus Greenville I-385 Inn & Suites
Reception hall
The Inn at Patrick Square

The Inn at Patrick Square

The Inn at Patrick Square
3.5 star property
Clemson
9.8 out of 10, Exceptional, (785)
"Everything was clean staff was courteous and accommodating. "
United States
Stewart
The price is ฿4,624
฿5,133 total
includes taxes & fees
28 Dec - 29 Dec
The Inn at Patrick Square
Lobby
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
2.5 star property
Seneca
9.2 out of 10, Wonderful, (799)
"Staff is amazing, hotel and amenities are great. "
United States
Shannon
The price is ฿3,079
฿3,387 total
includes taxes & fees
25 Jan - 26 Jan 2026
Tru by Hilton Seneca Clemson
Terrace/patio
Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center
3.5 star property
Greenville
9.0 out of 10, Wonderful, (1005)
"Great room, staff and location. "
United States
Neil
The price is ฿3,054
฿3,359 total
includes taxes & fees
4 Jan - 5 Jan 2026
Embassy Suites Greenville Golf Resort & Conference Center
Lobby
Best Western Seneca-Clemson

Best Western Seneca-Clemson

Best Western Seneca-Clemson
2.5 star property
Seneca
8.4 out of 10, Very good, (642)
"The stay was amazing "
United States
Tabatha
The price is ฿2,875
฿3,163 total
includes taxes & fees
11 Jan - 12 Jan 2026
Best Western Seneca-Clemson
Two queen beds nonsmoking | In-room safe, desk, blackout curtains, iron/ironing board
Hampton Inn Easley

Hampton Inn Easley

Hampton Inn Easley
2.5 star property
Easley
9.4 out of 10, Exceptional, (684)
"Friendly staff, very comfortable room, excellent hot breakfast."
United States
Thomas
The price is ฿4,301
฿4,774 total
includes taxes & fees
3 Jan - 4 Jan 2026
Hampton Inn Easley
Exterior
DoubleTree by Hilton Greenville Woodruff Road

DoubleTree by Hilton Greenville Woodruff Road

DoubleTree by Hilton Greenville Woodruff Road
3.0 star property
Greenville
9.4 out of 10, Exceptional, (1000)
"Clean modern comfortable convenient location great cookie "
United States
Jimmy
The price is ฿3,472
฿3,819 total
includes taxes & fees
30 Dec - 31 Dec
DoubleTree by Hilton Greenville Woodruff Road
Free daily full breakfast
La Quinta Inn & Suites by Wyndham Greenville Haywood

La Quinta Inn & Suites by Wyndham Greenville Haywood

La Quinta Inn & Suites by Wyndham Greenville Haywood
3.0 star property
Greenville
7.4 out of 10, Good, (1130)
"Kind staff, clean room, tasty continental breakfast!"
United States
Karen
The price is ฿2,123
฿2,335 total
includes taxes & fees
28 Dec - 29 Dec
La Quinta Inn & Suites by Wyndham Greenville Haywood
Lobby
Quality Inn Clinton - Laurens I-26

Quality Inn Clinton - Laurens I-26

Quality Inn Clinton - Laurens I-26
2.5 star property
Clinton
7.4 out of 10, Good, (519)
"Super clean and quiet and staff was extremely nice and friendly"
United States
Kimberly
The price is ฿1,987
฿2,329 total
includes taxes & fees
21 Jan - 22 Jan 2026
Quality Inn Clinton - Laurens I-26
Lobby lounge
Inn @ Clemson

Inn @ Clemson

Inn @ Clemson
2.5 star property
Clemson
8.0 out of 10, Very good, (1002)
"Staff and hotel was amazing "
United States
Keren
Inn @ Clemson
Exterior
Hilton Garden Inn Anderson

Hilton Garden Inn Anderson

Hilton Garden Inn Anderson
3.0 star property
Anderson
9.0 out of 10, Wonderful, (680)
"Staff were great. Room was clean."
United States
gary
The price is ฿3,283
฿3,644 total
includes taxes & fees
3 Jan - 4 Jan 2026
Hilton Garden Inn Anderson
Outdoor pool
Hampton Inn Greer Greenville, SC

Hampton Inn Greer Greenville, SC

Hampton Inn Greer Greenville, SC
2.5 star property
Greer
9.6 out of 10, Exceptional, (415)
"Very nice hotel! Clean! "
United States
Eric
The price is ฿4,314
฿4,702 total
includes taxes & fees
28 Dec - 29 Dec
Hampton Inn Greer Greenville, SC
Reception
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG
2.5 star property
Anderson
9.0 out of 10, Wonderful, (585)
"It was great. Room was clean and staff was friendly. "
United States
Veronica
The price is ฿3,197
฿3,548 total
includes taxes & fees
30 Dec - 31 Dec
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Holiday Rentals in Upstate South Carolina

Cottage
Signature Cottage, 2 Bedrooms | Living room | 43-inch Smart TV with cable channels, TV, Netflix
Clemson Memorabilia House

Clemson Memorabilia House

Clemson Memorabilia House
3.0 star property
Clemson
9.8 out of 10, Exceptional, (9)
"We enjoyed our stay, it was the perfect size for our family of four. "
Clemson Memorabilia House
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Stay near popular Southeastern United States attractions

"Clemson University is an American public, coeducational, land-grant and sea-grant research university located in Clemson, South Carolina, United States.More clemson images:"

Clemson University

4.7/5 (738 reviews)
Take a campus tour or just explore the area of Clemson University during your travels in Clemson. Experience the area's theatre scene or attend a football match.
See properties
Exploring Falls Park on the Reedy in Downtown Greenville, South Carolina during a peaceful afternoon stroll with scenic views

Falls Park on the Reedy

4.7/5 (1,399 reviews)
Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theatre scene or attend a sporting event in this family-friendly area.
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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina
The view from Caesars Head after a storm
Photo by Michelle Hendrix
Open Photo by Michelle Hendrix

Top Upstate South Carolina Hotel Reviews

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

10/10 Excellent
"Room clean, we had a 15 ft U-Haul towing a vehicle and the property was safe, the staff was friendly breakfast was good"
Sharon 1-night trip
Posted 4 days ago
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
ECHO Suites Extended Stay by Wyndham Spartanburg

ECHO Suites Extended Stay by Wyndham Spartanburg

10/10 Excellent
"Yes"
Adelaido 6-night trip
Posted 7 days ago
ECHO Suites Extended Stay by Wyndham Spartanburg

More cheap stays in Upstate South Carolina

Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson

1007 George Smith Mill Rd Anderson SC
The price is ฿1,952 per night from 30 Dec to 31 Dec
฿1,952
฿2,167 total
30 Dec - 31 Dec
includes taxes & fees
7.8/10 Good! (1,001 reviews)