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Search Hotels Near UCSF Mission Bay, San Francisco

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Our top choices for UCSF Mission Bay hotels

Exterior
LUMA Hotel San Francisco

LUMA Hotel San Francisco

LUMA Hotel San Francisco
4.0 star property
Mission Bay, 0.7 km from UCSF Mission Bay
9.6 out of 10, Exceptional, (2401)
"Staff were so nice, the rooms were clean will definitely come back "
United States
Karla
The price is ฿6,172
฿7,264 total
includes taxes & fees
4 Jan - 5 Jan 2026
LUMA Hotel San Francisco
Exterior
Hyatt Regency San Francisco Downtown SOMA

Hyatt Regency San Francisco Downtown SOMA

Hyatt Regency San Francisco Downtown SOMA
4.0 star property
South of Market, 2.2 km from UCSF Mission Bay
9.4 out of 10, Exceptional, (1309)
"Staff were helpful, kind and professional. The hotel was beautiful and easy to walk to restaurants, movies, and shopping."
United States
SHANNON
The price is ฿5,152
฿7,302 total
includes taxes & fees
30 Jan - 31 Jan 2026
Hyatt Regency San Francisco Downtown SOMA
Lobby
The Clancy, Autograph Collection by Marriott

The Clancy, Autograph Collection by Marriott

The Clancy, Autograph Collection by Marriott
4.0 star property
South Park, 1.9 km from UCSF Mission Bay
9.2 out of 10, Wonderful, (1001)
"Very professional staff! Central located walking distance to everything!"
United States
Edmundo
The price is ฿5,212
฿7,446 total
includes taxes & fees
10 Jan - 11 Jan 2026
The Clancy, Autograph Collection by Marriott
Lobby sitting area
The Marker Union Square San Francisco

The Marker Union Square San Francisco

The Marker Union Square San Francisco
4.0 star property
2.6 km from UCSF Mission Bay
9.0 out of 10, Wonderful, (1132)
"The staff was so fabulous, the hotel is gorgeous, and we are already having the best time!"
United States
Faith
The price is ฿4,632
฿5,452 total
includes taxes & fees
29 Jan - 30 Jan 2026
The Marker Union Square San Francisco
City view
Stanford Court San Francisco

Stanford Court San Francisco

Stanford Court San Francisco
4.0 star property
Nob Hill, 3 km from UCSF Mission Bay
9.0 out of 10, Wonderful, (1328)
"Very good location!"
United States
robin
The price is ฿3,775
฿5,831 total
includes taxes & fees
29 Jan - 30 Jan 2026
Stanford Court San Francisco
Junior Suite | Living area | Flat-screen TV
Cornell Hotel de France

Cornell Hotel de France

Cornell Hotel de France
3.5 star property
2.8 km from UCSF Mission Bay
8.8 out of 10, Excellent, (1002)
"Room was clean and comfortable, staff was friendly. Overall great stay. "
United States
Nia
The price is ฿2,932
฿4,084 total
includes taxes & fees
1 Jan - 2 Jan 2026
Cornell Hotel de France
Front of property – evening/night
Golden Gate Hotel

Golden Gate Hotel

Golden Gate Hotel
3.0 star property
2.8 km from UCSF Mission Bay
8.8 out of 10, Excellent, (423)
"Great location, staff, food."
United States
Nathan
The price is ฿4,273
฿5,662 total
includes taxes & fees
10 Jan - 11 Jan 2026
Golden Gate Hotel
Suite, 1 Bedroom, Kitchen | Private kitchen | Coffee/tea maker, eco-friendly cleaning products
Executive Hotel Vintage Court

Executive Hotel Vintage Court

Executive Hotel Vintage Court
3.0 star property
Chinatown, 2.8 km from UCSF Mission Bay
8.6 out of 10, Excellent, (1082)
"While the rooms are a tad shabby, the lobby is lovely, the staff is helpful, the location is great and the price can't be beat. I paid $96 per night and when I checked with the Wyndom across the street they wanted almost $400 a night. Wow!! A few things they could improve: the windows unit A/C was noisy and the halls could probably use a deep clean but for the price it was a real bargain. "
United States
Alexander
The price is ฿3,007
฿4,351 total
includes taxes & fees
1 Jan - 2 Jan 2026
Executive Hotel Vintage Court
Front of property
FOUND Hotel Carlton, Nob Hill

FOUND Hotel Carlton, Nob Hill

FOUND Hotel Carlton, Nob Hill
2.0 star property
3.1 km from UCSF Mission Bay
8.6 out of 10, Excellent, (1146)
"such clean rooms & wonderful staff they are very helpful felt so comfortable in my stay!"
United States
heidi
The price is ฿2,273
฿2,675 total
includes taxes & fees
25 Jan - 26 Jan 2026
FOUND Hotel Carlton, Nob Hill
Suite, Multiple Beds (The Two Bedroom) | Egyptian cotton sheets, premium bedding, pillow-top beds, minibar
Palihotel San Francisco

Palihotel San Francisco

Palihotel San Francisco
3.5 star property
Union Square, 2.7 km from UCSF Mission Bay
8.4 out of 10, Very good, (632)
"Great vibe here and the rooms and so cute . Excellent bar and bar staff . "
United States
Lana
The price is ฿3,323
฿4,703 total
includes taxes & fees
3 Jan - 4 Jan 2026
Palihotel San Francisco
Corner Queen Room | Hypo-allergenic bedding, in-room safe, laptop workspace
YOTEL San Francisco

YOTEL San Francisco

YOTEL San Francisco
3.0 star property
2.2 km from UCSF Mission Bay
8.2 out of 10, Very good, (1001)
"My room was clean, the staff is great and the amenities are great as well "
United States
Edwin
The price is ฿2,394
฿4,122 total
includes taxes & fees
4 Jan - 5 Jan 2026
YOTEL San Francisco
Meeting facility
The Barnes San Francisco, Tapestry Collection by Hilton

The Barnes San Francisco, Tapestry Collection by Hilton

The Barnes San Francisco, Tapestry Collection by Hilton
4.0 star property
Union Square, 2.4 km from UCSF Mission Bay
8.2 out of 10, Very good, (782)
"Wonderful Stay, Room was Clean. Close to Union Square. Would Stay Here again. "
United States
Raquel
The price is ฿4,399
฿5,178 total
includes taxes & fees
8 Jan - 9 Jan 2026
The Barnes San Francisco, Tapestry Collection by Hilton
Property amenity
The Urban

The Urban

The Urban
2.5 star property
Union Square, 2.7 km from UCSF Mission Bay
8.0 out of 10, Very good, (917)
"Clean, quiet and staff very polite. Had a really good stay."
United States
Pranita
The price is ฿1,877
฿2,209 total
includes taxes & fees
7 Jan - 8 Jan 2026
The Urban
Free daily continental breakfast
Hotel Garrett

Hotel Garrett

Hotel Garrett
3.0 star property
South of Market, 2 km from UCSF Mission Bay
7.8 out of 10, Good, (719)
"Great staff and clean room. "
United States
Colleen Sue
Hotel Garrett
Fireplace
Amsterdam Hostel

Amsterdam Hostel

Amsterdam Hostel
2.0 star property
2.9 km from UCSF Mission Bay
7.8 out of 10, Good, (202)
"Clean, walkable and quiet hostel with plenty of food within walking distance."
United States
Daniel
The price is ฿1,767
฿2,076 total
includes taxes & fees
25 Jan - 26 Jan 2026
Amsterdam Hostel
Shared kitchen
Hayes Valley Inn

Hayes Valley Inn

Hayes Valley Inn
2.0 star property
2.9 km from UCSF Mission Bay
7.8 out of 10, Good, (318)
"Basic accommodation but clean and in a good area"
United Kingdom
Daniel
The price is ฿2,405
฿2,798 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hayes Valley Inn
Lobby lounge
Kasa La Monarca San Francisco

Kasa La Monarca San Francisco

Kasa La Monarca San Francisco
3.5 star property
2.8 km from UCSF Mission Bay
7.8 out of 10, Good, (184)
"Completely contactless service which allows a calmer experience."
United States
Sicily
Kasa La Monarca San Francisco
Desk, laptop workspace, iron/ironing board, free WiFi
Bay Bridge Inn

Bay Bridge Inn

Bay Bridge Inn
2.0 star property
South of Market, 1.4 km from UCSF Mission Bay
7.6 out of 10, Good, (1005)
"Easy and affordable "
United States
Justin
Bay Bridge Inn
Lobby
Orange Village Hostel

Orange Village Hostel

Orange Village Hostel
1.5 star property
2.6 km from UCSF Mission Bay
7.4 out of 10, Good, (989)
"Some of the best staff Ive encountered in hostels. Very friendly overall atmosphere and vibe. "
United States
Eugene
Orange Village Hostel
Fusion cuisine
Hotel Bijou - Union Square

Hotel Bijou - Union Square

Hotel Bijou - Union Square
4.0 star property
Union Square, 2.3 km from UCSF Mission Bay
7.4 out of 10, Good, (861)
"Room was very clean and quiet. Staff very pleasant and helpful. "
United States
REBECCA
Hotel Bijou - Union Square
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top UCSF Mission Bay Hotel Reviews

Chancellor Hotel on Union Square

Chancellor Hotel on Union Square

10/10 Excellent
"Excellent service and comfort."
Nestor 1-night trip
Posted 2 days ago
Chancellor Hotel on Union Square

Hotels near other UCSF Mission Bay attractions

Chase Center San Francisco Skyline Aerial Photography

Chase Center

Catch an event at Chase Center during your trip to San Francisco. Amble around this vibrant area's Chinatown or experience its entertainment choices.
See properties
Anchor Brewing Company

Anchor Brewing Company

During your trip to San Francisco, you can do some window-shopping at Anchor Brewing Company. Discover the top-notch restaurants and acclaimed art galleries in this vibrant area.
See properties

Frequently asked questions

What's the area like around UCSF Mission Bay?
UCSF Mission Bay is located in a vibrant area of San Francisco known for its top museums and stunning architecture. If you're looking for a convenient place to stay, take a look at the 85 hotels and other accommodation options you'll find within a mile.
What's the best place to stay near UCSF Mission Bay?
Hyatt Place San Francisco Downtown is one of the top choices for your stay based on our traveller data, and this hotel offers a bar and free WiFi. It's located just a short 0.7 mi (1.1 km) from UCSF Mission Bay. Other good choices within a short distance include LUMA Hotel San Francisco and Hotel VIA.
How many hotels will I be able to find close to UCSF Mission Bay?
Expedia has 85 hotels and other accommodation options within a mile from UCSF Mission Bay.
If I need to cancel the hotel reservation for my stay near UCSF Mission Bay, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you have a reservation that's non-refundable, you might be able to cancel it and get a refund within a 24-hour period of your booking. Add dates, click "Search", then use the filter option "fully refundable" to view top deals close to UCSF Mission Bay.
What can I see and do near UCSF Mission Bay?
Study the collections at San Francisco Museum of Modern Art, Asian Art Museum of San Francisco or Market Street Railway Museum. Sights like San Francisco Mint, 450 Sutter Building and Ferry Building are landmarks to visit in the area. You can check out the local talent at Golden Gate Theatre, Warfield Theatre and Orpheum Theatre.
How can I get to UCSF Mission Bay?
With so many choices for transport, seeing all of the area near UCSF Mission Bay is simple. You can access metro transport at Market St & 5th St Stop, Market St & Taylor St Stop and Powell St & Market St Stop. If you're hopping a train into the city, San Francisco Station is the closest station to Downtown San Francisco.