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Our top choices for St. Louis Science Center hotels

Exterior
Hampton Inn & Suites St. Louis at Forest Park

Hampton Inn & Suites St. Louis at Forest Park

Hampton Inn & Suites St. Louis at Forest Park
2.5 star property
Dogtown, 1 km from St. Louis Science Center
9.4 out of 10, Exceptional, (1004)
"The staff was so friendly and made our stay enjoyable. "
United States
Tracy
The price is ฿3,580
฿4,222 total
includes taxes & fees
29 Dec - 30 Dec
Hampton Inn & Suites St. Louis at Forest Park
Lobby
Drury Inn & Suites St. Louis Forest Park

Drury Inn & Suites St. Louis Forest Park

Drury Inn & Suites St. Louis Forest Park
3.0 star property
2 km from St. Louis Science Center
9.4 out of 10, Exceptional, (1006)
"Very clean room and great breakfast/dinner and snacks options. "
United States
Megan
The price is ฿3,612
฿4,223 total
includes taxes & fees
25 Dec - 26 Dec
Drury Inn & Suites St. Louis Forest Park
Lobby
AC Hotel St. Louis Central West End

AC Hotel St. Louis Central West End

AC Hotel St. Louis Central West End
4.0 star property
Central West End, 1.8 km from St. Louis Science Center
9.0 out of 10, Wonderful, (684)
"Clean room, Helpful staff, Easy/cheap parking "
United States
Delaney
The price is ฿3,989
฿4,704 total
includes taxes & fees
26 Dec - 27 Dec
AC Hotel St. Louis Central West End
Seasonal outdoor pool
The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis
4.5 star property
Central West End, 1.8 km from St. Louis Science Center
9.0 out of 10, Wonderful, (1001)
"Always, a great time and place to stay."
United States
Lubna
The price is ฿4,743
฿6,519 total
includes taxes & fees
18 Jan - 19 Jan 2026
The Royal Sonesta Chase Park Plaza St. Louis
Dining room
Home2 Suites by Hilton St. Louis/Forest Park

Home2 Suites by Hilton St. Louis/Forest Park

Home2 Suites by Hilton St. Louis/Forest Park
3.0 star property
The Grove, 0.9 km from St. Louis Science Center
8.6 out of 10, Excellent, (1002)
"Nice hotel. Very nice breakfast"
United States
Amir
The price is ฿3,580
฿4,186 total
includes taxes & fees
4 Jan - 5 Jan 2026
Home2 Suites by Hilton St. Louis/Forest Park
Courtyard
Element St. Louis Midtown

Element St. Louis Midtown

Element St. Louis Midtown
3.0 star property
Midtown, 2.7 km from St. Louis Science Center
9.0 out of 10, Wonderful, (646)
"Everything was excellent. The staff were very friendly and helpful. The accommodations were excellent and it was a great location near every where we were going."
United States
Angela
The price is ฿4,114
฿4,811 total
includes taxes & fees
28 Dec - 29 Dec
Element St. Louis Midtown
Property amenity
Aloft St. Louis Cortex

Aloft St. Louis Cortex

Aloft St. Louis Cortex
3.0 star property
Central West End, 1.8 km from St. Louis Science Center
8.6 out of 10, Excellent, (831)
"Great Stay "
United States
Brandon Russell
The price is ฿3,444
฿4,027 total
includes taxes & fees
25 Dec - 26 Dec
Aloft St. Louis Cortex
In-room safe, desk, blackout curtains, iron/ironing board
DoubleTree by Hilton St. Louis Forest Park

DoubleTree by Hilton St. Louis Forest Park

DoubleTree by Hilton St. Louis Forest Park
4.0 star property
Central West End, 1.3 km from St. Louis Science Center
8.2 out of 10, Very good, (1006)
"The guy at check in was super nice. What I love the most is they give you freshly baked scrumptious oatmeal chocolate chip cookies (that melt in your mouth) throughout your stay. "
United States
Gloria
The price is ฿3,297
฿3,888 total
includes taxes & fees
15 Jan - 16 Jan 2026
DoubleTree by Hilton St. Louis Forest Park
Terrace/patio
The West End

The West End

The West End
2.0 star property
Central West End, 2.3 km from St. Louis Science Center
8.4 out of 10, Very good, (406)
"Great stay!"
United States
Shaniqua
The price is ฿2,194
฿3,162 total
includes taxes & fees
6 Jan - 7 Jan 2026
The West End
Restaurant
Hotel Indigo St Louis - Central West End by IHG

Hotel Indigo St Louis - Central West End by IHG

Hotel Indigo St Louis - Central West End by IHG
3.5 star property
Central West End, 1.7 km from St. Louis Science Center
8.2 out of 10, Very good, (1003)
"Very friendly staff. Clean modern hotel room with comfortable bed and spacious shower! "
United States
Courtney
The price is ฿3,643
฿4,641 total
includes taxes & fees
19 Jan - 20 Jan 2026
Hotel Indigo St Louis - Central West End by IHG
Comfort Apartment | Individually decorated, individually furnished, desk, laptop workspace
White House at Grand Central

White House at Grand Central

White House at Grand Central
4.0 star property
3 km from St. Louis Science Center
8.6 out of 10, Excellent, (124)
"Very clean and very friendly people "
United States
Mary
The price is ฿2,042
฿4,408 total
includes taxes & fees
19 Jan - 20 Jan 2026
White House at Grand Central
Lobby sitting area
Forest Park Hotel by MDR

Forest Park Hotel by MDR

Forest Park Hotel by MDR
3.0 star property
The Hill, 1.9 km from St. Louis Science Center
7.6 out of 10, Good, (1276)
"location attentive staff large king room"
United States
Stephen
Forest Park Hotel by MDR
(Lil Dynasty) No Private Bathroom | Premium bedding, iron/ironing board, free WiFi, bed sheets
Central West End B&B

Central West End B&B

Central West End B&B
3.5 star property
Central West End, 3 km from St. Louis Science Center
7.8 out of 10, Good, (53)
"Really enjoyed the comfort. I would recommend this place to anyone. Very nice breakfast also!!! "
United States
Stacee
The price is ฿5,171
฿6,505 total
includes taxes & fees
22 Dec - 23 Dec
Central West End B&B
Lobby
Red Roof Inn PLUS+ St Louis - Forest Park/ Hampton Ave 

Red Roof Inn PLUS+ St Louis - Forest Park/ Hampton Ave 

Red Roof Inn PLUS+ St Louis - Forest Park/ Hampton Ave 
2.5 star property
The Hill, 1.8 km from St. Louis Science Center
5.8 out of 10, (1002)
"Needs remodeling and new furniture "
United States
antwon
The price is ฿2,357
฿2,756 total
includes taxes & fees
25 Dec - 26 Dec
Red Roof Inn PLUS+ St Louis - Forest Park/ Hampton Ave 
Front of property
Grand Center Inn

Grand Center Inn

Grand Center Inn
3.0 star property
3.5 km from St. Louis Science Center
9.4 out of 10, Exceptional, (72)
"Great! "
United States
mike
The price is ฿5,622
฿6,630 total
includes taxes & fees
22 Dec - 23 Dec
Grand Center Inn
Pub
The Knight Center at Washington University

The Knight Center at Washington University

The Knight Center at Washington University
2.5 star property
4.3 km from St. Louis Science Center
9.4 out of 10, Exceptional, (447)
"Awesome place to stay!"
United States
james
The price is ฿3,978
฿4,574 total
includes taxes & fees
3 Jan - 4 Jan 2026
The Knight Center at Washington University
Exterior
Moonrise Hotel

Moonrise Hotel

Moonrise Hotel
4.0 star property
3.8 km from St. Louis Science Center
9.0 out of 10, Wonderful, (1917)
"Clean rooms, good coffee and fresh muffins and friendly service."
United States
Colleen
The price is ฿3,538
฿4,208 total
includes taxes & fees
24 Dec - 25 Dec
Moonrise Hotel
Terrace/patio
Courtyard by Marriott St. Louis Brentwood

Courtyard by Marriott St. Louis Brentwood

Courtyard by Marriott St. Louis Brentwood
3.0 star property
5.5 km from St. Louis Science Center
9.4 out of 10, Exceptional, (838)
"Clean, would stay again."
United States
Eryka
The price is ฿3,177
฿3,897 total
includes taxes & fees
22 Dec - 23 Dec
Courtyard by Marriott St. Louis Brentwood
Indoor pool
Drury Inn & Suites St. Louis Union Station

Drury Inn & Suites St. Louis Union Station

Drury Inn & Suites St. Louis Union Station
3.0 star property
Downtown West, 5.3 km from St. Louis Science Center
9.4 out of 10, Exceptional, (1300)
"Nice hotel"
United States
Vivian
The price is ฿3,737
฿4,445 total
includes taxes & fees
25 Dec - 26 Dec
Drury Inn & Suites St. Louis Union Station
Hallway
Benton Park Inn

Benton Park Inn

Benton Park Inn
3.5 star property
Benton Park, 5.5 km from St. Louis Science Center
9.6 out of 10, Exceptional, (313)
"Great place, great host!"
United States
Andrew
The price is ฿4,366
฿5,105 total
includes taxes & fees
30 Dec - 31 Dec
Benton Park Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top St. Louis Science Center Hotel Reviews

The Cheshire

The Cheshire

10/10 Excellent
"Great staff and love The Fox and Hounds Tavern. Great complimentary breakfast. "
John 1-night trip
Posted 1 day ago
The Cheshire

Hotels near other St. Louis Science Center attractions

Forest Park

Jewel Box

Made of stacked glass in a restored art deco style, this glass house from the 1930s continues to flourish with tropical trees, hanging plants and a large fountain.
See properties
Grand Basin looking from top of Art Hill in Forest Park, St. Louis, Missouri

Forest Park

4.6/5 (2,094 reviews)
Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit.
See properties

Frequently asked questions

What's the area like around St. Louis Science Center?
St. Louis Science Center is located in a welcoming area of St. Louis known for its picturesque gardens and sporting events. If you're looking for a convenient place to stay, take a look at the 69 hotels and other accommodation options you'll find within a mile.
What's the best hotel to stay near St. Louis Science Center?
Hampton Inn & Suites St. Louis at Forest Park is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and an indoor pool. It's located just a short 0.6 mi (1 km) from St. Louis Science Center. Other good choices within a short distance include DoubleTree by Hilton St. Louis Forest Park and Home2 Suites by Hilton St. Louis/Forest Park.
How many hotels should I expect to find close to St. Louis Science Center?
Expedia has 69 hotels and other accommodation options within a mile from St. Louis Science Center.
If I need to cancel the hotel reservation for my stay near St. Louis Science Center, will I receive a refund?
Yes, most hotel room reservations are refundable if you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best deals near St. Louis Science Center.
What can I see and do near St. Louis Science Center?
Cathedral Basilica of St. Louis, St. Louis Art Museum and City Museum feature captivating exhibits. St. Louis Union Station, Jewel Box and Cherokee Street are monuments to see when you're exploring the area around St. Louis Science Center. You can check out the local talent at The Muny Theater, Fox Theater and St. Louis Symphony Orchestra.