Search Hotels in South Central Houston, Houston

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Our top choices for South Central Houston hotels

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
South Central Houston
8.4 out of 10, Very good, (1,964 reviews)
"Great stay and clean room"
United States
Ethel
The price is ฿4,259
฿5,021 total
includes taxes & fees
4 Jul - 5 Jul
Hilton Houston Plaza/Medical Center

Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown
2.0 star property
South Central Houston
9.2 out of 10, Wonderful, (176 reviews)
"Great place. The staff is very friendly and the place is clean."
United States
Fernando
The price is ฿3,164
฿3,702 total
includes taxes & fees
30 Jun - 1 Jul
Downtowner Inns - Houston Downtown

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,161 reviews)
"The best hotel! Location/ pool/ fitness/ comfortable beds: beautiful views"
United States
Jennifer Noel
The price is ฿4,466
฿5,559 total
includes taxes & fees
5 Jul - 6 Jul
The Westin Houston Medical Center/Museum District

Sentral Forme Houston

Sentral Forme Houston
4.5 star property
South Central Houston
8.8 out of 10, Excellent, (57 reviews)
"Amazing stay!!"
Canada
Elizabeth
The price is ฿5,622
฿7,551 total
includes taxes & fees
7 Jul - 8 Jul
Sentral Forme Houston

Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District
4.0 star property
South Central Houston
9.0 out of 10, Wonderful, (1,001 reviews)
"This hotel has incredible staff"
United States
Susanne
The price is ฿4,761
฿6,630 total
includes taxes & fees
24 Jul - 25 Jul
Houston Marriott Medical Center/Museum District

Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown
2.0 star property
South Central Houston
8.0 out of 10, Very good, (1,003 reviews)
"Great AC, Clean room, would stay again"
United States
Haylie
The price is ฿3,263
฿3,818 total
includes taxes & fees
7 Jul - 8 Jul
Americas Best Value Inn Medical Center Downtown

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.2 out of 10, Wonderful, (1,000 reviews)
"Great place to stay"
United States
Gayathry
The price is ฿7,705
฿10,553 total
includes taxes & fees
6 Jul - 7 Jul
Hotel Zaza Houston Museum District

Affordable Houston Stay Near Fifa Events

Affordable Houston Stay Near Fifa Events
2.0 star property
South Central Houston
The price is ฿1,942
฿17,414 total
includes taxes & fees
25 Jun - 26 Jun
Affordable Houston Stay Near Fifa Events

InterContinental Houston by IHG

InterContinental Houston by IHG
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,000 reviews)
"Was a over great place to stay"
United States
Danny
The price is ฿5,489
฿7,088 total
includes taxes & fees
6 Jul - 7 Jul
InterContinental Houston by IHG

Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl
2.5 star property
South Central Houston
5.8 out of 10, (1,009 reviews)
"Love the pet friendly property"
United States
Nelda
The price is ฿2,694
฿3,162 total
includes taxes & fees
8 Jul - 9 Jul
Extended Stay America Suites Houston Med Ctr Braeswood Bl

DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites
4.0 star property
South Central Houston
8.4 out of 10, Very good, (612 reviews)
"was ok"
United States
Guillermo
The price is ฿4,073
฿4,765 total
includes taxes & fees
5 Jul - 6 Jul
DoubleTree by Hilton Houston Medical Center Hotel & Suites

Golden Motel Near Houston Medical Center

Golden Motel Near Houston Medical Center
2.5 star property
South Central Houston
2.0 out of 10, (4 reviews)
"Room smelt like cigarettes burnt wholes in the wall and bed sheet all 6 walls had stains toilet seat look like someone stood on it "
United States
Jacari
The price is ฿2,142
฿2,721 total
includes taxes & fees
7 Jul - 8 Jul
Golden Motel Near Houston Medical Center

Cozy 2BR Near NRG & Downtown FIFA World Cup

Cozy 2BR Near NRG & Downtown FIFA World Cup
3.0 star property
South Central Houston
The price is ฿3,869
฿10,199 total
includes taxes & fees
25 Jun - 26 Jun
Cozy 2BR Near NRG & Downtown FIFA World Cup

Walkable Eado Condo Near Dtwn: Modern + Chic!

Walkable Eado Condo Near Dtwn: Modern + Chic!
3.0 star property
South Central Houston
The price is ฿3,160
฿13,422 total
includes taxes & fees
8 Jul - 9 Jul
Walkable Eado Condo Near Dtwn: Modern + Chic!

Hilton University of Houston

Hilton University of Houston
3.5 star property
South Central Houston
9.0 out of 10, Wonderful, (951 reviews)
"The hotel was clean, staff were friendly and the location was perfect for our event. I will definitely stay there again. "
United States
Ricardo
The price is ฿4,797
฿5,612 total
includes taxes & fees
7 Jul - 8 Jul
Hilton University of Houston

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
South Central Houston
9.6 out of 10, Exceptional, (214 reviews)
"Beautiful place and wonderful management. Would definitely stay again! "
United States
Shelly
The price is ฿6,823
฿8,477 total
includes taxes & fees
7 Jul - 8 Jul
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Southmore Boulevard Motel

Southmore Boulevard Motel
2.0 star property
South Central Houston
5.6 out of 10, (241 reviews)
"I enjoyed my stay at this hotel."
United States
Tamela
The price is ฿2,395
฿2,803 total
includes taxes & fees
30 Jun - 1 Jul
Southmore Boulevard Motel

Houston Hideaway Near Dwntwn and City Attractions

Houston Hideaway Near Dwntwn and City Attractions
2.0 star property
South Central Houston
The price is ฿2,313
฿16,931 total
includes taxes & fees
14 Jul - 15 Jul
Houston Hideaway Near Dwntwn and City Attractions

La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B
3.5 star property
South Central Houston
9.8 out of 10, Exceptional, (582 reviews)
"Beautiful stay with wonderful hosts! Highly recommended!"
Canada
CEDRIC AUGUSTINE DE
The price is ฿5,900
฿6,903 total
includes taxes & fees
7 Jul - 8 Jul
La Maison in Midtown an urban B&B

Luxury Med Center Fully Equipped King Sized Bed Condos

Luxury Med Center Fully Equipped King Sized Bed Condos
4.0 star property
South Central Houston
8.4 out of 10, Very good, (92 reviews)
"Facility was nice. DRIFTRS, the management company, is really bad. We were there for 4 days. Upon arrival we noticed no toilet paper and half the light bulbs burned out. The place was so dark I needed a flashlight to use the kitchen. We reported these issues immediately. They told us to use kitchen paper towels as toilet paper and did not respond to all the burned out light bulbs. We woke up every morning with the apartment hot and stuffy. The NEST thermostat is programmed to continually...
United States
Gordon
The price is ฿4,646
฿8,596 total
includes taxes & fees
30 Jun - 1 Jul
Luxury Med Center Fully Equipped King Sized Bed Condos
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in South Central Houston

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Exterior
La Maison in Midtown an urban B&B
3.5 star property
9.8
Exceptional
582 reviews
View
Laptop workspace, blackout curtains, soundproofing, iron/ironing board
Downtowner Inns - Houston Downtown
2.0 star property
9.2
Wonderful
176 reviews
View
Outdoor pool, free pool cabanas, pool umbrellas
The Westin Houston Medical Center/Museum District
4.0 star property
9.2
Wonderful
1,161 reviews
View
Outdoor pool
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
9.6
Exceptional
214 reviews
View
Premium bedding, pillow-top beds, minibar, in-room safe
Hotel Zaza Houston Museum District
4.5 star property
9.2
Wonderful
1,000 reviews
View

Where to stay in South Central Houston

Find the best South Central Houston areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Gerald D. Hines Waterwall Park.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Top South Central Houston Hotel Reviews

Frequently asked questions

What's it like in South Central Houston?
Travellers are sure to enjoy a stay in Houston's South Central Houston neighbourhood. Make sure that you visit TDECU Stadium and Fertitta Center as part of your South Central Houston travel plans.
What's the best accommodation in South Central Houston?
Based on our traveller data, Hilton Houston Plaza/Medical Center is one of the top choices for your stay in South Central Houston. This hotel is a short 9-minute walk from MD Anderson Cancer Center, and it offers 2 restaurants and 2 bars. Other good options for your stay in the area include Hotel Zaza Houston Museum District and InterContinental Houston by IHG.
How many hotels can I expect to find in the South Central Houston area?
Expedia has 1211 hotels and other accommodation options in South Central Houston to choose from, making this an ideal home base for exploring the greater Houston area.
If I need to cancel my hotel reservation in South Central Houston, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals available in South Central Houston.
What is there to do around this Houston neighbourhood?
Spend some time exploring the great outdoors at Hermann Park, James Turrell's Twilight Epiphany Skyscape and Cullen Sculpture Garden. TDECU Stadium and Fertitta Center are some other stops worth a visit in the neighbourhood. Toyota Center and Daikin Park are some popular places to visit in the area around South Central Houston. Shape Community Center and Project Row Houses are also worth a visit when you're out sightseeing in Houston.
How can I get around South Central Houston and the greater Houston area?
For a quick way to explore the city, catch a ride on metro transit at Elgin/Third Ward Station, TSU/UH Athletics District Station or Ensemble/HCC Station. If you want to venture out of town, M. D. Anderson Station is the closest train station. You can also catch a ride at Kinder Station.